Understanding of Model Plant Arabidopsis thaliana Response to the Coexistence of BPA and TiO2-NPs in low environmental concentration: A Comparative Proteomics Study

This work presents the most extensive proteomic description of Arabidopsis thaliana in the knowledge of its responses to BPA and TiO 2 -NPs. Previous studies have reported that nanoparticles (NPs) and Bisphenol A (BPA) are toxic to the environment. However, the jointed toxicity is not yet well understood. This study was aimed to investigate the combined toxicity of BPA and TiO 2 -NPs to plants. Model plant Arabidopsis thaliana was selected as the target plant. The seedlings were randomly separated into 5 groups and treated with BPA (1000, 100, 10 and 0 µg/kg) and TiO 2 -NPs (100, 10, 1 and 0 mg/kg). The plant height, biomass and root length indicated no significant toxicity of low concentration of BPA and TiO 2 -NPs to the growth. In the results of comparative proteomics, both positive and negative effects were observed in root growth, plant development and energy metabolism, et.al , according to GO and KEGG analysis.