Unstable Angina is a syndrome correlated to Th17 inflammatory disorder

Purpose Unstable angina is common clinical manifestation of atherosclerosis. However, the detailed pathogenesis of unstable angina is still not known. Here, I propose that unstable angina is a TH17 dominant inflammatory disorder. Methods Microarray dataset from unstable angina patients from Gene Expression Omnibus publicly available website is used for further analysis compared to healthy control. Results I find out that TH17 related cytokine, cytokine receptor, chemokines, complement, immune-related transcription factors, anti-bacterial genes, Toll-like receptors, and heat shock proteins are all up-regulated in peripheral leukocytes of unstable angina. In addition, H + -ATPase, glycolytic genes, platelet and RBC related genes are also up-regulated in peripheral leukocytes of during unstable angina. Pathway analysis also supports that TH17 immunological pathway is over-represented in the unstable angina dataset. Conclusions This finding implies that atherosclerosis is correlated to TH17 inflammatory disease. If we know the etiology of unstable angina as well as atherosclerosis better, we can have better methods to control and prevent this detrimental illness.