Tianeptine's effects on spontaneous and Ca2+-induced uterine smooth muscle contraction

Zorana Oreščanin-Dušić, C D Miljević, Čedo Miljević, M Slavić, Marija Slavić, Aleksandra Nikolić‐Kokić, A Nikolić-Kokić, Duško Blagojević, R Paskulin, D Blagojević, Mihajlo Spasić, D. Lečić-Toševski, M B Spasić
Acta physiologica Hungarica · 2012 · vol. 99(2) , pp. 140–147 · doi:10.1556/aphysiol.99.2012.2.7 · PMID:22849838 · W2004012777
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Tianeptine inhibited spontaneous and calcium-induced uterine smooth muscle contractions in rats while modulating antioxidant enzyme activities, suggesting its antidepressant effects may involve reduced contractility and oxidative stress adaptation.

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Abstract

Tianeptine is a novel anti-depressant with an efficacy equivalent to that of classical anti-depressants. Additional beneficial effects include neuroprotection, anti-stress and anti-ulcer properties whose molecular mechanisms are still not completely understood but may involve changes in the anti-oxidant defence system. Herein, we have studied the effects of tianeptine on both contractile activity of isolated rat uteri and components of the endogenous anti-oxidative defence system. Tianeptine-induced dose-dependent inhibition of both spontaneous and Ca2+-induced contraction of uterine smooth muscle. The effect was more pronounced in the latter. Tianeptine treatment increased glutathione peroxidase (GSH-Px) and catalase (CAT) activities in spontaneous and Ca2+-stimulated uteri. A significant decrease in glutathione-reductase (GR) activity in both spontaneous and Ca2+-induced uterine contractions after tianeptine treatment indicated a reduction in reduced glutathione and consequently a shift toward a more oxidised state in the treated uteri. In spontaneously contracting uteri, tianeptine caused a decrease in copper-zinc SOD (CuZnSOD) activity. Tianeptine's anti-depressant effects may be accomplished by triggering a cascade of cellular adaptations including inhibition of smooth muscle contractility and an adequate anti-oxidative protection response.

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MeSH descriptors

Antidepressive Agents, Tricyclic Calcium Myometrium Thiazepines Uterine Contraction Animals Antidepressive Agents, Tricyclic Calcium Catalase Catalase Dose-Response Relationship, Drug Female Glutathione Peroxidase Glutathione Peroxidase Glutathione Reductase Glutathione Reductase Myometrium Myometrium Rats Rats, Wistar

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References (38)

SciLite annotations

chemicals 9
tianeptine (+-)-5-[3-(tert-butylammonio)-2-hydroxypropoxy]-3,4-dihydronaphthalen-1(2h)-one(1+) tianeptine tianeptine (+-)-5-[3-(tert-butylammonio)-2-hydroxypropoxy]-3,4-dihydronaphthalen-1(2h)-one(1+) (+-)-5-[3-(tert-butylammonio)-2-hydroxypropoxy]-3,4-dihydronaphthalen-1(2h)-one(1+) tianeptine reduced ferredoxin tianeptine
organisms 1
zitter rats

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