Surgery, gonadotropin-releasing hormone agonist downregulation and in vitro fertilisation in women with infertility and endometriomas.

Sara Johanna Bergenheim; Sara J Bergenheim; Signe Perlman; Marie Louise Vc Banner-Voigt; Tórur Dalsgaard; Torur Dalsgaard; Anette T Pedersen; Anette Tønnes Pedersen; A Nyboe Andersen; Anja Pinborg; Kristine Løssl

Surgery, gonadotropin-releasing hormone agonist downregulation and in vitro fertilisation in women with infertility and endometriomas.

Sara Johanna Bergenheim, Sara J Bergenheim, Signe Perlman, Marie Louise Vc Banner-Voigt, Tórur Dalsgaard, Torur Dalsgaard, Anette T Pedersen, Anette Tønnes Pedersen, A Nyboe Andersen, Anja Pinborg, Kristine Løssl

Danish medical journal · 2020 · vol. 67(9) · PMID:32800068 · W3081387521

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This study found that the rate of registered post-tonsillectomy hemorrhage increased significantly between 1991 and 2012, particularly in males aged 20-40, with the highest risk occurring on the day of surgery and six days later.

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This nationwide retrospective registry-based cohort study in Denmark examined tonsillectomies from 1991 to 2012 that were complicated by post-tonsillectomy haemorrhaging (PTH), assessing incidence trends and risk factors using hospital and private ORL data. Among 177,211 tonsillectomies, 9,221 had a registered PTH (5.2%), with the annual incidence of registered PTH increasing from 3% in 1991 to 13% in 2012, and males aged 20–40 years showing a significantly higher risk and a marked rise over time. About 12% had primary haemorrhage within 24 hours, and the maximum incidence occurred on day six (14%). The paper’s major limitation is that it relies on registry-registered haemorrhage data without detailing clinical adjudication or potential under/over-registration; however, it was approved by the Danish Data Protection Agency. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

INTRODUCTION: Tonsillectomy is one of the most common procedures in the field of ear, nose and throat procedures. In 2012, the annual incidence in Denmark was 129.4 per 100,000 inhabitants. A common complication is post-tonsillectomy haemorrhaging (PTH). The overall PTH rates vary widely among studies ranging from 0.5% to 33%. METHODS: This was a nationwide open-population, retrospective and registry-based cohort study in Danes who underwent tonsillectomy complicated by PTH in hospitals and private otorhinolaryngology (ORL) offices in the period from 1991 to 2012. RESULTS: In the 1991-2012 period, a total of 177,211 tonsillectomies were performed among which 9,221 had a registered PTH (rPTH) (5.2%). The annual incidence rate of rPTH increased from 3% in 1991 to 13% in 2012 (p less-than 0.05). Males aged 20-40 years had a significantly higher risk of rPTH with the highest increase in rPTH incidence rates from 9.0% in 1998 to 16.4% in 2012 (p less-than 0.05). Approx. 12% had a primary rPTH within the first 24 hours; the maximum incidence of rPTH was on day six (14%). CONCLUSIONS: The rate of rPTH increased from 1991 to 2012 in hospitals and in private ORL office settings alike. There was a significantly higher rate of rPTH in the age group of 20-40 years and a significant geographical difference in rPTH. The highest risk of rPTH was observed on the day of surgery and on day six. TRIAL REGISTRATION: The Danish Data Protection Agency (record number 2012-41-0158) approved this study. FUNDING: The Olga Bryde Nielsen Foundation and H. Skouby & E. Skouby's Foundation supported this study financially.

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Abstract

Methods

This was a nationwide open-population, retrospective and registry-based cohort study in Danes who underwent tonsillectomy complicated by PTH in hospitals and private otorhinolaryngology (ORL) offices in the period from 1991 to 2012.

Results

In the 1991-2012 period, a total of 177,211 tonsillectomies were performed among which 9,221 had a registered PTH (rPTH) (5.2%). The annual incidence rate of rPTH increased from 3% in 1991 to 13% in 2012 (p less-than 0.05). Males aged 20-40 years had a significantly higher risk of rPTH with the highest increase in rPTH incidence rates from 9.0% in 1998 to 16.4% in 2012 (p less-than 0.05). Approx. 12% had a primary rPTH within the first 24 hours; the maximum incidence of rPTH was on day six (14%).

Conclusions

The rate of rPTH increased from 1991 to 2012 in hospitals and in private ORL office settings alike. There was a significantly higher rate of rPTH in the age group of 20-40 years and a significant geographical difference in rPTH. The highest risk of rPTH was observed on the day of surgery and on day six. TRIAL REGISTRATION: The Danish Data Protection Agency (record number 2012-41-0158) approved this study. FUNDING: The Olga Bryde Nielsen Foundation and H. Skouby & E. Skouby's Foundation supported this study financially. | Originalsprog | Engelsk | |---|---| | Artikelnummer | A10190605 | | Tidsskrift | Danish Medical Journal | | Vol/bind | 67 | | Udgave nummer | 9 | | Antal sider | 11 | | ISSN | 1603-9629 | | Status | Udgivet - 2020 | Bibliografisk note Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.Citationsformater - APA - Standard - Harvard - Vancouver - Author - BIBTEX - RIS

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Fertilization in Vitro Gonadotropin-Releasing Hormone Gynecologic Surgical Procedures Infertility, Female Adult Birth Rate Combined Modality Therapy Denmark Denmark Down-Regulation Endometriosis Endometriosis Female Fertilization in Vitro Gonadotropin-Releasing Hormone Gynecologic Surgical Procedures Humans Infertility, Female Infertility, Female

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