Determination of Semaphorin 3A Levels in Behcet's Disease and Vascular Involvement of Behcet's Disease

Abstract Aim: Semaphorin 3A, may influence inflammatory and vasculopathic processes in Behçet's disease.The primary aim of our study is to evaluate serum semaphorin 3A levels in Behçet's disease patients. Methods: Patients over 18 years of age with Behçet's disease were studied. Serum semaphorin 3A levels were quantified by ELISA, and patients and healthy volunteers were statistically compared. Results: Behcet's patients had significantly lower semaphorin 3A levels than the control group.Within Behcet's patients, the vascular group had significantly lower levels than the non-vascular group. Conclusions: Serum semaphorin 3A levels were significantly decreased in both vascular and non-vascular Behcet's groups compared to controls.This is the first study in Behcet's patients to suggest semaphorin 3A as a potential biomarker of inflammation and vascular involvement.