Brown Umbilical Nodule: A Case of Primary Cutaneous Endometriosis

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This case report describes primary cutaneous endometriosis presenting as a painful, hemorrhagic umbilical nodule in a 41-year-old woman without prior surgical history or endometriosis.

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This case report describes a 41-year-old woman presenting with a painful, hemorrhagic brown umbilical nodule who had no history of endometriosis or prior abdominal surgeries. A shave biopsy confirmed the diagnosis of primary cutaneous endometriosis, a rare condition where endometrial tissue implants in the skin without a clear etiology or surgical cause. The authors note that while secondary cutaneous endometriosis typically arises from iatrogenic implantation during abdominal operations, this instance developed spontaneously, highlighting the need to consider this diagnosis in the differential for similar skin nodules. This paper is centrally about endometriosis — specifically the presentation and diagnosis of primary cutaneous endometriosis at the umbilicus.

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Abstract

BACKGROUND: Endometriosis is a common condition in which endometrial glands and stroma are implanted outside the uterine cavity. Rarely, the skin can be involved. CASE PRESENTATION: We describe a case of a 41-year-old woman who presented to the dermatology clinic complaining of a brown umbilical nodule with slight erythema. It was occasionally painful and hemorrhagic. She denied a history of endometriosis and abdominal surgeries. A shave biopsy of the nodule was consistent with a diagnosis of cutaneous endometriosis. The patient was referred to her gynecologist for further evaluation and treatment. CONCLUSION: This unique case demonstrates primary cutaneous endometriosis in the umbilicus of a female patient. Cutaneous endometriosis can be classified as primary or secondary. Primary cutaneous endometriosis is rarer and has an unclear etiology, developing seemingly spontaneously without history of surgical interventions. Secondary cutaneous endometriosis typically arises within surgical scars following abdominal operations, which is believed to be a result of iatrogenic implantation of endometrial cells. Definitive treatment involves surgery. This case highlights the importance of considering cutaneous endometriosis in the differential diagnosis of a female patient with painful and intermittently hemorrhagic skin nodules.
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Keywords

endometriosis; cutaneous endometriosis; umbilicus; umbilical nodule; case reports Disciplines Dermatology | Obstetrics and Gynecology | Pathology

Abstract

Background Endometriosis is a common condition in which endometrial glands and stroma are implanted outside the uterine cavity. Rarely, the skin can be involved. Case Presentation We describe a case of a 41-year-old woman who presented to the dermatology clinic complaining of a brown umbilical nodule with slight erythema. It was occasionally painful and hemorrhagic. She denied a history of endometriosis and abdominal surgeries. A shave biopsy of the nodule was consistent with a diagnosis of cutaneous endometriosis. The patient was referred to her gynecologist for further evaluation and treatment.

Conclusion

This unique case demonstrates primary cutaneous endometriosis in the umbilicus of a female patient. Cutaneous endometriosis can be classified as primary or secondary. Primary cutaneous endometriosis is rarer and has an unclear etiology, developing seemingly spontaneously without history of surgical interventions. Secondary cutaneous endometriosis typically arises within surgical scars following abdominal operations, which is believed to be a result of iatrogenic implantation of endometrial cells. Definitive treatment involves surgery. This case highlights the importance of considering cutaneous endometriosis in the differential diagnosis of a female patient with painful and intermittently hemorrhagic skin nodules. Recommended Citation Bindernagel, Richard G. Jr.; Boccardi, Aleia; Jindia, Taylor C.; Patel, Parth; Bryan, Jaimie; Walker, Addie; Moon, Summer; and Miller, Richard (2025) "Brown Umbilical Nodule: A Case of Primary Cutaneous Endometriosis," HCA Healthcare Journal of Medicine: Vol. 6: Iss. 4, Article 11. DOI: 10.36518/2689-0216.1974 Available at: https://scholarlycommons.hcahealthcare.com/hcahealthcarejournal/vol6/iss4/11

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endometriosis

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