Morphology and steroidogenesis of cultured granulosa cells from endometrioidally changed ovaries

Jana Skrzypczak, J Skrzypczak, Skrzypczak J
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2009 · vol. 103(04) , pp. 228–232 · doi:10.1055/s-0029-1211355 · PMID:7584528 · W2013181503
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Granulosa cells from endometriotic ovaries exhibited normal morphology in culture but showed defects in progesterone and testosterone production.

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This study investigated the morphology and steroidogenic function of granulosa cells harvested from ovaries affected by endometriosis. Researchers collected antral granulosa cells from 34 medium-sized follicles in eleven patients with third- or fourth-degree endometriosis and cultured them to assess cellular characteristics and hormone secretion. The findings indicated that while the cultured cells maintained normal morphological properties and formed a monolayer, their steroidogenesis was defective, specifically showing impaired production of progesterone and testosterone. This paper is centrally about endometriosis — specifically examining the functional deficits of granulosa cells derived from endometriotic ovarian cysts.

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Abstract

The aim of the study was to see the function of follicular cells collected from ovaries of women suffering from endometriosis. The material was granulosa cells taken from 11 patients operated on 3rd and 4th degree of endometriosis. Antral granulosa cells were harvested from 34 medium-size (5-10 mm in diameter) follicles located on the cysts' walls or in the cysts' vicinity. Using the culture method, morphology and steroid secretion was estimated. Morphological properties of the cells in the culture did not differ significantly from that of healthy ones. All cells formed a monolayer and achieved different degrees of luteinization. Steroidogenesis of these granulosa cells was defected, particularly in the production of progesterone and testosterone.
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Subscribe to RSS DOI: 10.1055/s-0029-1211355 © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York Morphology and steroidogenesis of cultured granulosa cells from endometrioidally changed ovaries Publication History Publication Date: 15 July 2009 (online) Summary The aim of the study was to see the function of follicular cells collected from ovaries of women suffering from endometriosis. The material was granulosa cells taken from 11 patients operated on 3rd and 4th degree of endometriosis. Antral granulosa cells were harvested from 34 medium-size (5—10 mm in diameter) follicles located on the cysts' walls or in the cysts' vicinity Using the culture method, morphology and steroid secretion was estimated. Morphological properties of the cells in the culture did not differ significantly from that of heal- thy ones. All cells formed a monolayer and achieved different degrees of luteinization. Steroidogenesis of these granulosa cells was defected, 1 particularly in the production of progesterone and testosterone. Key words Granulosa cells - steroidogenesis - endometriosis

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Granulosa Cells Granulosa Cells Ovary Steroids Adult Androstenedione Androstenedione Cells, Cultured Endometriosis Endometriosis Estradiol Estradiol Female Follicle Stimulating Hormone Follicle Stimulating Hormone Granulosa Cells Granulosa Cells Humans Luteinizing Hormone

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