Squamous cell carcinoma of the ovary arising from a mucinous cystic tumor of endocervical (müllerian) type

Emanuela D'Angelo, Emanuela D′Angelo, Dadmanesh F, Farnaz Dadmanesh, Sergio Pecorelli, Pecorelli S, Prat J, Jaime Prat
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2010 · doi:10.1097/PGP.0b013e3181e4b7ae · PMID:20881861
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This paper describes a rare case of ovarian squamous cell carcinoma arising from an endocervical-type mucinous cystic tumor, differentiating it from other ovarian malignancies.

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This case report describes an extremely rare instance of primary squamous cell carcinoma arising from a mucinous cystic tumor of endocervical type in a 58-year-old woman. The authors initially considered transitional cell carcinoma with squamous differentiation but excluded malignant Brenner tumors and other potential origins such as dermoid cysts or adenosquamous carcinoma. Histological examination revealed that the mucinous epithelial component was largely benign with focal proliferation, accompanied by numerous polymorphonuclear leukocytes typical of endocervical mucinous tumors. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Primary squamous cell carcinoma of the ovary is extremely rare. We studied a 58-year-old woman in whom a keratinizing squamous cell carcinoma of the ovary had arisen from a mucinous cystic tumor of endocervical (müllerian) type. The tumor was interpreted initially as a transitional cell carcinoma of the ovary with marked squamous differentiation, but there was no evidence of either transitional cell carcinoma or malignant Brenner tumor. Furthermore, features of dermoid cyst (mature cystic teratoma), endometriosis, or adenosquamous carcinoma were not seen. The mucinous columnar epithelial component was largely benign and only focally proliferative or borderline. As found typically in endocervical (müllerian) mucinous tumors, numerous polymorphonuclear leukocytes were seen in the stroma and the neoplastic mucinous epithelium.
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Squamous Cell Carcinoma of the Ovary Arising From a Mucinous Cystic Tumor of Endocervical (Müllerian) Type - Emanuela D'Angelo - Farnaz Dadmanesh - Sergio Pecorelli - Jaime Prat Primary squamous cell carcinoma of the ovary is extremely rare. We studied a 58-year-old woman in whom a keratinizing squamous cell carcinoma of the ovary had arisen from a mucinous cystic tumor of endocervical (müllerian) type. The tumor was interpreted initially as a transitional cell carcinoma of the ovary with marked squamous differentiation, but there was no evidence of either transitional cell carcinoma or malignant Brenner tumor. Furthermore, features of dermoid cyst (mature cystic teratoma), endometriosis, or adenosquamous carcinoma were not seen. The mucinous columnar epithelial component was largely benign and only focally proliferative or borderline. As found typically in endocervical (müllerian) mucinous tumors, numerous polymorphonuclear leukocytes were seen in the stroma and the neoplastic mucinous epithelium.

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Condition tags

endometriosis

MeSH descriptors

Carcinoma, Squamous Cell Cystadenoma, Mucinous Neoplasms, Multiple Primary Ovarian Neoplasms Carcinoma, Squamous Cell Carcinoma, Squamous Cell Cystadenoma, Mucinous Cystadenoma, Mucinous Female Humans Middle Aged Neoplasms, Multiple Primary Neoplasms, Multiple Primary Ovarian Neoplasms Ovarian Neoplasms

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europepmc
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pubmed
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