Morphology and steroidogenesis of cultured granulosa cells from endometrioidally changed ovaries
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Granulosa cells from endometriotic ovaries exhibited normal morphology in culture but showed defects in progesterone and testosterone production.
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Abstract
The aim of the study was to see the function of follicular cells collected from ovaries of women suffering from endometriosis. The material was granulosa cells taken from 11 patients operated on 3rd and 4th degree of endometriosis. Antral granulosa cells were harvested from 34 medium-size (5-10 mm in diameter) follicles located on the cysts' walls or in the cysts' vicinity. Using the culture method, morphology and steroid secretion was estimated. Morphological properties of the cells in the culture did not differ significantly from that of healthy ones. All cells formed a monolayer and achieved different degrees of luteinization. Steroidogenesis of these granulosa cells was defected, particularly in the production of progesterone and testosterone.
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Cited by (3)
- Endometriosis-associated infertility: From pathophysiology to tailored treatment 2022
- A Lifelong Impact on Endometriosis: Pathophysiology and Pharmacological Treatment 2023
- Expression and Function of 3beta Hydroxisteroid Dehydrogenase (3β HSD) Type II and Corticosteroid Binding Globulin (CBG) in Granulosa Cells from Ovaries of Women with and without Endometriosis 2002
Cited by (3)
- A Lifelong Impact on Endometriosis: Pathophysiology and Pharmacological Treatment 2023
- Endometriosis-associated infertility: From pathophysiology to tailored treatment 2022
- Expression and Function of 3beta Hydroxisteroid Dehydrogenase (3β HSD) Type II and Corticosteroid Binding Globulin (CBG) in Granulosa Cells from Ovaries of Women with and without Endometriosis 2002
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- europepmc
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- openalex
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- pubmed
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