Ploidy as a prognostic factor in ovarian cancer.

Friedlander ML, Taylor IW, Russell P, Musgrove EA, Hedley DW, Tattersall MH
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 1983 · doi:10.1097/00004347-198301000-00005 · PMID:6307906
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Flow cytometry analysis of 50 ovarian carcinomas revealed that aneuploidy correlates with advanced FIGO stage and higher S-phase fraction, suggesting DNA content reflects tumor behavior despite limited follow-up.

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This study analyzed the cellular DNA content of 50 ovarian common epithelial carcinomas using flow cytometry to classify tumors as diploid or aneuploid. The researchers found a significant association between tumor stage and ploidy, with all diploid tumors occurring in early stages while late-stage tumors were exclusively aneuploid. Additionally, aneuploid tumors exhibited a significantly higher proportion of S-phase cells compared to diploid tumors, indicating greater cellular proliferation, although no relationship was observed with histological grading due to limited sample size and follow-up. This paper is not centrally about endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

The cellular DNA content of 50 ovarian common epithelial carcinomas was determined by flow cytometry, and tumours were classified as being either diploid or aneuploid. A significant association between tumour stage and ploidy was demonstrated, with all diploid tumours being of an early stage (p less than 0.001). Forty percent of early-stage tumours (FIGO stages I and II) and all late-stage tumours (FIGO stages III and IV) were aneuploid. This heterogeneity with respect to DNA content among tumours of a similar stage may allow the identification of neoplasms with a different natural history. The proportion of S-phase cells determined by flow cytometry is a measure of cellular proliferation and may also be of prognostic significance. Diploid tumours had a median S phase of 9.8% (2.4-14.1%), while aneuploid tumours had a significantly higher S phase of 19.6% (7-24.7%; p less than 0.05). In this study there was no relationship between histological grading of invasive carcinomas and ploidy, but in view of the relatively small numbers and limited follow-up, it was not possible to perform a multivariate analysis of all known prognostic factors in ovarian cancer. Our results suggest that ploidy reflects tumour behaviour, but prolonged follow-up and increased patient accrual is necessary to assess whether the flow cytometric analysis of DNA content will provide clinically important information in ovarian cancer.
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Ploidy as a Prognostic Factor in Ovarian Cancer - M. L. Friedlander - I. W. Taylor - P. Russell - E. A. Musgrove - D. H. Hedley - M. H. N. Tattersall Summary The cellular DNA content of 50 ovarian common epithelial carcinomas was determined by flow cytometry, and tumours were classified as being either diploid or aneuploid. A significant association between tumour stage and ploidy was demonstrated, with all diploid tumours being of an early stage (p < 0.001). Forty percent of early-stage tumours (FIGO stages I and II) and all late-stage tumours (FIGO stages III and IV) were aneuploid. This heterogeneity with respect to DNA content among tumours of a similar stage may allow the identification of neoplasms with a different natural history. The proportion of S-phase cells determined by flow cytometry is a measure of cellular proliferation and may also be of prognostic significance. Diploid tumours had a median S phase of 9.8% (2.4–14.1%), while aneuploid tumours had a significantly higher S phase of 19.6% (7–24.7%; p < 0.05). In this study there was no relationship between histological grading of invasive carcinomas and ploidy, but in view of the relatively small numbers and limited follow-up, it was_not possible to perform a multivariate analysis of all known prognostic factors in ovarian cancer. Our results suggest that ploidy reflects tumour behaviour, but prolonged follow-up and increased patient accrual is necessary to assess whether the flow cytometric analysis of DNA content will provide clinically important information in ovarian cancer.

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