Polarographic Investigation of Dienogest

Melek Sirin Baymak, Hayati Celik, Bengi Uslu, Nurgül K. Bakırhan, Síbel A. Özkan
In: Journal of The Electrochemical Society · 2018 · vol. 165(10) , pp. G128–G132 · doi:10.1149/2.1211810jes · W2884393171
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This study electrochemically investigated Dienogest's reduction mechanism on a dropping mercury electrode, identifying a two-electron reduction of the 3-keto-delta-4-group, and developed a validated differential pulse polarography method for its determination.

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Abstract

Dienogest (DGN), is an orally administered synthetic progestin that has shown to have selective progesterone receptor (PR) agonistic activity and oral progestational potency on endometrium. In this paper, the investigation of electrochemical reduction of Dienogest on dropping mercury electrode (DME) is achieved and resulted in a reduction scheme that involves a two electron reduction of 3-keto-delta-4-group in the A-ring of the molecule. This observation is supported by comparison of the compound with model compounds of testosterone and norethisterone. In this study, electrochemical determination of the compound and its validation is also studied by differential pulse polarograhy (DPP). The results yielded good precision, accuracy and reproducibility. Calibration range was found as 2.00 x 10(-6)M to 1.00 x 10(-4)M, with LOD and LOQ values as 0.58 x 10(-6)M and 1.90 x 10(-6)M, respectively. (C) The Author(s) 2018. Published by ECS.

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