Relationship of serum VITD3, HSCRP and HbA1c level in non diabetic patients referring to tertiary hospital

Relationship of serum VITD3, HSCRP and HbA1c level in non diabetic patients referring to tertiary hospital | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Relationship of serum VITD3, HSCRP and HbA1c level in non diabetic patients referring to tertiary hospital ali zare-mirzaie, somayeh mehdizadeh, pegah babaheidarian This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-41499/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background: In diabetic patients high HbA1c is associated with high level of HSCRP and VITD3 deficiency could result in diabetes and high HbA1c level. The aim of this study was to determine the relation of HbA1c, HSCRP and vitamin D3 in healthy individuals who referred to Rasool Akram Hospital. Methods: In this cross sectional study, individuals who referred to our center between 2018 and 2019 for the measurement of HbA1c were classified to three groups based on the level of the HbA1c: <5, 5-5.6 and 5.7≤. Then the Serum level of HSCRP and vitamin D3 were measured and compared between these three groups. Results: In this study, 90 healthy individuals were studied. In subjects with BMI below 25, no significant difference in HSCRP level was seen in group with low and normal HbA1c, but group with high HbA1c has non-significant higher level of HSCRP rather than group with normal HbA1c. In subject with BMI higher than 25, group with high HbA1c and low HbA1c had non-significant higher level of HSCRP than group with normal HbA1c and in the subjects, no significance difference at serum level of vitamin D3 level has been identified between HbA1c groups. Conclusion: As immunomedulatory role of VitD3 is shown in many studies and low VitD3 could predispose people to diabetes independent of obesity, Conflicting results in various studies emerge an idea to mind that considering relation of other factors responsible in glucose metabolism such as insulin level, IGF-1, C-Peptide and VitD3 could be a better overview on vitD3 effect on glucose metabolism Nutrition & Dietetics VITD3 HSCRP HbA1c diabetes Figures Figure 1 Figure 2 Introduction A ssociation between VITD3 deficiency and diabetes has been well recognized. In the number of studies VITD3 level is much lower in diabetic patients than healthy ones. VITD3 has an immunomedulatory effect. It plays its role in different ways with regulation of cytokine production such as IL-6, CRP and also via insulin secretion and sensitivity. It has been shown that death of islet cell can be prevented by VITD3 (1). HbA1c is a valuable biomarker for detecting high risk group for cardiovascular disease even if the patient has no diabetes. Goto et al had reported both low and high level of HbA1c is related with increased risk of cardiovascular disease (2), on the other hand, high level of HSCRP which is an acute phase reactant protein and its level depends on inflammatory systemic response, is reported in diabetic patients with cardiovascular complications(3). VITD3 deficiency is linked to diabetes and cardiovascular disease and besides obesity it could itself alter the glucose metabolism. Alemzade et al showed that low level of VITD3 in children could result in high insulin resistance and high level of HbA1c(4).Ordooie et al demonstrated that VITD3 supplement therapy could lower the HbA1c level in diabetic patients(5). The present study is designed to investigate whether there is any correlation between VITD level, HSCRP and HbA1c in healthy individuals, which to the best of our knowledge has not been conducted till now. Methods & Materials Study design and participants This is an analytical cross- sectional study on patients being referred to central laboratory lab in a tertiary hospital in Tehran during 2018-2019.The patient anthropometric data was recorded using an individual questionnaire filled by each patient. The exclusion criteria were chronic kidney disease, thyroid disease, and liver failure, Consuming lowering lipid level drugs, anticonvulsive drugs, and VITD3 supplement. Each pregnant or breast feeding woman, alcohol or cigarette consumption, any blood donation since 6 months ago was excluded. Written consent form was taken from the patient. After recording data and calculating BMI, HbA1c, VID3 and HSCRP was measured on each blood sample. HbA1c was measured by immunoturbidometric assay using BT3000 machine. VID3 (euroimmune kit) and HSCRP (monobind) were measured by ELISA method according to principle protocol. HbA1c more than 6.5 were excluded from data and value less than 6.5 was categorized into 3 groups: 1) prediabetic Level; 5.7-6.4 2) Normal: 5-5.7 3) low level: less than 5. VITD3 values are categorized into 4 groups: 1) Normal: more than 50ng/ml 2) Mild deficiency: 25-49.9ng/ml 3) Moderate deficiency: 12.5-24.9ng/ml 4) Severe deficiency: less than 12.5ng/ml. BMI also is set as four groups: 1) low weight: BMI 30 Statistical analysis Collected data was analyzed using SPSS version 20(Chicago, Illinois's, USA).For describing quantitative variable, mean and standard deviation was used. For comparing different variable, chi square, ANOVA and post hoc test were used. 0.05 was set as significant level for statistical analysis. Results The study selected 90 healthy volunteer individuals in which 59 were female and 31 were male. Table 1 presents demographic and laboratory data. For better calculating correlation, the patients were categorized based on BMI, into two groups: less and more than 25. In group with BMI less than 25: HSCRP mean in HbA1c low, normal and high was 1.1mg/l, 1.4mg/l and 2.6mg/l with no significant difference (p- value>0.05). VItD3 mean in HbA1c low, normal and high level was 16.2ng/ml, 16.2ng/ml and 27.3 ng/ml which also had no significant difference (p-value>0.05) In group with BMI more than 25: HSCRP in 3 different HbA1c groups follow U shape curve. (Figure 1). People with higher HbA1c had higher HSCRP in comparison to normal HbA1c which also had no significant difference (p-value>0.05) and there is also the same result for VIT D3 in 3 different HbA1c group. (p- Value>0.05) In women, HSCRP mean level between HbA1c low (2.5mg/l) and normal (2.5mg/l) level was not statistically significant (p- value > 0.05) whereas in high level HbA1c group was 3.0mg/l which is higher than other group but with no significant difference (p- value >0.05). There is also the same result for each group for men, no significant difference in VITD3 and HSCRP between different HbA1C groups. HSCRP level in different VITD3 groups adjusted to BMI and sex Mean HSCRP level in severe deficiency VitD3 was 2.7mg/l, in moderate deficiency VitD3 1.8mg/l, in mild deficiency 1.7mg/l and in normal group was 3.1mg/l which after post hoc analysis there was no significant difference (p- value >0.05) HSCRP and VITD3 in different HbA1c group according to Age In different age groups, there is no significance difference between hscrp in different levels. After categorizing patients age into less and more than 60 years. There is also no significant difference (p- value>0.05) Discussion The current study showed that in both volunteer groups with BMI more and less than 25, people with high HbA1c in compare to normal HbA1c, have higher HSCRP level and in group with BMI more than 25 and low HbA1C, HSCRP were higher, However it was not statistically significant .In our study, no relation has been found between VITD3 level and different HbA1c groups. An inverse relation between VITD3 and HSCRP was found in people younger than 60 years which is in contrast to people older than 60 years. In people with BMI less than 25, in compare to people with normal HbA1c, people with high HbA1C level have higher HSCRP level which shows increase of this acute phase reactant in higher HbA1c level. As injury induced by mild systemic inflammation has an important role in pathogenesis of diabetes (6), HSCRP role in predicting diabetes in healthy individuals which can be deposited in atherosclerotic lesion and result in rupture of plaques (7,8). In the other hand, metabolic glucose products could lead to activation of macrophages, higher oxidative stress and production of IL-6 and HSCRP (9) .King et al showed that higher HbA1c has an association with higher HSCRP (10). Sahn et al demonstrated that decrease in HbA1c level could result in decrease of HSCRP level (11).Shnell et al showed that postprandial glucose effect on HSCRP level more than HbA1c alone(12). Sarinnapakorn et al showed that high HbA1c was associated with high HSCRP in obese diabetic women. (13). In our study , people with BMI more than 25 have different HSCRP pattern in compare to groups with BMI less than 25.In this group, along with higher HSCRP in high HbA1c level, people with low HbA1c has also high HSCRP which leads to U shape curve that is not demonstrated yet in latter studies. Selvin et al (14) showed low level of glucose and HbA1c could result in more ischemic heart attacks which the mechanism is not yet truly understood. We believed that like cholesterol, U shape curve of HbA1c could be a potential health risk for humans. Gotto et al have showed increased risk of cardiovascular disease in patients with low and high level of HbA1c which supporting our findings (2). Although there is no statistically difference, but different population sampling in our study, healthy individuals in contrast to diabetic patients in most of latter studies (15, 16) could justify this finding and there may be also an interfering factor besides HbA1c level which is not investigated in our study. Our study showed that people with high BMI and severe VIT D3 deficiency have higher HSCRP than other group when adjusted with age, in people younger than 60 year old; decrease in VITD3 level accompanied by high HSCRP whereas in people older than 60 year, this relation is reverse. Data from latter studies (17, 18,19) are very conflicting, This finding may be due to some other interfering factor such as inflammatory markers. Difference between results of our study and others may be due to different study population. Our study showed no relation between HbA1c and VITD3 in similar to Haidari et al (20) which demonstrated no relation between HbA1C and VITD3 in non obese diabetic patients in contrast to findings of Salehpoor et al (21) in diabetic patient. Conclusion As immunomedulatory role of VITD3 is shown in many studies and low VITD3 could predispose people to diabetes independent of obesity, Conflicting results in various studies emerge an idea to mind that considering relation of other factors responsible in glucose metabolism such as insulin level, IGF-1, C-Peptide and VITD3 could be a better overview on vitD3 effect on glucose metabolism and its effect on HSCRP level. Declarations The availability of data and materials The data is available from corresponding author for reasonable questions Acknowledgment We wish to thank you the technician team of Rasoul akram hospital Funding Not applicable Author information Affiliation Department of pathology, Rasoul akram hospital, Iran University of medical sciences. Tehran, Iran Author contribution Ali zare- mirzaie conducted and conceptualized the study, somayeh mehdizadeh gathering data and analyzed data, pegah babaheidarian wrote the manuscript and finalized it. Corresponding author Correspondence to Pegah Babaheidarian Ethical declaration Ethical approval and consent to participate The current study was approved by Iran university of medical sciences, ethical committee, written consent form was taken from participants Consent for publication There is a consent form for publication of data Competing interest The authors declare that there is no conflict of interest References International Expert Committee, “International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes,” Diabetes Care, vol. 32, no. 7, pp. 1327–1334, 2009. Goto A, Noda M, Matsushita Y, Goto M, Kato M, Isogawa A, Takahashi Y, Kurotani K, Oba S, Nanri A, Mizoue T, Yamagishi K, Yatsuya H, Saito I, Kokubo Y, Sawada N, Inoue M, Iso H, Kadowaki T, Tsugane S; JPHC Study Group.Hemoglobin a1c levels and the risk of cardiovascular disease in people without known diabetes: a population-based cohort study in Japan.Medicine (Baltimore). 2015;94(17):e785. Aggarwal V, Schneider AL, Selvin E. Low hemoglobin A1c in nondiabetic adults: an elevated risk state? Diabetes Care. 2012;35:2055–2060. Alemzadeh R1, Kichler J, Babar G, Calhoun M. Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity, and season. Metabolism. 2008;57(2):183-91. Ordooei M1, Shojaoddiny-Ardekani A, Hoseinipoor SH, Soleimanizad R, Miroliai M, Zare-Zardini H. Effect of vitamin d on hba1c levels of children and adolescents with diabetes mellitus type 1. Minerva Pediatr. 2014; 20. de Carvalho Vidigal F1, Guedes Cocate P, Gonçalves Pereira L, de Cássia Gonçalves Alfenas R. The role of hyperglycemia in the induction of oxidative stress and inflammatory process. Nutr Hosp. 2012;27(5):1391-8. Associations among. Shi CH, Wang C, Bai R, Zhang XY, Men LL, DU JL7- glycemic excursions, glycated hemoglobin and high-sensitivity C-reactive protein in patients with poorly controlled type 2 diabetes mellitus. Exp Ther Med. 2015; 10(5):1937-1942. Earl S. Ford, Guixiang Zhao, James Tsai, Chaoyang Li. Associations Between Concentrations of Vitamin D and Concentrations of Insulin, Glucose, and HbA1c Among Adolescents in the United States.Diabetes Care. 2011; 34(3): 646–648. Kostoglou-Athanassiou I, Athanassiou P, Gkountouvas A, Kaldrymides P. Vitamin D and glycemic control in diabetes mellitus type 2.Ther Adv Endocrinol Metab. 2013;4(4):122-8. King DE, Mainous AG , Buchanan TA, Pearson WS. C-reactive protein and glycemic control in adults with diabetes. Diabetes Care 2003; 26:1535–1539 markers (high sensitivity C reactive protein, nuclear Misra DP, Das S, Sahu PK11- factor κB and adiponectin) in Indian patients with type 2 diabetes mellitus with and without macrovascular complications. Metab Syndr Relat Disord 10: 209 213, 2012. Schnell O, Amann-Zalan I, Jelsovsky Z, Moritz A, Bermejo JL, Parkin CG, Schweitzer MA, Fisher L, Polonsky WH. Changes in A1C levels are significantly associated with changes in levels of the cardiovascular risk biomarker hs-CRP: results from the SteP study Diabetes Care. 2013;36(7):2084-9. Tutuncu Y, Satman I, Celik S, Dinccag N, Karsidag K, Telci A, Genc S, Issever H, Tuomilehto J, Omer B. A Comparison of hs-CRP Levels in New Diabetes Groups Diagnosed Based on FPG, 2-hPG, or HbA1c Criteria.J Diabetes Res. 2016; 2016:5827041. Selvin E, Steffes MW, Zhu H, et al. Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults. N Engl J Med. 2010;362:800–811 Selvin E, Coresh J, Shahar E, Zhang L, Steffes M, Sharrett AR. Glycaemia (haemoglobin A1c) and incident ischaemic stroke: the Atherosclerosis Risk in Communities (ARIC) Study. Lancet Neurol. 2005;4:821–6. Yazdchi R, Gargari BP, Asghari-Jafarabadi M, Sahhaf F. Effects of vitamin D3 supplementation on metabolic indices and hs-CRP levels in gestational diabetes mellitus patients: a randomized, double-blinded, placebo-controlled clinical trial. Nutr Res Pract. 2016;10(3):328-35. Sadiya A, Ahmed SM, Carlsson M, Tesfa Y, George M, Ali SH, Siddieg HH, Abusnana S. Vitamin D3 supplementation in obese type 2 diabetes subjects in Ajman, UAE: a randomized controlled doubleblinded clinical trial. Eur J Clin Nutr. 2015;69:707–711 Delvin EE, Lambert M, Levy E, et al. Vitamin D3 status is modestly associated with glycemia and indicators of lipid metabolism in French-Canadian children and adolescents. J Nutr 2010;140:987–991 Zare-Mirzaie A, Kazeminezhad B, Akbari Ghouchani M. The Correlation Between Serum Vitamin D Level and Total Antioxidant Capacity in Diabetic and Non-diabetic Subjects in Iran. Iran J Pathol. 2018;13(2):212-219. Haidari F, Zakerkish M, Karandish M, Saki A, Pooraziz S.Association between Serum Vitamin D Level and Glycemic and Inflammatory Markers in Non-obese Patients with Type 2 Diabetes. Iran J Med Sci. 2016;41(5):367-73. Salehpour A, Shidfar F, Hosseinpanah F, Vafa M, Razaghi M, Amiri F. Does vitamin D33 supplementation improve glucose homeostasis in overweight or obese women? A double-blind, randomized, placebo-controlled clinical trial. Diabet Med. 2013;30:1477–81. Table 1 800x600 Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 st1\:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman",serif;} Healthy subjects Subjects no. 90 Sex(Female) 56(65.1) Age(years) 46(18-79) HbA1c (%) 5.3(4.3-6.4) HbA1c groups Low(≤5) 32(35) Normal (5-5.7) 33(37) High(5.7<) 25(28) hsCRP ( mg/L) 2.2 (0.09-11.6) Vitamin D3 (ng/ml) 18.1(1-91) Vitamin D3 groups Normal (50≤) 4(4.7) mild (25-49.9) 1 1 (11.6) Moderate(12.5-24.9) 3 5 (41.9) Severe(≤12.4) 40 (41.9) BMI (Kg/m2) 26.9(15.5-43) BMI groups Underweight(≤18.5) 5(5.8) Normal (18.5-24.9) 25(24.4) Overweight(25-29.9) 33 (36) Obese(30≤) 19 (29.9) Table1.Demographic and laboratory data of selected patients Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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In the number of studies VITD3 level is much lower in diabetic patients than healthy ones. VITD3 has an immunomedulatory effect. It plays its role in different ways with regulation of cytokine production such as IL-6, CRP and also via insulin secretion and sensitivity. It has been shown that death of islet cell can be prevented by VITD3 (1).\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;HbA1c is a valuable biomarker for detecting high risk group for cardiovascular disease even if the patient has no diabetes. Goto et al had reported both low and high level of HbA1c is related with increased risk of cardiovascular disease (2), on the other hand, high level of HSCRP which is an acute phase reactant protein and its level depends on inflammatory systemic response, is reported in diabetic patients with cardiovascular complications(3).\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;VITD3 deficiency is linked to diabetes and cardiovascular disease and besides obesity it could itself alter the glucose metabolism. Alemzade et al showed that low level of VITD3 in children could result in high insulin resistance and high level of HbA1c(4).Ordooie et al demonstrated that VITD3 supplement therapy could lower the HbA1c level in diabetic patients(5). The present study is designed to investigate whether there is any correlation between VITD level, HSCRP and HbA1c in healthy individuals, which to the best of our knowledge has not been conducted till now.\u003c/p\u003e"},{"header":"Methods \u0026 Materials","content":"\u003cp\u003e\u003cstrong\u003eStudy design and participants\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis is an analytical cross- sectional study on patients being referred to central laboratory lab in a tertiary hospital in Tehran during 2018-2019.The patient anthropometric data was recorded using an individual questionnaire filled by each patient. The exclusion criteria were chronic kidney disease, thyroid disease, and liver failure, Consuming lowering lipid level drugs, anticonvulsive drugs, and VITD3 supplement. Each pregnant or breast feeding woman, alcohol or cigarette consumption, any blood donation since 6 months ago was excluded. \u0026nbsp;Written consent form was taken from the patient. After recording data and calculating BMI, HbA1c, VID3 and HSCRP was measured on each blood sample.\u003c/p\u003e\n\u003cp\u003eHbA1c was measured by immunoturbidometric assay using BT3000 machine. VID3 (euroimmune kit) and HSCRP (monobind) were measured by ELISA method according to principle protocol.\u003c/p\u003e\n\u003cp\u003eHbA1c more than 6.5 were excluded from data and value less than 6.5 was categorized into 3 groups: 1) prediabetic Level; 5.7-6.4 2) Normal: 5-5.7 3) low level: less than 5.\u003c/p\u003e\n\u003cp\u003eVITD3 values are categorized into 4 groups: 1) Normal: more than 50ng/ml 2) Mild deficiency: 25-49.9ng/ml 3) Moderate deficiency: 12.5-24.9ng/ml 4) Severe deficiency: less than 12.5ng/ml.\u003c/p\u003e\n\u003cp\u003eBMI also is set as four groups: 1) low weight: BMI \u0026lt;18\u0026nbsp;\u0026nbsp; 2) Normal: 18-24.9 3) overweight: 25-29.9 4) obese\u0026gt;30\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatistical analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eCollected data was analyzed using SPSS version 20(Chicago, Illinois's, USA).For describing quantitative variable, mean and standard deviation was used. For comparing different variable, chi square, ANOVA and post hoc test were used. 0.05 was set as significant level for statistical analysis.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003eThe study selected 90 healthy volunteer individuals in which 59 were female and 31 were male. Table 1 presents demographic and laboratory data.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eFor better calculating correlation, the patients were categorized based on BMI, into two groups: less and more than 25.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eIn group with BMI less than 25:\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;HSCRP mean in HbA1c low, normal and high was 1.1mg/l, 1.4mg/l and 2.6mg/l with no significant difference (p- value\u0026gt;0.05).\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;VItD3 mean in HbA1c low, normal and high level was 16.2ng/ml, 16.2ng/ml and 27.3 ng/ml which also had no significant difference (p-value\u0026gt;0.05)\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eIn group with BMI more than 25:\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eHSCRP in 3 different HbA1c groups follow U shape curve. (Figure 1). People with higher HbA1c had higher HSCRP in comparison to normal HbA1c which also had no significant difference (p-value\u0026gt;0.05) and there is also the same result for VIT D3 in 3 different HbA1c group. (p- Value\u0026gt;0.05)\u003c/p\u003e\n\u003cp\u003eIn women, \u0026nbsp;HSCRP mean level between HbA1c low (2.5mg/l) and normal (2.5mg/l) level was not statistically significant (p- value \u0026gt; 0.05) whereas in high level HbA1c group was 3.0mg/l which is higher than other group but with no significant difference (p- value \u0026gt;0.05). There is also the same result for each group for men, no significant difference in VITD3 and HSCRP between different HbA1C groups.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eHSCRP level in different VITD3 groups adjusted to BMI and sex \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;Mean HSCRP level in severe deficiency VitD3 was 2.7mg/l, in moderate deficiency VitD3 1.8mg/l, in mild deficiency 1.7mg/l and in normal group was 3.1mg/l which after post hoc analysis there was no significant difference (p- value \u0026gt;0.05)\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eHSCRP and VITD3 in different HbA1c group according to Age\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eIn different age groups, there is no significance difference between hscrp in different levels. After categorizing patients age into less and more than 60 years. There is also no significant difference (p- value\u0026gt;0.05)\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eThe current study showed that in both volunteer groups with BMI more and less than 25, people with high HbA1c in compare to normal HbA1c, have higher HSCRP level and in group with BMI more than 25 and low HbA1C, HSCRP were higher, However it was not statistically significant .In our study, no relation has been found between VITD3 level and different HbA1c groups.\u003c/p\u003e\n\u003cp\u003eAn inverse relation between VITD3 and HSCRP was found in people younger than 60 years which is in contrast to people older than 60 years.\u003c/p\u003e\n\u003cp\u003eIn people with BMI less than 25, in compare to people with normal HbA1c, people with high HbA1C level have higher HSCRP level which shows increase of this acute phase reactant in higher HbA1c level. As injury induced by mild systemic inflammation has an important role in pathogenesis of diabetes (6), HSCRP role in predicting diabetes in healthy individuals which can be deposited in atherosclerotic lesion and result in rupture of plaques (7,8). In the other hand, metabolic glucose products could lead to activation of macrophages, higher oxidative stress and production of IL-6 and HSCRP (9) .King et al showed that higher HbA1c has an association with higher HSCRP (10). Sahn et al demonstrated that decrease in HbA1c level could result in decrease of HSCRP level (11).Shnell et al showed that postprandial glucose effect on HSCRP level more than HbA1c alone(12). Sarinnapakorn et al showed that high HbA1c was associated with high HSCRP in obese diabetic women. (13). In\u0026nbsp; our study , people with BMI more than 25 have different \u0026nbsp;HSCRP pattern\u0026nbsp; in compare to groups with BMI less than 25.In this group,\u0026nbsp; along with\u0026nbsp; higher HSCRP\u0026nbsp; in\u0026nbsp; high HbA1c level, people with low HbA1c has also high HSCRP \u0026nbsp;which leads to U shape curve that is not demonstrated yet in latter studies.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eSelvin et al (14) showed low level of glucose and HbA1c could result in more ischemic heart attacks which the mechanism is not yet truly understood. We believed that like cholesterol, U shape curve of HbA1c could be a potential health risk for humans.\u003c/p\u003e\n\u003cp\u003eGotto et al have showed increased risk of cardiovascular disease in patients with low and high level of HbA1c which supporting our findings (2). Although there is no statistically difference, but different population sampling in our study, healthy individuals in contrast to\u0026nbsp; \u0026nbsp;diabetic patients in most of latter studies (15, 16) could justify this finding and there may be also an interfering factor besides HbA1c level which is not investigated in our study.\u003c/p\u003e\n\u003cp\u003eOur study showed that people with high BMI and severe VIT D3 deficiency have higher HSCRP than other group when adjusted with age, in people younger than 60 year old; decrease in VITD3 level accompanied by high HSCRP whereas in people older than 60 year, this relation is reverse. Data from latter studies (17, 18,19) are very conflicting,\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;This finding may be due to some other interfering factor such as inflammatory markers. Difference between results of our study and others may be due to different study population.\u003c/p\u003e\n\u003cp\u003eOur study showed no relation between HbA1c and VITD3 in similar to Haidari et al (20) which demonstrated no relation between HbA1C and VITD3 in non obese diabetic patients in contrast to findings of Salehpoor et al (21) in diabetic patient.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eAs immunomedulatory role of VITD3 is shown in many studies and low VITD3 could predispose people to diabetes independent of obesity, Conflicting results in various studies emerge an idea to mind that considering relation of other factors responsible in glucose metabolism such as insulin level, IGF-1, C-Peptide and VITD3 could be a better overview on vitD3 effect on glucose metabolism and its effect on HSCRP level.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eThe availability of data and materials\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe data is available from corresponding author for reasonable questions\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgment\u0026nbsp; \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;We wish to thank you the technician team of Rasoul akram hospital\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor information\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAffiliation\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eDepartment of pathology, Rasoul akram hospital, Iran University of medical sciences. Tehran, Iran\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor contribution\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAli zare- mirzaie conducted and conceptualized the study, somayeh mehdizadeh gathering data and analyzed data, pegah babaheidarian wrote the manuscript and finalized it.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCorresponding author\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;Correspondence to Pegah Babaheidarian\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthical declaration \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthical approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe current study was approved by Iran university of medical sciences, ethical committee, written consent form was taken from participants\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThere is a consent form for publication of data\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interest \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare that there is no conflict of interest\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eInternational Expert Committee, \u0026ldquo;International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes,\u0026rdquo; Diabetes Care, vol. 32, no. 7, pp. 1327\u0026ndash;1334, 2009.\u003c/li\u003e\n\u003cli\u003eGoto A, Noda M, Matsushita Y, Goto M, Kato M, Isogawa A, Takahashi Y, Kurotani K, Oba S, Nanri A, Mizoue T, Yamagishi K, Yatsuya H, Saito I, Kokubo Y, Sawada N, Inoue M, Iso H, Kadowaki T, Tsugane S; JPHC Study Group.Hemoglobin a1c levels and the risk of cardiovascular disease in people without known diabetes: a population-based cohort study in Japan.Medicine (Baltimore). 2015;94(17):e785.\u003c/li\u003e\n\u003cli\u003eAggarwal V, Schneider AL, Selvin E. Low hemoglobin A1c in nondiabetic adults: an elevated risk state? Diabetes Care. 2012;35:2055\u0026ndash;2060.\u003c/li\u003e\n\u003cli\u003eAlemzadeh R1, Kichler J, Babar G, Calhoun M. Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity, and season. Metabolism. 2008;57(2):183-91.\u003c/li\u003e\n\u003cli\u003e\u0026nbsp;Ordooei M1, Shojaoddiny-Ardekani A, Hoseinipoor SH, Soleimanizad R, Miroliai M, Zare-Zardini H. Effect of vitamin d on hba1c levels of children and adolescents with diabetes mellitus type 1. Minerva Pediatr. 2014; 20.\u003c/li\u003e\n\u003c/ol\u003e\n\u003col start=\"6\"\u003e\n\u003cli\u003ede Carvalho Vidigal F1, Guedes Cocate P, Gon\u0026ccedil;alves Pereira L, de C\u0026aacute;ssia Gon\u0026ccedil;alves Alfenas R. The role of hyperglycemia in the induction of oxidative stress and inflammatory process. Nutr Hosp. 2012;27(5):1391-8.\u003c/li\u003e\n\u003cli\u003eAssociations among. Shi CH, Wang C, Bai R, Zhang XY, Men LL, DU JL7- glycemic excursions, glycated hemoglobin and high-sensitivity C-reactive protein in patients with poorly controlled type 2 diabetes mellitus. Exp Ther Med. 2015; 10(5):1937-1942.\u003c/li\u003e\n\u003cli\u003eEarl S. Ford, Guixiang Zhao, James Tsai, Chaoyang Li. Associations Between Concentrations of Vitamin D and Concentrations of Insulin, Glucose, and HbA1c Among Adolescents in the United States.Diabetes Care. 2011; 34(3): 646\u0026ndash;648.\u003c/li\u003e\n\u003cli\u003eKostoglou-Athanassiou I, Athanassiou P, Gkountouvas A, Kaldrymides P. Vitamin D and glycemic control in diabetes mellitus type 2.Ther Adv Endocrinol Metab. 2013;4(4):122-8.\u003c/li\u003e\n\u003cli\u003eKing DE, Mainous AG , Buchanan TA, Pearson WS. C-reactive protein and glycemic control in adults with diabetes. Diabetes Care 2003; 26:1535\u0026ndash;1539\u003c/li\u003e\n\u003cli\u003emarkers (high sensitivity C reactive protein, nuclear Misra DP, Das S, Sahu PK11- factor \u0026kappa;B and adiponectin) in Indian patients with type 2 diabetes mellitus with and without macrovascular complications. Metab Syndr Relat Disord 10: 209 213, 2012.\u003c/li\u003e\n\u003cli\u003eSchnell O, Amann-Zalan I, Jelsovsky Z, Moritz A, Bermejo JL, Parkin CG, Schweitzer MA, Fisher L, Polonsky WH. Changes in A1C levels are significantly\u0026nbsp; associated with changes in levels of the cardiovascular risk biomarker hs-CRP: results from the SteP study Diabetes Care. 2013;36(7):2084-9.\u003c/li\u003e\n\u003cli\u003eTutuncu Y, Satman I, Celik S, Dinccag N, Karsidag K, Telci A, Genc S, Issever H, Tuomilehto J, Omer B. A Comparison of hs-CRP Levels in New Diabetes Groups Diagnosed Based on FPG, 2-hPG, or HbA1c Criteria.J Diabetes Res. 2016; 2016:5827041.\u003c/li\u003e\n\u003c/ol\u003e\n\u003col start=\"14\"\u003e\n\u003cli\u003eSelvin E, Steffes MW, Zhu H, et al. Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults. N Engl J Med. 2010;362:800\u0026ndash;811\u003c/li\u003e\n\u003cli\u003eSelvin E, Coresh J, Shahar E, Zhang L, Steffes M, Sharrett AR. Glycaemia (haemoglobin A1c) and incident ischaemic stroke: the Atherosclerosis Risk in Communities (ARIC) Study. Lancet Neurol. 2005;4:821\u0026ndash;6.\u003c/li\u003e\n\u003cli\u003eYazdchi R, Gargari BP, Asghari-Jafarabadi M, Sahhaf F. Effects of vitamin D3 supplementation on metabolic indices and hs-CRP levels in gestational diabetes mellitus patients: a randomized, double-blinded, placebo-controlled clinical trial. Nutr Res Pract. 2016;10(3):328-35.\u003c/li\u003e\n\u003c/ol\u003e\n\u003col start=\"17\"\u003e\n\u003cli\u003eSadiya A, Ahmed SM, Carlsson M, Tesfa Y, George M, Ali SH, Siddieg HH, Abusnana S. Vitamin D3 supplementation in obese type 2 diabetes subjects in Ajman, UAE: a randomized controlled doubleblinded clinical trial. Eur J Clin Nutr. 2015;69:707\u0026ndash;711\u003c/li\u003e\n\u003cli\u003eDelvin EE, Lambert M, Levy E, et al. Vitamin D3 status is modestly associated with glycemia and indicators of lipid metabolism in French-Canadian children and adolescents. J Nutr 2010;140:987\u0026ndash;991\u003c/li\u003e\n\u003cli\u003eZare-Mirzaie A, Kazeminezhad B, Akbari Ghouchani M. The Correlation Between Serum Vitamin D Level and Total Antioxidant Capacity in Diabetic and Non-diabetic Subjects in Iran. Iran J Pathol. 2018;13(2):212-219.\u003c/li\u003e\n\u003cli\u003eHaidari F, Zakerkish M, Karandish M, Saki A, Pooraziz S.Association between Serum Vitamin D Level and Glycemic and Inflammatory Markers in Non-obese Patients with Type 2 Diabetes. Iran J Med Sci. 2016;41(5):367-73.\u003c/li\u003e\n\u003cli\u003eSalehpour A, Shidfar F, Hosseinpanah F, Vafa M, Razaghi M, Amiri F. Does vitamin D33 supplementation improve glucose homeostasis in overweight or obese women? A double-blind, randomized, placebo-controlled clinical trial. Diabet Med. 2013;30:1477\u0026ndash;81.\u003c/li\u003e\n\u003c/ol\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e"},{"header":"Table 1","content":"\u003c!--[if gte mso 9]\u003e\u003cxml\u003e\n \u003co:OfficeDocumentSettings\u003e\n \u003co:TargetScreenSize\u003e800x600\u003c/o:TargetScreenSize\u003e\n \u003c/o:OfficeDocumentSettings\u003e\n\u003c/xml\u003e\u003c![endif]--\u003e\n\u003c!--[if gte mso 9]\u003e\u003cxml\u003e\n \u003cw:WordDocument\u003e\n \u003cw:View\u003eNormal\u003c/w:View\u003e\n \u003cw:Zoom\u003e0\u003c/w:Zoom\u003e\n \u003cw:TrackMoves/\u003e\n \u003cw:TrackFormatting/\u003e\n \u003cw:PunctuationKerning/\u003e\n \u003cw:ValidateAgainstSchemas/\u003e\n \u003cw:SaveIfXMLInvalid\u003efalse\u003c/w:SaveIfXMLInvalid\u003e\n \u003cw:IgnoreMixedContent\u003efalse\u003c/w:IgnoreMixedContent\u003e\n \u003cw:AlwaysShowPlaceholderText\u003efalse\u003c/w:AlwaysShowPlaceholderText\u003e\n \u003cw:DoNotPromoteQF/\u003e\n 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Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"macro\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"toa heading\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"List\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"List Bullet\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"List Number\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"List 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"List 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"List 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"List 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"List Bullet 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"List Bullet 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"List Bullet 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"List Bullet 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"List Number 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"List Number 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"List Number 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"List Number 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"10\" QFormat=\"true\" Name=\"Title\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Closing\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Signature\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"0\" SemiHidden=\"true\"\n UnhideWhenUsed=\"true\" Name=\"Default Paragraph Font\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Body Text\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Body Text Indent\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"List Continue\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"List Continue 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"List Continue 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"List Continue 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"List Continue 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Message Header\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"11\" QFormat=\"true\" Name=\"Subtitle\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Salutation\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Date\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Body Text First Indent\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Body Text First Indent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Note Heading\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Body Text 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Body Text 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Body Text Indent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Body Text Indent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Block Text\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"0\" SemiHidden=\"true\"\n UnhideWhenUsed=\"true\" Name=\"Hyperlink\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"FollowedHyperlink\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"22\" QFormat=\"true\" Name=\"Strong\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"20\" QFormat=\"true\" Name=\"Emphasis\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Document Map\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Plain Text\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"E-mail Signature\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"HTML Top of Form\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"HTML Bottom of Form\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Normal (Web)\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"HTML Acronym\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"HTML Address\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"HTML Cite\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"HTML Code\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"HTML Definition\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"HTML Keyboard\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"HTML Preformatted\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"HTML Sample\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"HTML Typewriter\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"HTML Variable\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Normal Table\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"annotation subject\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"No List\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Outline List 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Outline List 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Outline List 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Simple 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Simple 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Simple 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Classic 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Classic 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Classic 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Classic 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Colorful 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Colorful 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Colorful 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Columns 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Columns 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Columns 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Columns 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Columns 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Grid 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Grid 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Grid 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Grid 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Grid 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Grid 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Grid 7\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Grid 8\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table List 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table List 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table List 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table List 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table List 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table List 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table List 7\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table List 8\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table 3D effects 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table 3D effects 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table 3D effects 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Contemporary\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Elegant\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Professional\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Subtle 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Subtle 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Web 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Web 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Web 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Balloon Text\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"39\" Name=\"Table Grid\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Table Theme\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" Name=\"Placeholder Text\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"1\" QFormat=\"true\" Name=\"No Spacing\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"60\" Name=\"Light Shading\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"61\" Name=\"Light List\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"62\" Name=\"Light Grid\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"63\" Name=\"Medium Shading 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"64\" Name=\"Medium Shading 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"65\" Name=\"Medium List 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"66\" Name=\"Medium List 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"67\" Name=\"Medium Grid 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"68\" Name=\"Medium Grid 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"69\" Name=\"Medium Grid 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"70\" Name=\"Dark List\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"71\" Name=\"Colorful Shading\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"72\" Name=\"Colorful List\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"73\" Name=\"Colorful Grid\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"60\" Name=\"Light Shading Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"61\" Name=\"Light List Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"62\" Name=\"Light Grid Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"63\" Name=\"Medium Shading 1 Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"64\" Name=\"Medium Shading 2 Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"65\" Name=\"Medium List 1 Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" Name=\"Revision\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"34\" QFormat=\"true\"\n Name=\"List Paragraph\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"29\" QFormat=\"true\" Name=\"Quote\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"30\" QFormat=\"true\"\n Name=\"Intense Quote\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"66\" Name=\"Medium List 2 Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"67\" Name=\"Medium Grid 1 Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"68\" Name=\"Medium Grid 2 Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"69\" Name=\"Medium Grid 3 Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"70\" Name=\"Dark List Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"71\" Name=\"Colorful Shading Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"72\" Name=\"Colorful List Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"73\" Name=\"Colorful Grid Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"60\" Name=\"Light Shading Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"61\" Name=\"Light List Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"62\" Name=\"Light Grid Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"63\" Name=\"Medium Shading 1 Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"64\" Name=\"Medium Shading 2 Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"65\" Name=\"Medium List 1 Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"66\" Name=\"Medium List 2 Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"67\" Name=\"Medium Grid 1 Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"68\" Name=\"Medium Grid 2 Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"69\" Name=\"Medium Grid 3 Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"70\" Name=\"Dark List Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"71\" Name=\"Colorful Shading Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"72\" Name=\"Colorful List Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"73\" Name=\"Colorful Grid Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"60\" Name=\"Light Shading Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"61\" Name=\"Light List Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"62\" Name=\"Light Grid Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"63\" Name=\"Medium Shading 1 Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"64\" Name=\"Medium Shading 2 Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"65\" Name=\"Medium List 1 Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"66\" Name=\"Medium List 2 Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"67\" Name=\"Medium Grid 1 Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"68\" Name=\"Medium Grid 2 Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"69\" Name=\"Medium Grid 3 Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"70\" Name=\"Dark List Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"71\" Name=\"Colorful Shading Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"72\" Name=\"Colorful List Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"73\" Name=\"Colorful Grid Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"60\" Name=\"Light Shading Accent 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"61\" Name=\"Light List Accent 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"62\" Name=\"Light Grid Accent 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"63\" Name=\"Medium Shading 1 Accent 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"64\" Name=\"Medium Shading 2 Accent 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"65\" Name=\"Medium List 1 Accent 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"66\" Name=\"Medium List 2 Accent 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"67\" Name=\"Medium Grid 1 Accent 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"68\" Name=\"Medium Grid 2 Accent 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"69\" Name=\"Medium Grid 3 Accent 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"70\" Name=\"Dark List Accent 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"71\" Name=\"Colorful Shading Accent 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"72\" Name=\"Colorful List Accent 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"73\" Name=\"Colorful Grid Accent 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"60\" Name=\"Light Shading Accent 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"61\" Name=\"Light List Accent 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"62\" Name=\"Light Grid Accent 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"63\" Name=\"Medium Shading 1 Accent 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"64\" Name=\"Medium Shading 2 Accent 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"65\" Name=\"Medium List 1 Accent 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"66\" Name=\"Medium List 2 Accent 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"67\" Name=\"Medium Grid 1 Accent 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"68\" Name=\"Medium Grid 2 Accent 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"69\" Name=\"Medium Grid 3 Accent 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"70\" Name=\"Dark List Accent 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"71\" Name=\"Colorful Shading Accent 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"72\" Name=\"Colorful List Accent 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"73\" Name=\"Colorful Grid Accent 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"60\" Name=\"Light Shading Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"61\" Name=\"Light List Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"62\" Name=\"Light Grid Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"63\" Name=\"Medium Shading 1 Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"64\" Name=\"Medium Shading 2 Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"65\" Name=\"Medium List 1 Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"66\" Name=\"Medium List 2 Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"67\" Name=\"Medium Grid 1 Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"68\" Name=\"Medium Grid 2 Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"69\" Name=\"Medium Grid 3 Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"70\" Name=\"Dark List Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"71\" Name=\"Colorful Shading Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"72\" Name=\"Colorful List Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"73\" Name=\"Colorful Grid Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"19\" QFormat=\"true\"\n Name=\"Subtle Emphasis\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"21\" QFormat=\"true\"\n Name=\"Intense Emphasis\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"31\" QFormat=\"true\"\n Name=\"Subtle Reference\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"32\" QFormat=\"true\"\n Name=\"Intense Reference\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"33\" QFormat=\"true\" Name=\"Book Title\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"37\" SemiHidden=\"true\"\n UnhideWhenUsed=\"true\" Name=\"Bibliography\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"39\" SemiHidden=\"true\"\n UnhideWhenUsed=\"true\" QFormat=\"true\" Name=\"TOC Heading\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"41\" Name=\"Plain Table 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"42\" Name=\"Plain Table 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"43\" Name=\"Plain Table 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"44\" Name=\"Plain Table 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"45\" Name=\"Plain Table 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"40\" Name=\"Grid Table Light\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"46\" Name=\"Grid Table 1 Light\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"47\" Name=\"Grid Table 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"48\" Name=\"Grid Table 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"49\" Name=\"Grid Table 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"50\" Name=\"Grid Table 5 Dark\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"51\" Name=\"Grid Table 6 Colorful\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"52\" Name=\"Grid Table 7 Colorful\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"46\"\n Name=\"Grid Table 1 Light Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"47\" Name=\"Grid Table 2 Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"48\" Name=\"Grid Table 3 Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"49\" Name=\"Grid Table 4 Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"50\" Name=\"Grid Table 5 Dark Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"51\"\n Name=\"Grid Table 6 Colorful Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"52\"\n Name=\"Grid Table 7 Colorful Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"46\"\n Name=\"Grid Table 1 Light Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"47\" Name=\"Grid Table 2 Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"48\" Name=\"Grid Table 3 Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"49\" Name=\"Grid Table 4 Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"50\" Name=\"Grid Table 5 Dark Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"51\"\n Name=\"Grid Table 6 Colorful Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"52\"\n Name=\"Grid Table 7 Colorful Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"46\"\n Name=\"Grid Table 1 Light Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"47\" Name=\"Grid Table 2 Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"48\" Name=\"Grid Table 3 Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"49\" Name=\"Grid Table 4 Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"50\" Name=\"Grid Table 5 Dark Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"51\"\n Name=\"Grid Table 6 Colorful Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"52\"\n Name=\"Grid Table 7 Colorful Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"46\"\n Name=\"Grid Table 1 Light Accent 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"47\" Name=\"Grid Table 2 Accent 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"48\" Name=\"Grid Table 3 Accent 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"49\" Name=\"Grid Table 4 Accent 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"50\" Name=\"Grid Table 5 Dark Accent 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"51\"\n Name=\"Grid Table 6 Colorful Accent 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"52\"\n Name=\"Grid Table 7 Colorful Accent 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"46\"\n Name=\"Grid Table 1 Light Accent 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"47\" Name=\"Grid Table 2 Accent 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"48\" Name=\"Grid Table 3 Accent 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"49\" Name=\"Grid Table 4 Accent 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"50\" Name=\"Grid Table 5 Dark Accent 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"51\"\n Name=\"Grid Table 6 Colorful Accent 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"52\"\n Name=\"Grid Table 7 Colorful Accent 5\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"46\"\n Name=\"Grid Table 1 Light Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"47\" Name=\"Grid Table 2 Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"48\" Name=\"Grid Table 3 Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"49\" Name=\"Grid Table 4 Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"50\" Name=\"Grid Table 5 Dark Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"51\"\n Name=\"Grid Table 6 Colorful Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"52\"\n Name=\"Grid Table 7 Colorful Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"46\" Name=\"List Table 1 Light\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"47\" Name=\"List Table 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"48\" Name=\"List Table 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"49\" Name=\"List Table 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"50\" Name=\"List Table 5 Dark\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"51\" Name=\"List Table 6 Colorful\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"52\" Name=\"List Table 7 Colorful\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"46\"\n Name=\"List Table 1 Light Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"47\" Name=\"List Table 2 Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"48\" Name=\"List Table 3 Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"49\" Name=\"List Table 4 Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"50\" Name=\"List Table 5 Dark Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"51\"\n Name=\"List Table 6 Colorful Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"52\"\n Name=\"List Table 7 Colorful Accent 1\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"46\"\n Name=\"List Table 1 Light Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"47\" Name=\"List Table 2 Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"48\" Name=\"List Table 3 Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"49\" Name=\"List Table 4 Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"50\" Name=\"List Table 5 Dark Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"51\"\n Name=\"List Table 6 Colorful Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"52\"\n Name=\"List Table 7 Colorful Accent 2\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"46\"\n Name=\"List Table 1 Light Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"47\" Name=\"List Table 2 Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"48\" Name=\"List Table 3 Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"49\" Name=\"List Table 4 Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"50\" Name=\"List Table 5 Dark Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"51\"\n Name=\"List Table 6 Colorful Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"52\"\n Name=\"List Table 7 Colorful Accent 3\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"46\"\n Name=\"List Table 1 Light Accent 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"47\" Name=\"List Table 2 Accent 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"48\" Name=\"List Table 3 Accent 4\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"49\" Name=\"List Table 4 Accent 4\"/\u003e\n 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5\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"46\"\n Name=\"List Table 1 Light Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"47\" Name=\"List Table 2 Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"48\" Name=\"List Table 3 Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"49\" Name=\"List Table 4 Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"50\" Name=\"List Table 5 Dark Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"51\"\n Name=\"List Table 6 Colorful Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" Priority=\"52\"\n Name=\"List Table 7 Colorful Accent 6\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Mention\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\"\n Name=\"Smart Hyperlink\"/\u003e\n \u003cw:LsdException Locked=\"false\" SemiHidden=\"true\" 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dir=\"LTR\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:solid black 1.0pt;border-left:none;mso-border-left-alt: solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border:solid black 1.0pt;border-left:none;mso-border-left-alt: solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp align=\"center\" class=\"MsoNormal\" dir=\"RTL\" style=\"text-align:center;line-height: 200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003eHealthy subjects\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:solid black 1.0pt;border-top:none;mso-border-top-alt: solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003eSubjects no.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp align=\"center\" class=\"MsoNormal\" dir=\"RTL\" style=\"text-align:center;line-height: 200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003e90\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:solid black 1.0pt;border-top:none;mso-border-top-alt: solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003eSex(Female)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp align=\"center\" class=\"MsoNormal\" dir=\"RTL\" style=\"text-align:center;line-height: 200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003e56(65.1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:solid black 1.0pt;border-top:none;mso-border-top-alt: solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003eAge(years)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp align=\"center\" class=\"MsoNormal\" dir=\"RTL\" style=\"text-align:center;line-height: 200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003e46(18-79)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:solid black 1.0pt;border-top:none;mso-border-top-alt: solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003eHbA1c (%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp align=\"center\" class=\"MsoNormal\" dir=\"RTL\" style=\"text-align:center;line-height: 200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003e5.3(4.3-6.4)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:solid black 1.0pt;border-top:none;mso-border-top-alt: solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003eHbA1c groups\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003eLow(\u0026le;5)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp align=\"center\" class=\"MsoNormal\" dir=\"RTL\" style=\"text-align:center;line-height: 200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003e32(35)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:solid black 1.0pt;border-top:none;mso-border-top-alt: solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003eNormal\u003c/span\u003e\u003cspan dir=\"LTR\"\u003e(5-5.7)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp align=\"center\" class=\"MsoNormal\" dir=\"RTL\" style=\"text-align:center;line-height: 200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003e33(37)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:solid black 1.0pt;border-top:none;mso-border-top-alt: solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003eHigh(5.7\u0026lt;)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp align=\"center\" class=\"MsoNormal\" dir=\"RTL\" style=\"text-align:center;line-height: 200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003e25(28)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:solid black 1.0pt;border-top:none;mso-border-top-alt: solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003ehsCRP ( mg/L)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp align=\"center\" class=\"MsoNormal\" dir=\"RTL\" style=\"text-align:center;line-height: 200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp align=\"center\" class=\"MsoNormal\" dir=\"RTL\" style=\"text-align:center;line-height: 200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.2\u003cspan dir=\"LTR\"\u003e(0.09-11.6)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:solid black 1.0pt;border-top:none;mso-border-top-alt: solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003eVitamin D3 (ng/ml)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black 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dir=\"LTR\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003emild (25-49.9)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp align=\"center\" class=\"MsoNormal\" dir=\"RTL\" style=\"text-align:center;line-height: 200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003e1\u003c/span\u003e1\u003cspan dir=\"LTR\"\u003e(11.6)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:solid black 1.0pt;border-top:none;mso-border-top-alt: solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003eModerate(12.5-24.9)\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black 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dir=\"LTR\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003eSevere(\u0026le;12.4)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp align=\"center\" class=\"MsoNormal\" dir=\"RTL\" style=\"text-align:center;line-height: 200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e40\u003cspan dir=\"LTR\"\u003e(41.9)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:solid black 1.0pt;border-top:none;mso-border-top-alt: solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003eBMI (Kg/m2)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp align=\"center\" class=\"MsoNormal\" dir=\"RTL\" style=\"text-align:center;line-height: 200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003e26.9(15.5-43)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:solid black 1.0pt;border-top:none;mso-border-top-alt: solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003eBMI groups\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003eUnderweight(\u0026le;18.5)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp align=\"center\" class=\"MsoNormal\" dir=\"RTL\" style=\"text-align:center;line-height: 200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003e5(5.8)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:solid black 1.0pt;border-top:none;mso-border-top-alt: solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003eNormal\u003c/span\u003e\u003cspan dir=\"LTR\"\u003e(18.5-24.9)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp align=\"center\" class=\"MsoNormal\" dir=\"RTL\" style=\"text-align:center;line-height: 200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003e25(24.4)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:solid black 1.0pt;border-top:none;mso-border-top-alt: solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003eOverweight(25-29.9)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp align=\"center\" class=\"MsoNormal\" dir=\"RTL\" style=\"text-align:center;line-height: 200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e33\u003cspan dir=\"LTR\"\u003e(36)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:solid black 1.0pt;border-top:none;mso-border-top-alt: solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp class=\"MsoNormal\" dir=\"RTL\" style=\"line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan dir=\"LTR\"\u003eObese(30\u0026le;)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top:none;border-left:none;border-bottom:solid black 1.0pt;border-right:solid black 1.0pt;mso-border-top-alt:solid black .5pt;mso-border-left-alt:solid black .5pt;mso-border-alt:solid black .5pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp align=\"center\" class=\"MsoNormal\" dir=\"RTL\" style=\"text-align:center;line-height: 200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e19\u003cspan dir=\"LTR\"\u003e(29.9)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp class=\"MsoNormal\" style=\"text-align:left;line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp class=\"MsoNormal\" style=\"text-align:left;line-height:200%;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTable1.Demographic and laboratory data of selected patients\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c!--EndFragment--\u003e\n\u003cp\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"VITD3, HSCRP, HbA1c, diabetes","lastPublishedDoi":"10.21203/rs.3.rs-41499/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-41499/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\t\u003cstrong\u003eBackground: \u003c/strong\u003e\u0026nbsp;In diabetic patients high HbA1c is associated with high level of HSCRP and VITD3 deficiency could result in diabetes and high HbA1c level. The aim of this study was to determine the relation of HbA1c, HSCRP and vitamin D3 in healthy individuals who referred to Rasool Akram Hospital.\u003c/p\u003e\u003cp\u003e\t\u003cstrong\u003eMethods: \u003c/strong\u003eIn this cross sectional study, individuals who referred to our center between 2018 and 2019 for the measurement of HbA1c were classified to three groups based on the level of the HbA1c: \u0026lt;5, 5-5.6 and 5.7≤. Then the Serum level of HSCRP and vitamin D3 were measured and compared between these three groups.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eResults: \u003c/strong\u003eIn this study, 90 healthy individuals were studied. In subjects with BMI below 25, no significant difference in HSCRP level was seen in group with low and normal HbA1c, but group with high HbA1c has non-significant higher level of HSCRP rather than group with normal HbA1c. In subject with BMI higher than 25, group with high HbA1c and low HbA1c had non-significant higher level of HSCRP than group with normal HbA1c and in the subjects, no significance difference at serum level of vitamin D3 level has been identified between HbA1c groups. \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eConclusion: \u003c/strong\u003eAs immunomedulatory role of VitD3 is shown in many studies and low VitD3 could predispose people to diabetes independent of obesity, Conflicting results in various studies emerge an idea to mind that considering relation of other factors responsible in glucose metabolism such as insulin level, IGF-1, C-Peptide and VitD3 could be a better overview on vitD3 effect on glucose metabolism\u0026nbsp;\u003c/p\u003e","manuscriptTitle":"Relationship of serum VITD3, HSCRP and HbA1c level in non diabetic patients referring to tertiary hospital","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2020-08-19 15:09:07","doi":"10.21203/rs.3.rs-41499/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"c922e744-d643-4b1e-ba1f-742a925a8d06","owner":[],"postedDate":"August 19th, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":321783,"name":"Nutrition \u0026 Dietetics"}],"tags":[],"updatedAt":"2020-08-19T15:09:08+00:00","versionOfRecord":[],"versionCreatedAt":"2020-08-19 15:09:07","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-41499","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-41499","identity":"rs-41499","version":["v1"]},"buildId":"WrCJVZZCHTDjtuVLN7oU0","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}