Complete response to cetuximab plus paclitaxel therapy in nivolumab-refractory patients in distant metastasis of squamous cell carcinoma of the tongue: a report of two cases

Herein, we report two cases of patients diagnosed with nivolumab-refractory distant metastatic squamous cell carcinoma of the tongue who were successfully treated with a combination of paclitaxel and cetuximab, thus demonstrating that some nivolumab-refractory patients with recurrent or distant metastatic oral squamous cell carcinoma may benefit from subsequent salvage chemotherapy.