Abstract
Accurate and timely documentation in the electronic health record (EHR) is essential for
delivering safe and effective patient care. AI-enabled medical tools powered by automatic speech
recognition (ASR) offer to streamline this process by transcribing clinical conversations directly
into structured notes. However, a critical challenge in deploying these technologies at scale is
their variable performance across speakers with diverse accents, which leads to transcription
inaccuracies, misinterpretation, and downstream clinical risks. We measured transcription
accuracy of Whisper and WhisperX on clinical texts across native and non-native English
speakers and found that both models have significantly higher errors for non-native speakers.
Fortunately, we found that post-processing the transcripts using GPT-4o recovers the lost
accuracy. Our findings indicate that using a chained model approach, WhisperX-GPT, will
enhance transcription quality significantly and reduce errors associated with accented speech. We
make all code, models, and pipelines freely available.
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Introduction
There has been a marked acceleration in the development and application of artificial
intelligence (AI) systems within healthcare in recent years. AI-driven technologies have been
developed and introduced across the clinical continuum including decision support, clinical
documentation, and patient engagement tools. (1–3) These systems are designed to support both
healthcare professionals and patients, with the aim of improving care delivery, streamlining
workflows, and enhancing health outcomes. Automatic speech recognition (ASR) technology
forms the foundation of audio transcription within AI systems, enabling the conversion of spoken
language into structured, machine-readable text. ASR models often serve as a critical bridge
between AI systems and their human users by enabling seamless communication in clinical
workflows. Despite their growing utilization, concerns have been raised regarding the equitable
performance of ASR models across diverse user populations. (4–6)
ASR models process audio by segmenting speech into discrete units, extracting acoustic features,
and applying statistical models to predict corresponding text. These models are further refined by
language models that assign probabilities to likely word sequences, enabling contextual
interpretation. While these approaches have achieved remarkable progress in many domains,
their performance may vary when confronted with linguistic variation, including differences in
accent, intonation, and grammatical structure. Studies have found ASR models often exhibit
reduced transcription accuracy when processing speech from non-native English speakers,
attributable to variations in pronunciation, syntax, and prosody. (7,8) We observed these errors
first hand when evaluating an AI-scribe for endoscopic procedural notes and hypothesized that
this problem may be a challenge in across healthcare settings. Such errors would have important
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implications for healthcare, where precise communication between AI systems and users is
critical for safe and effective implementation.
Characterizing and addressing this disparity in ASR performance is critical to ensuring equitable
implementation of AI technologies within the healthcare system. The healthcare workforce in the
United States is notably diverse, with an estimated 18% of healthcare workers being
foreign-born. (9) Furthermore, data from the U.S. Census Bureau indicate that the number of
non-English speakers in the United States has been steadily increasing over the past four
decades. (10)
In this pilot study, we evaluated the performance of two ASR models, Whisper and WhisperX, in
transcribing standardized clinical audio from both native and non-native English speakers,
including physicians and non-clinical participants. We found that both models performed
significantly worse for non-native speakers, with Whisper more greatly affected. To reduce these
disparities, we developed a post-processing pipeline using a large language model (LLM) and
found significant reduction in these errors. Our results demonstrate that combining ASR with
LLM correction enhances the reliability of AI-generated clinical documentation, particularly for
diverse speaker populations. To our knowledge, this is the first study to systematically examine
transcription bias based on language background and medical expertise, an essential step toward
equitable AI integration in clinical workflows.
Materials and methods
We conducted a cross-sectional study of 20 participants who were stratified into four groups
based on two binary variables: whether they were native English speakers and whether they had
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formal medical training. Native English speakers were defined as individuals who had completed
formal education beginning in the sixth grade or earlier in the United States. Formal medical
training was defined as current or prior enrollment in an accredited medical education program,
including medical students, residents, fellows, or independently practicing physicians. This
stratification resulted in four distinct groups each with 5 participants:
(1) Native English speakers with formal medical training
(2) Native English speakers without medical training
(3) Non-native English speakers with formal medical training
(4) Non-native English speakers without medical training.
We developed four standardized medical texts that represented typical clinical scenarios for the
participants to read:
- TEXT 1: Gastroenterologist explaining latest colonoscopy results to a patient.
- TEXT 2: Cardiologist describing patients’ clinical history to another physician.
- TEXT 3: Gastroenterologist describing patients’ clinical history to another physician.
- TEXT 4: Pulmonologist describing patients’ clinical history to another physician.
We instructed each participant to record themselves reading these four standardized medical texts
aloud using their personal computers and built-in microphones. They were asked to use their
natural speaking voice and typical conversational pace to simulate real-world use conditions.
We used two ASR models for transcription, Whisper and WhisperX. (11,12) Whisper is an ASR
system trained on extensive multilingual and multitask data from the web, utilizing an
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encoder-decoder transformer architecture to transcribe speech segments into text. WhisperX
enhances Whisper by incorporating voice activity detection (V AD), forced phoneme alignment
and diarization methods, providing precise word-level timestamps and speaker attribution. These
features make WhisperX particularly suited for detailed analyses required in clinical
transcription and video subtitling. Additionally, we implemented a unique approach by chaining
WhisperX outputs to GPT-4o for further correction, which we call WhisperX-GPT. This two-step
process aims to enhance transcription accuracy without compromising content integrity or overly
summarizing the transcripts.
We evaluated the models using two metrics: Levenshtein distance, which measures the number
of single-character edits required to match the transcription with the original text, and Word
Error Rate (WER), a standard metric that calculates transcription accuracy at the word level as a
percentage. To test sensitivity to accented speech, we used one-tailed t-tests to compare the
differences between native and non-native groups for each standardized medical text and then for
all texts grouped. For the grouped analyses, we normalized all the calculated values using a mean
centered approach within each standardized medical text standardized medical text. Finally, we
used paired t-tests to compare the performance of non-native groups with (WhisperX-GPT) and
without (WhisperX) correction. We conducted all analyses using Python programming language,
and the analysis scripts are publicly available on Github
(https://github.com/tatonetti-lab/Accent-Project/tree/main).
Additionally, we built an AI engine publicly hosted on the UnityPredict
(https://console.unitypredict.com/medical-transcription-engine-with-llm-correction)
platform. This engine accepts two types of inputs—audio or transcription files—processes them
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through WhisperX, then forwards the transcription to GPT-4o for correction, providing users
with both the original and corrected transcriptions. This engine is publicly accessible and hosted
here.
Results
We used all 20 audio recordings, consisting of five participants within each subgroup, to assess
transcription accuracy. As a baseline, we tested transcription accuracy using the Whisper ASR
model across all four participant subgroups for each standardized medical text and for the
combined dataset. The model’s performance was evaluated using WER as shown in Figure 1,
along with statistical analysis comparing the native and non-native groups presented in Table 1.a.
The model performance was significantly better for the native group compared to the non-native
group in the combined dataset (WER difference of 11.45, p = 0.003). Supplementary Figure 1,
and Supplementary Table 1 present the performance of the model using Levenshtein distance
metric.
We then applied the same analysis to assess the performance of the WhisperX ASR model. The
Results
using WER are shown in Figure 2, with corresponding statistical comparisons between
native and non-native groups presented in Table 1.b. WhisperX demonstrated improved
accuracy, reflected by lower error rates across all four medical text groups and the combined
dataset, for both native and non-native speakers compared with Whisper. However, a significant
difference in performance (WER difference of 3.40, p value = 0.001) between native and
non-native groups remained. Supplementary Figure 2 and Supplementary Table 2 present the
performance of WhisperX using the Levenshtein distance metric.
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For correction, we passed the transcription results from the WhisperX model to GPT-4o
(WhisperX-GPT) and evaluated the performance after correction using both Levenshtein
distance and WER metrics. We found that WhisperX-GPT significantly improved the WER for
every medical text, with reductions in errors ranging from 4.52 to 6.89 (p<0.001 for all
comparisons). Figure 3 illustrates this improvement in performance and Table 2 contains the
statistical analysis.
Discussion
AI systems will become increasingly integrated into healthcare. As they do, automated speech
recognition (ASR) models will serve as a critical bridge between users and AI, playing an
essential role in ensuring accurate and efficient clinical communication. However, concerns
regarding the variable performance of ASR models across diverse user populations, particularly
among individuals with different language backgrounds, limit their effectiveness and may
contribute to poor clinical outcomes. In this study, we evaluated the transcription accuracy of two
ASR models, Whisper and WhisperX, across native and non-native English speakers with and
without formal medical training. WhisperX demonstrated superior performance compared to
Whisper. However, both models suffered when transcribing accented speech. Implementation of
a post-processing pipeline Whisper-X-GPT significantly improved the transcription accuracy,
reduced errors, and minimized outliers for non-native English speakers. The correction process
narrowed the distribution of transcription performance, suggesting that large language model
integration provides a stabilizing effect. This reduction in variability is clinically meaningful, as
it minimizes the risk of unpredictable or egregious transcription failures that could compromise
clinical documentation or decision-making. In clinical workflows, where precision is paramount
and even minor transcription errors can lead to miscommunication, diagnostic inaccuracies, or
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inappropriate interventions, reducing variability is critical to patient safety. These findings
highlight the importance of evaluating not only mean performance metrics but also distributional
characteristics when assessing the fairness and reliability of AI tools in healthcare.
Performance metrics such as the Word Error Rate (WER) and Levenshtein distance provide
useful benchmarks, however, they may not fully capture clinically consequential errors. In
medical contexts, transcription inaccuracies that affect medication names, dosages, procedural
terms, or patient instructions may carry disproportionate clinical risk despite contributing
minimally to overall error rates. Thus, future evaluations of ASR systems in healthcare should
incorporate clinically weighted error assessments that reflect the relative importance of
transcription fidelity across different types of content. Moreover, the lack of diverse linguistic
representation in model training datasets may exacerbate these issues, underscoring the need for
equitable model development and subgroup-specific performance reporting. This study also has
other limitations that highlight opportunities for future research. Our sample size was small,
limiting statistical power to detect subtle differences across groups. Participants recorded audio
using personal devices in uncontrolled environments, introducing variability in sound quality and
Background
noise—factors that, while realistic, may confound performance assessment.
Additionally, our operational definition of native versus non-native English speakers may not
fully capture the complexity of linguistic identity or accent variation, and the use of scripted
medical texts likely does not reflect the spontaneity and nuance of real clinical communication.
As ASR systems become increasingly embedded in real-time clinical documentation, future
work should focus on expanding evaluations to larger and more diverse cohorts, incorporating
unscripted conversations, and developing domain-specific error classification frameworks. These
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efforts will be essential to ensure that ASR and LLM technologies are integrated into clinical
workflows in a manner that preserves safety, accuracy, and equity.
Nonetheless, our benchmarking approach provides a notable competitive advantage over existing
studies by uniquely incorporating accent and medical expertise as evaluation components. To the
best of our knowledge, this is the first study systematically examining transcription biases across
these dimensions and proposing a practical method of addressing these biases through chaining
with additional language models. This methodology is publicly accessible and testable on the
UnityPredict platform, facilitating transparency and replicability.
Conclusion
This study highlights the importance of evaluating and addressing transcription biases in
automated speech recognition (ASR) models in clinical settings, particularly those related to
speaker accent and domain expertise. We found that WhisperX is a more robust model,
particularly when chained with a large language model (GPT-4o) for post-processing, especially
for non-native speakers. Moving forward, deploying ASR models in clinical settings will require
broader evaluations across more diverse domains, speaker scenarios, and languages. Establishing
multi-dimensional evaluation frameworks will be essential to ensure these systems remain
reliable and meet the demands of inclusive, high-quality healthcare delivery.
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Figure 1: Performance of the Whisper ASR model across four participant subgroups and four Medical Text categories
using Word Error Rate (WER) analysis, with values normalized using mean-centered approach within each Text
category. Participant groups are defined by accent (Native vs. Non-Native) and medical domain expertise (MD vs.
non-MD).
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Figure 2: Performance of the Whisper-X ,ASR model across four participant subgroups and four Medical Text
categories using Word Error Rate (WER) analysis, with values normalized using mean-centered approach within
each Text category. Participant groups are defined by accent (Native vs. Non-Native) and medical domain expertise
(MD vs. non-MD).
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Figure 3: Comparison of Whisper-X and WhisperX-GPT performance using WER scores across non-native speaker
groups and four medical text categories. We calculated p-values using paired t-tests, with statistical significance
indicated by *** within each group.
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Table 1: a) T-test statistical analysis of Whisper performance using WER as the evaluation metric across different text
groups and the total dataset, comparing native and non-native groups. The model performed significantly better for
the native group than for the non-native group in the total dataset . b) T-test statistical analysis of Whisper-X
performance using WER as the evaluation metric across different text groups and the total dataset, comparing native
and non-native groups. The model performance was significantly better for the native group compared to the
non-native group in the total dataset , indicating higher transcription error rates among non-native speakers.
a) Whisper (WER analysis)
Group -
Whisper (WER
analysis)
Degree of
Freedom (df)
T- statistics
One-tailed-
p value
T critical one
tail
Accuracy of Group
1 – (Non-Native)
Accuracy of Group
2 – (Native) Difference Confidence Interval
TEXT1 18 0.77 0.225 1.73 19.13 15.37 3.76 (-20.42, 12.90)
TEXT2 18 1.08 0.148 1.73 22.92 15.37 7.55 (-22.26, 7.16)
TEXT3 14 2.65 0.009 1.76 38.82 17.21 21.62 (-39.1,-4.14)
TEXT4 18 1.48 0.078 1.73 40.44 29.93 10.52 (-25.46,4.42)
Total 60 2.85 0.003 1.67 30.33 18.88 11.45 (19.43, -3.47)
b) Whisper -X (WER analysis)
Group - WhisperX
(WER analysis)
Degree of
Freedom (df) T-statistics
One-tailed-
p value
T critical one
tail
Accuracy of Group
1 – (Non-Native)
Accuracy of Group
2 –(Native) Difference Confidence Interval
TEXT1 18 0.80 0.217 1.73 10.4 9.1 1.35 (-4.89, 2.19)
TEXT2 18 1.30 0.106 1.73 12.5 9.9 2.58 (-6.77, 1.60)
TEXT3 18 2.17 0.022 1.73 19.8 14.3 5.53 (-10.89, -0.14)
TEXT4 18 1.78 0.046 1.73 19.5 15.3 4.15 (-9.11, 0.76)
Total 78 3.22 0.001 1.66 15.5 12.1 3.40 (-5.50, -1.30)
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Table 2: T-test statistical analysis comparing WhisperX and WhisperX-GPT performance using WER as the
evaluation metric across non-native groups. The results show significant improvement in transcription accuracy for
the WhisperX-GPT model across all medical text groups and in the total dataset compared with the same subgroups
of nonnative group.
Group – Whisper-X vs
WhisperX GPT4(WER
analysis)
Degree of
Freedom
(df) T-statistics
One-tailed-p
value
T critical
once tail
Accuracy of Group
1(Whisper-X-
Non-Native)
Accuracy of Group 2
(Whisper-X-GPT
Non-Native)
Differenc
e Confidence Interval
TEXT1 9 4.03 0.0015 1.833 10.397 5.87 4.52 (-5.35, 3.69)
TEXT2 9 3.62 0.0028 1.833 12.518 6.09 6.43 (-6.82, 6.03)
TEXT3 9 3.90 0.0018 1.833 19.823 13.71 6.12 (-7.04, -5.2)
TEXT4 9 5.60 0.0002 1.833 19.481 12.59 6.89 (-7.82, -5.96)
Total 39 8.43 1.27E-10 1.685 15.555 9.57 5.99 (-6.40, -5.58)
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Supplementary Materials
Figure 1 Supp: Performance of the Whisper model across four participant subgroups and four Medical Text
categories using Levenshtein Distance analysis, with values normalized using mean-centered approach within each
Text category.
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Figure 2 Supp: Performance of the Whisper -X model across four participant subgroups and four Medical Text
categories using Levenshtein Distance analysis, with values normalized using mean-centered approach within each
Text category.
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Figure 3 Supp: Performance of the Whisper X -GPT4o model across four participant subgroups and four Medical Text
categories using Levenshtein Distance analysis, with values normalized using mean-centered approach within each
Text category.
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Figure 4 Supp: Performance of the Whisper-X+GPT4o , model across four participant subgroups and four Medical
Text categories using Word Error Rate (WER) analysis, with values normalized using mean-centered approach within
each Text category.
Group - Whisper
Distance analysis)
Degree of
Freedom (df) T-statistics
One-tailed-p
value T critical once tail
Accuracy of Group 1 –
(Non-Native)
Accuracy of Group
2 –
(Native) Difference
Confidence
Interval
TEXT1 18 0.72 0.240 1.73 0.12 0.07 0.05 (-0.19, 0.09)
TEXT2 18 1.10 0.142 1.73 0.16 0.09 0.07 (-0.20, 0.06)
TEXT3 15 2.03 0.030 1.75 0.24 0.08 0.16 (-0.30, -0.02)
TEXT4 18 0.58 0.283 1.73 0.24 0.19 0.05 (-0.18, 0.08)
Total 75 2.07 0.021 1.67 0.19 0.11 0.08 (-0.14, -0.01)
Table 1 Supp: T-test statistical analysis of Whisper using Distance as the evaluation metric across different text
groups and the total dataset, comparing native and non-native groups.
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Table 2 Supp: T-test statistical analysis of Whisper-X using Distance as the evaluation metric across different text
groups and the total dataset, comparing native and non-native groups.
Table 3 Supp: T-test statistical analysis of Whisper-X+ GPT4o using Distance as the evaluation metric across
different text groups and the total dataset, comparing native and non-native groups.
Group –
WhisperX+GPT4o
Distance analysis)
Degree of
Freedom (df) T-statistics
One-tailed-p
value T critical once tail
Accuracy of Group 1 –
(Non-Native)
Accuracy of Group
2 –
(Native) Difference
Confidence
Interval
TEXT1 18 0.608 0.275 1.734 0.016 0.013 0.003 (-0.013, 0.01)
TEXT2 18 -0.256 0.401 1.734 0.028 0.029 -0.001 (-0.01, 0.01)
TEXT3 18 1.715 0.052 1.734 0.034 0.022 0.012 (-0.03, 0.003)
TEXT4 18 1.546 0.070 1.734 0.042 0.030 0.012 (-0.02, 0.002)
Total 78 1.697 0.047 1.665 0.03 0.023 0.006 (-0.014, 0.00)
Group - WhisperX
Distance analysis)
Degree of
Freedom (df) T-statistics
One-tailed-p
value T critical once tail
Accuracy of Group 1 –
(Non-Native)
Accuracy of Group 2
–
(Native) Difference
Confidence
Interval
TEXT1 18 1.36 0.095 1.73 0.03 0.02 0.01 (-0.02, 0.003)
TEXT2 18 1.30 0.105 1.73 0.04 0.03 0.01 (-0.03, 0.006)
TEXT3 18 1.93 0.035 1.73 0.05 0.03 0.02 (-0.044, 0.004)
TEXT4 18 1.88 0.038 1.73 0.06 0.04 0.02 (-0.04, 0.001)
Total 78 3.01 0.002 1.66 0.05 0.03 0.02 (-0.03, -0.01)
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Table 4 Supp: T-test statistical analysis of Whisper-X+GPT4o using WER as the evaluation metric across different
text groups and the total dataset, comparing native and non-native groups.
Group –
WhisperX+GPT4o
corrected (WER
analysis)
Degree of
Freedom (df) T-statistics
One-tailed-
p value T critical once tail
Accuracy of Group
1 –
(Non-Native)
Accuracy of Group 2
–
(Native) Difference
Confidence
Interval
TEXT1 TEXT1 18 0.80 0.218 5.87 5.08 0.79 (-2.90, 1.31)
TEXT2 TEXT2 18 0.30 0.383 6.09 5.83 0.27 (-2.16, 1.56)
TEXT3 TEXT3 18 2.59 0.009 13.71 10.18 3.53 (-6.40, -0.66)
TEXT4 TEXT4 17 1.51 0.075 12.59 10.30 2.30 (-5.72, 095)
Total Total 78 2.87 0.003 9.57 7.84 1.72 (-2.92, -0.53)
. CC-BY-NC 4.0 International licenseIt is made available under a
is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (which was not certified by peer review)
The copyright holder for this preprintthis version posted September 2, 2025. ; https://doi.org/10.1101/2025.08.29.25333548doi: medRxiv preprint
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