Anthracycline Chemotherapy and Its Acute Cardiovascular Impact: A Tanzanian Quasi- Experimental Study on Blood Pressure and Heart Rate Variations

Anthracycline Chemotherapy and Its Acute Cardiovascular Impact: A Tanzanian Quasi- Experimental Study on Blood Pressure and Heart Rate Variations | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Anthracycline Chemotherapy and Its Acute Cardiovascular Impact: A Tanzanian Quasi- Experimental Study on Blood Pressure and Heart Rate Variations Vicent Bankanie This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-5633373/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background Effect of anthracyclines on the autonomic nervous system is linked to changes in blood pressure and heartrate. Such changes may predict future cardiac failure and other cardiovascular complications which may be influenced by other risk factors such as race. However, little has been conducted on this topic within African population. Objectives To determine the immediate anthracycline-related blood pressure and heart rate changes as signs of acute autonomic nervous system involvement. Methods This study was a pretest-posttest quasi experimental study involving cancer patients using anthracycline-based chemotherapy at Ocean Road Cancer Institute in Dar es Salaam, Tanzania. Results Among the 11188 newly diagnosed cancer patients, 430 participants receiving doxorubicin 60 mg/m2 over 30 minutes per day were systematically recruited. Majority were females. The average age was 47.9 ± 11.1 years, of which 276 (64.2%) were 40-59 years old. The majority (64.4%) had breast cancer. About 37% had an increase of heart rate greater than 10 beats/min after anthracycline infusion, suggesting a subsequent risk for heart failure. Both the SBP and DBP were significantly higher after infusion (SBP =121.7±9.8mmHg) Vs (124.3±12.3mmHg), (P=0.000), and DBP was 75.1±7.1 vs (78.7±10.0) (P=0.000). The linear mixture model (LMM) analysis showed that gender and diabetes were the influencing factors to DBP changes (P < 0.05), while gender, marital status, education, type of cancer, BMI, and history of diabetes mellitus were the influencing factors of SBP changes (P < 0.05). Conclusion The small change in blood pressure following anthracycline chemotherapy is statistically significant but clinically not significant. However, a significant number of patients have an increased risk of heart failure, defined by a pressure difference of >10mmhg. Risk factors for blood pressure may be used to stratify interventions to prevent changes in blood pressure. Monitoring blood pressure and heart rate during chemotherapy remains important, especially to high-risk patients. Anthracycline Cardio-oncology Chemotherapy Blood pressure Heart rate Tanzania Cancer Doxorubicin Figures Figure 1 Figure 2 Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-5633373","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":392303348,"identity":"19f21609-df68-4a31-97c6-e025a5a11828","order_by":0,"name":"Vicent Bankanie","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABDUlEQVRIie3RwUrDMBjA8W8EssuHvVYK9RUyAl4s9VVSCunFjcmuHgqDHed14sFXyCMUiu1lDxDQyxA8CwMRJrq0yoSRrVcP+V+SHH4kHwFwuf5j5GcRANQsDMJ2303EH+E7gkfdjgAkeRdhNVm9XH/AyLufJevxOMpUnT4quInh0ivspKScLwRM/OeqDBZMDtXyVWqoUnOLnZxOkQYozHt0lgfIyqHSV+caaAHYyw+R/qYhDzqbbpB9Z6wlX4YQ+yweQUoaorSszC2FaElvZgg9RCgPUPqTgZbyAlk6uGtmSeYp4tJOqFeu1hhFo1BL/oSf8dlJnVb67T0O+7f28X/z986i6yddLpfLdbQtxWlV2P2zHt4AAAAASUVORK5CYII=","orcid":"","institution":"The university of Dodoma","correspondingAuthor":true,"prefix":"","firstName":"Vicent","middleName":"","lastName":"Bankanie","suffix":""}],"badges":[],"createdAt":"2024-12-12 17:08:24","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-5633373/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-5633373/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":72289431,"identity":"96e0cd30-27f4-449a-a222-e69da4cf50ba","added_by":"auto","created_at":"2024-12-24 17:20:27","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":319723,"visible":true,"origin":"","legend":"\u003cp\u003eThe roadmap of the project\u003c/p\u003e","description":"","filename":"Fig1Roadmapoftheproject1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-5633373/v1/b4618b3faed53265f5a945ff.jpg"},{"id":72291452,"identity":"db3e477b-46eb-4484-9031-8f8c8f04dad3","added_by":"auto","created_at":"2024-12-24 17:28:26","extension":"jpg","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":120239,"visible":true,"origin":"","legend":"\u003cp\u003eThe sampling procedure\u003c/p\u003e","description":"","filename":"Fig2.SamplingProcedure1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-5633373/v1/5552465b0fa9df1c323a18db.jpg"},{"id":74100681,"identity":"12cb7771-9127-4ff6-b462-2707ddf1f320","added_by":"auto","created_at":"2025-01-17 18:16:39","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":996141,"visible":true,"origin":"","legend":"","description":"","filename":"AAMAINDOCEFFECTOFANTHRACYCLINECHEMOTHERAPYONBLOODPRESSUREmaindoc1.pdf","url":"https://assets-eu.researchsquare.com/files/rs-5633373/v1_covered_d6ef7ea1-de7e-41bf-840f-0d34da567c29.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Anthracycline Chemotherapy and Its Acute Cardiovascular Impact: A Tanzanian Quasi- Experimental Study on Blood Pressure and Heart Rate Variations","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Anthracycline, Cardio-oncology, Chemotherapy, Blood pressure, Heart rate, Tanzania, Cancer, Doxorubicin","lastPublishedDoi":"10.21203/rs.3.rs-5633373/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-5633373/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eEffect of anthracyclines on the autonomic nervous system is linked to changes in blood pressure and heartrate. Such changes may predict future cardiac failure and other cardiovascular complications which may be influenced by other risk factors such as race. However, little has been conducted on this topic within African population.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eObjectives\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTo determine the immediate anthracycline-related blood pressure and heart rate changes as signs of acute autonomic nervous system involvement.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study was a pretest-posttest quasi experimental study involving cancer patients using anthracycline-based chemotherapy at Ocean Road Cancer Institute in Dar es Salaam, Tanzania.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAmong the 11188 newly diagnosed cancer patients, 430 participants receiving doxorubicin 60 mg/m2 over 30 minutes per day were systematically recruited. Majority were females. The average age was 47.9 ± 11.1 years, of which 276 (64.2%) were 40-59 years old. The majority (64.4%) had breast cancer. About 37% had an increase of heart rate greater than 10 beats/min after anthracycline infusion, suggesting a subsequent risk for heart failure. Both the SBP and DBP were significantly higher after infusion (SBP =121.7±9.8mmHg) Vs (124.3±12.3mmHg), (P=0.000), and DBP was 75.1±7.1 vs (78.7±10.0) (P=0.000).\u003c/p\u003e\n\u003cp\u003eThe linear mixture model (LMM) analysis showed that gender and diabetes were the influencing factors to DBP changes (P \u0026lt; 0.05), while gender, marital status, education, type of cancer, BMI, and history of diabetes mellitus were the influencing factors of SBP changes (P \u0026lt; 0.05).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe small change in blood pressure following anthracycline chemotherapy is statistically significant but clinically not significant. However, a significant number of patients have an increased risk of heart failure, defined by a pressure difference of \u0026gt;10mmhg. Risk factors for blood pressure may be used to stratify interventions to prevent changes in blood pressure. Monitoring blood pressure and heart rate during chemotherapy remains important, especially to high-risk patients.\u003c/p\u003e","manuscriptTitle":"Anthracycline Chemotherapy and Its Acute Cardiovascular Impact: A Tanzanian Quasi- Experimental Study on Blood Pressure and Heart Rate Variations","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-12-24 17:20:21","doi":"10.21203/rs.3.rs-5633373/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"399a82eb-39b7-4efc-84dc-aa65d47f4d59","owner":[],"postedDate":"December 24th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2025-01-17T18:08:26+00:00","versionOfRecord":[],"versionCreatedAt":"2024-12-24 17:20:21","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-5633373","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-5633373","identity":"rs-5633373","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}