A METHOD FOR TREATING ENDOMETRIOSIS BY ADMINISTERING MULLERIAN INHIBITING SUBSTANCE

We have discovered that Müllerian Inhibiting Substance (MIS) can be used therapeutically to treat or prevent endometriosis in mammals, particularly humans. In a preferred embodiment a therapeutically effective amount of human MIS or a biologically active fragment or variant thereof is administered to treat a patient having endometriosis, or to prevent endometriosis in a patient who is at risk of developing it or to prevent a reoccurrence of endometriosis. The therapeutically effective amount of MIS is an amount that decreases the proliferation of endometriotic cells, an amount that our results show is significantly higher than the normal circulating levels of endogenous MIS.