Case Report: Case report: a rare case of dentigerous cyst in 1-year-old patient.

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Dentigerous cysts in infants may manifest as swelling or a firm mass in the oral cavity. Such cysts arise from dental follicles, and their development can lead to dental complications such as tooth displacement, root resorption of the adjacent teeth, or infection if not treated carefully. Enucleation is the method of choice for the treatment of such lesions. In the current case report, a rare age presented with 1 a old patient was referred to oral and maxillofacial clinics. In the case of right facial swelling and pain for five days ago, intra- and extra-oral examinations were performed. Computed Tomography (CT) demonstrated a well-defined expansile lytic lesion, and parents consented and agreed to proceed with the surgery option. Enucleation was performed surgically, and the patient was followed up for up to 8 months. Significant improvement was noted, with no further complications or recorded complaints." } { "@context": "http://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": "1", "item": { "@id": "https://f1000research.com/", "name": "Home" } }, { "@type": "ListItem", "position": "2", "item": { "@id": "https://f1000research.com/browse/articles", "name": "Browse" } }, { "@type": "ListItem", "position": "3", "item": { "@id": "https://f1000research.com/articles/14-6/v1", "name": "Case Report: Case report: a rare case of dentigerous cyst in 1-year-old..." } } ] } Home Browse Case Report: Case report: a rare case of dentigerous cyst in 1-year-old... ALL Metrics - Views Downloads Get PDF Get XML Cite How to cite this article Alshehri S. Case Report: Case report: a rare case of dentigerous cyst in 1-year-old patient. [version 1; peer review: 1 approved, 1 approved with reservations] . F1000Research 2025, 14 :6 ( https://doi.org/10.12688/f1000research.157880.1 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. Close Copy Citation Details Export Export Citation Sciwheel EndNote Ref. Manager Bibtex ProCite Sente EXPORT Select a format first Track Share ▬ ✚ Case Report Case Report: Case report: a rare case of dentigerous cyst in 1-year-old patient. [version 1; peer review: 1 approved, 1 approved with reservations] Sami Alshehri https://orcid.org/0000-0003-0155-5035 Sami Alshehri https://orcid.org/0000-0003-0155-5035 PUBLISHED 02 Jan 2025 Author details Author details Department of Biomedical Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Eastern Province, Saudi Arabia Sami Alshehri Roles: Conceptualization, Data Curation, Funding Acquisition, Investigation, Methodology, Project Administration, Resources, Supervision, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing OPEN PEER REVIEW DETAILS REVIEWER STATUS This article is included in the Global Public Health gateway. Abstract One of the most common benign lesions is dentigerous cyst, which is commonly associated with unerupted tooth crowns. Dentigerous cysts in infants may manifest as swelling or a firm mass in the oral cavity. Such cysts arise from dental follicles, and their development can lead to dental complications such as tooth displacement, root resorption of the adjacent teeth, or infection if not treated carefully. Enucleation is the method of choice for the treatment of such lesions. In the current case report, a rare age presented with 1 a old patient was referred to oral and maxillofacial clinics. In the case of right facial swelling and pain for five days ago, intra- and extra-oral examinations were performed. Computed Tomography (CT) demonstrated a well-defined expansile lytic lesion, and parents consented and agreed to proceed with the surgery option. Enucleation was performed surgically, and the patient was followed up for up to 8 months. Significant improvement was noted, with no further complications or recorded complaints. READ ALL READ LESS Keywords Dentigerous cyst, radiograph, dental cyst, pediatric patients, surgery Corresponding Author(s) Sami Alshehri ( [email protected] ) Close Corresponding author: Sami Alshehri Competing interests: No competing interests were disclosed. Grant information: The author(s) declared that no grants were involved in supporting this work. Copyright: © 2025 Alshehri S. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. How to cite: Alshehri S. Case Report: Case report: a rare case of dentigerous cyst in 1-year-old patient. [version 1; peer review: 1 approved, 1 approved with reservations] . F1000Research 2025, 14 :6 ( https://doi.org/10.12688/f1000research.157880.1 ) First published: 02 Jan 2025, 14 :6 ( https://doi.org/10.12688/f1000research.157880.1 ) Latest published: 02 Jan 2025, 14 :6 ( https://doi.org/10.12688/f1000research.157880.1 ) Introduction Dentigerous cysts are considered one of the most common benign developmental lesions faced by maxillofacial surgeons during their training and practice. 1 , 2 Historically, an early report by Gabell, James and Payne documented 84 dentigerous cysts in 1914. The authors reported that these cysts present with the following typical features: asymptomatic, accidental finding, associated with supernumerary or failure of tooth eruption in the maxilla or mandible. 3 These manifestations remain the same in the current literature, with more studies reporting the hallmark of the cyst lining attached to the cementoenamel junction. 2 , 4 The authors agree that dentigerous cysts are the second most common odontogenic cyst. 5 – 7 The pathogenesis of dentigerous cyst formation relies on fluid accumulation between the reduced enamel epithelium and tooth, which is released from compromised follicular veins around the tooth. 8 , 9 In terms of age and sex prevalence, Zhang et al. analyzed 2082 dentigerous cysts diagnosed in British Columbia, Canada. The authors found that dentigerous cysts are more likely to be encountered in male patients in their twenties and thirties. These observations are considered rare in younger and older age groups. 2 Radiographically, dentigerous cysts in most cases show well-defined radiolucent lesions associated with an unerupted tooth. However, some instances demonstrated ill-defined borders if they get infected 10 , 11 In terms of surgical management, enucleation of the cyst is usually the method of choice. However, marsupialization is considered a surgical modality, especially when the cysts are adjacent to vital structures. This technique induces cyst decompression, which aids total enucleation in the second surgery with fewer postoperative complications. 12 We report a rare case of dentigerous cyst in a 1-year-old boy. To the best of our knowledge, this is the second documented case in the literature since the first report by Suresh et al. in 2011. 13 Case report A 1-year-old boy medically fit and pain was referred to the Oral and Maxillofacial Surgery Department of King Fahad Hospital University (KFHU), Khobar, Saudi Arabia as case right facial swelling and pain with history of 5 days. General examination showed that all vital signs were normal, with no signs of dehydration or dysphagia. Extraoral examination revealed a right buccal swelling that was consistent with good mouth opening. Intraoral examination revealed a bluish color on the right posterior mandibular ridge with no vestibular swelling. Computed tomography (CT) demonstrated a well-defined expansile lytic lesion in the posterior body of the mandible involving an unerupted tooth measuring approximately 1.6 × 1.3 cm ( Figure 1 ). The radiographic appearance is highly suggestive of a dentigerous cyst or inflammatory cyst based on histopathological correlation. Figure 1. Pre-operative CT showed mandibular lesion A. sagittal, B. axial, C. coronal and D. 3D views. The parents were reassured, and the treatment plan options were explained in detail. The parents agreed to proceed with surgical enucleation of the lesion under general anesthesia. The patient was admitted to the KFHU, and consent was signed. Under all aseptic conditions, the patient was prepared using povidone-iodine solution, and the patient was covered with a sterile towel. Good exposure of the lesion was achieved by raising a full mucoperiosteal flap, enucleation of the entire cyst along with the associated tooth, and bleeding from all margins of the cavity lesion. The specimen was placed in a labelled container for histopathological examination. Irrigation with normal saline and hemostasis were achieved, and the surgical site was closed with 3/0 Vicryl sutures. A gross examination of the specimen consists of tooth and cyst lining (1.5 cm × 1.5 cm with a wall thickness of 0.2). Microscopic analysis revealed a cyst wall lined by non-keratinized squamous epithelium with intraepithelial neutrophil infiltration and pus formation. This finding is consistent with an inflamed dentigerous cyst. The patient was followed on a regular basis for up to 8 months after the surgery. The parents were informed of the outcomes of the surgical operation. The surgical site was intact, swelling was reduced significantly, and no complaints were reported. Three-month post-operative CT) scan was requested and reviewed. Compared with the previous CT, no evidence of bone destruction, pathology, or soft tissue abnormalities was observed or noted ( Figure 2 ). Figure 2. Three-months post-operative CT showed complete healing A. sagittal, B. axial, C. coronal and D. 3D views. Discussion Dentigerous cysts are a major area of interest in the field of oral and maxillofacial surgery as they are the second most common developmental cysts. Therefore, a deeper understanding of different presentations can play a crucial role in providing the optimum care to the patients. 14 , 15 Several studies have explored the pathophysiological processes that underlie dentigerous cysts. Benn and Altini (1996) suggested that three possible mechanisms could initiate the pathological process based on the source of the inflammation. First, the radicular cyst in the pathway of eruption of the successor’s tooth was left in situ following exfoliation or extraction of primary teeth. The second is the presence of a nonvital tooth. Finally, there are other sources of inflammation in the jaw. 16 However, as mentioned previously, the pressure from fluid accumulation between the reduced enamel epithelium and unerupted tooth seems to be the most common pathophysiological theme of dentigerous cysts. 8 , 9 , 12 , 17 In our case, the pathological process mirrored the generally agreed pathological pattern of a dentigerous cyst. A dentigerous cyst is usually discovered incidentally during routine dental examinations. 9 – 11 Our patient presented with right facial swelling and pain, which could be attributed to the fact that fluid accumulation over time results in expansion, leading to facial swelling accompanied by pain. No intervention to break the expansion pressure could result in a negative effect on the surrounding vital structures such as the inferior alveolar nerve and maxillary sinus. 12 , 17 Authors are in agreement that dentigerous are commonly associated with unerupted mandibular third molars followed by maxillary canines. 2 , 10 , 12 This finding broadly supports the current literature on the most commonly impacted teeth. 12 , 17 , 18 In terms of age range, despite global population variations, the current evidence suggests that the second and third decades of life are the peak incidences of dentigerous cysts at approximately 23% and 20%, respectively. Notably, a considerable percentage of cases were reported in the fourth, fifth, and sixth cases. 2 Several reports in the literature were published in the first decade. Hedge reported a case of 9 years old boy with left mandible swelling and pain, 19 Dave reported two cases of 9 years old boy with asymptomatic swelling and 7 years old boy who was discovered during a routine dental examination, 12 Deepa documented a case of 10 years old girl with a history of difficulty in mastication due to a dentigerous cyst in her lower right jaw 20 and McKinney also reported 4 years old child with asymptomatic facial swelling related to dentigerous cyst. 21 The first documented case in one a old boy was reported by Suresh et al. in 2011. The patient presented with left mandibular angle swelling associated with a history of pain, difficulty in swallowing, and an obliterated buccal sulcus. 13 Our case is the second documented case after Suresh et al. at this very young age. However, the case we reported differed in some clinical manifestations, as our patient presented with a history of rapid right facial swelling and pain. No difficulty in swallowing or buccal sulcus obliteration. This difference illustrates the benefit of reporting such cases to aid and build up evidence-based practice, as this will result in positive reflections on the care that we provide for our patients. A unilateral and single presentation is considered a classic demonstration of a dentigerous cyst, similar to our case. Nevertheless, multiple dentigerous cysts can be observed in patients with basal cell nevus, mucopolysaccharidoses, and cleidocranial dysplasia syndromes. 20 However, few cases of bilateral dentigerous cysts have been reported in the literature in non-syndromic patients. 22 In terms of radiographic presentation, based on a CT scan, our case showed a well-defined radiolucent lesion associated with an unerupted tooth which is in alignment with the characteristic appearance of a dentigerous cyst. 12 , 13 , 20 Surgical treatment techniques for dentigerous cysts include enucleation and marsupialization. The surgical decision is formulated based on several factors, such as the patient’s medical history, location and size of the lesion, and the facilities where the surgery will take place. 20 Dave et al. suggested that a multidisciplinary approach is required for such cases to establish a fully comprehensive treatment plan. The authors acknowledge that enucleation is the gold standard surgical option for most dentigerous cyst cases. However. Marsupialization followed by complete removal of the cyst should be considered in cases of close proximity to vital structures. 12 The recurrence of dentigerous cysts is not a concern for most patients. 11 , 13 Our patient underwent complete removal of the cyst under general anesthesia with the associated tooth to eliminate the need for second-stage surgery, as well as to improve the patient and family’s quality of life by reducing the required time in the hospital. Ethical approval Not required. Consent Written informed consent for publication was obtained from the patient’s parent. Additionally, we confirm that we have obtained permission to use radiographic images from the patients’ parents included in this presentation. Data availability statement No data are associated with this article. References 1. Agrawal M, Sharma S, Gupta K: Multiple teeth in a single dentigerous cyst follicle: a perplexity. Ann. Maxillofac. Surg. 2011; 1 (2): 187–189. PubMed Abstract | Publisher Full Text | Free Full Text 2. Zhang LL, Yang R, Zhang L, et al. : Dentigerous cyst: A retrospective clinicopathological analysis of 2082 dentigerous cysts in British Columbia, Canada. Int. J. Oral Maxillofac. Surg. 2010; 39 (9): 878–882. PubMed Abstract | Publisher Full Text 3. Gabell D, James W, Payne J: The Report on Odontomes: The Committee Appointed by the British Dental Association. London, England: John Bale, Sons and Danielsson, Ltd.; 1914; p. 133. 4. Hasan S, Ahmed SA, Reddy LB: Dentigerous cyst in association with impacted inverted mesiodens: Report of a rare case with a brief review of literature. Int. J. Appl. Basic Med. Res. 2014; 4 (Suppl 1): S61–S64. PubMed Abstract | Publisher Full Text 5. Johnson NR, Gannon OM, Savage NW, et al. : Frequency of odontogenic cysts and tumors: A systematic review. J. Investig. Clin. Dent. 2014; 5 (1): 9–14. PubMed Abstract | Publisher Full Text 6. Ochsenius G, Escobar E, Godoy L, et al. : Analysis of 2,944 cases in Chile. Med. Oral Patol. Oral Cir. Bucal. 2007; 12 (2): 85–91. 7. Kambalimath DH, Kambalimath HV, Agrawal SM, et al. : Prevalence and distribution of odontogenic cysts in the Indian population: A 10-year retrospective study. J. Maxillofac. Oral Surg. 2014; 13 : 10–15. PubMed Abstract | Publisher Full Text | Free Full Text 8. Browne R: Pathogenesis of odontogenic cysts: review. J. Oral Pathol. Med. 1975; 4 (1): 31–46. Publisher Full Text 9. Mortha N, Uppala D: Pathogenesis of odontogenic cysts. Oral Maxillofac. Pathol. J. 2021; 12 (1). 10. Neville BW, Damm DD, Allen CM, et al. : Oral and maxillofacial pathology. Elsevier Health Sciences; 2015. 11. Zerrin E, Husniye D: Peruze C: Dentigerous cysts of the jaws: Clinical and radiological findings of 18 cases. J. Oral Maxillofac. Radiol. 2014; 2 (3): 77–81. Publisher Full Text 12. Dave M, Clarke L, Grindrod M, et al. : Adapting trees for dentigerous cysts in pediatric and adult patients: a case series. Oral Surg. 2021; 14 (3): 277–284. Publisher Full Text 13. Suresh R, Janardhanan M, Joseph AP, et al. : A rare case of a dentigerous cyst in a one-year-old child: The earliest reported occurrence. Head Neck Pathol. 2011; 5 : 171–174. PubMed Abstract | Publisher Full Text | Free Full Text 14. Motamedi MH, Talesh KT: Management of extensive dentigerous cysts. Br. Dent. J. 2005; 198 (4): 203–206. PubMed Abstract | Publisher Full Text 15. Ewbank L, El-Nashar R, Middlefell L: Spontaneous regression of a dentigerous cyst associated with an impacted mandibular canine: A case report. Oral Surg. 2019; 12 (1): 48–50. Publisher Full Text 16. Benn A, Altini M: Dentigerous cysts of inflammatory origin: a clinicopathologic study. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 1996; 81 (2): 203–209. Publisher Full Text 17. Shetty RM, Dixit U: Dentigerous cyst of inflammatory origin. Int. J. Clin. Pediatr. Dent. 2010; 3 (3): 195–198. PubMed Abstract | Publisher Full Text | Free Full Text 18. Suresh R, Janardhanan M, Joseph AP, et al. : A rare case of a dentigerous cyst in a one-year-old child: The earliest reported occurrence. Head Neck Pathol. 2011; 5 : 171–174. PubMed Abstract | Publisher Full Text | Free Full Text 19. Hegde R, Khare S, Devrukhkar V: Dentigerous cyst in a young child: clinical insight and a case report. J. Indian Soc. Pedod. Prev. Dent. 2013; 31 (3): 209–211. PubMed Abstract | Publisher Full Text 20. Deepa KK, Jannu A, Kulambi M, et al. : A case of dentigerous cyst in a pediatric patient: an insight into differential diagnostic entities. Adv. Oral Maxillofac. Surg. 2021; 3 : 100130. Publisher Full Text 21. McKinney SL, Lukes SM: Dentigerous cyst in a young child: A case report. Can. J. Dent. Hyg. 2021; 55 (3): 177–181. PubMed Abstract 22. Freitas DQ, Tempest LM, Sicoli E, et al. : Bilateral dentigerous cysts: Review of the literature and report of an unusual case. Dentomaxillofac. Radiol. 2006; 35 (6): 464–468. PubMed Abstract | Publisher Full Text Comments on this article Comments (0) Version 1 VERSION 1 PUBLISHED 02 Jan 2025 ADD YOUR COMMENT Comment Author details Author details Department of Biomedical Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Eastern Province, Saudi Arabia Sami Alshehri Roles: Conceptualization, Data Curation, Funding Acquisition, Investigation, Methodology, Project Administration, Resources, Supervision, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Competing interests No competing interests were disclosed. Grant information The author(s) declared that no grants were involved in supporting this work. Article Versions (1) version 1 Published: 02 Jan 2025, 14:6 https://doi.org/10.12688/f1000research.157880.1 Copyright © 2025 Alshehri S. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Download Export To Sciwheel Bibtex EndNote ProCite Ref. Manager (RIS) Sente metrics Views Downloads F1000Research - - PubMed Central info_outline Data from PMC are received and updated monthly. - - Citations open_in_new 0 open_in_new 0 open_in_new SEE MORE DETAILS CITE how to cite this article Alshehri S. Case Report: Case report: a rare case of dentigerous cyst in 1-year-old patient. [version 1; peer review: 1 approved, 1 approved with reservations] . F1000Research 2025, 14 :6 ( https://doi.org/10.12688/f1000research.157880.1 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS track receive updates on this article Track an article to receive email alerts on any updates to this article. TRACK THIS ARTICLE Share Open Peer Review Current Reviewer Status: ? Key to Reviewer Statuses VIEW HIDE Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Version 1 VERSION 1 PUBLISHED 02 Jan 2025 Views 0 Cite How to cite this report: Rosa ACG. Reviewer Report For: Case Report: Case report: a rare case of dentigerous cyst in 1-year-old patient. [version 1; peer review: 1 approved, 1 approved with reservations] . F1000Research 2025, 14 :6 ( https://doi.org/10.5256/f1000research.173397.r388993 ) The direct URL for this report is: https://f1000research.com/articles/14-6/v1#referee-response-388993 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 03 Jun 2025 Ana Cláudia Garcia Rosa , Federal University of Tocantins, Palmas, Brazil Approved VIEWS 0 https://doi.org/10.5256/f1000research.173397.r388993 The manuscript has several strengths, particularly in its clinical relevance and the detailed description of diagnostic and therapeutic approaches. However, there are areas where the manuscript could be enhanced. First, the introduction would benefit from the inclusion of ... Continue reading READ ALL The manuscript has several strengths, particularly in its clinical relevance and the detailed description of diagnostic and therapeutic approaches. However, there are areas where the manuscript could be enhanced. First, the introduction would benefit from the inclusion of a brief paragraph discussing the existing literature on dentigerous cysts in pediatric populations to contextualize the rarity and clinical significance of this case. Additionally, including images of the histopathological findings would strengthen the diagnostic evidence and provide readers with visual references. Moreover, including a histological comparison with other odontogenic cysts in the discussion would help differentiate dentigerous cysts from other odontogenic lesions based on their histopathological features. To enhance the discussion, the authors could also incorporate one or two paragraphs comparing potential differential diagnoses, as well as considerations for the early detection and management of such lesions in infants. These additions would enrich the educational value of the manuscript. Regarding ethical considerations, although the authors state that informed consent was obtained, it is important to note that some institutions require all indexed clinical case reports to be reviewed or acknowledged by an ethics committee. It is good practice to state whether institutional policies exempt single-case reports from formal ethical review. In conclusion, this case report illustrates an entity that is relatively common in adults but rare in pediatric oral pathology, underscoring its clinical significance. With the incorporation of the suggested improvements, the manuscript will offer enhanced educational value and serve as a helpful resource for clinicians. This article is suitable for indexing, pending minor revisions. Is the background of the case’s history and progression described in sufficient detail? Yes Are enough details provided of any physical examination and diagnostic tests, treatment given and outcomes? Yes Is sufficient discussion included of the importance of the findings and their relevance to future understanding of disease processes, diagnosis or treatment? Partly Is the case presented with sufficient detail to be useful for other practitioners? Yes Competing Interests: No competing interests were disclosed. Reviewer Expertise: Oral Pathology I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Rosa ACG. Reviewer Report For: Case Report: Case report: a rare case of dentigerous cyst in 1-year-old patient. [version 1; peer review: 1 approved, 1 approved with reservations] . F1000Research 2025, 14 :6 ( https://doi.org/10.5256/f1000research.173397.r388993 ) The direct URL for this report is: https://f1000research.com/articles/14-6/v1#referee-response-388993 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Cobo Vázquez C. Reviewer Report For: Case Report: Case report: a rare case of dentigerous cyst in 1-year-old patient. [version 1; peer review: 1 approved, 1 approved with reservations] . F1000Research 2025, 14 :6 ( https://doi.org/10.5256/f1000research.173397.r356556 ) The direct URL for this report is: https://f1000research.com/articles/14-6/v1#referee-response-356556 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 08 Jan 2025 Carlos Cobo Vázquez , Universidad Complutense de Madrid, Madrid, Spain Approved with Reservations VIEWS 0 https://doi.org/10.5256/f1000research.173397.r356556 Thank you for your submission. The article presented describes the second case of a young child with the appearance of a dentigerous cyst. The presentation of this case contributes to the expansion of scientific knowledge since, as ... Continue reading READ ALL Thank you for your submission. The article presented describes the second case of a young child with the appearance of a dentigerous cyst. The presentation of this case contributes to the expansion of scientific knowledge since, as the authors describe, the highest incidence of these cysts occurs in the lower third molars. However, despite the value of the work, it presents a series of limitations that prevent the reader from understanding the pathology. It would be of great value to provide previous clinical, intra-operative and follow-up photographs of the patient. We understand the limitation to photograph a young patient, but radiological tests are provided without difficulty, and by performing the surgical treatment under general anesthesia an adequate record could have been made. On the other hand, regarding therapeutic alternatives, more conservative options could be considered regarding the molar germ. Neither in the description of the case nor in the discussion, the reason for ruling out alternatives such as cystectomy, marsupialization or drainage, while maintaining the molar germ, is mentioned. It would also be interesting to provide information on the success rates of these more conservative treatments Your work is interesting. However, readers are missing previous clinical photos of the pathology, as well as photographs of the surgical intervention, the pathological anatomy and the subsequent follow-up. If this could be corrected it would be of great interest due to the low frequency of the case. Is the background of the case’s history and progression described in sufficient detail? Yes Are enough details provided of any physical examination and diagnostic tests, treatment given and outcomes? No Is sufficient discussion included of the importance of the findings and their relevance to future understanding of disease processes, diagnosis or treatment? Yes Is the case presented with sufficient detail to be useful for other practitioners? Partly Competing Interests: No competing interests were disclosed. Reviewer Expertise: Oral surgery I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Cobo Vázquez C. Reviewer Report For: Case Report: Case report: a rare case of dentigerous cyst in 1-year-old patient. [version 1; peer review: 1 approved, 1 approved with reservations] . F1000Research 2025, 14 :6 ( https://doi.org/10.5256/f1000research.173397.r356556 ) The direct URL for this report is: https://f1000research.com/articles/14-6/v1#referee-response-356556 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Comments on this article Comments (0) Version 1 VERSION 1 PUBLISHED 02 Jan 2025 ADD YOUR COMMENT Comment keyboard_arrow_left keyboard_arrow_right Open Peer Review Reviewer Status info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Reviewer Reports Invited Reviewers 1 2 Version 1 02 Jan 25 read read Carlos Cobo Vázquez , Universidad Complutense de Madrid, Madrid, Spain Ana Cláudia Garcia Rosa , Federal University of Tocantins, Palmas, Brazil Comments on this article All Comments (0) Add a comment Sign up for content alerts Sign Up You are now signed up to receive this alert Browse by related subjects keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2025 Rosa A. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 03 Jun 2025 | for Version 1 Ana Cláudia Garcia Rosa , Federal University of Tocantins, Palmas, Brazil 0 Views copyright © 2025 Rosa A. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions The manuscript has several strengths, particularly in its clinical relevance and the detailed description of diagnostic and therapeutic approaches. However, there are areas where the manuscript could be enhanced. First, the introduction would benefit from the inclusion of a brief paragraph discussing the existing literature on dentigerous cysts in pediatric populations to contextualize the rarity and clinical significance of this case. Additionally, including images of the histopathological findings would strengthen the diagnostic evidence and provide readers with visual references. Moreover, including a histological comparison with other odontogenic cysts in the discussion would help differentiate dentigerous cysts from other odontogenic lesions based on their histopathological features. To enhance the discussion, the authors could also incorporate one or two paragraphs comparing potential differential diagnoses, as well as considerations for the early detection and management of such lesions in infants. These additions would enrich the educational value of the manuscript. Regarding ethical considerations, although the authors state that informed consent was obtained, it is important to note that some institutions require all indexed clinical case reports to be reviewed or acknowledged by an ethics committee. It is good practice to state whether institutional policies exempt single-case reports from formal ethical review. In conclusion, this case report illustrates an entity that is relatively common in adults but rare in pediatric oral pathology, underscoring its clinical significance. With the incorporation of the suggested improvements, the manuscript will offer enhanced educational value and serve as a helpful resource for clinicians. This article is suitable for indexing, pending minor revisions. Is the background of the case’s history and progression described in sufficient detail? Yes Are enough details provided of any physical examination and diagnostic tests, treatment given and outcomes? Yes Is sufficient discussion included of the importance of the findings and their relevance to future understanding of disease processes, diagnosis or treatment? Partly Is the case presented with sufficient detail to be useful for other practitioners? Yes Competing Interests No competing interests were disclosed. Reviewer Expertise Oral Pathology I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (0) Rosa ACG. Peer Review Report For: Case Report: Case report: a rare case of dentigerous cyst in 1-year-old patient. [version 1; peer review: 1 approved, 1 approved with reservations] . F1000Research 2025, 14 :6 ( https://doi.org/10.5256/f1000research.173397.r388993) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/14-6/v1#referee-response-388993 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2025 Cobo Vázquez C. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 08 Jan 2025 | for Version 1 Carlos Cobo Vázquez , Universidad Complutense de Madrid, Madrid, Spain 0 Views copyright © 2025 Cobo Vázquez C. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved With Reservations info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Thank you for your submission. The article presented describes the second case of a young child with the appearance of a dentigerous cyst. The presentation of this case contributes to the expansion of scientific knowledge since, as the authors describe, the highest incidence of these cysts occurs in the lower third molars. However, despite the value of the work, it presents a series of limitations that prevent the reader from understanding the pathology. It would be of great value to provide previous clinical, intra-operative and follow-up photographs of the patient. We understand the limitation to photograph a young patient, but radiological tests are provided without difficulty, and by performing the surgical treatment under general anesthesia an adequate record could have been made. On the other hand, regarding therapeutic alternatives, more conservative options could be considered regarding the molar germ. Neither in the description of the case nor in the discussion, the reason for ruling out alternatives such as cystectomy, marsupialization or drainage, while maintaining the molar germ, is mentioned. It would also be interesting to provide information on the success rates of these more conservative treatments Your work is interesting. However, readers are missing previous clinical photos of the pathology, as well as photographs of the surgical intervention, the pathological anatomy and the subsequent follow-up. If this could be corrected it would be of great interest due to the low frequency of the case. Is the background of the case’s history and progression described in sufficient detail? Yes Are enough details provided of any physical examination and diagnostic tests, treatment given and outcomes? No Is sufficient discussion included of the importance of the findings and their relevance to future understanding of disease processes, diagnosis or treatment? Yes Is the case presented with sufficient detail to be useful for other practitioners? Partly Competing Interests No competing interests were disclosed. Reviewer Expertise Oral surgery I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. reply Respond to this report Responses (0) Cobo Vázquez C. Peer Review Report For: Case Report: Case report: a rare case of dentigerous cyst in 1-year-old patient. [version 1; peer review: 1 approved, 1 approved with reservations] . F1000Research 2025, 14 :6 ( https://doi.org/10.5256/f1000research.173397.r356556) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/14-6/v1#referee-response-356556 Alongside their report, reviewers assign a status to the article: Approved - the paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations - A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved - fundamental flaws in the paper seriously undermine the findings and conclusions Adjust parameters to alter display View on desktop for interactive features Includes Interactive Elements View on desktop for interactive features Competing Interests Policy Provide sufficient details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to question your impartiality. 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