Numerical simulation of the influence of venous valve geometric structure on mechanical indices in the Peri-thrombotic Area

Numerical simulation of the influence of venous valve geometric structure on mechanical indices in the Peri-thrombotic Area | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Numerical simulation of the influence of venous valve geometric structure on mechanical indices in the Peri-thrombotic Area Jiahao Wu, Boyuan Lin, Mingrui Huang, Qidong Jiang, Yan Ren This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8350312/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Venous valve geometric structure significantly influences thrombotic flow regime. The fluid region near the thrombus (Peri-thrombotic Area) is an important physical space for thrombus evolution, and establishing a computational fluid dynamics (CFD) numerical model for analysis in this region is important. However, it is how the venous valve geometric structure affects mechanical indices in the Peri-thrombotic Area that has not been fully investigated. In this study, we focus on the Peri-thrombotic Area, propose a bio-hydrodynamic model in which the venous valve is treated as a hyperelastic material, the thrombus as a porous medium, the blood as a Carreau fluid. We further employ numerical analysis to compare the influence of different venous valve geometric structures on flow regime under fluid-solid interaction. Abnormalities in valve length and curve are common geometric variations in valve structure, and these abnormalities affect the flow regime and mechanical indices of the Peri-thrombotic Area. The results showed that the maximum pressure difference reaches 54.9% as the valve length changed, and the maximum flow rate difference reached 61.1% as the curvature shifted. Heterogeneity in the valve geometric structure leads to alterations in the length and constriction degree of the narrow channel between the valve leaflets, consequently causing abnormalities in mechanical indices in the Peri-thrombotic Area. This study demonstrates that considering valve structure can predict the mechanical state in the Peri-thrombotic Area, which provides assistance for the treatment of venous thrombosis and other venous diseases. Mechanical indices Numerical simulation Venous valve Peri-thrombotic Area Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8350312","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":562639035,"identity":"eb0dbaf7-811b-4435-b4bb-9296161a39ed","order_by":0,"name":"Jiahao Wu","email":"","orcid":"","institution":"Wenzhou University","correspondingAuthor":false,"prefix":"","firstName":"Jiahao","middleName":"","lastName":"Wu","suffix":""},{"id":562639036,"identity":"e4611f8f-94be-4d32-9302-e9b98ec64167","order_by":1,"name":"Boyuan 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in the Peri-thrombotic Area","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Mechanical indices, Numerical simulation, Venous valve, Peri-thrombotic Area","lastPublishedDoi":"10.21203/rs.3.rs-8350312/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8350312/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eVenous valve geometric structure significantly influences thrombotic flow regime. The fluid region near the thrombus (Peri-thrombotic Area) is an important physical space for thrombus evolution, and establishing a computational fluid dynamics (CFD) numerical model for analysis in this region is important. However, it is how the venous valve geometric structure affects mechanical indices in the Peri-thrombotic Area that has not been fully investigated. In this study, we focus on the Peri-thrombotic Area, propose a bio-hydrodynamic model in which the venous valve is treated as a hyperelastic material, the thrombus as a porous medium, the blood as a Carreau fluid. We further employ numerical analysis to compare the influence of different venous valve geometric structures on flow regime under fluid-solid interaction. Abnormalities in valve length and curve are common geometric variations in valve structure, and these abnormalities affect the flow regime and mechanical indices of the Peri-thrombotic Area. The results showed that the maximum pressure difference reaches 54.9% as the valve length changed, and the maximum flow rate difference reached 61.1% as the curvature shifted. Heterogeneity in the valve geometric structure leads to alterations in the length and constriction degree of the narrow channel between the valve leaflets, consequently causing abnormalities in mechanical indices in the Peri-thrombotic Area. This study demonstrates that considering valve structure can predict the mechanical state in the Peri-thrombotic Area, which provides assistance for the treatment of venous thrombosis and other venous diseases.\u003c/p\u003e","manuscriptTitle":"Numerical simulation of the influence of venous valve geometric structure on mechanical indices in the Peri-thrombotic Area","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-12-19 11:59:44","doi":"10.21203/rs.3.rs-8350312/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"03758847-170e-4a5d-aff2-6098bc8a88f2","owner":[],"postedDate":"December 19th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2026-01-11T08:38:55+00:00","versionOfRecord":[],"versionCreatedAt":"2025-12-19 11:59:44","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8350312","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8350312","identity":"rs-8350312","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}