A study of Protein C level and Activated Partial Thromboplastin Time among neonates suffering of sepsis-Omdurman Maternity Hospital, Sudan.

Abstract Objectives: The study aimed to assess Activated Partial Thromboplastin Time (APTT) and Protein C (PC) among Sudanese neonates with sepsis (Cases) in Omdurman maternity hospital, Sudan compared with healthy neonates (controls) for recognizing haemostatic alteration in APTT and PC, considering the gender, gestational age, delivery mode among both groups, case group categorized additionally regarding; sepsis onset, outcome, and Gram stain typing of the causative agent. Results: A total of 100 neonates divided equally into septic cases and healthy controls, died neonates were constituted 10 (20%) while 40 (80%) were recovered among case group. APTT showed significant prolongation in septic neonates compared to controls (mean; 47.8 and 37.5 sec for cases and controls, respectively) P. value was 0.00. Among case group; dead neonates showed significant prolongation compared recovered (mean; 61.5 and 44.4sec) P.value 0.00. PC showed significant decrease in dead neonates compared to recovered (mean; 25.4 and 36.2% for dead and improved) p value 0.04. APTT&PC can be useful as marker of neonatal sepsis mortality.Insignificant difference in PC reported between case and control group. None of the gender, gestational age, delivery mode, sepsis onset, and causative agent showed significant correlation with APTT and PC.