Causal Relationships between IL-17C and Psoriasis and Atopic Dermatitis in European Populations: A Mendelian Randomization Analysis

Abstract Psoriasis and atopic dermatitis are only two of the inflammatory diseases that have been linked to IL-17C. However, it is unclear if there is a genetic link between IL-17C and developing psoriasis and atopic dermatitis. In this study, the possible link between genetically predisposed IL-17C and the risk of psoriasis and atopic dermatitis was comprehensively investigated. There was no overlap in the participant populations between IL-17C and psoriasis and atopic dermatitis genome-wide association studies, which provide the genetic resources. Inverse variance weighting, often used as MR analysis, is the main method. To guarantee the accuracy of our findings, a number of sensitivity studies were carried out. MR analysis revealed that IL-17C was reported to increase the risk of psoriasis (OR = 1.15, 95%CI[1.02ཞ1.3], P = 0.02) in this study. At the same time, this study did not observe that IL-17C would increase the risk of atopic dermatitis (OR = 0.96, 95%CI [0.87ཞ1.08], P = 0.53). Under all sensitivity assessments, the results remained stable. There is evidence that IL-17C raises the risk of psoriasis, but there is no such rise in the risk of atopic dermatitis.