Effect of acupuncture for diminished ovarian reserve: study protocol for a randomized controlled trial

Abstract Background: Diminished ovarian reserve (DOR) is described as reduced fecundity. A satisfactory treatment is lacking despite the upward trend of the prevalence. Acupuncture has been reported as an alternative therapy for female infertility. The purpose of this study is to investigate the effect of acupuncture for women with DOR.Methods/Design: In this randomized controlled trial, a total of 120 women with DOR will be randomized to receive either acupuncture or sham acupuncture for 12 weeks. The primary outcome is the antral follicle counting (AFC). Discussion: This study is expect to investigate the effect of acupuncture versus superficial needling in improving ovarian reserve for women with DOR.Trial registration:Acupuncture-Moxibustion Clinical Trial Registry (ChiCTR1800014988).