Understanding the preferences of younger women for the delivery of a service to predict breast cancer risk: a discrete choice experiment

Understanding the preferences of younger women for the delivery of a service to predict breast cancer risk: a discrete choice experiment | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Understanding the preferences of younger women for the delivery of a service to predict breast cancer risk: a discrete choice experiment Stuart J Wright, Shabnam Thapa, Amber Salisbury, Sarah Hindmarch, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7355445/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 9 You are reading this latest preprint version Abstract Background: This study aimed to understand the preferences of a sample of younger women (30-39 years) for the attributes of models of service delivery for a breast cancer risk-prediction service to identify how best to design a service to optimise uptake. Methods: A discrete choice experiment was used to quantify the preferences of a purposive sample of younger women (aged 30 to 39) without prior knowledge of their risk of developing breast cancer. Respondents chose from a series of questions including two unlabelled alternatives, representing different models of a risk-prediction service, and an opt-out alternative. Data were analysed using random parameter logit and latent class models to explore potential heterogeneity in preferences for the intervention. Results: The predicted uptake for a risk-prediction service ranged from 77-89%. Participants preferred a service with more flexible appointments which could be booked by the individual themselves. Latent class analysis suggested that around 7% of women would never have their risk predicted and for approximately 30% of women the choice would depend on the design of the service. Conclusion: Younger women would be likely to choose to have their breast cancer risk, although some groups were sensitive to the design of the prediction service. breast cancer risk-prediction discrete choice experiment preferences Introduction In the UK, breast cancer is the most common type of cancer among women with around 56,000 new cases diagnosed every year (1). The NHS Breast Screening Programme invites women between 50 to 71 years every three years for breast screening (2). Although, breast cancer is most commonly diagnosed in women aged 50 years or older, around 18% of cases are found in women under 50 years, and BC is the most common cause of death in women aged 35-49 years (1). Women under 50 years can only get access to screening and preventative measures if they have a strong familial history of breast cancer conferring at least a 17% lifetime risk of the disease (3). However, around two-thirds of women under the age of 50 years who develop breast cancer do not have any first or second degree family history at all (4). Breast cancer in these younger women is more commonly lethal, due to and increased incidence of more aggressive subtypes and later stage presentation due to the lack of screening provision (5,6). The current surveillance strategy of relying on the presence of a strong family history may be inadequate because it fails to find the majority of younger women who are at increased risk of breast cancer. To address this gap the ‘Breast Cancer Risk Assessment in Young Women’ (BCAN-RAY) study (NCT05305963) has designed and evaluated a novel model of service delivery to offer risk assessment for breast cancer in women aged 30-39 years (hereafter ‘younger women’) (6). There are a number of benefits to identifying younger women at higher risk of breast cancer. For these women, screening could be started at a younger age to catch cancers at an early stage. Alternatively, women could be provided with advice about lifestyle changes which could help to reduce their breast cancer risk or could be prescribed risk-reducing medicines (7,8). The potential benefits of such risk assessment to identify younger women at risk of breast cancer will only be realised if there is sufficient uptake of the service. The uptake of any service will be influenced by an individual’s preference for how the service is designed (9). Before a model of service delivery has been rolled out it is clearly impossible to collect data on preferences for aspects of the model (revealed preferences) or uptake of the model. Stated preference methods, such as discrete choice experiments (DCEs), have a role when designing new models of service delivery (10). A DCE asks a pre-defined group of relevant individuals (the sample) a series of choice questions in which they select their preferred option described using a set of attributes (the characteristics of the service delivery model) defined using levels (the possible range to define each characteristic) (11,12). The respondents’ choices are then analysed (using regression methods) to generate a measure of the samples’ preferences which can be used to understand the relative importance of each attribute and the trade-offs between attributes (11,13). The outputs from the regression analysis can also be used to estimate the future uptake for exemplar models of service delivery (14). This study aimed to understand the preferences of a sample of younger women (30-39 years) for the attributes of models of service delivery for a breast cancer risk assessment service. The study also aimed to generate estimates of the potential uptake of specified models of service delivery. Methods A discrete choice experiment, embed in an on-line survey, was designed to elicit the preferences of a sample of younger women for a model of service delivery for a breast cancer risk-prediction service. The DCE was designed and analysed following published methodological recommendations (15) and reported in line with a published checklist (16) (see Appendix 1) . Ethical approval was obtained from The University of Manchester’s Proportionate Research Ethics Committee (reference: 2024-21125-37858). Conceptualising the Choice Question To conceptualise the choice question, the integrated screening action model (I-SAM) of cancer screening behaviour was used as a framework for considering the steps needed for a woman to take part in a breast cancer risk-prediction service to guide decisions about early intervention such as receiving earlier breast screening (17). This framework suggests that women have to go through multiple stages to take up the intervention on offer: becoming aware; becoming informed; deciding to act; acting; and repeating if necessarily. When considering a breast cancer risk-prediction service there are likely to be more required steps for a woman to take up the service and experience health benefit. This will include becoming aware of the service, becoming informed about the service, making a decision to have their risk predicted, acting to have their risk predicted, deciding to receive their risk feedback, acting to receive their feedback, decided to act on their risk information to reduce their risk, actually acting to change their cancer risk. As the BCAN-RAY study aimed to explore the feasibility of introducing a breast cancer risk-prediction service for younger women, this DCE focuses on women’s decision as to whether in principle they would like their risk to be predicted or not. It was decided that including questions to ascertain if women would then decide to receive their risk feedback and act on their risk information to reduce their risk (using strategies provided by the health service), would make a single survey too long to complete. Firstly, for women to choose to receive risk-prediction, they must be aware of the service. As such, the sample to be recruited for this study was defined as women who would potentially receive the service: women between the ages of 30-39. Secondly, to decide to receive risk-prediction, women must be adequately informed about the service. As such, in the discrete choice experiment, information materials explaining the concepts of breast cancer risk-prediction were included at the start of the study. These were modelled as closely as possible on existing National Health Service leaflets for breast cancer screening (18). Survey Design The DCE was embedded into an online survey which was programmed in Qualtrics. The survey (Appendix 2) comprised 5 sections: (i) an introduction to the survey explaining what is involved with risk-prediction for breast cancer in younger women (referred to as ‘training materials’ in a DCE); (ii) the choice questions; (iii) questions regarding respondents’ views on the survey; (iv) attitudinal questions about their risk behaviour and healthcare decision-making and (v) sociodemographic questions about themselves. DCE Design The DCE was framed around the choice question: “If you had to choose between the following breast cancer risk-prediction services, which would you choose?”. The respondents were asked to choose between two unlabelled (generic) alternatives and an opt-out option. The alternatives and opt-out option were described using six attributes assigned levels (see Table 1). The opt out option was described with fixed text: “You would not have your breast cancer risk predicted, you would be invited to breast cancer screening at age 50, if you were worried about cancer before this you would visit your GP”. An infographic was also included showing that 0 out of 100 people would be identified at high risk. The attributes and levels for this study were identified using seven focus groups (with 29 women) and eight semi-structured interviews conducted online with women aged 30-39 years for a breast cancer risk assessment (19). These semi-structured focus groups and interviews were designed with input from patient and public involvement. The qualitative data were used to generate a long list of 19 potential attributes. This long list was grouped into three categories: attributes of information about the risk-prediction service; attributes of the risk-prediction intervention itself; attributes of the process of returning risk information. A final list of six attributes was produced by the research team (see table 1). The research team focussed on defining attributes and levels that would describe a risk assessment service that was feasible to deliver. Table 1: Attributes and levels included in the DCE Attribute Description Levels Attribute Type (coding for analysis) How risk is predicted The combination of interventions used to predict a woman’s risk of breast cancer A questionnaire only A questionnaire and mammographic breast density A questionnaire and radiofrequency breast density A questionnaire and genetic test A questionnaire, mammographic breast density, and genetic test A questionnaire, radiofrequency breast density, and genetic test Categorical (Effects coded) Appointments needed to predict risk How many appointments would a woman need to attend to have her risk predicted One Two Categorical (Effects coded) Location of appointment Where the woman would need to go to have her risk predicted Home General Practitioner (GP) A mobile van Hospital Community Centre Categorical (Effects coded) Possible Times for the Appointment Which days and what times of day appointments are available to book 9am-5pm weekdays 9am-5pm weekdays and evenings or weekends Categorical (Effects coded) How appointments are booked What the woman needs to do to book an appointment to have her risk predicted You are sent a litter with a fixed date and time You can book a date and time yourself online or on the phone Categorical (Effects coded) The likelihood that you are predicted to be at high risk of breast cancer The probability that the results suggest a woman should be classed as high risk and receive earlier interventions to reduce the risk of cancer or identify cancers at an earlier stage 5 out of every 100 (5%) people would be predicted to be high risk 10 out of every 100 (10%) people would be predicted to be high risk 15 out of every 100 (15%) people would be predicted to be high risk 20 out of every 100 (20%) people would be predicted to be high risk Continuous (Linear in main analysis; with checks for non-linear functional forms) The Experimental Design Experimental design for discrete choice experiments is the creation of choice questions by combining attributes and levels in a way which maximises the probability that preferences for all of the attributes and levels can be estimated with the lowest level of statistical uncertainty (statistical efficiency) (20). A full factorial design would result in an unfeasible number of 921,600 potential combinations of attributes and levels in choice sets. A D-efficient, main effects design was created using the choiceDes package in the programming software R (21). Illogical combinations of attributes and levels such as having a mammogram at home were removed from the design informed by expert clinical advice. The final experimental design comprised three blocks of ten questions with each participant randomised to receive one block. As 5 out of 6 attributes were categorical, a dominance test question was not included in the DCE design. Background questions Background questions were included in the online survey to enable a description of the study sample and also for use when analysing for preference heterogeneity. The questions included were: sociodemographic questions including level of education, religion, ethnicity and whether they had children. Respondents were also asked about their attitude to risk and questions about their level of health information seeking or avoiding behaviour. Piloting The survey was quantitatively piloted using a purposive sample of younger women (n=50) adults recruited through an online panel-provider (Pureprofile). The results were then analysed using a conditional logit model to ensure that the coefficients for all attributes and levels could be estimated. The experimental design for the study was not updated using the results of the quantitative pilot. Study Population and Sample The relevant study population was framed around younger women (aged between30 and 39 years) who by definition, all have an as yet (undefined) risk of developing breast cancer at some point in their lives. Participants who had previously been diagnosed with breast cancer or had a close relative with breast cancer were also excluded as individuals with a family history of cancer are already potential eligible for earlier interventions in the NHS. The online survey was fielded to a sample of younger women living in the UK recruited using an online panel-provider (Pureprofile). There are no acceptable statistical approaches to set the required sample size for a DCE. This study used the Orme rule of thumb to calculate a minimum sample size of 150 participants needed. Although a sample size of 150 was the minimum required to estimate the preferences of the sample, a final target sample size of 1000 was set to allow for understanding heterogeneity in preferences. Respondents were sent a link to the online survey and reminders were not used. Respondents who completed the survey in a time that was under 2 standard deviations from the median were defined as ‘speedsters’ and not engaging with the survey and removed from the dataset. These speedsters were then ‘replaced’ by a sample of further respondents identified by the panel-provider. Using Qualtrics also allowed the identification of responses which were likely from ‘bots’ completing the survey. These bots were ‘replaced’ by a sample of further respondents identified by the panel-provider. Data Analysis An analysis plan was created which specified that individuals who did not complete the survey and those who always chose the same alternative would be excluded. Speedsters and bots were replaced at the data collection phase. Descriptive statistics for sociodemographic characteristics, behavioural questions and survey feedback were produced for respondents in the final sample. Following data cleaning, the choice data were analysed using conditional logit models in which the continuous attributes were specified as linear, continuous variables and categorial attributes effects coded. A single constant was included to represent the probability of opting in versus opting out. Different model functional forms will be estimated whereby two constants are used to represent the probability of selecting hypothetical risk-prediction or feedback scenario A or scenario B. This serves as a test as to whether participants were always choosing scenario A or B regardless of the levels shown. A series of regression models were then used to assess non-linearity in preferences for the probability of being identified as high risk attribute. All tests of model specification will be made by comparing the Bayesian Information Criterion (BIC) of the different models. If a model specification is found to result in a lower BIC value then this suggests that the model specification adds sufficient additional explanatory power for the number of additional parameters in the model. When a final functional form was selected, a random parameter logit model was then estimated to determine if a model which allows for preference heterogeneity provided a better fit for the data. A two-step process was followed, with an uncorrelated random parameter logit estimated first and then a fully correlated random parameter logit estimated. The fully correlated model allows for both differences in error between participants as well as differences in preferences. To better understand whether there were particular groups with similar preferences, a latent class model was also be estimated. The best number of classes was chosen using the BIC statistic. When the number of classes was chosen, a further model was estimated to determine if any demographic characteristics were correlated with membership of the classes. All of the collected demographic classes were tested for class membership prediction. Coefficients and associated robust standard errors (SEs) from the best fitting model were used to calculate predicted uptake probabilities for different hypothetical risk-prediction services. The hypothetical services reported in this paper are the most and least preferred services based on the choice model for aggregated preferences as well as an exemplar service representing the risk-prediction approach used in the BCAN-RAY study. Differences in predicted uptake among the different predicted classes from the latent class analysis will be explored. All analyses were conducted using the Apollo package (version 0.3.5) in the open source software R (22,23). Results A sample of 936 younger women were included in the final analysis in this study. A total of 2512 woman entered the survey from the link sent by Pureprofile. Of these women, 1312 consented to take part and 1144 of these completed the whole survey. The reCAPTCHA tool included in the survey identified 158 responses which were likely to have been provided by bots (with a score over 0.5). A further 28 responses removed due to fast completion times (< 192 seconds: over 2 standard deviations from the mean). 22 respondents did not complete all the DCE questions and were excluded. In the final sample of 936 participants the median survey completion time was 9.38 minutes. Descriptive statistics summarising the final sample are provided in Table 2 . A summary of the results of the attitudinal questions is provided in Table 3 . Table 2 Demographic composition of the sample Characteristic Number (Percentage) Highest education No formal education 13 (1.4) 1–4 O levels/GCSEs 50 (5.3) 5 + O levels/GCSEs 44 (4.7) National Vocation Qualification (NVQs) 86 (9.2) A levels/AS levels 148 (15.8) Undergraduate degree 383 (40.9) Postgraduate degree 175 (18.7) PhD/Doctorate 15 (1.6) Other formal qualification 22 (2.4) Religion No religion 479 (51.1) Christian 354 (37.8) Buddhist 8 (0.9) Hindu 11 (1.2) Jewish 1 (0.1) Muslim 65 (6.9) Sikh 5 (0.5) Other 13 (1.4) Ethnicity White English/Welsh/Scottish/Northern Irish/British 639 (68.2) White Irish 10 (1.1) White Gypsy or Traveller 2 (0.2) Other white background 61 (6.5) White and Black Caribbean 8 (0.8) White and Black African 12 (1.3) White and Asian 10 (1.1) Other mixed/multiple background 7 (0.7) Indian 26 (2.7) Pakistani 19 (2.0) Bangladeshi 11 (1.2) Chinese 11 (1.2) Other Asian Background 18 (1.9) Black African 79 (8.4) Black Caribbean 14 (1.5) Any other Black/African\Caribbean Background 3 (0.3) Arab 2 (0.2) Any other ethnic group 4 (0.4) Do you have any children? Yes 572 (61.1) No 364 (38.9) Table 3 Summary of responses to attitudinal questions Risk preferences Overall level of risk taking (from 0 for risk averse to 10 for fully prepared to take risk) 5.41 (CI 5.24 to 5.58) Willingness to take risks when driving 3.34 (CI 3.16 to 3.52) Willingness to take risks in financial matters 4.44 (CI 4.26 to 4.62) Willingness to take risks during leisure and sport 5.58 (CI 5.41 to 5.74) Willingness to take risks in your occupation 5.20 (CI 5.03 to 5.38) Willingness to take risks with your health 3.70 (CI 3.52 to 3.89) Willingness to take risks in your faith in other people 4.94 (CI 4.77 to 5.11) Information Engagement (from 0 for not at all true for me to 4 for very much true for me) I like to gather as much information as I can before making a decision 3.15 (CI 3.09 to 3.22) I like to review information multiple times before making a decision 2.97 (CI 2.91 to 3.02) After I’ve made a decision, I continue to look for related information 2.90 (CI 2.84 to 2.95) I like to make decisions quickly (reverse scored when creating overall score) 1.97 (CI 1.90 to 2.05) Mean Information Engagement 2.76 (CI 2.72 to 2.80) Information Apprehension (from 0 for not at all true for me to 4 for very much true for me) I have difficulty making sense of information from multiple sources 1.80 (CI 1.72 to 1.87) I fear that I might find out something that I don’t want to know 2.24 (CI 2.17 to 2.32) I think it’s the doctor’s job to deal with information, not mine 1.54 (CI 1.47 to 1.61) I feel overwhelmed by the amount of information available 2.20 (CI 2.13 to 2.27) Mean information apprehension 1.94 (1.89 to 2.00) The average age of respondents in the final survey was 34.63 with an interquartile range of 5. Most participants were of white ethnicity (76%) and of no religion (51.1%) or Christian (37.8%). 61.1% of women had children. As a narrow age group was used for this study, statistics were not available to determine how representative the sample was of the UK population of women aged 30 to 39. On average the participants stated that they were slightly more likely than average to take risks, although they were less likely to take risks with their health. Women in the sample tended to prefer to engage with information but had only average levels of information apprehension. However, the participants were more likely than average to agree with the statement “I fear that I might find out something that I don’t want to know” which may be particularly relevant when considering the concept of breast cancer risk-prediction. On average the participants found the survey easy to complete (mean 3.87 out of 5). 54.6% of participants stated that they always used all of the attributes to make their decisions, 42.0% used a sub-set of attributes, and 3.4% said they never chose the risk-prediction service. Preferences The results of the model selection process suggested that a model with a single constant for the opt in options was superior (BIC: 18187) to having separate constants for each opt in option (BIC: 18194). This suggested that there was no evidence that participants disproportionately chose either the left or right hand options in the choice tasks. In addition, no evidence was found of non-linearity in the likelihood of being predicted to be high risk attribute and as such a single linear coefficient was used for this attribute. Different model specifications were explored to allow for preference and scale heterogeneity in the responses. The model fit statistics are available in supplementary appendix 3. The best model was an uncorrelated random parameter logit with pseudo panel effects. This model allows for differences in preferences among individuals as well as differences in error in completing the survey. The coefficients for this model are presented in Table 4 : Table 4 Model coefficients Attribute or Level Estimate Standard Error P value Number of appointments -0.081 0.054 0.068 Appointments available at evenings and weekends 0.213*** 0.025 < 0.001 Appointments only available during work hours -0.213*** 0.025 < 0.001 You can book the appointment yourself 0.141*** 0.023 < 0.001 An appointment is booked for you -0.141*** 0.023 < 0.001 Location Hospital -0.254*** 0.053 < 0.001 Community Centre -0.012 0.066 0.425 Mobile Van 0.008 0.054 0.443 Home 0.312** 0.128 0.008 General Practitioner -0.052 0.054 0.328 Probability of being predicted to be at high risk 0.028*** 0.006 < 0.001 Mode of risk-prediction Questionnaire only -0.829*** 0.069 < 0.001 Questionnaire and genetic test 0.127** 0.048 0.004 Questionnaire and mammography 0.071 0.067 0.146 Questionnaire, mammography, and genetic test 0.465*** 0.069 < 0.001 Questionnaire and radiofrequency scan -0.186*** 0.045 < 0.001 Questionnaire, radiofrequency scan and genetic test 0.353*** 0.059 < 0.001 Alternative specific constant 1 3.993*** 0.230 < 0.001 Sigma for the Panel Effect 2 -0.283 0.053 < 0.001 1 Representing the likelihood an individual would choose a risk-prediction service with mean effect for location, mode of risk-prediction, how the appointment is booked, and whether you can book yourself compared to no risk-prediction service. 2 This coefficient represents the correlation of error in an individual’s responses across the multiple choice sets they answer The results of the random parameter logit model suggest that the participants in this study were likely to choose to have their risk predicted, as shown by the large constant term. Participants valued a service that was more likely to identify women at higher risk. They were more likely to choose a service which was available in the evenings or weekends and could be booked themselves. Participants did not want to have to go to a hospital for risk assessment but were more likely to choose a service available at home. Participants were less likely to choose a risk-prediction service that only used a questionnaire to assess risk or used a questionnaire and radiofrequency scan. However, participants were more likely to choose a risk-prediction service with a genetic component to risk-prediction. Latent Class Analysis In the latent class analysis it was found that a model with four classes minimised the BIC, providing the most explanatory power for the number of parameters included. No demographic or attitudinal parameters were found to adequately predict class membership based on BIC, although the level of information apprehension did reduce the Akaike Information Criterion. As such, only a constant term was included to explain class membership. The results of the latent class analysis are reported in Table 5 . Nearly 60% of the sample belonged to class 1 which had strong preferences for a risk-prediction service. The preferences of this class were broadly similar to those of the aggregate sample, although they were also likely to attend a risk-prediction service provided in a mobile van. Class 2 comprised 18.4% of the sample and did not have strong preferences for any of the attributes and levels apart from the constant and adding a genetic test to questionnaire-based assessment. They also appeared to be sensitive to the number of appointments needed, although this was not statistically significant (p = 0.07). They were potentially a group who answered the survey in a random manner. People in class 3 (14.9%) of the sample were the only group without a significant alternative specific constant suggesting that they were more concerned with how a risk-prediction service was delivered than the other classes. They preferred appointments which were available at evenings and weekends and being able to book appointments themselves. They were averse to attending appointments at a mobile van and had a strong preference for a service which found more women at higher risk. Class 4 (7.4%) appeared to be unlikely to ever use a risk-prediction service, as demonstrated by their negative alternative specific constant. This may also be supported by their dislike of services with more appointments as no risk-prediction service involves no appointments. Table 5 Results of the Latent Class Analysis Class 1 (59.3%) Class 2 (18.4%) Class 3 (14.9%) Class 4 (7.4%) Attribute or Level Coefficient P value Coefficient P value Coefficient P value Coefficient P value Number of appointments -0.016 0.800 -0.168 0.070 0.02 0.917 -1.18** 0.013 Appointments available at evenings and weekends 0.194*** 0.000 -0.002 0.974 0.529*** 0.000 0.183 0.316 Appointments only available during work hours -0.194*** 0.000 0.002 0.974 -0.529*** 0.000 -0.183 0.316 You can book the appointment yourself 0.13*** 0.000 0.015 0.715 0.276* 0.013 0.037 0.854 An appointment is booked for you -0.13*** 0.000 -0.015 0.715 -0.276* 0.013 -0.037 0.854 Location Hospital -0.209** 0.004 -0.058 0.510 -0.259 0.366 0.029 0.932 Community Centre 0.004 0.962 -0.011 0.909 0.152 0.724 0.412 0.263 Mobile Van 0.196** 0.004 0.073 0.426 -0.589* 0.041 -0.098 0.814 Home -0.055 0.802 0.035 0.810 1.017 0.352 0.111 0.818 General Practitioner 0.064 0.425 -0.039 0.643 -0.321 0.333 -0.454 0.255 Probability of being predicted to be at high risk -0.002 0.764 -0.014 0.069 0.247*** 0.000 0.028 0.400 Mode of risk-prediction Questionnaire only -0.995*** 0.000 0.071 0.487 0.225 0.456 -0.555 0.249 Questionnaire and genetic test 0.008 0.889 0.318*** 0.000 0.105 0.515 0.159 0.710 Questionnaire and mammography 0.037 0.633 0.075 0.498 0.277 0.436 0.286 0.544 Questionnaire, mammography and genetic test 0.647*** 0.000 -0.173 0.146 -0.169 0.559 0.212 0.660 Questionnaire and radiofrequency scan -0.196*** 0.000 -0.157 0.098 -0.216 0.210 -0.265 0.581 Questionnaire, radiofrequency scan, and genetic test 0.499*** 0.000 -0.135 0.250 -0.223 0.230 0.163 0.741 Alternative specific constant 4.175*** 0.000 0.528** 0.003 0.912 0.092 -2.202** 0.002 Class Membership Constant Reference -1.171*** 0.000 -1.378*** 0.000 -2.087*** 0.000 Uptake for a breast cancer risk-prediction service Table 6 presents the predicted uptake for the most and least preferred breast cancer risk-prediction services and a service provided in a way similar to that in the BCAN-RAY study. Uptake was predicted using the random parameter logit model with pseudo panel effects and the latent class analysis, with uptake presented for each class and aggregated. For the full sample, both in the RPL and latent class analysis, predicted uptake for a breast cancer risk-prediction service is high regardless of the composition of the service (77–89%). In the latent class analysis it can be seen that class 1 virtually always choose to have their risk predicted while uptake for the BCAN-RAY and least preferred services are marginally lower in class 2 and class 3. The predicted uptake is more variable in class 3 who have different preferences for the attributes and levels to the other classes. This is driven by their dislike for the mobile van used in the overall optimal service and their increased willingness to use the questionnaire in the risk-prediction service which is otherwise least preferred. Table 6 Predicted uptake for different breast cancer risk-prediction services using different models Random Parameter Logit Latent Class Analysis Risk-prediction Service Total Class 1 (59.3%) Class 2 (18.4%) Class 3 (14.9%) Class 4 (7.4%) Total 1 Best 2 89% 100% 100% 66% 14% 87% BCAN-RAY 3 85% 99% 99% 63% 11% 86% Worst 4 77% 97% 90% 73% 4% 84% 1 Total predicted uptake based on a weighted average of the uptake of each individual class 2 One appointment, available evenings and weekends, can book yourself, in a mobile van, with a questionnaire, mammography, and genetic test, 20% predicted to be at high risk 3 One appointment, available weekdays only, appointment booked for you, in a hospital, with a questionnaire, mammography, and genetic test, 20% predicted to be at high risk 4 One appointment, available weekdays only, appointment booked for you, in a hospital, with a questionnaire only, 5% predicted to be at high risk Discussion This discrete choice experiment has demonstrated that there would be significant demand for a breast cancer risk-prediction service among younger women if this were provided by the NHS. Uptake for an optimised risk-prediction service could be as high as 89%, with the worst potential service in this DCE still predicted to have uptake of 77%. Evidence provided by the latent class analysis demonstrates that while most women would attend a breast cancer risk-prediction service regardless of its design, around 7% of women would never want to have their risk predicted. In addition, the decision of around 30% of women in classes 2 and 3 to attend the service would be sensitive to the design of the service, with those in class 3 less likely to attend services which the majority of women find preferrable. This suggests the potential need to tailor services to different groups. To date, the majority of research around breast cancer risk-prediction has focussed on its use to stratify screening intervals by risk. In such studies, risk assessment and interval stratification had “high, but not universal, acceptability” (24). For example, in a cross-sectional survey of women aged 40–70 in England, Ghanouni et al found that 85% of women thought breast cancer risk assessment was a good idea while 74% were willing to have it (25). These results are similar to the predicted uptake of 77–89% in this study. While risk-prediction at the age of population screening may be acceptable for women, there may be additional barriers to risk-prediction in younger women compared to in its use for population screening. For example, risk-prediction for stratified screening is likely to be conducted at the first screening appointment so would not need additional visits. Similarly, breast density measurement can be conducted using the mammogram images taken as part of the woman’s first screen. A risk-prediction service for women attending at a younger age would require them attending a stand-alone appointment for risk-prediction unless this could be incorporated into another service such as cervical screening which currently invites women from the age of 25 in the UK. If a mammogram was required to measure breast density then this would likely involve having to attend an appointment at a hospital or mobile van. These factors mean that women offered risk-prediction at a younger age may face additional barriers to attending compared to women invited for risk-prediction at screening age. This discrete choice experiment suggested that for some women, these barriers may impact their decision as to whether to attend or not. Flexibility about appointment booking and availability of appointments were important factors in women’s choices about risk-prediction and women were averse to having to go to a hospital for risk-prediction. While women valued a service they could participate in from home, they disliked only completing a questionnaire and risk-prediction services with fewer women predicted to be at higher risk potentially offsetting the value of a home-based service. This discrete choice experiment found that women appeared to place a higher value on services with a genetic testing component included in risk-prediction. This effect is independent on any increase in the ability of the service to find women at higher risk of cancer despite the known clinical utility of genetic testing in breast cancer risk-prediction in practice. Previous discrete choice experiments have also found that people value genetic testing when the clinical utility of this is predicted to be low (26,27). Further research is needed to understand why women were more likely to choose genetics-based risk-prediction service. Possible explanations could be the additional benefit to a woman’s family of identifying particular genetic variations such as in the BRCA 1 and 2 genes. Alternatively, higher awareness in the influence of such genes on cancer risk than factors such as breast density may have influenced women’s choices. Another explanation may lie in the concept of genetic essentialism whereby individuals believe that it is genetics which fundamentally determine our health and outcomes in life and not other factors such as the environment (28). There were a number of limitations to this study. Firstly, while attempts were made to recruit a representative sample of UK women for the study, the use of an online only survey means that potential participants without a device which could access the internet were excluded. This means the survey is unlikely to be truly representative and may have excluded some women in lower sociodemographic groups. In addition, while the survey was representative in terms of the proportion of individuals of different ethnicities recruited, the small sample size of individuals from each ethnicity limits the ability to observe differences in preferences between groups. As such, further research is needed regarding preferences for breast cancer risk-prediction among different groups who struggle to access the health system. Over-sampling of women from specific groups or the use of different recruitment approaches may be required to recruit women from these groups. While strategies were enacted to ensure the validity of responses, including the use of bot detection questions and filtering by completion speed, some responders may not have completed the survey in a manner that reflected their true preferences. While the chosen models allow for preference and scale heterogeneity, care must be taken when interpreting the results for the latent class analysis as groups may differ on either their preferences or error variance. In particular, participants in class 2 only have statistically significant preferences for the constant and using a questionnaire with genetic test. It may be that this group were quite random in their responses so care may be required when interpreting the results for this group. Conclusion This study suggests that there would be strong demand from women between the ages of 30 and 39 for a service to predict their risk of breast cancer. While most women would want their risk predicted regardless of the design of the service, the choices of a minority would depend on how the service is offered by the health system. Consideration should be given to making services accessible to all to realise the benefits of the service in reducing the number of cancers in this age group or in finding cancers at an earlier stage. Declarations Funding: This work was funded by grants from Cancer Research UK Alliance for Cancer Early Detection (ref: EDDAMC-2021\100003) and The Christie Charity. SJW, AS, DF, SH, and KP are supported by the NIHR Manchester Biomedical Research Centre (BRC) (NIHR203308). Stuart Wright is supported by an Early Career Award from the Wellcome Trust (226922/Z/23/Z).Professors David French and Katherine Payne are NIHR Senior Investigators (NIHR305827/NIHR205089).The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. All decisions concerning data collection, analysis, interpretation and publication are made independently of the funding bodies. Acknowledgements: The authors are grateful to the attendees at the Netherlands Cancer Institute Early Detection conference for their feedback on an early version of this work. The authors would also like to thank all respondents who contributed to the survey design and completed the survey, and Cancer Research UK for funding this research. Availability of data and material: The survey used to collate the data for this study is made available in supplementary appendix 1 as a pdf version of the online survey. The data generated by the survey has been made publicly available with consent from the research participants via figshare. Participants gave their consent to the publishing of the data. No personal information is contained in the data: https://figshare.com/articles/dataset/BCAN-RAY_DCE_raw_data/29597318?file=56376407 https://figshare.com/articles/dataset/BCAN-RAY_DCE_cleaned_data_for_analysis/29597330?file=56376617 Author Contributions: SJW conceived the study and contributed to acquisition of funding, led the survey design and pilot study, generated the experimental design, programmed the survey, undertook data collection, analysed the data and produced a first draft of the manuscript. ST contributed to survey design and pilot study and writing the manuscript. AS contributed to interpretation of the data and writing the manuscript. SHi contributed to formulating the research question, acquisition of funding and writing the manuscript. DPF contributed to formulating the research question, acquisition of funding and writing the manuscript. SJH contributed to formulating the research question, acquisition of funding and writing the manuscript. KP contributed to formulating the research question and conceptualisation of the survey, oversaw data analysis and interpretation, contributed to acquisition of funding and writing the manuscript. All authors contributed to the production of the final manuscript. KP acts as guarantor for this work. Ethics approval: Ethical approval (reference: 2022-10479-21671) for this study was granted by The University of Manchester’s Research Ethics Committee. Participants were asked to consent to taking part in the study by selecting a box in the survey. This study was performed in accordance with the declaration of Helsinki. Competing Interests: The authors declare that they have no conflicts of interest. References Cancer Research UK. Breast cancer incidence (invasive) statistics [Internet]. 2025 [cited 2022 Apr 14]. Available from: https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/breast-cancer/incidence-invasive#heading-One NHS Digital. NHS Digital. 2021 [cited 2023 Aug 14]. Breast Screening Programme, England 2019-20. Available from: https://digital.nhs.uk/data-and-information/publications/statistical/breast-screening-programme/england---2019-20 National Institute for Health and Care Excellence. Clinical Guideline [CG164]. 2013 [cited 2022 May 31]. Familial breast cancer: classification, care and managing breast cancer and related risks in people with a family history of breast cancer. Available from: https://www.nice.org.uk/guidance/cg164/ifp/chapter/drug-treatment-to-reduce-the-risk-of-breast-cancer Eccles BK, Copson ER, Cutress RI, Maishman T, Altman DG, Simmonds P, et al. Family history and outcome of young patients with breast cancer in the UK (POSH study). Br J Surg. 2015 Jul;102(8):924–35. Gnerlich JL, Deshpande AD, Jeffe DB, Sweet A, White N, Margenthaler JA. Elevated Breast Cancer Mortality in Young Women (<40 Years) Compared with Older Women Is Attributed to Poorer Survival in Early Stage Disease. J Am Coll Surg. 2009 Mar;208(3):341–7. Cancer Research UK. Cancer Research UK. 2023 [cited 2025 May 20]. A study looking at improving the risk assessment of breast cancer in young women (BCAN-RAY). Available from: https://www.cancerresearchuk.org/about-cancer/find-a-clinical-trial/a-study-looking-at-improving-the-risk-assessment-of-breast-cancer-in-young-women-bcan-ray Harvie M, Howell A, Evans DG. Can diet and lifestyle prevent breast cancer: what is the evidence? Am Soc Clin Oncol Educ Book Am Soc Clin Oncol Annu Meet. 2015 May;(35):e66–73. Cuzick J, Sestak I, Bonanni B, Costantino JP, Cummings S, DeCensi A, et al. Selective oestrogen receptor modulators in prevention of breast cancer: an updated meta-analysis of individual participant data. Lancet Lond Engl. 2013;381(9880):1827–34. Szinay D, Cameron R, Naughton F, Whitty JA, Brown J, Jones A. Understanding Uptake of Digital Health Products: Methodology Tutorial for a Discrete Choice Experiment Using the Bayesian Efficient Design. J Med Internet Res. 2021 Oct 11;23(10):e32365. Terris-Prestholt F, Neke N, Grund JM, Plotkin M, Kuringe E, Osaki H, et al. Using discrete choice experiments to inform the design of complex interventions. Trials. 2019 Mar 4;20(1):157. Lancsar E, Louviere J. Conducting discrete choice experiments to inform healthcare decision making: a user’s guide. PharmacoEconomics. 2008;26(8):661–77. Soekhai V, de Bekker-Grob EW, Ellis AR, Vass CM. Discrete Choice Experiments in Health Economics: Past, Present and Future. PharmacoEconomics. 2018;1–26. McFadden D. Conditional logit analysis of qualitative choice behaviour. Zarembka P, editor. Front Econom. 1974;105–42. Terris-Prestholt F, Quaife M, Vickerman P. PARAMETERISING USER UPTAKE IN ECONOMIC EVALUATIONS: THE ROLE OF DISCRETE CHOICE EXPERIMENTS. 2016; Bridges JF, Hauber AB, Marshall D, Lloyd A, Prosser L, Regier D a, et al. Conjoint analysis applications in health-a checklist: a report of the ISPOR Good Research Practices for Conjoint Analysis Task Force. Value Health. 2011 Jun;14(4):403–13. Ride J, Goranitis I, Meng Y, LaBond C, Lancsar E. A Reporting Checklist for Discrete Choice Experiments in Health: The DIRECT Checklist. PharmacoEconomics. 2024 Sep 3; Robb KA. The integrated screening action model (I-SAM): A theory-based approach to inform intervention development. Prev Med Rep. 2021 Sep 1;23:101427. NHS England. Your guide to NHS breast screening. [cited 2025 Jul 22]. Your guide to NHS breast screening. Available from: https://www.gov.uk/government/publications/breast-screening-helping-women-decide/nhs-breast-screening-helping-you-decide Hindamarch, S, Gorman, L, Hawkes, RE, Howell, SJ, French, DP. Optimising the delivery of breast cancer risk assessment for women aged 30–39 years: A qualitative study of women’s views. Womens Health. 2023;19:1–11. Johnson F, Lancsar E, Marshall D, Kilambi V, Mulbacher A, Regier D, et al. Constructing experimental designs for discrete-choice experiments: report of the ISPOR conjoint analysis experimental design good research practices task. Value Health. 2013;16:3–13. Horne, J. _choiceDes: Design Functions for Choice Studies_. 2018. Hess S, Palma D. Apollo: A flexible, powerful and customisable freeware package for choice model estimation and application. J Choice Model. 2019 Sep 1;32:100170. R Core Team. R: A language and environment for statistical computing [Internet]. Vienna, Austria; 2019. Available from: https://www.r-project.org Kelley-Jones C, Scott S, Waller J. UK Women’s Views of the Concepts of Personalised Breast Cancer Risk Assessment and Risk-Stratified Breast Screening: A Qualitative Interview Study. Cancers. 2021 Nov 19;13(22):5813. Ghanouni A, Sanderson SC, Pashayan N, Renzi C, von Wagner C, Waller J. Attitudes towards risk-stratified breast cancer screening among women in England: A cross-sectional survey. J Med Screen. 2020 Sep;27(3):138–45. Taber JM, Peters E, Klein WMP, Cameron LD, Turbitt E, Biesecker BB. Motivations to learn genomic information are not exceptional: Lessons from behavioral science. Clin Genet. 2023;104(4):397–405. Griffith GL, Edwards RT, Williams JMG, Gray J, Morrison V, Wilkinson C, et al. Patient preferences and National Health Service costs: a cost-consequences analysis of cancer genetic services. Fam Cancer. 2009 Dec 1;8(4):265–75. Dar-Nimrod I, Heine SJ. Genetic Essentialism: On the Deceptive Determinism of DNA. Psychol Bull. 2011 Sep;137(5):800–18. Additional Declarations No competing interests reported. Supplementary Files SupplementaryAppendix1.pdf SupplementaryAppendix2.docx Cite Share Download PDF Status: Under Review Version 1 posted Editorial decision: Revision requested 08 Dec, 2025 Reviews received at journal 09 Nov, 2025 Reviews received at journal 09 Oct, 2025 Reviewers agreed at journal 09 Oct, 2025 Reviewers agreed at journal 16 Sep, 2025 Reviewers invited by journal 14 Sep, 2025 Editor assigned by journal 19 Aug, 2025 Submission checks completed at journal 19 Aug, 2025 First submitted to journal 12 Aug, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7355445","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":502726482,"identity":"04227888-d739-4b9f-98f3-d760ac528e7d","order_by":0,"name":"Stuart J 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11:53:27","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-7355445/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-7355445/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":89914445,"identity":"9f9e566d-6b78-4712-9bc1-a524e09d9e76","added_by":"auto","created_at":"2025-08-26 11:30:25","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1467752,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-7355445/v1/4b3b7118-6fcf-4a03-96f2-961800cd76ac.pdf"},{"id":89912130,"identity":"8f10fd5b-f21b-40aa-9e3a-b19d0e473d13","added_by":"auto","created_at":"2025-08-26 11:06:25","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":12293329,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryAppendix1.pdf","url":"https://assets-eu.researchsquare.com/files/rs-7355445/v1/fb0e72ea1ac719a9f1436564.pdf"},{"id":89912126,"identity":"6a331900-1fe7-49f1-a569-34e3ad2d8c7d","added_by":"auto","created_at":"2025-08-26 11:06:25","extension":"docx","order_by":2,"title":"","display":"","copyAsset":false,"role":"supplement","size":25975,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryAppendix2.docx","url":"https://assets-eu.researchsquare.com/files/rs-7355445/v1/bb618a3a6513fe3aca1c2ec2.docx"}],"financialInterests":"No competing interests reported.","formattedTitle":"\u003cp\u003eUnderstanding the preferences of younger women for the delivery of a service to predict breast cancer risk: a discrete choice experiment\u003c/p\u003e","fulltext":[{"header":"Introduction","content":"\u003cp\u003eIn the UK, breast cancer is the most common type of cancer among women with around 56,000 new cases diagnosed every year (1). The NHS Breast Screening Programme invites women between 50 to 71 years every three years for breast screening (2). Although, breast cancer is most commonly diagnosed in women aged 50 years or older, around 18% of cases are found in women under 50 years, and BC is the most common cause of death in women aged 35-49 years (1). Women under 50 years can only get access to screening and preventative measures if they have a strong familial history of breast cancer conferring at least a 17% lifetime risk of the disease (3). However, around two-thirds of women under the age of 50 years who develop breast cancer do not have any first or second degree family history at all (4). Breast cancer in these younger women is more commonly lethal, due to and increased incidence of more aggressive subtypes and later stage presentation due to the lack of screening provision (5,6). The current surveillance strategy of relying on the presence of a strong family history may be inadequate because it fails to find the majority of younger women who are at increased risk of breast cancer. To address this gap the \u0026lsquo;Breast Cancer Risk Assessment in Young Women\u0026rsquo; (BCAN-RAY) study (NCT05305963) has designed and evaluated a novel model of service delivery to offer risk assessment for breast cancer in women aged 30-39 years (hereafter \u0026lsquo;younger women\u0026rsquo;) (6). \u003c/p\u003e\n\n\u003cp\u003eThere are a number of benefits to identifying younger women at higher risk of breast cancer. For these women, screening could be started at a younger age to catch cancers at an early stage. Alternatively, women could be provided with advice about lifestyle changes which could help to reduce their breast cancer risk or could be prescribed risk-reducing medicines (7,8). The potential benefits of such risk assessment to identify younger women at risk of breast cancer will only be realised if there is sufficient uptake of the service. The uptake of any service will be influenced by an individual\u0026rsquo;s preference for how the service is designed (9). Before a model of service delivery has been rolled out it is clearly impossible to collect data on preferences for aspects of the model (revealed preferences) or uptake of the model. Stated preference methods, such as discrete choice experiments (DCEs), have a role when designing new models of service delivery (10). A DCE asks a pre-defined group of relevant individuals (the sample) a series of choice questions in which they select their preferred option described using a set of attributes (the characteristics of the service delivery model) defined using levels (the possible range to define each characteristic) (11,12). The respondents\u0026rsquo; choices are then analysed (using regression methods) to generate a measure of the samples\u0026rsquo; preferences which can be used to understand the relative importance of each attribute and the trade-offs between attributes (11,13). The outputs from the regression analysis can also be used to estimate the future uptake for exemplar models of service delivery (14). \u003c/p\u003e\n\n\u003cp\u003eThis study aimed to understand the preferences of a sample of younger women (30-39 years) for the attributes of models of service delivery for a breast cancer risk assessment service. The study also aimed to generate estimates of the potential uptake of specified models of service delivery. \u003c/p\u003e"},{"header":"Methods","content":"\u003cp\u003eA discrete choice experiment, embed in an on-line survey, was designed to elicit the preferences of a sample of younger women for a model of service delivery for a breast cancer risk-prediction service. The DCE was designed and analysed following published methodological recommendations\u0026nbsp;(15) and reported in line with a published checklist (16) (see Appendix 1)\u003cstrong\u003e.\u0026nbsp;\u003c/strong\u003e Ethical approval was obtained from The University of Manchester’s Proportionate Research Ethics Committee (reference: 2024-21125-37858).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConceptualising the Choice Question\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTo conceptualise the choice question, the integrated screening action model (I-SAM) of cancer screening behaviour was used as a framework for considering the steps needed for a woman to take part in a breast cancer risk-prediction service to guide decisions about early intervention such as receiving earlier breast screening (17). This framework suggests that women have to go through multiple stages to take up the intervention on offer: becoming aware; becoming informed; deciding to act; acting; and repeating if necessarily.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eWhen considering a breast cancer risk-prediction service there are likely to be more required steps for a woman to take up the service and experience health benefit. This will include becoming aware of the service, becoming informed about the service, making a decision to have their risk predicted, acting to have their risk predicted, deciding to receive their risk feedback, acting to receive their feedback, decided to act on their risk information to reduce their risk, actually acting to change their cancer risk.\u003c/p\u003e\n\u003cp\u003eAs the BCAN-RAY study aimed to explore the feasibility of introducing a breast cancer risk-prediction service for younger women, this DCE focuses on women’s decision as to whether in principle they would like their risk to be predicted or not. It was decided that including questions to ascertain if women would then decide to receive their risk feedback and act on their risk information to reduce their risk (using strategies provided by the health service), would make a single survey too long to complete.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eFirstly, for women to choose to receive risk-prediction, they must be aware of the service. As such, the sample to be recruited for this study was defined as women who would potentially receive the service: women between the ages of 30-39. Secondly, to decide to receive risk-prediction, women must be adequately informed about the service. As such, in the discrete choice experiment, information materials explaining the concepts of breast cancer risk-prediction were included at the start of the study. These were modelled as closely as possible on existing National Health Service leaflets for breast cancer screening (18).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eSurvey Design\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe DCE was embedded into an online survey which was programmed in Qualtrics. The survey (Appendix 2) comprised 5 sections: (i) an introduction to the survey explaining what is involved with risk-prediction for breast cancer in younger women (referred to as ‘training materials’ in a DCE); (ii) the choice questions; (iii) questions regarding respondents’ views on the survey; (iv) attitudinal questions about their risk behaviour and healthcare decision-making and (v) sociodemographic questions about themselves.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eDCE Design\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe DCE was framed around the choice question: “If you had to choose between the following breast cancer risk-prediction services, which would you choose?”. The respondents were asked to choose between two unlabelled (generic) alternatives and an opt-out option. The alternatives and opt-out option were described using six attributes assigned levels (see Table 1). The opt out option was described with fixed text: “You would not have your breast cancer risk predicted, you would be invited to breast cancer screening at age 50, if you were worried about cancer before this you would visit your GP”. An infographic was also included showing that 0 out of 100 people would be identified at high risk.\u003c/p\u003e\n\u003cp\u003eThe attributes and levels for this study were identified using seven focus groups (with 29 women) and eight semi-structured interviews conducted online with women aged 30-39 years for a breast cancer risk assessment (19). These semi-structured focus groups and interviews were designed with input from patient and public involvement. The qualitative data were used to generate a long list of 19 potential attributes. This long list was grouped into three categories: attributes of information about the risk-prediction service; attributes of the risk-prediction intervention itself; attributes of the process of returning risk information. A final list of six attributes was produced by the research team (see table 1). The research team focussed on defining attributes and levels that would describe a risk assessment service that was feasible to deliver.\u003c/p\u003e\n\u003cp\u003eTable 1: Attributes and levels included in the DCE\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eAttribute\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eDescription\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eLevels\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eAttribute Type (coding for analysis)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cp\u003eHow risk is predicted\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cp\u003eThe combination of interventions used to predict a woman’s risk of breast cancer\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cul\u003e\n \u003cli\u003eA questionnaire only\u003c/li\u003e\n \u003cli\u003eA questionnaire and mammographic breast density\u003c/li\u003e\n \u003cli\u003eA questionnaire and radiofrequency breast density\u003c/li\u003e\n \u003cli\u003eA questionnaire and genetic test\u003c/li\u003e\n \u003cli\u003eA questionnaire, mammographic breast density, and genetic test\u003c/li\u003e\n \u003cli\u003eA questionnaire, radiofrequency breast density, and genetic test\u003c/li\u003e\n \u003c/ul\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cp\u003eCategorical (Effects coded)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cp\u003eAppointments needed to predict risk\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cp\u003eHow many appointments would a woman need to attend to have her risk predicted\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cul\u003e\n \u003cli\u003eOne\u003c/li\u003e\n \u003cli\u003eTwo\u003c/li\u003e\n \u003c/ul\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cp\u003eCategorical (Effects coded)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cp\u003eLocation of appointment\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cp\u003eWhere the woman would need to go to have her risk predicted\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cul\u003e\n \u003cli\u003eHome\u003c/li\u003e\n \u003cli\u003eGeneral Practitioner (GP)\u003c/li\u003e\n \u003cli\u003eA mobile van\u003c/li\u003e\n \u003cli\u003eHospital\u003c/li\u003e\n \u003cli\u003eCommunity Centre\u003c/li\u003e\n \u003c/ul\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cp\u003eCategorical (Effects coded)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cp\u003ePossible Times for the Appointment\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cp\u003eWhich days and what times of day appointments are available to book\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cul\u003e\n \u003cli\u003e9am-5pm weekdays\u003c/li\u003e\n \u003cli\u003e9am-5pm weekdays and evenings or weekends\u003c/li\u003e\n \u003c/ul\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cp\u003eCategorical (Effects coded)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cp\u003eHow appointments are booked\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cp\u003eWhat the woman needs to do to book an appointment to have her risk predicted\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cul\u003e\n \u003cli\u003eYou are sent a litter with a fixed date and time\u003c/li\u003e\n \u003cli\u003eYou can book a date and time yourself online or on the phone\u003c/li\u003e\n \u003c/ul\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cp\u003eCategorical (Effects coded)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cp\u003eThe likelihood that you are predicted to be at high risk of breast cancer\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cp\u003eThe probability that the results suggest a woman should be classed as high risk and receive earlier interventions to reduce the risk of cancer or identify cancers at an earlier stage\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cul\u003e\n \u003cli\u003e5 out of every 100 (5%) people would be predicted to be high risk\u003c/li\u003e\n \u003cli\u003e10 out of every 100 (10%) people would be predicted to be high risk\u003c/li\u003e\n \u003cli\u003e15 out of every 100 (15%) people would be predicted to be high risk\u003c/li\u003e\n \u003cli\u003e20 out of every 100 (20%) people would be predicted to be high risk\u003c/li\u003e\n \u003c/ul\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\"\u003e\n \u003cp\u003eContinuous (Linear in main analysis; with checks for non-linear functional forms)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cstrong\u003eThe Experimental Design\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eExperimental design for discrete choice experiments is the creation of choice questions by combining attributes and levels in a way which maximises the probability that preferences for all of the attributes and levels can be estimated with the lowest level of statistical uncertainty (statistical efficiency) (20). A full factorial design would result in an unfeasible number of 921,600 potential combinations of attributes and levels in choice sets. A D-efficient, main effects design was created using the choiceDes package in the programming software R (21). Illogical combinations of attributes and levels such as having a mammogram at home were removed from the design informed by expert clinical advice. The final experimental design comprised three blocks of ten questions with each participant randomised to receive one block. As 5 out of 6 attributes were categorical, a dominance test question was not included in the DCE design.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eBackground questions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eBackground questions were included in the online survey to enable a description of the study sample and also for use when analysing for preference heterogeneity. The questions included were: sociodemographic questions including level of education, religion, ethnicity and whether they had children. Respondents were also asked about their attitude to risk and questions about their level of health information seeking or avoiding behaviour.\u0026nbsp;\u003c/p\u003e\n\u003ch2\u003e\u0026nbsp;\u003cstrong\u003ePiloting\u003c/strong\u003e\u003c/h2\u003e\n\u003cp\u003eThe survey was quantitatively piloted using a purposive sample of younger women (n=50) adults recruited through an online panel-provider (Pureprofile). The results were then analysed using a conditional logit model to ensure that the coefficients for all attributes and levels could be estimated. The experimental design for the study was not updated using the results of the quantitative pilot.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStudy Population and Sample\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe relevant study population was framed around younger women (aged between30 and 39 years) who by definition, all have an as yet (undefined) risk of developing breast cancer at some point in their lives. Participants who had previously been diagnosed with breast cancer or had a close relative with breast cancer were also excluded as individuals with a family history of cancer are already potential eligible for earlier interventions in the NHS. The online survey was fielded to a sample of younger women living in the UK recruited using an online panel-provider (Pureprofile). \u0026nbsp;There are no acceptable statistical approaches to set the required sample size for a DCE. This study used the Orme rule of thumb to calculate a minimum sample size of 150 participants needed.\u003c/p\u003e\n\u003cp\u003eAlthough a sample size of 150 was the minimum required to estimate the preferences of the sample, a final target sample size of 1000 was set to allow for understanding heterogeneity in preferences. Respondents were sent a link to the online survey and reminders were not used. Respondents who completed the survey in a time that was under 2 standard deviations from the median were defined as ‘speedsters’ and not engaging with the survey and removed from the dataset. These speedsters were then ‘replaced’ by a sample of further respondents identified by the panel-provider. Using Qualtrics also allowed the identification of responses which were likely from ‘bots’ completing the survey. These bots were ‘replaced’ by a sample of further respondents identified by the panel-provider.\u003c/p\u003e\n\u003ch2\u003e\u0026nbsp;\u003cstrong\u003eData Analysis\u003c/strong\u003e\u003c/h2\u003e\n\u003cp\u003eAn analysis plan was created which specified that individuals who did not complete the survey and those who always chose the same alternative would be excluded. Speedsters and bots were replaced at the data collection phase. Descriptive statistics for sociodemographic characteristics, behavioural questions and survey feedback were produced for respondents in the final sample.\u003c/p\u003e\n\u003cp\u003eFollowing data cleaning, the choice data were analysed using conditional logit models in which the continuous attributes were specified as linear, continuous variables and categorial attributes effects coded. A single constant was included to represent the probability of opting in versus opting out.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eDifferent model functional forms will be estimated whereby two constants are used to represent the probability of selecting hypothetical risk-prediction or feedback scenario A or scenario B. This serves as a test as to whether participants were always choosing scenario A or B regardless of the levels shown.\u003c/p\u003e\n\u003cp\u003eA series of regression models were then used to assess non-linearity in preferences for the probability of being identified as high risk attribute. All tests of model specification will be made by comparing the Bayesian Information Criterion (BIC) of the different models. If a model specification is found to result in a lower BIC value then this suggests that the model specification adds sufficient additional explanatory power for the number of additional parameters in the model.\u003c/p\u003e\n\u003cp\u003eWhen a final functional form was selected, a random parameter logit model was then estimated to determine if a model which allows for preference heterogeneity provided a better fit for the data. A two-step process was followed, with an uncorrelated random parameter logit estimated first and then a fully correlated random parameter logit estimated. The fully correlated model allows for both differences in error between participants as well as differences in preferences.\u003c/p\u003e\n\u003cp\u003eTo better understand whether there were particular groups with similar preferences, a latent class model was also be estimated. The best number of classes was chosen using the BIC statistic. When the number of classes was chosen, a further model was estimated to determine if any demographic characteristics were correlated with membership of the classes. All of the collected demographic classes were tested for class membership prediction.\u003c/p\u003e\n\u003cp\u003eCoefficients and associated robust standard errors (SEs) from the best fitting model were used to calculate predicted uptake probabilities for different hypothetical risk-prediction services. The hypothetical services reported in this paper are the most and least preferred services based on the choice model for aggregated preferences as well as an exemplar service representing the risk-prediction approach used in the BCAN-RAY study. Differences in predicted uptake among the different predicted classes from the latent class analysis will be explored.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eAll analyses were conducted using the Apollo package (version 0.3.5) in the open source software R (22,23).\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003eA sample of 936 younger women were included in the final analysis in this study. A total of 2512 woman entered the survey from the link sent by Pureprofile. Of these women, 1312 consented to take part and 1144 of these completed the whole survey. The reCAPTCHA tool included in the survey identified 158 responses which were likely to have been provided by bots (with a score over 0.5). A further 28 responses removed due to fast completion times (\u0026lt;\u0026thinsp;192 seconds: over 2 standard deviations from the mean). 22 respondents did not complete all the DCE questions and were excluded. In the final sample of 936 participants the median survey completion time was 9.38 minutes.\u003c/p\u003e\u003cp\u003eDescriptive statistics summarising the final sample are provided in Table\u0026nbsp;\u003cspan refid=\"Tab2\" class=\"InternalRef\"\u003e2\u003c/span\u003e. A summary of the results of the attitudinal questions is provided in Table \u003cspan refid=\"Tab3\" class=\"InternalRef\"\u003e3\u003c/span\u003e.\u003c/p\u003e\u003cp\u003e\u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab2\" border=\"1\"\u003e\u003ccaption language=\"En\"\u003e\u003cdiv class=\"CaptionNumber\"\u003eTable 2\u003c/div\u003e\u003cdiv class=\"CaptionContent\"\u003e\u003cp\u003eDemographic composition of the sample\u003c/p\u003e\u003c/div\u003e\u003c/caption\u003e\u003ccolgroup cols=\"2\"\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e\u003cthead\u003e\u003ctr\u003e\u003cth align=\"left\" colname=\"c1\"\u003e\u003cp\u003eCharacteristic\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c2\"\u003e\u003cp\u003eNumber (Percentage)\u003c/p\u003e\u003c/th\u003e\u003c/tr\u003e\u003ctr\u003e\u003cth align=\"left\" colname=\"c1\"\u003e\u003cp\u003eHighest education\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/th\u003e\u003c/tr\u003e\u003c/thead\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eNo formal education\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e13 (1.4)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e1\u0026ndash;4 O levels/GCSEs\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e50 (5.3)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e5\u0026thinsp;+\u0026thinsp;O levels/GCSEs\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e44 (4.7)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eNational Vocation Qualification (NVQs)\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e86 (9.2)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eA levels/AS levels\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e148 (15.8)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eUndergraduate degree\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e383 (40.9)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003ePostgraduate degree\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e175 (18.7)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003ePhD/Doctorate\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e15 (1.6)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eOther formal qualification\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e22 (2.4)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eReligion\u003c/b\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eNo religion\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e479 (51.1)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eChristian\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e354 (37.8)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eBuddhist\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e8 (0.9)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eHindu\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e11 (1.2)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eJewish\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e1 (0.1)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eMuslim\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e65 (6.9)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eSikh\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e5 (0.5)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eOther\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e13 (1.4)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eEthnicity\u003c/b\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eWhite English/Welsh/Scottish/Northern Irish/British\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e639 (68.2)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eWhite Irish\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e10 (1.1)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eWhite Gypsy or Traveller\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e2 (0.2)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eOther white background\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e61 (6.5)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eWhite and Black Caribbean\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e8 (0.8)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eWhite and Black African\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e12 (1.3)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eWhite and Asian\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e10 (1.1)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eOther mixed/multiple background\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e7 (0.7)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eIndian\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e26 (2.7)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003ePakistani\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e19 (2.0)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eBangladeshi\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e11 (1.2)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eChinese\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e11 (1.2)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eOther Asian Background\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e18 (1.9)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eBlack African\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e79 (8.4)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eBlack Caribbean\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e14 (1.5)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eAny other Black/African\\Caribbean Background\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e3 (0.3)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eArab\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e2 (0.2)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eAny other ethnic group\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e4 (0.4)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eDo you have any children?\u003c/b\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eYes\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e572 (61.1)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eNo\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e364 (38.9)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/colgroup\u003e\u003c/table\u003e\u003c/div\u003e\u003c/p\u003e\u003cp\u003e\u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab3\" border=\"1\"\u003e\u003ccaption language=\"En\"\u003e\u003cdiv class=\"CaptionNumber\"\u003eTable 3\u003c/div\u003e\u003cdiv class=\"CaptionContent\"\u003e\u003cp\u003eSummary of responses to attitudinal questions\u003c/p\u003e\u003c/div\u003e\u003c/caption\u003e\u003ccolgroup cols=\"2\"\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e\u003cthead\u003e\u003ctr\u003e\u003cth align=\"left\" colname=\"c1\"\u003e\u003cp\u003eRisk preferences\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/th\u003e\u003c/tr\u003e\u003c/thead\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eOverall level of risk taking (from 0 for risk averse to 10 for fully prepared to take risk)\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e5.41 (CI 5.24 to 5.58)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eWillingness to take risks when driving\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e3.34 (CI 3.16 to 3.52)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eWillingness to take risks in financial matters\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e4.44 (CI 4.26 to 4.62)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eWillingness to take risks during leisure and sport\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e5.58 (CI 5.41 to 5.74)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eWillingness to take risks in your occupation\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e5.20 (CI 5.03 to 5.38)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eWillingness to take risks with your health\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e3.70 (CI 3.52 to 3.89)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eWillingness to take risks in your faith in other people\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e4.94 (CI 4.77 to 5.11)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eInformation Engagement (from 0 for not at all true for me to 4 for very much true for me)\u003c/b\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eI like to gather as much information as I can before making a decision\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e3.15 (CI 3.09 to 3.22)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eI like to review information multiple times before making a decision\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e2.97 (CI 2.91 to 3.02)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eAfter I\u0026rsquo;ve made a decision, I continue to look for related information\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e2.90 (CI 2.84 to 2.95)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eI like to make decisions quickly (reverse scored when creating overall score)\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e1.97 (CI 1.90 to 2.05)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eMean Information Engagement\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e2.76 (CI 2.72 to 2.80)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eInformation Apprehension (from 0 for not at all true for me to 4 for very much true for me)\u003c/b\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eI have difficulty making sense of information from multiple sources\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e1.80 (CI 1.72 to 1.87)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eI fear that I might find out something that I don\u0026rsquo;t want to know\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e2.24 (CI 2.17 to 2.32)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eI think it\u0026rsquo;s the doctor\u0026rsquo;s job to deal with information, not mine\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e1.54 (CI 1.47 to 1.61)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eI feel overwhelmed by the amount of information available\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e2.20 (CI 2.13 to 2.27)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eMean information apprehension\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e1.94 (1.89 to 2.00)\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/colgroup\u003e\u003c/table\u003e\u003c/div\u003e\u003c/p\u003e\u003cp\u003eThe average age of respondents in the final survey was 34.63 with an interquartile range of 5. Most participants were of white ethnicity (76%) and of no religion (51.1%) or Christian (37.8%). 61.1% of women had children. As a narrow age group was used for this study, statistics were not available to determine how representative the sample was of the UK population of women aged 30 to 39.\u003c/p\u003e\u003cp\u003eOn average the participants stated that they were slightly more likely than average to take risks, although they were less likely to take risks with their health. Women in the sample tended to prefer to engage with information but had only average levels of information apprehension. However, the participants were more likely than average to agree with the statement \u0026ldquo;I fear that I might find out something that I don\u0026rsquo;t want to know\u0026rdquo; which may be particularly relevant when considering the concept of breast cancer risk-prediction.\u003c/p\u003e\u003cp\u003eOn average the participants found the survey easy to complete (mean 3.87 out of 5). 54.6% of participants stated that they always used all of the attributes to make their decisions, 42.0% used a sub-set of attributes, and 3.4% said they never chose the risk-prediction service.\u003c/p\u003e\n\u003ch3\u003ePreferences\u003c/h3\u003e\n\u003cp\u003eThe results of the model selection process suggested that a model with a single constant for the opt in options was superior (BIC: 18187) to having separate constants for each opt in option (BIC: 18194). This suggested that there was no evidence that participants disproportionately chose either the left or right hand options in the choice tasks. In addition, no evidence was found of non-linearity in the likelihood of being predicted to be high risk attribute and as such a single linear coefficient was used for this attribute.\u003c/p\u003e\u003cp\u003eDifferent model specifications were explored to allow for preference and scale heterogeneity in the responses. The model fit statistics are available in supplementary appendix 3. The best model was an uncorrelated random parameter logit with pseudo panel effects. This model allows for differences in preferences among individuals as well as differences in error in completing the survey. The coefficients for this model are presented in Table \u003cspan refid=\"Tab4\" class=\"InternalRef\"\u003e4\u003c/span\u003e:\u003c/p\u003e\u003cp\u003e\u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab4\" border=\"1\"\u003e\u003ccaption language=\"En\"\u003e\u003cdiv class=\"CaptionNumber\"\u003eTable 4\u003c/div\u003e\u003cdiv class=\"CaptionContent\"\u003e\u003cp\u003eModel coefficients\u003c/p\u003e\u003c/div\u003e\u003c/caption\u003e\u003ccolgroup cols=\"4\"\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e\u003cthead\u003e\u003ctr\u003e\u003cth align=\"left\" colname=\"c1\"\u003e\u003cp\u003eAttribute or Level\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c2\"\u003e\u003cp\u003eEstimate\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c3\"\u003e\u003cp\u003eStandard Error\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c4\"\u003e\u003cp\u003eP value\u003c/p\u003e\u003c/th\u003e\u003c/tr\u003e\u003c/thead\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eNumber of appointments\u003c/b\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e-0.081\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.054\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e0.068\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eAppointments available at evenings and weekends\u003c/b\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e0.213***\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.025\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e\u0026lt;\u0026thinsp;0.001\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eAppointments only available during work hours\u003c/b\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e-0.213***\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.025\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e\u0026lt;\u0026thinsp;0.001\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eYou can book the appointment yourself\u003c/b\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e0.141***\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.023\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e\u0026lt;\u0026thinsp;0.001\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eAn appointment is booked for you\u003c/b\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e-0.141***\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.023\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e\u0026lt;\u0026thinsp;0.001\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eLocation\u003c/b\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eHospital\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e-0.254***\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.053\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e\u0026lt;\u0026thinsp;0.001\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eCommunity Centre\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e-0.012\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.066\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e0.425\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eMobile Van\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e0.008\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.054\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e0.443\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eHome\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e0.312**\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.128\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e0.008\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eGeneral Practitioner\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e-0.052\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.054\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e0.328\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eProbability of being predicted to be at high risk\u003c/b\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e0.028***\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.006\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e\u0026lt;\u0026thinsp;0.001\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eMode of risk-prediction\u003c/b\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eQuestionnaire only\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e-0.829***\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.069\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e\u0026lt;\u0026thinsp;0.001\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eQuestionnaire and genetic test\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e0.127**\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.048\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e0.004\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eQuestionnaire and mammography\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e0.071\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.067\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e0.146\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eQuestionnaire, mammography, and genetic test\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e0.465***\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.069\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e\u0026lt;\u0026thinsp;0.001\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eQuestionnaire and radiofrequency scan\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e-0.186***\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.045\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e\u0026lt;\u0026thinsp;0.001\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eQuestionnaire, radiofrequency scan and genetic test\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e0.353***\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.059\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e\u0026lt;\u0026thinsp;0.001\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eAlternative specific constant\u003c/b\u003e\u003csup\u003e\u003cb\u003e1\u003c/b\u003e\u003c/sup\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e3.993***\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.230\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e\u0026lt;\u0026thinsp;0.001\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eSigma for the Panel Effect\u003c/b\u003e\u003csup\u003e\u003cb\u003e2\u003c/b\u003e\u003c/sup\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e\u003cp\u003e-0.283\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.053\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e\u0026lt;\u0026thinsp;0.001\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/colgroup\u003e\u003c/table\u003e\u003c/div\u003e\u003c/p\u003e\u003cp\u003e\u003csup\u003e1\u003c/sup\u003e Representing the likelihood an individual would choose a risk-prediction service with mean effect for location, mode of risk-prediction, how the appointment is booked, and whether you can book yourself compared to no risk-prediction service.\u003c/p\u003e\u003cp\u003e\u003csup\u003e2\u003c/sup\u003e This coefficient represents the correlation of error in an individual\u0026rsquo;s responses across the multiple choice sets they answer\u003c/p\u003e\u003cp\u003eThe results of the random parameter logit model suggest that the participants in this study were likely to choose to have their risk predicted, as shown by the large constant term. Participants valued a service that was more likely to identify women at higher risk. They were more likely to choose a service which was available in the evenings or weekends and could be booked themselves. Participants did not want to have to go to a hospital for risk assessment but were more likely to choose a service available at home. Participants were less likely to choose a risk-prediction service that only used a questionnaire to assess risk or used a questionnaire and radiofrequency scan. However, participants were more likely to choose a risk-prediction service with a genetic component to risk-prediction.\u003c/p\u003e\u003cdiv id=\"Sec4\" class=\"Section2\"\u003e\u003ch2\u003eLatent Class Analysis\u003c/h2\u003e\u003cp\u003eIn the latent class analysis it was found that a model with four classes minimised the BIC, providing the most explanatory power for the number of parameters included. No demographic or attitudinal parameters were found to adequately predict class membership based on BIC, although the level of information apprehension did reduce the Akaike Information Criterion. As such, only a constant term was included to explain class membership.\u003c/p\u003e\u003cp\u003eThe results of the latent class analysis are reported in Table \u003cspan refid=\"Tab5\" class=\"InternalRef\"\u003e5\u003c/span\u003e. Nearly 60% of the sample belonged to class 1 which had strong preferences for a risk-prediction service. The preferences of this class were broadly similar to those of the aggregate sample, although they were also likely to attend a risk-prediction service provided in a mobile van. Class 2 comprised 18.4% of the sample and did not have strong preferences for any of the attributes and levels apart from the constant and adding a genetic test to questionnaire-based assessment. They also appeared to be sensitive to the number of appointments needed, although this was not statistically significant (p\u0026thinsp;=\u0026thinsp;0.07). They were potentially a group who answered the survey in a random manner.\u003c/p\u003e\u003cp\u003ePeople in class 3 (14.9%) of the sample were the only group without a significant alternative specific constant suggesting that they were more concerned with how a risk-prediction service was delivered than the other classes. They preferred appointments which were available at evenings and weekends and being able to book appointments themselves. They were averse to attending appointments at a mobile van and had a strong preference for a service which found more women at higher risk. Class 4 (7.4%) appeared to be unlikely to ever use a risk-prediction service, as demonstrated by their negative alternative specific constant. This may also be supported by their dislike of services with more appointments as no risk-prediction service involves no appointments.\u003c/p\u003e\u003cp\u003e\u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab5\" border=\"1\"\u003e\u003ccaption language=\"En\"\u003e\u003cdiv class=\"CaptionNumber\"\u003eTable 5\u003c/div\u003e\u003cdiv class=\"CaptionContent\"\u003e\u003cp\u003eResults of the Latent Class Analysis\u003c/p\u003e\u003c/div\u003e\u003c/caption\u003e\u003ccolgroup cols=\"9\"\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c6\" colnum=\"6\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c7\" colnum=\"7\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c8\" colnum=\"8\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c9\" colnum=\"9\"\u003e\u003c/div\u003e\u003cthead\u003e\u003ctr\u003e\u003cth align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/th\u003e\u003cth align=\"left\" colspan=\"2\" nameend=\"c3\" namest=\"c2\"\u003e\u003cp\u003eClass 1 (59.3%)\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colspan=\"2\" nameend=\"c5\" namest=\"c4\"\u003e\u003cp\u003eClass 2 (18.4%)\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colspan=\"2\" nameend=\"c7\" namest=\"c6\"\u003e\u003cp\u003eClass 3 (14.9%)\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colspan=\"2\" nameend=\"c9\" namest=\"c8\"\u003e\u003cp\u003eClass 4 (7.4%)\u003c/p\u003e\u003c/th\u003e\u003c/tr\u003e\u003ctr\u003e\u003cth align=\"left\" colname=\"c1\"\u003e\u003cp\u003eAttribute or Level\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c2\"\u003e\u003cp\u003eCoefficient\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c3\"\u003e\u003cp\u003eP value\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c4\"\u003e\u003cp\u003eCoefficient\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c5\"\u003e\u003cp\u003eP value\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c6\"\u003e\u003cp\u003eCoefficient\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c7\"\u003e\u003cp\u003eP value\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c8\"\u003e\u003cp\u003eCoefficient\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c9\"\u003e\u003cp\u003eP value\u003c/p\u003e\u003c/th\u003e\u003c/tr\u003e\u003c/thead\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eNumber of appointments\u003c/b\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e-0.016\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.800\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e-0.168\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e\u003cp\u003e0.070\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c6\"\u003e\u003cp\u003e0.02\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c7\"\u003e\u003cp\u003e0.917\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c8\"\u003e\u003cp\u003e-1.18**\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c9\"\u003e\u003cp\u003e0.013\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eAppointments available at evenings and weekends\u003c/b\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e0.194***\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.000\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e-0.002\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e\u003cp\u003e0.974\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c6\"\u003e\u003cp\u003e0.529***\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c7\"\u003e\u003cp\u003e0.000\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c8\"\u003e\u003cp\u003e0.183\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c9\"\u003e\u003cp\u003e0.316\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eAppointments only available during work hours\u003c/b\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e-0.194***\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.000\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e0.002\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e\u003cp\u003e0.974\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c6\"\u003e\u003cp\u003e-0.529***\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c7\"\u003e\u003cp\u003e0.000\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c8\"\u003e\u003cp\u003e-0.183\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c9\"\u003e\u003cp\u003e0.316\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eYou can book the appointment yourself\u003c/b\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e0.13***\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.000\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e0.015\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e\u003cp\u003e0.715\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c6\"\u003e\u003cp\u003e0.276*\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c7\"\u003e\u003cp\u003e0.013\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c8\"\u003e\u003cp\u003e0.037\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c9\"\u003e\u003cp\u003e0.854\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eAn appointment is booked for you\u003c/b\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e-0.13***\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.000\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e-0.015\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e\u003cp\u003e0.715\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c6\"\u003e\u003cp\u003e-0.276*\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c7\"\u003e\u003cp\u003e0.013\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c8\"\u003e\u003cp\u003e-0.037\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c9\"\u003e\u003cp\u003e0.854\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eLocation\u003c/b\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eHospital\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e-0.209**\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.004\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e-0.058\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e\u003cp\u003e0.510\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c6\"\u003e\u003cp\u003e-0.259\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c7\"\u003e\u003cp\u003e0.366\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c8\"\u003e\u003cp\u003e0.029\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c9\"\u003e\u003cp\u003e0.932\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eCommunity Centre\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e0.004\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.962\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e-0.011\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e\u003cp\u003e0.909\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c6\"\u003e\u003cp\u003e0.152\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c7\"\u003e\u003cp\u003e0.724\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c8\"\u003e\u003cp\u003e0.412\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c9\"\u003e\u003cp\u003e0.263\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eMobile Van\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e0.196**\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.004\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e0.073\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e\u003cp\u003e0.426\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c6\"\u003e\u003cp\u003e-0.589*\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c7\"\u003e\u003cp\u003e0.041\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c8\"\u003e\u003cp\u003e-0.098\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c9\"\u003e\u003cp\u003e0.814\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eHome\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e-0.055\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.802\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e0.035\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e\u003cp\u003e0.810\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c6\"\u003e\u003cp\u003e1.017\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c7\"\u003e\u003cp\u003e0.352\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c8\"\u003e\u003cp\u003e0.111\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c9\"\u003e\u003cp\u003e0.818\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eGeneral Practitioner\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e0.064\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.425\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e-0.039\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e\u003cp\u003e0.643\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c6\"\u003e\u003cp\u003e-0.321\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c7\"\u003e\u003cp\u003e0.333\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c8\"\u003e\u003cp\u003e-0.454\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c9\"\u003e\u003cp\u003e0.255\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eProbability of being predicted to be at high risk\u003c/b\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e-0.002\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.764\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e-0.014\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e\u003cp\u003e0.069\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c6\"\u003e\u003cp\u003e0.247***\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c7\"\u003e\u003cp\u003e0.000\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c8\"\u003e\u003cp\u003e0.028\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c9\"\u003e\u003cp\u003e0.400\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eMode of risk-prediction\u003c/b\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eQuestionnaire only\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e-0.995***\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.000\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e0.071\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e\u003cp\u003e0.487\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c6\"\u003e\u003cp\u003e0.225\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c7\"\u003e\u003cp\u003e0.456\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c8\"\u003e\u003cp\u003e-0.555\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c9\"\u003e\u003cp\u003e0.249\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eQuestionnaire and genetic test\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e0.008\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.889\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e0.318***\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e\u003cp\u003e0.000\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c6\"\u003e\u003cp\u003e0.105\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c7\"\u003e\u003cp\u003e0.515\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c8\"\u003e\u003cp\u003e0.159\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c9\"\u003e\u003cp\u003e0.710\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eQuestionnaire and mammography\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e0.037\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.633\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e0.075\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e\u003cp\u003e0.498\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c6\"\u003e\u003cp\u003e0.277\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c7\"\u003e\u003cp\u003e0.436\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c8\"\u003e\u003cp\u003e0.286\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c9\"\u003e\u003cp\u003e0.544\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eQuestionnaire, mammography and genetic test\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e0.647***\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.000\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e-0.173\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e\u003cp\u003e0.146\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c6\"\u003e\u003cp\u003e-0.169\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c7\"\u003e\u003cp\u003e0.559\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c8\"\u003e\u003cp\u003e0.212\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c9\"\u003e\u003cp\u003e0.660\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eQuestionnaire and radiofrequency scan\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e-0.196***\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.000\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e-0.157\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e\u003cp\u003e0.098\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c6\"\u003e\u003cp\u003e-0.216\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c7\"\u003e\u003cp\u003e0.210\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c8\"\u003e\u003cp\u003e-0.265\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c9\"\u003e\u003cp\u003e0.581\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eQuestionnaire, radiofrequency scan, and genetic test\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e0.499***\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.000\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e-0.135\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e\u003cp\u003e0.250\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c6\"\u003e\u003cp\u003e-0.223\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c7\"\u003e\u003cp\u003e0.230\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c8\"\u003e\u003cp\u003e0.163\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c9\"\u003e\u003cp\u003e0.741\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eAlternative specific constant\u003c/b\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e4.175***\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0.000\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e0.528**\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e\u003cp\u003e0.003\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c6\"\u003e\u003cp\u003e0.912\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c7\"\u003e\u003cp\u003e0.092\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c8\"\u003e\u003cp\u003e-2.202**\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c9\"\u003e\u003cp\u003e0.002\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eClass Membership\u003c/b\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c8\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c9\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eConstant\u003c/b\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003eReference\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c4\"\u003e\u003cp\u003e-1.171***\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e\u003cp\u003e0.000\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c6\"\u003e\u003cp\u003e-1.378***\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c7\"\u003e\u003cp\u003e0.000\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c8\"\u003e\u003cp\u003e-2.087***\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c9\"\u003e\u003cp\u003e0.000\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/colgroup\u003e\u003c/table\u003e\u003c/div\u003e\u003c/p\u003e\u003c/div\u003e\n\u003ch3\u003eUptake for a breast cancer risk-prediction service\u003c/h3\u003e\n\u003cp\u003eTable\u0026nbsp;\u003cspan refid=\"Tab6\" class=\"InternalRef\"\u003e6\u003c/span\u003e presents the predicted uptake for the most and least preferred breast cancer risk-prediction services and a service provided in a way similar to that in the BCAN-RAY study. Uptake was predicted using the random parameter logit model with pseudo panel effects and the latent class analysis, with uptake presented for each class and aggregated. For the full sample, both in the RPL and latent class analysis, predicted uptake for a breast cancer risk-prediction service is high regardless of the composition of the service (77\u0026ndash;89%). In the latent class analysis it can be seen that class 1 virtually always choose to have their risk predicted while uptake for the BCAN-RAY and least preferred services are marginally lower in class 2 and class 3. The predicted uptake is more variable in class 3 who have different preferences for the attributes and levels to the other classes. This is driven by their dislike for the mobile van used in the overall optimal service and their increased willingness to use the questionnaire in the risk-prediction service which is otherwise least preferred.\u003c/p\u003e\u003cp\u003e\u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab6\" border=\"1\"\u003e\u003ccaption language=\"En\"\u003e\u003cdiv class=\"CaptionNumber\"\u003eTable 6\u003c/div\u003e\u003cdiv class=\"CaptionContent\"\u003e\u003cp\u003ePredicted uptake for different breast cancer risk-prediction services using different models\u003c/p\u003e\u003c/div\u003e\u003c/caption\u003e\u003ccolgroup cols=\"7\"\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c6\" colnum=\"6\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c7\" colnum=\"7\"\u003e\u003c/div\u003e\u003cthead\u003e\u003ctr\u003e\u003cth align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/th\u003e\u003cth align=\"left\" colname=\"c2\"\u003e\u003cp\u003eRandom Parameter Logit\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colspan=\"5\" nameend=\"c7\" namest=\"c3\"\u003e\u003cp\u003eLatent Class Analysis\u003c/p\u003e\u003c/th\u003e\u003c/tr\u003e\u003ctr\u003e\u003cth align=\"left\" colname=\"c1\"\u003e\u003cp\u003eRisk-prediction Service\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c2\"\u003e\u003cp\u003eTotal\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c3\"\u003e\u003cp\u003eClass 1 (59.3%)\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c4\"\u003e\u003cp\u003eClass 2 (18.4%)\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c5\"\u003e\u003cp\u003eClass 3 (14.9%)\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c6\"\u003e\u003cp\u003eClass 4 (7.4%)\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c7\"\u003e\u003cp\u003eTotal\u003csup\u003e1\u003c/sup\u003e\u003c/p\u003e\u003c/th\u003e\u003c/tr\u003e\u003c/thead\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eBest\u003c/b\u003e\u003csup\u003e\u003cb\u003e2\u003c/b\u003e\u003c/sup\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e89%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003e100%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e100%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e66%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cp\u003e14%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cp\u003e87%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eBCAN-RAY\u003c/b\u003e\u003csup\u003e\u003cb\u003e3\u003c/b\u003e\u003c/sup\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e85%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003e99%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e99%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e63%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cp\u003e11%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cp\u003e86%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003e\u003cb\u003eWorst\u003c/b\u003e\u003csup\u003e\u003cb\u003e4\u003c/b\u003e\u003c/sup\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e77%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003e97%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e90%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e73%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c6\"\u003e\u003cp\u003e4%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c7\"\u003e\u003cp\u003e84%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/colgroup\u003e\u003ctfoot\u003e\u003ctr\u003e\u003ctd colspan=\"7\"\u003e\u003csup\u003e1\u003c/sup\u003e Total predicted uptake based on a weighted average of the uptake of each individual class\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd colspan=\"7\"\u003e\u003csup\u003e2\u003c/sup\u003e One appointment, available evenings and weekends, can book yourself, in a mobile van, with a questionnaire, mammography, and genetic test, 20% predicted to be at high risk\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd colspan=\"7\"\u003e\u003csup\u003e3\u003c/sup\u003e One appointment, available weekdays only, appointment booked for you, in a hospital, with a questionnaire, mammography, and genetic test, 20% predicted to be at high risk\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd colspan=\"7\"\u003e\u003csup\u003e4\u003c/sup\u003e One appointment, available weekdays only, appointment booked for you, in a hospital, with a questionnaire only, 5% predicted to be at high risk\u003c/td\u003e\u003c/tr\u003e\u003c/tfoot\u003e\u003c/table\u003e\u003c/div\u003e\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eThis discrete choice experiment has demonstrated that there would be significant demand for a breast cancer risk-prediction service among younger women if this were provided by the NHS. Uptake for an optimised risk-prediction service could be as high as 89%, with the worst potential service in this DCE still predicted to have uptake of 77%. Evidence provided by the latent class analysis demonstrates that while most women would attend a breast cancer risk-prediction service regardless of its design, around 7% of women would never want to have their risk predicted. In addition, the decision of around 30% of women in classes 2 and 3 to attend the service would be sensitive to the design of the service, with those in class 3 less likely to attend services which the majority of women find preferrable. This suggests the potential need to tailor services to different groups.\u003c/p\u003e\u003cp\u003eTo date, the majority of research around breast cancer risk-prediction has focussed on its use to stratify screening intervals by risk. In such studies, risk assessment and interval stratification had \u0026ldquo;high, but not universal, acceptability\u0026rdquo; (24). For example, in a cross-sectional survey of women aged 40\u0026ndash;70 in England, Ghanouni et al found that 85% of women thought breast cancer risk assessment was a good idea while 74% were willing to have it (25). These results are similar to the predicted uptake of 77\u0026ndash;89% in this study.\u003c/p\u003e\u003cp\u003eWhile risk-prediction at the age of population screening may be acceptable for women, there may be additional barriers to risk-prediction in younger women compared to in its use for population screening. For example, risk-prediction for stratified screening is likely to be conducted at the first screening appointment so would not need additional visits. Similarly, breast density measurement can be conducted using the mammogram images taken as part of the woman\u0026rsquo;s first screen. A risk-prediction service for women attending at a younger age would require them attending a stand-alone appointment for risk-prediction unless this could be incorporated into another service such as cervical screening which currently invites women from the age of 25 in the UK. If a mammogram was required to measure breast density then this would likely involve having to attend an appointment at a hospital or mobile van. These factors mean that women offered risk-prediction at a younger age may face additional barriers to attending compared to women invited for risk-prediction at screening age.\u003c/p\u003e\u003cp\u003eThis discrete choice experiment suggested that for some women, these barriers may impact their decision as to whether to attend or not. Flexibility about appointment booking and availability of appointments were important factors in women\u0026rsquo;s choices about risk-prediction and women were averse to having to go to a hospital for risk-prediction. While women valued a service they could participate in from home, they disliked only completing a questionnaire and risk-prediction services with fewer women predicted to be at higher risk potentially offsetting the value of a home-based service.\u003c/p\u003e\u003cp\u003eThis discrete choice experiment found that women appeared to place a higher value on services with a genetic testing component included in risk-prediction. This effect is independent on any increase in the ability of the service to find women at higher risk of cancer despite the known clinical utility of genetic testing in breast cancer risk-prediction in practice. Previous discrete choice experiments have also found that people value genetic testing when the clinical utility of this is predicted to be low (26,27). Further research is needed to understand why women were more likely to choose genetics-based risk-prediction service. Possible explanations could be the additional benefit to a woman\u0026rsquo;s family of identifying particular genetic variations such as in the BRCA 1 and 2 genes. Alternatively, higher awareness in the influence of such genes on cancer risk than factors such as breast density may have influenced women\u0026rsquo;s choices. Another explanation may lie in the concept of genetic essentialism whereby individuals believe that it is genetics which fundamentally determine our health and outcomes in life and not other factors such as the environment (28).\u003c/p\u003e\u003cp\u003eThere were a number of limitations to this study. Firstly, while attempts were made to recruit a representative sample of UK women for the study, the use of an online only survey means that potential participants without a device which could access the internet were excluded. This means the survey is unlikely to be truly representative and may have excluded some women in lower sociodemographic groups. In addition, while the survey was representative in terms of the proportion of individuals of different ethnicities recruited, the small sample size of individuals from each ethnicity limits the ability to observe differences in preferences between groups. As such, further research is needed regarding preferences for breast cancer risk-prediction among different groups who struggle to access the health system. Over-sampling of women from specific groups or the use of different recruitment approaches may be required to recruit women from these groups.\u003c/p\u003e\u003cp\u003eWhile strategies were enacted to ensure the validity of responses, including the use of bot detection questions and filtering by completion speed, some responders may not have completed the survey in a manner that reflected their true preferences. While the chosen models allow for preference and scale heterogeneity, care must be taken when interpreting the results for the latent class analysis as groups may differ on either their preferences or error variance. In particular, participants in class 2 only have statistically significant preferences for the constant and using a questionnaire with genetic test. It may be that this group were quite random in their responses so care may be required when interpreting the results for this group.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eThis study suggests that there would be strong demand from women between the ages of 30 and 39 for a service to predict their risk of breast cancer. While most women would want their risk predicted regardless of the design of the service, the choices of a minority would depend on how the service is offered by the health system. Consideration should be given to making services accessible to all to realise the benefits of the service in reducing the number of cancers in this age group or in finding cancers at an earlier stage.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eFunding: \u003c/strong\u003eThis work was funded by grants from Cancer Research UK Alliance for Cancer Early Detection (ref: EDDAMC-2021\\100003) and The Christie Charity. SJW, AS, DF, SH, and KP are supported by the NIHR Manchester Biomedical Research Centre (BRC) (NIHR203308). Stuart Wright is supported by an Early Career Award from the Wellcome Trust (226922/Z/23/Z).Professors David French and Katherine Payne are NIHR Senior Investigators (NIHR305827/NIHR205089).The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care.\u003c/p\u003e\n\u003cp\u003eAll decisions concerning data collection, analysis, interpretation and publication are made independently of the funding bodies.\u003c/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eAcknowledgements: \u003c/strong\u003eThe authors are grateful to the attendees at the Netherlands Cancer Institute Early Detection conference for their feedback on an early version of this work. The authors would also like to thank all respondents who contributed to the survey design and completed the survey, and Cancer Research UK for funding this research. \u003c/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eAvailability of data and material: \u003c/strong\u003eThe survey used to collate the data for this study is made available in supplementary appendix 1 as a pdf version of the online survey. The data generated by the survey has been made publicly available with consent from the research participants via figshare. Participants gave their consent to the publishing of the data. No personal information is contained in the data:\u003c/p\u003e\n\u003cp\u003ehttps://figshare.com/articles/dataset/BCAN-RAY_DCE_raw_data/29597318?file=56376407\u003c/p\u003e\n\u003cp\u003ehttps://figshare.com/articles/dataset/BCAN-RAY_DCE_cleaned_data_for_analysis/29597330?file=56376617\u003c/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eAuthor Contributions:\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eSJW conceived the study and contributed to acquisition of funding, led the survey design and pilot study, generated the experimental design, programmed the survey, undertook data collection, analysed the data and produced a first draft of the manuscript. \u003c/p\u003e\n\u003cp\u003eST contributed to survey design and pilot study and writing the manuscript. \u003c/p\u003e\n\u003cp\u003eAS contributed to interpretation of the data and writing the manuscript. \u003c/p\u003e\n\u003cp\u003eSHi contributed to formulating the research question, acquisition of funding and writing the manuscript.\u003c/p\u003e\n\u003cp\u003eDPF contributed to formulating the research question, acquisition of funding and writing the manuscript.\u003c/p\u003e\n\u003cp\u003eSJH contributed to formulating the research question, acquisition of funding and writing the manuscript. \u003c/p\u003e\n\u003cp\u003eKP contributed to formulating the research question and conceptualisation of the survey, oversaw data analysis and interpretation, contributed to acquisition of funding and writing the manuscript. \u003c/p\u003e\n\u003cp\u003eAll authors contributed to the production of the final manuscript. \u003c/p\u003e\n\u003cp\u003eKP acts as guarantor for this work.\u003c/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eEthics approval:\u003c/strong\u003e Ethical approval (reference: 2022-10479-21671) for this study was granted by The University of Manchester\u0026rsquo;s Research Ethics Committee. Participants were asked to consent to taking part in the study by selecting a box in the survey. This study was performed in accordance with the declaration of Helsinki.\u003c/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eCompeting Interests: \u003c/strong\u003e\u003c/p\u003e\n\n\u003cp\u003eThe authors declare that they have no conflicts of interest.\u003c/p\u003e\n\n"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eCancer Research UK. Breast cancer incidence (invasive) statistics [Internet]. 2025 [cited 2022 Apr 14]. Available from: https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/breast-cancer/incidence-invasive#heading-One\u003c/li\u003e\n\u003cli\u003eNHS Digital. NHS Digital. 2021 [cited 2023 Aug 14]. Breast Screening Programme, England 2019-20. Available from: https://digital.nhs.uk/data-and-information/publications/statistical/breast-screening-programme/england---2019-20\u003c/li\u003e\n\u003cli\u003eNational Institute for Health and Care Excellence. Clinical Guideline [CG164]. 2013 [cited 2022 May 31]. Familial breast cancer: classification, care and managing breast cancer and related risks in people with a family history of breast cancer. Available from: https://www.nice.org.uk/guidance/cg164/ifp/chapter/drug-treatment-to-reduce-the-risk-of-breast-cancer\u003c/li\u003e\n\u003cli\u003eEccles BK, Copson ER, Cutress RI, Maishman T, Altman DG, Simmonds P, et al. Family history and outcome of young patients with breast cancer in the UK (POSH study). Br J Surg. 2015 Jul;102(8):924\u0026ndash;35. \u003c/li\u003e\n\u003cli\u003eGnerlich JL, Deshpande AD, Jeffe DB, Sweet A, White N, Margenthaler JA. Elevated Breast Cancer Mortality in Young Women (\u0026lt;40 Years) Compared with Older Women Is Attributed to Poorer Survival in Early Stage Disease. J Am Coll Surg. 2009 Mar;208(3):341\u0026ndash;7. \u003c/li\u003e\n\u003cli\u003eCancer Research UK. Cancer Research UK. 2023 [cited 2025 May 20]. A study looking at improving the risk assessment of breast cancer in young women (BCAN-RAY). Available from: https://www.cancerresearchuk.org/about-cancer/find-a-clinical-trial/a-study-looking-at-improving-the-risk-assessment-of-breast-cancer-in-young-women-bcan-ray\u003c/li\u003e\n\u003cli\u003eHarvie M, Howell A, Evans DG. Can diet and lifestyle prevent breast cancer: what is the evidence? Am Soc Clin Oncol Educ Book Am Soc Clin Oncol Annu Meet. 2015 May;(35):e66\u0026ndash;73. \u003c/li\u003e\n\u003cli\u003eCuzick J, Sestak I, Bonanni B, Costantino JP, Cummings S, DeCensi A, et al. Selective oestrogen receptor modulators in prevention of breast cancer: an updated meta-analysis of individual participant data. Lancet Lond Engl. 2013;381(9880):1827\u0026ndash;34. \u003c/li\u003e\n\u003cli\u003eSzinay D, Cameron R, Naughton F, Whitty JA, Brown J, Jones A. Understanding Uptake of Digital Health Products: Methodology Tutorial for a Discrete Choice Experiment Using the Bayesian Efficient Design. J Med Internet Res. 2021 Oct 11;23(10):e32365. \u003c/li\u003e\n\u003cli\u003eTerris-Prestholt F, Neke N, Grund JM, Plotkin M, Kuringe E, Osaki H, et al. Using discrete choice experiments to inform the design of complex interventions. Trials. 2019 Mar 4;20(1):157. \u003c/li\u003e\n\u003cli\u003eLancsar E, Louviere J. Conducting discrete choice experiments to inform healthcare decision making: a user\u0026rsquo;s guide. PharmacoEconomics. 2008;26(8):661\u0026ndash;77. \u003c/li\u003e\n\u003cli\u003eSoekhai V, de Bekker-Grob EW, Ellis AR, Vass CM. 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The integrated screening action model (I-SAM): A theory-based approach to inform intervention development. Prev Med Rep. 2021 Sep 1;23:101427. \u003c/li\u003e\n\u003cli\u003eNHS England. Your guide to NHS breast screening. [cited 2025 Jul 22]. Your guide to NHS breast screening. Available from: https://www.gov.uk/government/publications/breast-screening-helping-women-decide/nhs-breast-screening-helping-you-decide\u003c/li\u003e\n\u003cli\u003eHindamarch, S, Gorman, L, Hawkes, RE, Howell, SJ, French, DP. Optimising the delivery of breast cancer risk assessment for women aged 30\u0026ndash;39\u0026thinsp;years: A qualitative study of women\u0026rsquo;s views. Womens Health. 2023;19:1\u0026ndash;11. \u003c/li\u003e\n\u003cli\u003eJohnson F, Lancsar E, Marshall D, Kilambi V, Mulbacher A, Regier D, et al. Constructing experimental designs for discrete-choice experiments: report of the ISPOR conjoint analysis experimental design good research practices task. Value Health. 2013;16:3\u0026ndash;13. \u003c/li\u003e\n\u003cli\u003eHorne, J. _choiceDes: Design Functions for Choice Studies_. 2018. \u003c/li\u003e\n\u003cli\u003eHess S, Palma D. Apollo: A flexible, powerful and customisable freeware package for choice model estimation and application. J Choice Model. 2019 Sep 1;32:100170. \u003c/li\u003e\n\u003cli\u003eR Core Team. R: A language and environment for statistical computing [Internet]. Vienna, Austria; 2019. Available from: https://www.r-project.org\u003c/li\u003e\n\u003cli\u003eKelley-Jones C, Scott S, Waller J. UK Women\u0026rsquo;s Views of the Concepts of Personalised Breast Cancer Risk Assessment and Risk-Stratified Breast Screening: A Qualitative Interview Study. Cancers. 2021 Nov 19;13(22):5813. \u003c/li\u003e\n\u003cli\u003eGhanouni A, Sanderson SC, Pashayan N, Renzi C, von Wagner C, Waller J. Attitudes towards risk-stratified breast cancer screening among women in England: A cross-sectional survey. J Med Screen. 2020 Sep;27(3):138\u0026ndash;45. \u003c/li\u003e\n\u003cli\u003eTaber JM, Peters E, Klein WMP, Cameron LD, Turbitt E, Biesecker BB. Motivations to learn genomic information are not exceptional: Lessons from behavioral science. Clin Genet. 2023;104(4):397\u0026ndash;405. \u003c/li\u003e\n\u003cli\u003eGriffith GL, Edwards RT, Williams JMG, Gray J, Morrison V, Wilkinson C, et al. Patient preferences and National Health Service costs: a cost-consequences analysis of cancer genetic services. Fam Cancer. 2009 Dec 1;8(4):265\u0026ndash;75. \u003c/li\u003e\n\u003cli\u003eDar-Nimrod I, Heine SJ. Genetic Essentialism: On the Deceptive Determinism of DNA. Psychol Bull. 2011 Sep;137(5):800\u0026ndash;18. \u003cstrong\u003e\u003c/strong\u003e\u003c/li\u003e\n\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bjc-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"","sideBox":"Learn more about [BJC Reports](https://www.springer.com/journal/44276) ","snPcode":"44276","submissionUrl":"https://submission.springernature.com/new-submission/44276/3","title":"BJC Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Nature","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"breast cancer, risk-prediction, discrete choice experiment, preferences","lastPublishedDoi":"10.21203/rs.3.rs-7355445/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7355445/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground: \u003c/strong\u003eThis study aimed to understand the preferences of a sample of younger women (30-39 years) for the attributes of models of service delivery for a breast cancer risk-prediction service to identify how best to design a service to optimise uptake.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods: \u003c/strong\u003eA discrete choice experiment was used to quantify the preferences of a purposive sample of younger women (aged 30 to 39) without prior knowledge of their risk of developing breast cancer. Respondents chose from a series of questions including two unlabelled alternatives, representing different models of a risk-prediction service, and an opt-out alternative. Data were analysed using random parameter logit and latent class models to explore potential heterogeneity in preferences for the intervention.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults: \u003c/strong\u003eThe predicted uptake for a risk-prediction service ranged from 77-89%. Participants preferred a service with more flexible appointments which could be booked by the individual themselves. Latent class analysis suggested that around 7% of women would never have their risk predicted and for approximately 30% of women the choice would depend on the design of the service.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion: \u003c/strong\u003eYounger women would be likely to choose to have their breast cancer risk, although some groups were sensitive to the design of the prediction service.\u003c/p\u003e","manuscriptTitle":"Understanding the preferences of younger women for the delivery of a service to predict breast cancer risk: a discrete choice experiment","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-08-26 11:06:20","doi":"10.21203/rs.3.rs-7355445/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2025-12-08T18:32:38+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-11-09T15:23:43+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-10-09T10:33:19+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"338292121725965292753443946105775549141","date":"2025-10-09T04:07:02+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"134634857272231979067075510364785890113","date":"2025-09-16T09:38:37+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2025-09-14T17:52:34+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2025-08-19T18:22:26+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2025-08-19T11:12:48+00:00","index":"","fulltext":""},{"type":"submitted","content":"BJC Reports","date":"2025-08-12T11:47:20+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bjc-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"","sideBox":"Learn more about [BJC Reports](https://www.springer.com/journal/44276) ","snPcode":"44276","submissionUrl":"https://submission.springernature.com/new-submission/44276/3","title":"BJC Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Nature","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"99485bbf-6d04-4f49-9e67-355658db0a3e","owner":[],"postedDate":"August 26th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[],"tags":[],"updatedAt":"2026-01-30T15:10:47+00:00","versionOfRecord":[],"versionCreatedAt":"2025-08-26 11:06:20","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-7355445","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7355445","identity":"rs-7355445","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}