jabbrv-ltwa-all.ldf jabbrv-ltwa-en.ldf Linezolid, daptomycin, levofloxacin, and vancomycin in the treatment of diseases related to spinal fusion: adverse event profile: a pharmacovigilance study based on the FAERS database

jabbrv-ltwa-all.ldf jabbrv-ltwa-en.ldf Linezolid, daptomycin, levofloxacin, and vancomycin in the treatment of diseases related to spinal fusion: adverse event profile: a pharmacovigilance study based on the FAERS database | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 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Data may be preliminary. 12 November 2025 V1 Latest version Share on jabbrv-ltwa-all.ldf jabbrv-ltwa-en.ldf Linezolid, daptomycin, levofloxacin, and vancomycin in the treatment of diseases related to spinal fusion: adverse event profile: a pharmacovigilance study based on the FAERS database Authors : Jinzhu Liu 0009-0003-7601-744X , Wei Lin , and Zirui Zhan [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.176291120.06892922/v1 148 views 92 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Background: This study analyzed Adverse Events (AEs) for linezolid, daptomycin, levofloxacin, and vancomycin used in spinal fusion (SF) via the FDA Adverse Event Reporting System (FAERS). Methods: Reports where these drugs were the Primary Suspect in SF-related treatment were selected from FAERS. AEs were categorized using MedDRA Preferred Terms (PT) and System Organ Classes (SOC). Characteristics of reports and temporal trends were evaluated. Analyses were performed at SOC and PT levels, and correlations between osteomyelitis and AEs were assessed. Results: Females accounted for a higher proportion of levofloxacin reports. Vancomycin was more frequently reported in patients under 18. Congenital anomalies were mainly associated with levofloxacin. Overall reports increased over time. For levofloxacin, musculoskeletal disorders were predominant at the SOC level, with arthralgia common at the PT level. Osteomyelitis was associated with multiple AEs across the four drugs. Conclusion: This analysis of AEs for these antibiotics in SF-related treatment provides references for clinical drug safety. Supplementary Material File (pds-25-0850-file001.docx) Download 89.87 KB File (pds-25-0850-file002.tif) Download 13.57 MB Information & Authors Information Version history V1 Version 1 12 November 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords adverse drug event faers osteomyelitis spinal fusion Authors Affiliations Jinzhu Liu 0009-0003-7601-744X Shenzhen Third People's Hospital View all articles by this author Wei Lin Shenzhen Third People's Hospital View all articles by this author Zirui Zhan [email protected] Shenzhen Third People's Hospital View all articles by this author Metrics & Citations Metrics Article Usage 148 views 92 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Jinzhu Liu, Wei Lin, Zirui Zhan. jabbrv-ltwa-all.ldf jabbrv-ltwa-en.ldf Linezolid, daptomycin, levofloxacin, and vancomycin in the treatment of diseases related to spinal fusion: adverse event profile: a pharmacovigilance study based on the FAERS database. Authorea . 12 November 2025. DOI: https://doi.org/10.22541/au.176291120.06892922/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. 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