Cancer Immunotherapy Based on Carbon-Quantum-Dots

Cancer Immunotherapy Based on Carbon-Quantum-Dots | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Cancer Immunotherapy Based on Carbon-Quantum-Dots Tao Liang, Josh Haipeng Lei, Jinsong Tao, Sen Guo, Hanlu Gao, and 18 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-457550/v2 This work is licensed under a CC BY 4.0 License Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Abstract Cancer immunotherapy based on carbon-quantum-dots (CQDs) has proven effective. The CQDs composited cancer cell (CM-cancer) exhibit robust customized immunogenicity, which can recruit macrophages and dendritic cells to effectively deliver the cancer antigens into lymph nodes to activate CD8+ T cells, and eventually leads to an anti-cancer immune response all over the body. The CM-cancer is not only able to inhibit primary tumors, but also clearly eliminate metastatic tumors. Our research demonstrates a promising personalized cancer immunotheraputic technology for potential clinical applications. Cancer Biology Carbon Quantum Dots Cancer Immunotherapy Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Full Text Additional Declarations There is NO Competing Interest. Cite Share Download PDF Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-457550","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":23376690,"identity":"bc250cf6-c7e1-4606-9b35-6f7cb638ca2a","order_by":0,"name":"Tao Liang","email":"","orcid":"","institution":"University of Macau","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Tao","middleName":"","lastName":"Liang","suffix":""},{"id":23376691,"identity":"150937e5-3267-4981-804d-30448b07c007","order_by":1,"name":"Josh Haipeng Lei","email":"","orcid":"","institution":"University of 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09:20:33","currentVersionCode":2,"declarations":"","doi":"10.21203/rs.3.rs-457550/v2","doiUrl":"https://doi.org/10.21203/rs.3.rs-457550/v2","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":8569664,"identity":"e77fd316-c282-4b6b-a792-12f66a5c193d","added_by":"auto","created_at":"2021-04-28 21:37:46","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":417101,"visible":true,"origin":"","legend":"Characterization of CQDs. (a) TEM image of CQDs; inset: HRTEM image of a CQD; (b) AFM image of CQDs; inset: height distribution of the CQDs.","description":"","filename":"Fig01.jpg","url":"https://assets-eu.researchsquare.com/files/rs-457550/v2/733f5cf2e004e75659ae755a.jpg"},{"id":8569737,"identity":"16b09fd3-b733-49bf-bd3c-76ecd95d0b46","added_by":"auto","created_at":"2021-04-28 21:40:47","extension":"jpg","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":863529,"visible":true,"origin":"","legend":"CM-cancer induced hyperactivation of MPs and anti-cancer immune response in zebrafish\n model. (a) CLSM images of the MPs, from left to right : after co-incubating with CQDs, H-4T1 and CM-\n 4T1, respectively; (b) MHC-II marked fluorescence intensities (MFI) from the MP cells in different\n treating groups; data were collected using a flow cytometer after the MPs were cultured in vitro with H-\n4T1 (n = 6), CQDs (n = 6) and CM-4T1 (n = 7), respectively, for 24 hr. p \u003c 0.0001 (****). CQDs: 50\n μg/ml, 4T1 cells: 1×107/ml, respectively. Data plotted are mean ± S.E.M; (c) From left to right, CLSM\nimages of MPs (Green) response in Tg(mpeg1:EGFP) transgenic zebrafish model after abdominal\n injection with CQDs (Red), DiI dyes labeled H-B16F10 (Red) and CM-B16F10 (Red), respectively, at\n equivalent dose at 4 nl for 6 hr and 24 hr; CQDs: 200 μg/ml, B16F10 cells: 1×107/ml, 4 nl; (d) CLSM\n images of the MPs response in DiI labelled B16F10 cancer xenograft Tg(mpeg1:EGFP) zebrafish model\n treated with CM-B16F10; MPs (Green), B16F10 cells (Red); (e) CLSM images of the anti-cancer T cells\n response in DiI labelled B16F10 cancer xenograft Tg(lck:EGFP) zebrafish model treated with CM448\nB16F10, T cells (Green), B16F10 cells (Red); (f) CLSM images of monitoring the cancer cell\n proliferation growth (Green) and detect the caspase-3 activation based apoptotic (Blue) by FRET imaging\n in B16F10‐C3 cancer xenograft zebrafish model after PBS, CQDs, H-B16F10-C3 and CM-B16F10-C3treatments at day 6, respectively.","description":"","filename":"Fig02.jpg","url":"https://assets-eu.researchsquare.com/files/rs-457550/v2/7e308e43c65987c5938fee79.jpg"},{"id":8570214,"identity":"f5027858-7a67-4417-9b7e-e8b600936c48","added_by":"auto","created_at":"2021-04-28 21:43:47","extension":"jpg","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":1544888,"visible":true,"origin":"","legend":"The CM-cancer generates robust immune responses in lymph node. Fluorescent images of\n the 4th mammary tissue with inguinal lymph node (left) after abdominal injection with CQDs, H-4T1\nlabeled with fluorescent dyes (DID 700) and CM-4T1, respectively, at equivalent dose (200 μl per mice)\n at 4 hr and 24 hr (Scale bar: 3 mm), 647 nm excitation (BA 700 nm). IHC staining of the lymph nodes against CD11c, F4/80, IFNγ, and CD8+ with indicated treatment groups (Scale bar: 100 μm).","description":"","filename":"Fig03.jpg","url":"https://assets-eu.researchsquare.com/files/rs-457550/v2/5732b862f51148190f866add.jpg"},{"id":8569739,"identity":"7dd96b8c-3867-4254-aaa0-28f1ebe51717","added_by":"auto","created_at":"2021-04-28 21:40:47","extension":"jpg","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":1095510,"visible":true,"origin":"","legend":"CM-cancer inhibits tumor growth and metastasis on murine mammary cancer models. (a)\n Schematic illustration of CM-545 and CM-4T1 to inhibit primary 545 tumor in FVB and 4T1 tumor in\n Balb/c murine mammary model, respectively; (b) Growth curves of 545 tumors and (c), percent survival\nof FVB murine treated with CM-545 (n = 6), CM-EMT6 (n = 5), H-545 (n = 5), PBS (n = 5) and CQDs\n (n = 5), p \u003c 0.0001 (****). Data plotted are mean ± S.E.M.; (d) Growth curves of 4T1 tumors in mice\n treated with CM-4T1 (n = 6), CM-EMT6 (n = 6), H-4T1 (n = 6), PBS (n = 6) and CQDs (n = 6), p \u003c\n 0.0001 (****). Data plotted are mean ± S.E.M; (e) IHC staining of tumor sections from orthotopic\n transplantation model showing that the CM-4T1 treatment suppressed the expression of CD8+, Ki67 and\n induced Cleaved Casp3. Scale bar: 50 μm; (f) Representative flow cytometry ratios of activated CD8+ T\n cells in the tumors from different groups after CM-4T1, CQDs, H-4T1 and PBS treatments (n = 4),\n respectively. p \u003c 0.0001 (****). Data plotted are mean ± S.E.M; (g) Statistics, and (h) images of\nmetastatic tumors in lungs from P0-4 groups after PBS, CQDs, H-4T1, CM-EMT6 and CM-4T1\ntreatments (n = 5), respectively. p \u003c 0.0001 (****), p = 0.0007 (***), p = 0.0004 (***), p = 0.0008 (***).\n Data plotted are mean ± S.E.M; (i) H\u0026E staining of lungs from P0-4 groups of 4T1 ","description":"","filename":"Fig04.jpg","url":"https://assets-eu.researchsquare.com/files/rs-457550/v2/b63cd39f7065a532ec5b0af3.jpg"},{"id":8569666,"identity":"1b7e1b7a-f9b7-4b03-ac21-c66376704dd4","added_by":"auto","created_at":"2021-04-28 21:37:47","extension":"jpg","order_by":5,"title":"Figure 5","display":"","copyAsset":false,"role":"figure","size":3111871,"visible":true,"origin":"","legend":"CM-4T1 cures metastic cancer on a postoperative 4T1 murine mammary model. (a) Schematic illustration of CM-4T1 treating the post-surgical 4T1 murine mammary model; (c) H\u0026E and IHC staining of lung tissues from M0-M4 groups after PBS, CQDs, H-4T1, CM-EMT6 and CM-4T1 treatments, respectively. Scale bar: 100 μm.","description":"","filename":"Fig05.jpg","url":"https://assets-eu.researchsquare.com/files/rs-457550/v2/921a892ce1d8966f80df6431.jpg"},{"id":13626723,"identity":"4e6df24e-4083-4dca-bcec-8a06896443d9","added_by":"auto","created_at":"2021-09-17 07:50:41","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":2852817,"visible":true,"origin":"","legend":"","description":"","filename":"Naturemanuscriptrevision.pdf","url":"https://assets-eu.researchsquare.com/files/rs-457550/v2_covered.pdf"},{"id":8570330,"identity":"ce8c9a8d-d6ad-4f33-b74f-c60512b3e6c6","added_by":"auto","created_at":"2021-04-28 21:46:53","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":7839539,"visible":true,"origin":"","legend":"","description":"","filename":"Naturemanuscriptrevision.pdf","url":"https://assets-eu.researchsquare.com/files/rs-457550/v2_stamped.pdf"}],"financialInterests":"There is \u003cb\u003eNO\u003c/b\u003e Competing Interest.","formattedTitle":"\u003cp\u003eCancer Immunotherapy Based on Carbon-Quantum-Dots\u003c/p\u003e","fulltext":[{"header":"Full Text","content":"This preprint is available for \u003ca href='/article/rs-457550/latest.pdf' target='_blank'\u003edownload as a PDF\u003c/a\u003e."}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Carbon Quantum Dots, Cancer Immunotherapy","lastPublishedDoi":"10.21203/rs.3.rs-457550/v2","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-457550/v2","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eCancer immunotherapy based on carbon-quantum-dots (CQDs) has proven effective. The CQDs composited cancer cell (CM-cancer) exhibit robust customized immunogenicity, which can recruit macrophages and dendritic cells to effectively deliver the cancer antigens into lymph nodes to activate CD8+ T cells, and eventually leads to an anti-cancer immune response all over the body. The CM-cancer is not only able to inhibit primary tumors, but also clearly eliminate metastatic tumors. Our research demonstrates a promising personalized cancer immunotheraputic technology for potential clinical applications.\u003c/p\u003e","manuscriptTitle":"Cancer Immunotherapy Based on Carbon-Quantum-Dots","msid":"","msnumber":"","nonDraftVersions":[{"code":2,"date":"2021-04-28 21:37:45","doi":"10.21203/rs.3.rs-457550/v2","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2021-04-26 16:32:13","doi":"10.21203/rs.3.rs-457550/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"439d2e8c-e684-48d0-a8b6-16a2275919a3","owner":[],"postedDate":"April 28th, 2021","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":3970907,"name":"Cancer Biology"}],"tags":[],"updatedAt":"2021-05-15T15:00:48+00:00","versionOfRecord":[],"versionCreatedAt":"2021-04-28 21:37:45","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v2","identity":"rs-457550","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-457550","identity":"rs-457550","version":["v2"]},"buildId":"7rjqhiLT3MXkJMwkYKINL","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}