Discloremia as a Clinical Predictor in Neurocritical Patients: A Retrospective Observational Study in the Intensive Care Unit at Hospital Manolo Morales Peralta, Nicaragua

Discloremia as a Clinical Predictor in Neurocritical Patients: A Retrospective Observational Study in the Intensive Care Unit at Hospital Manolo Morales Peralta, Nicaragua | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Discloremia as a Clinical Predictor in Neurocritical Patients: A Retrospective Observational Study in the Intensive Care Unit at Hospital Manolo Morales Peralta, Nicaragua Rosa Natalia Fonseca Latino, Manuel Enrique Pedroza, Erling Salazar Tejada, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4858537/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Introduction: Discloremia, encompassing hypochloremia and hyperchloremia, is a frequent complication in critically ill patients receiving chloride-rich solutions. This study explores the associations between discloremia, osmotic solution use, and clinical outcomes in neurocritical patients. Methods: A descriptive, correlational, and analytical study was conducted at Manolo Morales Peralta Hospital. We evaluated 75 patients with neurocritical pathologies, analyzing their demographics, clinical characteristics, osmotic therapy use, discloremia development, and clinical outcomes. Results: The study population predominantly comprised males (62.67%) with a mean age of 61 years. Ischemic cerebrovascular events were the most frequent diagnosis (38.67%). Notably, 65.52% of patients received 3% saline solution. Discloremia development was associated with chloride levels at 48 hours (p = 0.009). Serum chloride levels above 114 mEq/L correlated with prolonged ICU/hospital stay (p = 0.007). However, no significant associations were observed between discloremia and mortality or Rankin scale scores (p = 0.75). Discussion: Our findings suggest a complex relationship between discloremia and clinical outcomes in neurocritical patients. Future studies should explore tailored chloride management strategies to optimize clinical outcomes in this patient population. Internal Medicine Critical Care & Emergency Medicine Neurology Neurosurgery Discloremia Chloride Neurocritical care Osmotic therapy Clinical outcomes. Full Text Additional Declarations The authors declare no competing interests. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4858537","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":335867713,"identity":"4e3f676e-24c0-498b-ab2d-09eeff4f0489","order_by":0,"name":"Rosa Natalia Fonseca Latino","email":"","orcid":"https://orcid.org/0000-0003-3028-3761","institution":"Internal Medicine Physician, Subspecialist in Critical Care Medicine, Master of Biomedical Research, National Autonomous University of Nicaragua, Managua, Nicaragua.","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Rosa","middleName":"Natalia 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4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eIntroduction:\u003c/strong\u003e Discloremia, encompassing hypochloremia and hyperchloremia, is a frequent complication in critically ill patients receiving chloride-rich solutions. This study explores the associations between discloremia, osmotic solution use, and clinical outcomes in neurocritical patients.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods: \u003c/strong\u003eA descriptive, correlational, and analytical study was conducted at Manolo Morales Peralta Hospital. We evaluated 75 patients with neurocritical pathologies, analyzing their demographics, clinical characteristics, osmotic therapy use, discloremia development, and clinical outcomes.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults:\u003c/strong\u003e The study population predominantly comprised males (62.67%) with a mean age of 61 years. Ischemic cerebrovascular events were the most frequent diagnosis (38.67%). Notably, 65.52% of patients received 3% saline solution. Discloremia development was associated with chloride levels at 48 hours (p = 0.009). Serum chloride levels above 114 mEq/L correlated with prolonged ICU/hospital stay (p = 0.007). 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Future studies should explore tailored chloride management strategies to optimize clinical outcomes in this patient population.\u003c/p\u003e","manuscriptTitle":"Discloremia as a Clinical Predictor in Neurocritical Patients: A Retrospective Observational Study in the Intensive Care Unit at Hospital Manolo Morales Peralta, Nicaragua","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-08-07 06:21:17","doi":"10.21203/rs.3.rs-4858537/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"4f47d7ff-719f-4550-b99d-352ad4f4bf74","owner":[],"postedDate":"August 7th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":35569278,"name":"Internal Medicine"},{"id":35569279,"name":"Critical Care \u0026 Emergency Medicine"},{"id":35569280,"name":"Neurology"},{"id":35569281,"name":"Neurosurgery"}],"tags":[],"updatedAt":"2024-08-07T06:21:17+00:00","versionOfRecord":[],"versionCreatedAt":"2024-08-07 06:21:17","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-4858537","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4858537","identity":"rs-4858537","version":["v1"]},"buildId":"WrCJVZZCHTDjtuVLN7oU0","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}