Trend, treatment outcome and associated factors of breast cancer at TGSH and FHRH, West Amhara, Ethiopia from January 2018 to December 2022

Trend, treatment outcome and associated factors of breast cancer at TGSH and FHRH, West Amhara, Ethiopia from January 2018 to December 2022 | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Trend, treatment outcome and associated factors of breast cancer at TGSH and FHRH, West Amhara, Ethiopia from January 2018 to December 2022 Dr Assefa This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4408086/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background: Breast cancer is a leading cause of death worldwide and ranks the 5th cause of death among all cancers, and most common cause of cancer death in women both developing and developed countries. Purpose: This study assessed the trend, treatment outcomes, and associated factors of breast cancer at the TGSH and FHRH from January 1, 2018, to December 30, 2022. Methods: An institution-based retrospective study was conducted from January 1, 2018, to December 30, 2022, at TGSH and FHRH, Bahir Dar. Secondary data were collected by reviewing patients’ charts. The collected data were entered into Epi data and exported to SPSS for further analyses. Univariate logistic regression analysis was performed to identify associated factors. Variables with a P-value ≤ 0.25 in binary logistic regression analysis were candidates for multi-variable analysis. Statistical significance was set at p < 0.05. AOR with 95% CI was used to measure the strength of association. Results: Among the 132 patients, 90.2% were females. The median age and mean symptom duration were 38 years and 7.87 months respectively. Only 75.3% of patients presented with breast lumps. One patient had bilateral breast cancers. Most patients present late with a locally advanced stage. The predominant histological finding was ductal carcinoma (53.0%). NACT was administered to only 6 (4.5%) patients. During follow-up, 34.1% and 3.8% of the patients developed local wound complications and recurrences, respectively. Only one patient was referred for radiotherapy. Presenting symptoms and waiting time for surgery were significantly associated with short-term complications (AOR=0.28; 95% CI (0.09,0.93)) and (AOR=0.16; 95% CI (0.03,0.89)) respectively. In multivariable models, performing surgery within 10 days of diagnosis decreased the incidence of short-term complications. Conclusion: Our study showed that relatively young females are commonly affected, the majority presenting with locally advanced stage of the disease. Surgery breast cancer treatment outcome recurrence Ethiopia Full Text Additional Declarations The authors declare no competing interests. Ethical clearance obtained from the Institutional Review Board (IRB) of College of Medicine and health sciences, Bahir Dar University, Ethiopia. Then, I got letter of permission from TGSH and FHRH medical director office research unit. Oral informed consent taken during a phone call while collecting missed information from the chart. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4408086","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":301507599,"identity":"4e5dcd8a-dfa7-4a4e-8536-04623fbd2325","order_by":0,"name":"Dr Assefa","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA4UlEQVRIiWNgGAWjYFACHgaGBCDF2N4AJA0sSNDC3HMApEWCSC0gwD4DpJGBCC38/WcPf3jwxy6xd+bzqxt+FEgw8Ld3J+DVInEjL00isS05cebsnLKbPUCHSZw5uwG/NTd4zBgSG5gTN87OSbvBA9RiIJGLX4v8+TPGHxL+1Cfuv3km7eYfYrQYHMgxkEhgO5zYOIP92G2ibDGE+OW4cWNPDtttGQMJHoJ+kTt/9vDHH3+qZRvbjz+7+eaPjRx/ey8B70OBYwMDjwGIwUOUchCwB0bmA6JVj4JRMApGwcgCAB8cTcL63ngXAAAAAElFTkSuQmCC","orcid":"https://orcid.org/0009-0003-5894-3642","institution":"Dessie","correspondingAuthor":true,"submittingAuthor":false,"prefix":"Dr","firstName":"","middleName":"","lastName":"Assefa","suffix":""}],"badges":[],"createdAt":"2024-05-12 10:21:37","currentVersionCode":1,"declarations":{"humanSubjects":true,"vertebrateSubjects":false,"conflictsOfInterestStatement":false,"humanSubjectEthicalGuidelines":true,"humanSubjectConsent":true,"humanSubjectClinicalTrial":false,"humanSubjectCaseReport":false,"vertebrateSubjectEthicalGuidelines":false,"coiExplicitlySet":false},"doi":"10.21203/rs.3.rs-4408086/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4408086/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":56598142,"identity":"182ba4a5-8e00-4efd-9b76-cc8ce5497888","added_by":"auto","created_at":"2024-05-16 11:08:18","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":335316,"visible":true,"origin":"","legend":"","description":"","filename":"Researchonbreastcancer.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4408086/v1_covered_fb5ea67e-47a6-45bf-a7f5-11caec0cd06d.pdf"}],"financialInterests":"\u003cp\u003eThe authors declare no competing interests.\u003c/p\u003e\n\u003cp\u003eEthical clearance obtained from the Institutional Review Board (IRB) of College of Medicine and health sciences, Bahir Dar University, Ethiopia. Then, I got letter of permission from TGSH and FHRH medical director office research unit. Oral informed consent taken during a phone call while collecting missed information from the chart.\u003c/p\u003e","formattedTitle":"\u003cp\u003eTrend, treatment outcome and associated factors of breast cancer at TGSH and FHRH, West Amhara, Ethiopia from January 2018 to December 2022\u003c/p\u003e","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"breast cancer, treatment outcome, recurrence, Ethiopia","lastPublishedDoi":"10.21203/rs.3.rs-4408086/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4408086/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground: \u003c/strong\u003eBreast cancer is a leading cause of death worldwide and ranks the 5th cause of death among all cancers, and most common cause of cancer death in women both developing and developed countries.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurpose:\u003c/strong\u003e This study assessed the trend, treatment outcomes, and associated factors of breast cancer at the TGSH and FHRH from January 1, 2018, to December 30, 2022.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods:\u003c/strong\u003e An institution-based retrospective study was conducted from January 1, 2018, to December 30, 2022, at TGSH and FHRH, Bahir Dar. Secondary data were collected by reviewing patients’ charts. The collected data were entered into Epi data and exported to SPSS for further analyses. Univariate logistic regression analysis was performed to identify associated factors. Variables with a P-value ≤ 0.25 in binary logistic regression analysis were candidates for multi-variable analysis. Statistical significance was set at p \u0026lt; 0.05. AOR with 95% CI was used to measure the strength of association.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults: \u003c/strong\u003eAmong the 132 patients, 90.2% were females. The median age and mean symptom duration were 38 years and 7.87 months respectively. Only 75.3% of patients presented with breast lumps. One patient had bilateral breast cancers. Most patients present late with a locally advanced stage. The predominant histological finding was ductal carcinoma (53.0%). NACT was administered to only 6 (4.5%) patients. During follow-up, 34.1% and 3.8% of the patients developed local wound complications and recurrences, respectively. Only one patient was referred for radiotherapy. \u003cstrong\u003ePresenting symptoms and waiting time for surgery\u003c/strong\u003e were significantly associated with short-term complications (AOR=0.28; 95% CI (0.09,0.93)) and (AOR=0.16; 95% CI (0.03,0.89)) respectively. In multivariable models, performing surgery within 10 days of diagnosis decreased the incidence of short-term complications.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion:\u003c/strong\u003e Our study showed that relatively young females are commonly affected, the majority presenting with locally advanced stage of the disease.\u0026nbsp;\u003c/p\u003e","manuscriptTitle":"Trend, treatment outcome and associated factors of breast cancer at TGSH and FHRH, West Amhara, Ethiopia from January 2018 to December 2022","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-05-16 11:00:11","doi":"10.21203/rs.3.rs-4408086/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"245cbce1-2f28-41af-92fb-0d694de06414","owner":[],"postedDate":"May 16th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":31812163,"name":"Surgery"}],"tags":[],"updatedAt":"2024-05-16T11:00:11+00:00","versionOfRecord":[],"versionCreatedAt":"2024-05-16 11:00:11","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-4408086","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4408086","identity":"rs-4408086","version":["v1"]},"buildId":"zQwnuV7TCBrMSSSToR1PI","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}