Reactivation of an Embryonic Cardiac Neural Crest Transcriptional Subcircuit During Zebrafish Heart Regeneration

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The paper investigates gene regulatory programs governing migratory cardiac neural crest cells during zebrafish heart development and regeneration by integrating bulk and single-cell RNA-seq with ATAC-seq to define a neural-crest-specific transcriptional subcircuit involving egr1, sox9a, tfap2a, and ets1. It reports that sox10-expressing cells are essential for proper adult heart regeneration, and that injury triggers reactivation of all transcription factors in the migratory cardiac crest subcircuit at the wound edge. A limitation acknowledged in the framing is that zebrafish regeneration differs from human hearts, which have limited regenerative capacity, so direct translation is not established. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

ABSTRACT During vertebrate development, the heart primarily arises from mesoderm, with crucial contributions from cardiac neural crest cells that migrate to the heart and form a variety of cardiovascular derivatives. Here, by integrating bulk and single cell RNA-seq with ATAC-seq, we identify a gene regulatory subcircuit specific to migratory cardiac crest cells composed of key transcription factors egr1, sox9a, tfap2a and ets1 . Notably, we show that cells expressing the canonical neural crest gene sox10 are essential for proper cardiac regeneration in adult zebrafish. Furthermore, expression of all transcription factors from the migratory cardiac crest gene subcircuit are reactivated after injury at the wound edge. Together, our results uncover a developmental gene regulatory network that is important for cardiac neural crest fate determination, with key factors reactivated during regeneration. SIGNIFICANCE Many common human congenital heart defects are linked to problems that arise during cardiac neural crest development. Here, we use the zebrafish, which has the remarkable ability to regenerate their adult heart, to understand the genetic programs that control cardiac development and adult repair. We discover a set of genes that control the development of the cardiac neural crest and find that these genes are reactivated after heart injury in the adult zebrafish. Unlike the zebrafish, human hearts have a very limited ability to regenerate after injury. Our findings in zebrafish can provide insight to potential clinical interventions for congenital heart defects and adult heart damage.
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ABSTRACT During vertebrate development, the heart primarily arises from mesoderm, with crucial contributions from cardiac neural crest cells that migrate to the heart and form a variety of cardiovascular derivatives. Here, by integrating bulk and single cell RNA-seq with ATAC-seq, we identify a gene regulatory subcircuit specific to migratory cardiac crest cells composed of key transcription factors egr1, sox9a, tfap2a and ets1. Notably, we show that cells expressing the canonical neural crest gene sox10 are essential for proper cardiac regeneration in adult zebrafish. Furthermore, expression of all transcription factors from the migratory cardiac crest gene subcircuit are reactivated after injury at the wound edge. Together, our results uncover a developmental gene regulatory network that is important for cardiac neural crest fate determination, with key factors reactivated during regeneration. SIGNIFICANCE Many common human congenital heart defects are linked to problems that arise during cardiac neural crest development. Here, we use the zebrafish, which has the remarkable ability to regenerate their adult heart, to understand the genetic programs that control cardiac development and adult repair. We discover a set of genes that control the development of the cardiac neural crest and find that these genes are reactivated after heart injury in the adult zebrafish. Unlike the zebrafish, human hearts have a very limited ability to regenerate after injury. Our findings in zebrafish can provide insight to potential clinical interventions for congenital heart defects and adult heart damage. Competing Interest Statement The authors have declared no competing interest.

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europepmc
last seen: 2026-05-20T01:45:00.602351+00:00
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License: CC-BY-NC-ND-4.0