Fluorescence diagnosis of pre-tumor and tumor pathology of endometrium

Е. В. Филоненко; O. V. Chulkova; E. G. Novikova; L. G. Serova

Fluorescence diagnosis of pre-tumor and tumor pathology of endometrium

Е. В. Филоненко, O. V. Chulkova, E. G. Novikova, L. G. Serova

In: Biomedical Photonics; Том 3, № 3 (2014); 25-30 · 2016 · W4297903479

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This study evaluates the efficacy of fluorescence hysteroscopy using alacens, a photosensitizer that induces protoporphyrin IX, for the early detection of pre-tumor and tumor pathologies of the endometrium. The authors report that this technology significantly improves diagnostic accuracy by allowing visual assessment and local fluorescent spectroscopy to reliably determine the extent of disease. The method demonstrated high sensitivity of 100% and specificity of 98% in identifying early forms of endometrial cancer. Relevance to endometriosis: While the paper focuses on endometrial cancer, it cites prior research on using 5-aminolevulinic acid for fluorescence diagnosis of endometriosis, indicating a tangential connection to the condition through shared diagnostic techniques.

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Abstract

The technique of fluorescence hysteroscopy with Alasens includes visual assessment of fluorescence of Alasens-induced protoporphyrin IX and local fluorescence spectroscopy. The technique allows to improve the efficacy of early diagnosis for endometrial pathology including early endometrial cancer, to assess definitely an extent of pre-tumor and tumor process. The sensitivity of fluorescence hysteroscopy accounts for 100%, the specificity – 98%.

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Флюоресцентная диагностика предопухолевой и опухолевой патологии эндометрия Аннотация Технология флюоресцентной гистероскопии с препаратом аласенс включает визуальную оценку флюоресценции аласенс-индуцированного протопорфирина IX и локальную флюоресцентную спектроскопию. Технология позволяет повысить эффективность ранней диагностики патологии эндометрия, в том числе ранних форм рака эндометрия, достоверно оценить распространенность предопухолевого и опухолевого процесса. Чувствительность флюоресцентной гистероскопии составляет 100%, специфичность 98%. Об авторах Е. В. ФилоненкоРоссия О. В. Чулкова Россия Е. Г. Новикова Россия Л. Г. Серова Россия Список литературы 1. Ашрафян Л.А., Харченко Н.В., Огрызкова В.Л. Современные принципы первичной и уточняющей диагностики рака эндометрия // Практическая онкология. – 2004. – Т. 5, №1. – С. 16–24. 2. Чиссов В.И., Соколов В.В., Филоненко Е.В. Флюоресцентная эндоскопия, дермаскопия и спектрофотометрия в диагностике злокачественных опухолей основных локализаций // Российский биотерапевтический журнал. – 2003. – №4. – С. 45–56. 3. Hurnung R., Fehr M., Major A., Tadir Y. Uptake of the photosensitizer benzoporphyrin derivative in human endometrium after topical application in vivo // J. Am Assoc Gynecol. Laparosc. – 1998. – Vol. 5, No 4. – P. 367–74. 4. Fehr M.K., Wyss P., Tadir Y. Selective photosensitizer localization in the human endometrial after intrauterine application of 5-aminolevulinic acid // Obstetrics Am J Obstet Gynecol. – 2003. – Vol. 175, No 5. – P. 1253–9. 5. Sabban F., Collinet P., Cosson M., Mordon S. Fluorescence imaging technique: diagnostic and therapeutic interest in gynecology // J.Gynecol. Biol. Reprod. – 2004. – Vol. 33, No 8. – P. 734–8. 6. Лукин В.А, Филоненко Е.В, Вашакмадже Л.А. Флюоресцентная лапароскопия у больных раком желудка // Фотодинамическая терапия и фотодиагностика. – 2013. – №4. – C. 17–25. 7. Lang K, Lehmann P, Bolsen K. Aminolevulinic acid pharmacological profile and clinical indication // Obstetrics Expert Opin Investig Drugs. – 2001. – Vol. 72, No 10. – P. 829–37. 8. Malik E., Berg C., Meyhofer-Malik A., Buchweitz O. et al. Fluorescence diagnosis of endometriosis using 5-aminolevulinic acid // Surg. Endosc. – 2000. – Vol. 14, No 5. – P. 452–455. 9. Nowis D., Makowski M., Legat M., Golab J. Direct tumor damage mechanisms of photodynamic therapy // Obstetrics Acta Biochim Pol. – 2005. – Vol. 52, No 2. – P. 339–52. 10. Wyss P. Haller U. Berns MW. Accumulation of 5-aminolevulinic acid – induced protoporphyrin IX in normal and neoplastic human endometrial epithelial cell // Obstetrics Biochim Biohys Res Commum. – 2006. – Vol. 224, No 3. – P. 819–24. Рецензия Для цитирования: Филоненко Е.В., Чулкова О.В., Новикова Е.Г., Серова Л.Г. Флюоресцентная диагностика предопухолевой и опухолевой патологии эндометрия. Фотодинамическая терапия и фотодиагностика. 2014;3(3):25-30. For citation: Filonenko E.V., Chulkova O.V., Novikova E.G., Serova L.G. Fluorescence diagnosis of pre-tumor and tumor pathology of endometrium. Photodynamic therapy and photodyagnosis. 2014;3(3):25-30. (In Russ.) JATS XML

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