CURATIVE EFFECTS OF LAPAROSCOPE COMBINED WITH DRUG THERAPY ON OVARIAN ENDOMETRIOSIS CYST COMBINED WITH INFERTILITY

Objective To study the curative effect of laparoscope combined with medication on ovarian endometriosis cyst( OEM) combined with infertility. Methods 120 patients with moderate to severe OEM combined with infertility admitted in our hospital from January 2011 to January 2014 were selected and divided into group A,group B and the control group. The patients in all the three groups underwent laparoscopic conservative surgery. Besides,the control group was not combined with drug therapy,and groups A and B received postoperative therapy,with group A given intramuscular injection of Zoladex,and group B oral administration with Gestrinone capsule. The postoperative sex hormone levels,pregnancy rate,recurrence rate and safety of the three groups were then compared among the groups. Results In terms of the sex hormone levels,FSH,LH,E2,CA125 and other indicators of groups A and B six months after surgery were significantly better than the control group( p 0. 05); The pregnancy rate and recurrence rate in groups A and B were significantly higher than the control group( p 0. 05) and the recurrence rate was significantly lower than the control group( p 0. 05) : the recurrence rate of group A was significantly lower than that in group B( p 0. 05). 4 patients in group A( 10%) suffered from increasing alanine aminotransferase( ALT),aspartate aminotransferase( AST). There was no other adverse reactions. Conclusion Laparoscope combined with medication is significant in severe OEM with infertility in that it may significantly reduce the recurrence rate and increase pregnancy rate. Besides,therapy with Zoladex can better reduce the recurrence rate and increase the safety.