Corpus callosum in COVID-19 cytokinopathy, an update

Abstract The corpus callosum (CC) connects frontal, parietal, occipital and temporal cortices in the brain. We report a disconnection syndrome as a manifestation of coronavirus disease 2019 (COVID-19) encephalopathy. Like prior coronaviridae, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affects the brain over a spectrum of injury. Present communication is the first description of white matter involvement confined to CC’s commissural fibers in their entirety. Until case registries, longitudinal studies and animal models clarify any direct neurotropism of SARS-CoV-2; this case is consistent with recent biological evidence suggesting a cytokine mediated excitotoxic injury concomitant with the severity of infection.