Factors Associated With Drug-resistant Tuberculosis in the Deprived Population in the State of Paraná – Brazil

Background: Tuberculosis remains a serious public health issue worldwide, affecting people in vulnerable situations. The study aimed to analyze factors associated with drug resistant tuberculosis among patients who were in prison in the state of Paraná. MethodAn ecological study was carried out on Drug-Resistant tuberculosis cases registered through the Information System of Paraná, Brazil (from 2008 to 2018). Descriptive statistics of quantitative parameters was applied, being calculated with absolute frequencies. Additionally, binary logistic regression was performed, where the Odds Ratio was calculated with its respective confidence interval. The Akaike Information Criterion and the likelihood ratio tests, Wald test, Anova and Mc Fadden tests were performed to choose and validate the model. The IBM SPSS and Statistics version 25 and RStudio software version 4.0.4 were used for data analysis. Result653 cases were registered as tuberculosis cases in prison, and among these, 98 cases were Drug-Resistant TB. The schooling level among the study population was 8 to 11 years of education (OR: 0.41, 95%CI: 0.16 – 0.93), negative culture (OR: 0, 29; 95%CI: 0.09– 0.74) and smoking (0.02, 95%CI: 0.01 – 0.74) all these were factors associated with drug-Resistant TB. With the study population having the clinical pulmonary form (OR: 9.87, 95%CI: 1.55 – 23.81) and having a positive microscopy in the fourth month of follow-up (OR: 6, 46, 95%CI: 1.04 – 53.79), it was more likely to develop resistance. ConclusionThe study showed that the variables; education, culture exam, smoking, pulmonary clinical form, and follow-up microscopy were associated with drug resistance in the treatment of tuberculosis.