A Fully Integrated Smart Ring for Daily Biochemical Monitoring

A Fully Integrated Smart Ring for Daily Biochemical Monitoring | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article A Fully Integrated Smart Ring for Daily Biochemical Monitoring Joseph Wang, Tamoghna Saha, Shichao Ding, Siyu Qin, Hannah Fishman, and 13 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8703969/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted You are reading this latest preprint version Abstract Biochemical analysis complements biophysical measurements by capturing the underlying molecular and metabolic changes that drive physiological health. Here, we introduce a compact, fully integrated smart ring capable of simultaneously monitoring multiple chemical biomarkers in real-time — marking a true biochemical counterpart to existing smart rings. Our ring can continuously measure glucose, ketone, ascorbic acid, uric acid, lactate, and alcohol from passive osmotically extracted sweat, is powered by custom-built high-capacity flexible Zn-AgO batteries, and comprises ultra-compact, energy-efficient electronics for data processing and wireless transmission. It can support ~12 hours of continuous monitoring and preserves personalized calibration stability for ~2 months. The simultaneous biomarker monitoring was validated under diverse daily settings. Reliable, continuous monitoring of glucose and ketone levels showed strong agreement with commercial blood meters and continuous glucose monitors in both healthy and type 1 diabetic individuals, confirming the ring’s accuracy even for at-risk population. Overall, our ring extends beyond commercial smart rings focusing on only biophysical signals, by enabling continuous assessment of biochemical changes and advancing the development of next generation personalized and miniaturized healthcare technologies. Physical sciences/Engineering/Biomedical engineering Health sciences/Biomarkers/Diagnostic markers Full Text Additional Declarations There is NO Competing Interest. Supplementary Files Hydrogelpressure.avi Stress disribution of the hydrogel-skin interface NutritionRingSupplementaryFINAL02172026.pdf Supplemental Information CHARMVideo480p.mp4 Video demonstrating CHARM’s operation. Cite Share Download PDF Status: Under Review Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8703969","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":596161124,"identity":"059ce80f-8022-4f4b-b21d-5820587e952a","order_by":0,"name":"Joseph 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Here, we introduce a compact, fully integrated smart ring capable of simultaneously monitoring multiple chemical biomarkers in real-time — marking a true biochemical counterpart to existing smart rings. Our ring can continuously measure glucose, ketone, ascorbic acid, uric acid, lactate, and alcohol from passive osmotically extracted sweat, is powered by custom-built high-capacity flexible Zn-AgO batteries, and comprises ultra-compact, energy-efficient electronics for data processing and wireless transmission. It can support ~12 hours of continuous monitoring and preserves personalized calibration stability for ~2 months. The simultaneous biomarker monitoring was validated under diverse daily settings. Reliable, continuous monitoring of glucose and ketone levels showed strong agreement with commercial blood meters and continuous glucose monitors in both healthy and type 1 diabetic individuals, confirming the ring’s accuracy even for at-risk population. 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