Role of 1, 25(OH)2 vitamin D3 and vitamin D receptor in chronic kidney kiseases

1, 25(OH)2 D vitamin3 is the activated form of vitamin D in human body.Mediated by specific vitamin D receptor, 1, 25(OH)2 vitamin D3 plays an important role in many physiological and pathological process.In recent years, researches have shown that 1, 25(OH)2 vitamin D3 can protect podocytes, inhibit the proliferation of mesenteric cells, regulate the apoptosis of mesenteric cells, anti-inflammation, and have negative effect in rennin-angiotensin system, so as to protect the renal function.This paper reviews the progress of the effect of 1, 25(OH)2 vitamin D3 and vitamin D receptor in chronic renal disease. Key words: Vitamin D; Vitamin D receptor; Chronic kidney disease