Atypical ductal hyperplasia on percutaneous breast biopsy: Scoring system to identify the lowest risk for upgrade

Atypical ductal hyperplasia on percutaneous breast biopsy: Scoring system to identify the lowest risk for upgrade | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Atypical ductal hyperplasia on percutaneous breast biopsy: Scoring system to identify the lowest risk for upgrade Amanda L Amin, Onalisa D Winblad, Allison H Zupon, Fang Fan, Ossama Tawfik, and 6 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-388478/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Purpose NCCN guidelines recommend surgical excision for all patients with atypical ductal hyperplasia (ADH) on percutaneous biopsy. Improved imaging and biopsy techniques have lower contemporary upgrade rates, challenging standard practice. Methods A retrospective analysis identified 87 percutaneous biopsies diagnosing ADH who underwent surgical excision at a single institution from 01/2008 to 10/2015. Imaging was reviewed for lesion size and residual calcifications. Biopsy slides were reviewed for ADH features. Categorical variables were analyzed using Chi-square and Fisher’s exact tests; continuous variables with T- and Wilcoxon tests. Logistic regression model was used to determine association between odds of upgrade and number of low-risk features. Results Upgrade was identified in 13 cases (14.9%; 11 ductal carcinoma in situ and 2 invasive breast cancer). Imaging features associated with lowest risk of upgrade included imaging size 50% removed by biopsy ( p = 0.03). The only pathologic feature significantly associated with upgrade was the presence of micropapillary features ( p = 0.10), with lower extent of ADH (1–2 foci, p = 0.12) trending toward significance. Those with the lowest risk of upgrade (0%) had all 4 low risk features (n = 17, 20%). The loss of a low-risk feature increased the odds of upgrade by 189% (OR = 1.89, 95% CI 0.241,0.742, p = 0.001). Conclusion Contemporary imaging and biopsy techniques have resulted in lower upgrade rates for ADH. Patients at lowest risk for upgrade can be identified using a scoring system and may be safely offered active surveillance over surgical excision. Oncology Breast Cancer Aytpical Ductal Hyperplasia ADH Breast Surgery Upgrade Ductal Carcinoma In Situ Figures Figure 1 Figure 2 Introduction Breast cancer is the second most common cancer among women in the United States, with more than 280,000 cases of invasive breast cancer (IBC) and ductal carcinoma in situ (DCIS) predicted to be diagnosed in 2021.[ 1 ] This translates into nearly 1 in 8 women in the United States being diagnosed with breast cancer over the course of her lifetime. There are multiple risk factors associated with the development of breast cancer, including family history and lifetime exposure to estrogen, as well as a personal history of a biopsy with atypical hyperplasia.[ 2 ] Atypical ductal hyperplasia (ADH) is a high-risk breast lesion. Calcifications are the most common radiologic finding associated with ADH.[ 3 ] However, the lesion could be identified incidentally (not with the targeted calcifications) or in association with other lesions such as a radial sclerosing lesion or intraductal papilloma.[ 4 , 5 ] Microscopically, ADH is a proliferative lesion that fulfills some but not all the criteria for low grade DCIS. Pathologists evaluate several quantitative and qualitative parameters to accurately diagnosis this lesion. The most recent World Health Organization (WHO) Classification of Breast Tumors endorses the traditional quantitative criteria of Page and Tavassoli requiring at least 2 fully involved duct cross sections and ≤ 0.2cm in size.[ 6 ] 6 Identification of ADH results in a 4-fold increase in future breast cancer risk.[ 2 ] Standard of care for an abnormal breast imaging finding is percutaneous image-guided core needle biopsy, with or without vacuum assistance (VAB).[ 7 ] More than 1 million breast biopsies are performed for women with an abnormal imaging finding, 10–15% of which yield a finding of atypical hyperplasia.[ 2 ] When these women underwent surgical excision for ADH identified on percutaneous biopsy, the upgrade rate to underlying malignancy has ranged in the literature anywhere from 4–54%.[ 3 , 8 – 11 ] NCCN guidelines continue to recommend surgical excision for patients with ADH on percutaneous biopsy due to this high risk of upgrade to DCIS or IBC.[ 12 ] However, as imaging and biopsy techniques have improved over the last decade, the need for routine excision of all ADH has been called into question.[ 13 , 14 ] Multiple studies have been performed in an attempt to stratify which patients have the lowest risk of underlying malignancy and may therefore avoid surgical excision.[ 8 , 9 , 13 , 15 – 20 ] Attention has been focused on a combination of specific pathologic and radiographic features of ADH. However, no criteria have been consistently able to accurately predict the rate of upgrade in patients with ADH on core needle biopsy. Therefore, the purpose of this study was to calculate our institutional upgrade rate in a contemporary cohort of patients diagnosed with ADH on percutaneous biopsy, and determine if specific pathologic and radiographic features could result in defining a group at the lowest risk of upgrade to underlying DCIS or IBC. Materials And Methods Study Population This study is an IRB-approved, HIPAA compliant retrospective chart review from a single institution. A patient list was generated from a query of breast imaging reports for the keyword “atypical ductal hyperplasia.” All consecutive female patients ≥ 18 years of age with a diagnosed with ADH on percutaneous biopsy from January 2008 to October 2015 were identified. A total of 600 percutaneous needle biopsies were associated with ADH during this study period. This study was designed to specifically examine patients with ADH diagnosed on stereotactic biopsy, as screen detected calcifications were expected to yield the lowest risk of upgrade, when compared to masses biopsied via ultrasound guidance or magnetic resonance imaging (MRI) mass enhancement. Therefore all patients undergoing ultrasound-guided or MRI-guided biopsies with ADH were excluded (n = 460). Because of the need to have surgical pathology to accurately define surgical upgrade rate, cases were excluded if they did not undergo surgical excision or if excision was performed at another institution (n = 19). Cases were also excluded if there was a concurrent ipsilateral malignancy, for the concern that upgrade rate may be higher in those circumstances (n = 25). Cases with a concurrent contralateral breast were allowed. Finally, as ADH upgrade rate has been known to be higher when ADH is associated with another lesion such as a papilloma or radial sclerosing lesion, all cases where ADH was not pure were excluded (n = 9). (Fig. 1 ) Imaging Analysis Patient demographics, clinical presentation, personal history of breast cancer, or family history of breast cancer were obtained from the medical record. All patients underwent stereotactic biopsy for their imaging abnormality with multiple cores using 9g needle with vacuum assistance (VAB). All core biopsy specimens undergo specimen radiograph to document removal of the target, and all patients have post biopsy mammogram to document clip placement and assessment of extent of the target removed by the biopsy. All breast imaging, with the exception of one case where the images were unavailable, was re-reviewed by 1 of 4 breast-specific radiologists. Imaging presentation and indications for biopsy (calcifications v. mass/asymmetry/distortion) was documented, as well as number of cores obtained, lesion size on mammogram, mammographic breast density, and estimated percent of lesion removed by the biopsy. Pathology Analysis All biopsy slides, with the exception of one case where the slides were unavailable, were re-reviewed by 1 of 2 dedicated breast pathologists. ADH was identified as associated with targeted histologic calcifications or as incidental. The number of foci of ADH were documented as focal (1–2) or extensive ( ≥ 3), and attention was directed to the presence or absence of individual cell necrosis or micropapillary features. The pathology report from surgical excision was also reviewed to determine final diagnosis. ADH upgrade was defined as the presence of DCIS or IBC at the biopsy site on surgical excision. The patient chart was also reviewed for additional percutaneous biopsies or surgeries diagnosis a subsequent breast cancer after the excision of ADH to determine future cancer risk associated with the ADH diagnosis. Statistical Analysis Radiographic and pathologic associations were investigated at the biopsy level, as there were two patients with bilateral ADH and two patients who underwent percutaneous biopsy in the same breast followed by surgical excision twice during the study period. Categorical variables, including demographic, radiologic, and pathologic characteristics were summarized using frequencies and percentages. Continuous variables are summarized using means and standard deviations. Chi-square and Fisher’s exact tests are used to test for associations between upgrade and categorical demographic, clinical, radiologic, and pathologic characteristics. T-tests and Wilcoxon-Mann-Whitney tests are used to test for associations between upgrade and continuous variables. A logistic regression model was used to examine the association between odds of upgrade and the number of significant low-risk factors. All analyses were performed with SAS software version 9.4 (SAS Institute Inc., Cary, NC), and a p -value of < 0.10 was used to determine statistical significance. Results In total, 83 patients underwent 87 stereotactic biopsies during this study period with the diagnosis of pure ADH, meeting all inclusion criteria for the study. (Table 1 ) The majority of biopsies were performed in Caucasian, non-Hispanic women (80.5%) at a mean age of 56 years (std 10.6). A large number of women had a family history of breast cancer (47%) and 19.5% had a personal history of breast cancer, which included 9 with concurrent contralateral breast cancer at the time of ADH diagnosis. Patient demographics and personal history or family history of breast cancer were not statistically associated with an upgrade at surgical excision. (Table 2 ) Upon review of the radiologic characteristics, the vast majority had calcifications as the indication for biopsy (92%). Multiple core specimens were obtained during stereotactic biopsy with a significant majority of cases having > 6 cores removed (94%). The median size of the lesion was smaller for lesions that did not upgrade to malignancy (0.8 v. 2.0 cm, p = 0.004). Following the biopsy, an assessment was performed for the amount of the imaging target that was removed by the percutaneous biopsy and 78% of lesions had > 50% of the targeted lesion removed by the stereotactic biopsy, which was also significantly associated with lower upgrade risk ( p = 0.03). Breast density and the number of cores removed were not statistically associated with an upgrade at surgical excision. (Table 2 ) Upon review of the pathologic characteristics, the presence of micropapillary features was significantly associated with upgrade to IBC or DCIS ( p = 0.10). Additional pathologic features of ADH such as individual cell necrosis ( p = 0.40) and the number of ADH foci or extent of disease ( p = 0.12) did not reach statistical significance for association with an upgrade to underlying malignancy. Slides were also reviewed to determine if ADH was associated with the radiographic targeted calcifications for biopsy or if it was an incidental finding by the association of calcifications with ADH, which also did not reach statistical significance ( p = 0.18). Thirteen cases of ADH (14.9%) upgraded to either DCIS (n = 11) or IBC (n = 2) on final pathology. Of the 11 cases of DCIS, 10 were nuclear grade I or II and were hormone-receptor positive (91%) and the remaining case of DCIS was hormone-receptor negative and associated with microinvasion. The lowest rate of upgrade was in those who had an imaging abnormality 50% removed by the stereotactic biopsy and had < 3 foci of ADH without associated with micropapillary features. ( p = 0.001, Table 3 ) While this accounted for a small number of patients in this cohort (n = 17, 20%), none of these patients upgraded to an underlying malignancy (0%). When fewer than all 4 low-risk features are present the odds of upgrade increases. For example, when a patient has only 2 low-risk features compared to a patient with 3 low-risk features, the odds of upgrade is nearly double (OR 1.89). (Table 3 ) Because ADH is a known risk factor for the development of subsequent breast cancer, all patient charts were reviewed for development of a diagnosis of subsequent breast cancer after surgical excision of ADH. Of the 74 who did not upgrade to DCIS or IBC at the time of ADH excision, 9 (12%) were diagnosed with a subsequent cancer during follow up (4 DCIS and 5 IDC), 7 in the ipsilateral breast and 2 in the contralateral breast. The median follow up of these 74 patients was 71.3 months (IQR 53.3,100.9) with a median time to subsequent cancer diagnosis of 18 months (IQR 13.5–55). Discussion Percutaneous image-guided biopsy has greatly reduced the need for open excisional biopsy in obtaining a diagnosis for a mammographic abnormality. ADH is present in a significant proportion of benign core biopsy specimens. Following a diagnosis of ADH, it is currently recommended that excisional biopsy follow to rule out underlying malignancy.[12] The reasons for this include significant inter- and intraobserver variation among pathologists when diagnosing ADH,[21] histologic similarities between ADH and DCIS, and the potential for under sampling of the lesion due to a relatively small sample size obtained by percutaneous biopsy. In this study of patients with mammographic abnormality followed by stereotactic biopsy, we demonstrated an upgrade rate of 14.9% at our institution, which is at the lower end of the historically quoted range, though still too high to recommend observation to all patients with ADH on stereotactic biopsy. We further attempted to identify low-risk features that when present could reassure a low likelihood of upstaging of ADH to DCIS or invasive breast cancer. We found in our population that age, personal or family history of breast cancer, breast density, and the number of cores removed were not associated with risk of upgrade. Though none of these features reached statistical significance, there was a trend toward low risk for an upgrade if ADH was not associated with the target calcifications (incidental) or if ADH was focal (limited to 1-2 foci). Features that were significantly identified as low risk for upgrade included lesions smaller than 1cm, >50% of the lesion removed by stereotactic biopsy, and if ADH was associated with micropapillary features. The literature has been varied as to what patient demographic, radiologic, and pathologic findings have been associated with a higher risk of an upgrade at the time of surgical excision, emphasizing the importance of understanding one’s patient population and radiologic and pathologic resources. Jensen et al. were one of the first to describe micropapillary features and extent of ADH to be associated with a higher rate of upgrade,[8] both of which we were found to be significantly associated with upgrade in our study. Similar to other studies, we found the percent of the lesion removed and the size of the lesion to also be a risk of upgrade upon excision.[9,13,16,17] Patient demographic features such as age at diagnosis of ADH and family history of breast cancer as risk factors[18,20] were not reproducible in our study. There have been no randomized controlled trials to determine the need for surgical excision of ADH. Interestingly, we continue to push the edge of where we are comfortable de-escalating surgical intervention. There are currently several trials actively enrolling, one in the US (AFT-25 COMET, NCT02926911)[22] and two in Europe (LORD NCT02492607[23] in the Netherlands and Belgium, LORIS in the UK[24]), attempting to identify which patients with DCIS can be offered active monitoring over excision. Separating ADH from low-risk DCIS can be controversial and arbitrary, fraught with interobserver variability and lacking biological validation.[25] Some accept Tavassoli’s definition of DCIS being > 2mm[26], regardless of the number of involved ducts and others prefer Page’s original proposal that DCIS must include at least two fully involved duct cross-sections.[27] In our patient population, when ADH upgraded to malignancy, the majority (n=10, 77%) met criteria for low-risk DCIS, acceptable for randomization in the above mentioned trials (grade I-II and hormone-receptor positive). Though not yet standard of care, if COMET concludes a low rate of progression to IBC when surgical excision is omitted for low risk DCIS, and this becomes accepted as standard of care, only 3 of the 87 biopsies with ADH (3.4%) would have benefited from surgical excision and identification of a more aggressive underlying malignancy. Our study has several limitations, including the retrospective nature of this analysis and the relatively small sample size. Also, there is potential for selection bias in that all of our patients had to undergo surgical excision to be included in the analysis. There were multiple patients during this time period that were excluded because it was determined they did not need surgical excision or the patient declined excision. One patient who did upgrade did not have biopsy slides or imaging available for re-review, which may have limited the strength of our findings. However, the strengths of this study included the contemporary time frame of our study, the re-interpretation of all available patients’ imaging and biopsy slides by breast-specific radiologists and pathologists for the above detailed characteristics, and the extensive length of follow-up. In summary, we were able to conclude that for patients with ADH identified on stereotactic biopsy, the overall risk of upgrade to underlying malignancy is lower than historically quoted, though may still be too high to offer active monitoring to all. With careful radiologic and pathologic correlation, patients with the lowest risk for upgrade to DCIS or IBC may be selected, allowing clinicians to appropriately offer alternatives to surgical excision. Our study was able to demonstrate that the lowest risk for upgrade in our patient population are those with an imaging target of 50% of the lesion removed by the percutaneous biopsy, 1-2 foci of ADH, and the absence of micropapillary features. Further application of these low-risk criteria in a prospective manner will be necessary, including the management of ADH identified by other imaging modalities. The oncologic safety of surgical de-escalation and offering active surveillance for ADH will also be necessary to establish in future studies. Tables Table 1. Patient and Tumor Factors at a biopsy-level Characteristics N=87 biopsies Age (year) at diagnosis; mean (std) 56 (10.6) Race/Ethnicity Caucasian/Non-Hispanic African American Hispanic Asian 70 (80.5%) 11 (12.6%) 4 (4.6%) 2 (2.3%) Side of biopsy Left Right 37 (42.5%) 50 (57.5%) No. of lesions upgraded DCIS/DCIS-M IBC 13 (14.9%) 11 (84.6%) 2 (15.4%) Table 2. Univariate analysis of factors associated with upgrade at biopsy level Variable Upgrade (n=13) No upgrade (n=74) p -value Age (mean, std, year) 55.8 (9.8) 56.4 (14.6) 0.90 Personal history of breast cancer 1 (7.7%) 16 (21.6%) 0.45 Family history of breast cancer 4 (30.8%) 35 (47.3%) 0.23 Breast density A B C 1 (7.7%) 8 (61.5%) 4 (30.8%) 6 (8.1%) 35 (47.3%) 33 (44.6%) 0.62 Radiologic presentation Calcifications Mass/asymmetry/distortion 13 (100%) 0 67 (90.5%) 7 (9.5%) 1.00 Imaging size (cm, median, IQR) a 2.0 (1.0,5.1) 0.8 (0.6,1.2) 0.004* No. cores removed 6 0 13 (100%) 5 (6.8%) 69 (93.2%) 1.00 Percent of lesion removed by biopsy 50% 6 (46.2%) 7 (53.9%) 13 (17.6%) 61 (82.4%) 0.03* ADH associated with target calcifications 12 (92.3%) 54 (73%) 0.18 Individual cell necrosis b 3 (23.1%) 11 (14.9%) 0.40 Micropapillary features b 6 (46.2%) 19 (25.7%) 0.10* Extent of ADH 1-2 foci (focal) > 3 foci (extensive) 2 (15.4%) 11 (84.6%) 29 (39.2%) 45 (60.8%) 0.12 a 1 case with images not available for review, b 1 case with biopsy slides not available for review Table 3. Logistic regression model of low-risk features and association with upgrade with the loss of a low-risk feature Number of Low risk Features No upgrade (n=74) Upgrade (n=13) Rate of No upgrade Odds of upgrade 0 4 (5.4%) 5 (38.5%) 0.44 7.13 1 7 (9.5%) 1 (7.7%) 0.88 0.81 2 19 (25.7%) 4 (30.8%) 0.83 1.20 3 27 (36.5%) 3 (23.1%) 0.90 0.63 4 17 (23%) 0 1.00 -- References https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/breast-cancer-facts-and-figures/breast-cancer-facts-and-figures-2019-2020.pdf . Accessed 20 September 2020. Hartmann LC, Degnim AC, Santen RJ, Dupont WD, Ghosh K. (2015) Atypical hyperplasia of the breast—Risk assessment and management options. N Engl J Med 372:78-89. https://doi.org/10.1056/NEJMsr1407164 Amin AL, Wagner JL. (2021) Contemporary management of atypical breast lesions identified on percutaneous biopsy: a narrative review. Ann Breast Surg 5:9. https://doi.org/10.21037/abs-20-117 Quinn EM, Dunne E, Flanagan F, et al. 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Cancer 55:2698-708. https://doi.org/10.1002/1097-0142(19850601)55:113.0.co;2-a Abbreviations invasive breast cancer (IBC) ductal carcinoma in situ (DCIS) National Comprehensive Cancer Network (NCCN) atypical ductal hyperplasia (ADH) vacuum assisted biopsy (VAB) Declarations Funding: The authors received no financial support for the research, authorship, and/or publication of this article. Conflicts Of Interest/Competing Interests: The authors declare that there is no conflict of interest. Availability Of Data And Material (Data Transparency): No datasets were generated or analyzed during the current study. Code Availability (Software Application Or Custom Code): No custom codes were generated or analyzed during the current study. Authors' Contributions: ALA, ODW, OT, and JLW conceived the original idea. ODW, FF, and JLW supervised the project. ALA and JLW took the lead in writing the mansucript. SH and JW provided statistical support. All authors provided critical feedback and helped shape the research, analysis and manuscript. Ethics Approval: Approval for the study was obtained from the University of Kansas Institutional Review Board. The study was conducted in accordance with Helsinki Declaration as revised in 2013. Consent To Participate: As this was a retrospective review, informed consent was waived by IRB. Consent For Publication: No identifying information (including patients’ images, names, initials, or hospital numbers) was included in recordings, written descriptions, or photographs, for this study. All personal details of patients in any part of the paper and in any supplementary materials (including illustrations) were removed before submission. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-388478","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":23419943,"identity":"cb1afe2d-b72c-4c85-8e72-d24aedf05387","order_by":0,"name":"Amanda L Amin","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAArElEQVRIiWNgGAWjYJCCA4x/bAwgTDaitTSkkaiFgbHhMAla+NtPJx4u3HHe2ODa4QcMH8oOE9YicSZ3w+GZZ26bGdxOM2CccY4ILQwHgFp42G7bGNzOYWDmbSNCi/z5tyAt5yBa/hKjxeAG0BbetgNmYC2MxGgxvAGy5UyysSTQLwd7zqUT1iJ3PnfzZ54KO8O+28kPH/wosyasBQUcIFH9KBgFo2AUjAJcAAAbfkDSy9lmQQAAAABJRU5ErkJggg==","orcid":"https://orcid.org/0000-0002-9784-6226","institution":"University of Kansas Medical Center","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Amanda","middleName":"L","lastName":"Amin","suffix":""},{"id":23419944,"identity":"0a97e574-acff-4ca7-9be1-bff321395361","order_by":1,"name":"Onalisa D Winblad","email":"","orcid":"","institution":"University of Kansas Medical Center","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Onalisa","middleName":"D","lastName":"Winblad","suffix":""},{"id":23419945,"identity":"7702202c-e9a3-47c0-b2e4-a6b8fde040fb","order_by":2,"name":"Allison H Zupon","email":"","orcid":"","institution":"Imaging for Women","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Allison","middleName":"H","lastName":"Zupon","suffix":""},{"id":23419946,"identity":"3b6913e8-0a22-468b-acea-638ff43aae50","order_by":3,"name":"Fang Fan","email":"","orcid":"","institution":"City of Hope Comprehensive Cancer Center Duarte","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Fang","middleName":"","lastName":"Fan","suffix":""},{"id":23419947,"identity":"0f797ae4-d3b8-4d9f-b756-aae75882e374","order_by":4,"name":"Ossama Tawfik","email":"","orcid":"","institution":"Saint Luke's Hospital of Kansas City","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Ossama","middleName":"","lastName":"Tawfik","suffix":""},{"id":23419948,"identity":"0cc2318a-22ed-4901-a97c-98a71de3d0e5","order_by":5,"name":"Jo Wick","email":"","orcid":"","institution":"University of Kansas Medical Center","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Jo","middleName":"","lastName":"Wick","suffix":""},{"id":23419949,"identity":"cd048fd0-5e19-4f31-99f8-52a161a02b7f","order_by":6,"name":"Suzanne Hunt","email":"","orcid":"","institution":"University of Kansas Medical Center","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Suzanne","middleName":"","lastName":"Hunt","suffix":""},{"id":23419950,"identity":"5bb8ff69-f547-4c97-9749-eb80d9cc8f87","order_by":7,"name":"Jason Gatewood","email":"","orcid":"","institution":"University of Kansas Medical Center","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Jason","middleName":"","lastName":"Gatewood","suffix":""},{"id":23419951,"identity":"73d35fd9-3df5-4a52-b570-1edfbe1692b5","order_by":8,"name":"Marc Incardi","email":"","orcid":"","institution":"University of Kansas Medical Center","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Marc","middleName":"","lastName":"Incardi","suffix":""},{"id":23419952,"identity":"e46cc24e-8a16-4240-af56-2bfa556598f8","order_by":9,"name":"Mark Redick","email":"","orcid":"","institution":"University of Kansas Medical Center","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Mark","middleName":"","lastName":"Redick","suffix":""},{"id":23419953,"identity":"ecd07c31-6249-4c61-8035-f3b58da95798","order_by":10,"name":"Jamie L. Wagner","email":"","orcid":"","institution":"University of Kansas Medical Center","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Jamie","middleName":"L.","lastName":"Wagner","suffix":""}],"badges":[],"createdAt":"2021-04-03 07:21:37","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-388478/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-388478/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":8563014,"identity":"4eeed03b-75fa-4e41-a9dd-3f56631cca1b","added_by":"auto","created_at":"2021-04-28 18:46:33","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":22784,"visible":true,"origin":"","legend":"Flow chart of patient selection with ADH during the study period","description":"","filename":"drawingimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-388478/v1/5a709eaa48d9470f411f2073.png"},{"id":8563113,"identity":"a35b1dd5-c659-4a51-8cef-a06e0d21bf10","added_by":"auto","created_at":"2021-04-28 18:49:33","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":13271,"visible":true,"origin":"","legend":"ADH size on imaging by upgrade status\n*1 case with images unavailable to review for imaging size\n","description":"","filename":"drawingimage2.png","url":"https://assets-eu.researchsquare.com/files/rs-388478/v1/e33a74fc0482d70eb3c76199.png"},{"id":13689779,"identity":"bdb16025-8bf7-47ab-a02b-1a2c560a796e","added_by":"auto","created_at":"2021-09-17 12:30:53","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":292739,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-388478/v1/e736c9bf-2cf8-4d18-b4c6-d16215b8910a.pdf"}],"financialInterests":"","formattedTitle":"Atypical ductal hyperplasia on percutaneous breast biopsy: Scoring system to identify the lowest risk for upgrade","fulltext":[{"header":"Introduction","content":" \u003cp\u003eBreast cancer is the second most common cancer among women in the United States, with more than 280,000 cases of invasive breast cancer (IBC) and ductal carcinoma in situ (DCIS) predicted to be diagnosed in 2021.[\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e] This translates into nearly 1 in 8 women in the United States being diagnosed with breast cancer over the course of her lifetime. There are multiple risk factors associated with the development of breast cancer, including family history and lifetime exposure to estrogen, as well as a personal history of a biopsy with atypical hyperplasia.[\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e]\u003c/p\u003e \u003cp\u003eAtypical ductal hyperplasia (ADH) is a high-risk breast lesion. Calcifications are the most common radiologic finding associated with ADH.[\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e] However, the lesion could be identified incidentally (not with the targeted calcifications) or in association with other lesions such as a radial sclerosing lesion or intraductal papilloma.[\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e, \u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e] Microscopically, ADH is a proliferative lesion that fulfills some but not all the criteria for low grade DCIS. Pathologists evaluate several quantitative and qualitative parameters to accurately diagnosis this lesion. The most recent World Health Organization (WHO) Classification of Breast Tumors endorses the traditional quantitative criteria of Page and Tavassoli requiring at least 2 fully involved duct cross sections and \u003cspan type=\"Underline\" class=\"Underline\" name=\"Emphasis\"\u003e\u0026le;\u003c/span\u003e\u0026thinsp;0.2cm in size.[\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e]\u003csup\u003e6\u003c/sup\u003e Identification of ADH results in a 4-fold increase in future breast cancer risk.[\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e]\u003c/p\u003e \u003cp\u003eStandard of care for an abnormal breast imaging finding is percutaneous image-guided core needle biopsy, with or without vacuum assistance (VAB).[\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e] More than 1\u0026nbsp;million breast biopsies are performed for women with an abnormal imaging finding, 10\u0026ndash;15% of which yield a finding of atypical hyperplasia.[\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e] When these women underwent surgical excision for ADH identified on percutaneous biopsy, the upgrade rate to underlying malignancy has ranged in the literature anywhere from 4\u0026ndash;54%.[\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e, \u003cspan additionalcitationids=\"CR9 CR10\" citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e] NCCN guidelines continue to recommend surgical excision for patients with ADH on percutaneous biopsy due to this high risk of upgrade to DCIS or IBC.[\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e] However, as imaging and biopsy techniques have improved over the last decade, the need for routine excision of all ADH has been called into question.[\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e, \u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e]\u003c/p\u003e \u003cp\u003eMultiple studies have been performed in an attempt to stratify which patients have the lowest risk of underlying malignancy and may therefore avoid surgical excision.[\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e, \u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e, \u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e, \u003cspan additionalcitationids=\"CR16 CR17 CR18 CR19\" citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e] Attention has been focused on a combination of specific pathologic and radiographic features of ADH. However, no criteria have been consistently able to accurately predict the rate of upgrade in patients with ADH on core needle biopsy. Therefore, the purpose of this study was to calculate our institutional upgrade rate in a contemporary cohort of patients diagnosed with ADH on percutaneous biopsy, and determine if specific pathologic and radiographic features could result in defining a group at the lowest risk of upgrade to underlying DCIS or IBC.\u003c/p\u003e "},{"header":"Materials And Methods","content":" \u003cdiv id=\"Sec3\" class=\"Section2\"\u003e \u003ch2\u003eStudy Population\u003c/h2\u003e \u003cp\u003eThis study is an IRB-approved, HIPAA compliant retrospective chart review from a single institution. A patient list was generated from a query of breast imaging reports for the keyword \u0026ldquo;atypical ductal hyperplasia.\u0026rdquo; All consecutive female patients\u0026thinsp;\u003cspan type=\"Underline\" class=\"Underline\" name=\"Emphasis\"\u003e\u0026ge;\u003c/span\u003e\u0026thinsp;18 years of age with a diagnosed with ADH on percutaneous biopsy from January 2008 to October 2015 were identified. A total of 600 percutaneous needle biopsies were associated with ADH during this study period. This study was designed to specifically examine patients with ADH diagnosed on stereotactic biopsy, as screen detected calcifications were expected to yield the lowest risk of upgrade, when compared to masses biopsied via ultrasound guidance or magnetic resonance imaging (MRI) mass enhancement. Therefore all patients undergoing ultrasound-guided or MRI-guided biopsies with ADH were excluded (n\u0026thinsp;=\u0026thinsp;460). Because of the need to have surgical pathology to accurately define surgical upgrade rate, cases were excluded if they did not undergo surgical excision or if excision was performed at another institution (n\u0026thinsp;=\u0026thinsp;19). Cases were also excluded if there was a concurrent ipsilateral malignancy, for the concern that upgrade rate may be higher in those circumstances (n\u0026thinsp;=\u0026thinsp;25). Cases with a concurrent contralateral breast were allowed. Finally, as ADH upgrade rate has been known to be higher when ADH is associated with another lesion such as a papilloma or radial sclerosing lesion, all cases where ADH was not pure were excluded (n\u0026thinsp;=\u0026thinsp;9). (Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003e)\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec4\" class=\"Section2\"\u003e \u003ch2\u003eImaging Analysis\u003c/h2\u003e \u003cp\u003ePatient demographics, clinical presentation, personal history of breast cancer, or family history of breast cancer were obtained from the medical record. All patients underwent stereotactic biopsy for their imaging abnormality with multiple cores using 9g needle with vacuum assistance (VAB). All core biopsy specimens undergo specimen radiograph to document removal of the target, and all patients have post biopsy mammogram to document clip placement and assessment of extent of the target removed by the biopsy. All breast imaging, with the exception of one case where the images were unavailable, was re-reviewed by 1 of 4 breast-specific radiologists. Imaging presentation and indications for biopsy (calcifications v. mass/asymmetry/distortion) was documented, as well as number of cores obtained, lesion size on mammogram, mammographic breast density, and estimated percent of lesion removed by the biopsy.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec5\" class=\"Section2\"\u003e \u003ch2\u003ePathology Analysis\u003c/h2\u003e \u003cp\u003eAll biopsy slides, with the exception of one case where the slides were unavailable, were re-reviewed by 1 of 2 dedicated breast pathologists. ADH was identified as associated with targeted histologic calcifications or as incidental. The number of foci of ADH were documented as focal (1\u0026ndash;2) or extensive (\u003cspan type=\"Underline\" class=\"Underline\" name=\"Emphasis\"\u003e\u0026ge;\u003c/span\u003e\u0026thinsp;3), and attention was directed to the presence or absence of individual cell necrosis or micropapillary features. The pathology report from surgical excision was also reviewed to determine final diagnosis. ADH upgrade was defined as the presence of DCIS or IBC at the biopsy site on surgical excision. The patient chart was also reviewed for additional percutaneous biopsies or surgeries diagnosis a subsequent breast cancer after the excision of ADH to determine future cancer risk associated with the ADH diagnosis.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec6\" class=\"Section2\"\u003e \u003ch2\u003eStatistical Analysis\u003c/h2\u003e \u003cp\u003eRadiographic and pathologic associations were investigated at the biopsy level, as there were two patients with bilateral ADH and two patients who underwent percutaneous biopsy in the same breast followed by surgical excision twice during the study period. Categorical variables, including demographic, radiologic, and pathologic characteristics were summarized using frequencies and percentages. Continuous variables are summarized using means and standard deviations. Chi-square and Fisher\u0026rsquo;s exact tests are used to test for associations between upgrade and categorical demographic, clinical, radiologic, and pathologic characteristics. T-tests and Wilcoxon-Mann-Whitney tests are used to test for associations between upgrade and continuous variables. A logistic regression model was used to examine the association between odds of upgrade and the number of significant low-risk factors. All analyses were performed with SAS software version 9.4 (SAS Institute Inc., Cary, NC), and a \u003cem\u003ep\u003c/em\u003e-value of \u0026lt;\u0026thinsp;0.10 was used to determine statistical significance.\u003c/p\u003e \u003c/div\u003e "},{"header":"Results","content":" \u003cp\u003eIn total, 83 patients underwent 87 stereotactic biopsies during this study period with the diagnosis of pure ADH, meeting all inclusion criteria for the study. (Table\u0026nbsp;\u003cspan refid=\"Tab1\" class=\"InternalRef\"\u003e1\u003c/span\u003e) The majority of biopsies were performed in Caucasian, non-Hispanic women (80.5%) at a mean age of 56 years (std 10.6). A large number of women had a family history of breast cancer (47%) and 19.5% had a personal history of breast cancer, which included 9 with concurrent contralateral breast cancer at the time of ADH diagnosis. Patient demographics and personal history or family history of breast cancer were not statistically associated with an upgrade at surgical excision. (Table\u0026nbsp;\u003cspan refid=\"Tab2\" class=\"InternalRef\"\u003e2\u003c/span\u003e)\u003c/p\u003e \u003cp\u003eUpon review of the radiologic characteristics, the vast majority had calcifications as the indication for biopsy (92%). Multiple core specimens were obtained during stereotactic biopsy with a significant majority of cases having\u0026thinsp;\u0026gt;\u0026thinsp;6 cores removed (94%). The median size of the lesion was smaller for lesions that did not upgrade to malignancy (0.8 v. 2.0 cm, \u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0.004). Following the biopsy, an assessment was performed for the amount of the imaging target that was removed by the percutaneous biopsy and 78% of lesions had\u0026thinsp;\u0026gt;\u0026thinsp;50% of the targeted lesion removed by the stereotactic biopsy, which was also significantly associated with lower upgrade risk (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0.03). Breast density and the number of cores removed were not statistically associated with an upgrade at surgical excision. (Table\u0026nbsp;\u003cspan refid=\"Tab2\" class=\"InternalRef\"\u003e2\u003c/span\u003e)\u003c/p\u003e \u003cp\u003eUpon review of the pathologic characteristics, the presence of micropapillary features was significantly associated with upgrade to IBC or DCIS (\u003cem\u003ep\u0026thinsp;=\u003c/em\u003e\u0026thinsp;0.10). Additional pathologic features of ADH such as individual cell necrosis (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0.40) and the number of ADH foci or extent of disease (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0.12) did not reach statistical significance for association with an upgrade to underlying malignancy. Slides were also reviewed to determine if ADH was associated with the radiographic targeted calcifications for biopsy or if it was an incidental finding by the association of calcifications with ADH, which also did not reach statistical significance (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0.18).\u003c/p\u003e \u003cp\u003eThirteen cases of ADH (14.9%) upgraded to either DCIS (n\u0026thinsp;=\u0026thinsp;11) or IBC (n\u0026thinsp;=\u0026thinsp;2) on final pathology. Of the 11 cases of DCIS, 10 were nuclear grade I or II and were hormone-receptor positive (91%) and the remaining case of DCIS was hormone-receptor negative and associated with microinvasion. The lowest rate of upgrade was in those who had an imaging abnormality\u0026thinsp;\u0026lt;\u0026thinsp;1cm with \u0026gt;\u0026thinsp;50% removed by the stereotactic biopsy and had\u0026thinsp;\u0026lt;\u0026thinsp;3 foci of ADH without associated with micropapillary features. (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0.001, Table\u0026nbsp;\u003cspan refid=\"Tab3\" class=\"InternalRef\"\u003e3\u003c/span\u003e) While this accounted for a small number of patients in this cohort (n\u0026thinsp;=\u0026thinsp;17, 20%), none of these patients upgraded to an underlying malignancy (0%). When fewer than all 4 low-risk features are present the odds of upgrade increases. For example, when a patient has only 2 low-risk features compared to a patient with 3 low-risk features, the odds of upgrade is nearly double (OR 1.89). (Table\u0026nbsp;\u003cspan refid=\"Tab3\" class=\"InternalRef\"\u003e3\u003c/span\u003e)\u003c/p\u003e \u003cp\u003eBecause ADH is a known risk factor for the development of subsequent breast cancer, all patient charts were reviewed for development of a diagnosis of subsequent breast cancer after surgical excision of ADH. Of the 74 who did not upgrade to DCIS or IBC at the time of ADH excision, 9 (12%) were diagnosed with a subsequent cancer during follow up (4 DCIS and 5 IDC), 7 in the ipsilateral breast and 2 in the contralateral breast. The median follow up of these 74 patients was 71.3 months (IQR 53.3,100.9) with a median time to subsequent cancer diagnosis of 18 months (IQR 13.5\u0026ndash;55).\u003c/p\u003e "},{"header":"Discussion","content":"\u003cp\u003ePercutaneous image-guided biopsy has greatly reduced the need for open excisional biopsy in obtaining a diagnosis for a mammographic abnormality. ADH is present in a significant proportion of benign core biopsy specimens. Following a diagnosis of ADH, it is currently recommended that excisional biopsy follow to rule out underlying malignancy.[12] The reasons for this include significant inter- and intraobserver variation among pathologists when diagnosing ADH,[21] histologic similarities between ADH and DCIS, and the potential for under sampling of the lesion due to a relatively small sample size obtained by percutaneous biopsy.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; In this study of patients with mammographic abnormality followed by stereotactic biopsy, we demonstrated an upgrade rate of 14.9% at our institution, which is at the lower end of the historically quoted range, though still too high to recommend observation to all patients with ADH on stereotactic biopsy. We further attempted to identify low-risk features that when present could reassure a low likelihood of upstaging of ADH to DCIS or invasive breast cancer. We found in our population that age, personal or family history of breast cancer, breast density, and the number of cores removed were not associated with risk of upgrade. Though none of these features reached statistical significance, there was a trend toward low risk for an upgrade if ADH was not associated with the target calcifications (incidental) or if ADH was focal (limited to 1-2 foci). Features that were significantly identified as low risk for upgrade included lesions smaller than 1cm, \u0026gt;50% of the lesion removed by stereotactic biopsy, and if ADH was associated with micropapillary features.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; The literature has been varied as to what patient demographic, radiologic, and pathologic findings have been associated with a higher risk of an upgrade at the time of surgical excision, emphasizing the importance of understanding one\u0026rsquo;s patient population and radiologic and pathologic resources. Jensen et al. were one of the first to describe micropapillary features and extent of ADH to be associated with a higher rate of upgrade,[8] both of which we were found to be significantly associated with upgrade in our study. Similar to other studies, we found the percent of the lesion removed and the size of the lesion to also be a risk of upgrade upon excision.[9,13,16,17] Patient demographic features such as age at diagnosis of ADH and family history of breast cancer as risk factors[18,20] were not reproducible in our study.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; There have been no randomized controlled trials to determine the need for surgical excision of ADH. Interestingly, we continue to push the edge of where we are comfortable de-escalating surgical intervention. There are currently several trials actively enrolling, one in the US (AFT-25 COMET, NCT02926911)[22] and two in Europe (LORD NCT02492607[23] in the Netherlands and Belgium, LORIS in the UK[24]), attempting to identify which patients with DCIS can be offered active monitoring over excision. Separating ADH from low-risk DCIS can be controversial and arbitrary, fraught with interobserver variability and lacking biological validation.[25] Some accept Tavassoli\u0026rsquo;s definition of DCIS being \u003cu\u003e\u0026gt;\u003c/u\u003e2mm[26], regardless of the number of involved ducts and others prefer Page\u0026rsquo;s original proposal that DCIS must include at least two fully involved duct cross-sections.[27] In our patient population, when ADH upgraded to malignancy, the majority (n=10, 77%) met criteria for low-risk DCIS, acceptable for randomization in the above mentioned trials (grade I-II and hormone-receptor positive). Though not yet standard of care, if COMET concludes a low rate of progression to IBC when surgical excision is omitted for low risk DCIS, and this becomes accepted as standard of care, only 3 of the 87 biopsies with ADH (3.4%) would have benefited from surgical excision and identification of a more aggressive underlying malignancy.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Our study has several limitations, including the retrospective nature of this analysis and the relatively small sample size. Also, there is potential for selection bias in that all of our patients had to undergo surgical excision to be included in the analysis. There were multiple patients during this time period that were excluded because it was determined they did not need surgical excision or the patient declined excision. One patient who did upgrade did not have biopsy slides or imaging available for re-review, which may have limited the strength of our findings. However, the strengths of this study included the contemporary time frame of our study, the re-interpretation of all available patients\u0026rsquo; imaging and biopsy slides by breast-specific radiologists and pathologists for the above detailed characteristics, and the extensive length of follow-up.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; In summary, we were able to conclude that for patients with ADH identified on stereotactic biopsy, the overall risk of upgrade to underlying malignancy is lower than historically quoted, though may still be too high to offer active monitoring to all. With careful radiologic and pathologic correlation, patients with the lowest risk for upgrade to DCIS or IBC may be selected, allowing clinicians to appropriately offer alternatives to surgical excision. Our study was able to demonstrate that the lowest risk for upgrade in our patient population are those with an imaging target of \u0026lt;1 cm in size, \u0026gt;50% of the lesion removed by the percutaneous biopsy, 1-2 foci of ADH, and the absence of micropapillary features. Further application of these low-risk criteria in a prospective manner will be necessary, including the management of ADH identified by other imaging modalities. The oncologic safety of surgical de-escalation and offering active surveillance for ADH will also be necessary to establish in future studies.\u003c/p\u003e"},{"header":"Tables","content":"\u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eTable 1.\u003c/span\u003e\u003c/strong\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;Patient and Tumor Factors at a biopsy-level\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 224.75pt;border: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height: 200%;font-family:\"Times New Roman\",serif;'\u003eCharacteristics\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 206.75pt;border-color: windowtext windowtext windowtext currentcolor;border-style: solid solid solid none;border-width: 1pt 1pt 1pt medium;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height: 200%;font-family:\"Times New Roman\",serif;'\u003eN=87 biopsies\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 224.75pt;border-color: currentcolor windowtext windowtext;border-style: none solid solid;border-width: medium 1pt 1pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eAge (year) at diagnosis; mean (std)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 206.75pt;border-color: currentcolor windowtext windowtext currentcolor;border-style: none solid solid none;border-width: medium 1pt 1pt medium;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e56 (10.6)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:224.75pt;border:solid windowtext 1.0pt;border-top: none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eRace/Ethnicity\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;Caucasian/Non-Hispanic\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;African American\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;Hispanic\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;Asian\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.75pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e70 (80.5%)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e11 (12.6%)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e4 (4.6%)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e2 (2.3%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:224.75pt;border:solid windowtext 1.0pt;border-top: none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eSide of biopsy\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; Left\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; Right\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.75pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e37 (42.5%)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e50 (57.5%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:224.75pt;border:solid windowtext 1.0pt;border-top: none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eNo. of lesions upgraded\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;DCIS/DCIS-M\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;IBC\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:206.75pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e13 (14.9%)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e11 (84.6%)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e2 (15.4%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eTable 2.\u003c/span\u003e\u003c/strong\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;Univariate analysis of factors associated with upgrade at biopsy level\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"margin-left:5.4pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 155.15pt;border: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height: 200%;font-family:\"Times New Roman\",serif;'\u003eVariable\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 88.55pt;border-color: windowtext windowtext windowtext currentcolor;border-style: solid solid solid none;border-width: 1pt 1pt 1pt medium;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height: 200%;font-family:\"Times New Roman\",serif;'\u003eUpgrade (n=13)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 88.55pt;border-color: windowtext windowtext windowtext currentcolor;border-style: solid solid solid none;border-width: 1pt 1pt 1pt medium;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height: 200%;font-family:\"Times New Roman\",serif;'\u003eNo upgrade (n=74)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 88.6pt;border-color: windowtext windowtext windowtext currentcolor;border-style: solid solid solid none;border-width: 1pt 1pt 1pt medium;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003ep\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height: 200%;font-family:\"Times New Roman\",serif;'\u003e-value\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:155.15pt;border:solid windowtext 1.0pt;border-top: none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eAge (mean, std, year)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.55pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e55.8 (9.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.55pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e56.4 (14.6)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.6pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e0.90\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:155.15pt;border:solid windowtext 1.0pt;border-top: none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003ePersonal history of breast cancer\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.55pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e1 (7.7%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.55pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e16 (21.6%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.6pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e0.45\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:155.15pt;border:solid windowtext 1.0pt;border-top: none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eFamily history of breast cancer\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.55pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e4 (30.8%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.55pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e35 (47.3%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.6pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e0.23\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:155.15pt;border:solid windowtext 1.0pt;border-top: none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eBreast density\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eA\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eB\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eC\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.55pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e1 (7.7%)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e8 (61.5%)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e4 (30.8%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.55pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e6 (8.1%)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e35 (47.3%)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e33 (44.6%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 88.6pt;border-color: currentcolor windowtext windowtext currentcolor;border-style: none solid solid none;border-width: medium 1pt 1pt medium;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e0.62\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:155.15pt;border:solid windowtext 1.0pt;border-top: none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eRadiologic presentation\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; Calcifications\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; Mass/asymmetry/distortion\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.55pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e13 (100%)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.55pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e67 (90.5%)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e7 (9.5%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 88.6pt;border-color: currentcolor windowtext windowtext currentcolor;border-style: none solid solid none;border-width: medium 1pt 1pt medium;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e1.00\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:155.15pt;border:solid windowtext 1.0pt;border-top: none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eImaging size (cm, median, IQR)\u003csup\u003ea\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.55pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e2.0 (1.0,5.1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.55pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e0.8 (0.6,1.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 88.6pt;border-color: currentcolor windowtext windowtext currentcolor;border-style: none solid solid none;border-width: medium 1pt 1pt medium;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e0.004*\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:155.15pt;border:solid windowtext 1.0pt;border-top: none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eNo. cores removed\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cu\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026lt;\u003c/span\u003e\u003c/u\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e6\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026gt;6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.55pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e13 (100%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.55pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e5 (6.8%)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e69 (93.2%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 88.6pt;border-color: currentcolor windowtext windowtext currentcolor;border-style: none solid solid none;border-width: medium 1pt 1pt medium;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e1.00\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:155.15pt;border:solid windowtext 1.0pt;border-top: none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003ePercent of lesion removed by biopsy\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cu\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026lt;\u003c/span\u003e\u003c/u\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e50%\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026gt;50%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.55pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e6 (46.2%)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e7 (53.9%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.55pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e13 (17.6%)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e61 (82.4%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 88.6pt;border-color: currentcolor windowtext windowtext currentcolor;border-style: none solid solid none;border-width: medium 1pt 1pt medium;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e0.03*\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:155.15pt;border:solid windowtext 1.0pt;border-top: none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eADH associated with target calcifications\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.55pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e12 (92.3%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.55pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e54 (73%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 88.6pt;border-color: currentcolor windowtext windowtext currentcolor;border-style: none solid solid none;border-width: medium 1pt 1pt medium;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e0.18\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:155.15pt;border:solid windowtext 1.0pt;border-top: none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eIndividual cell necrosis\u003csup\u003eb\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.55pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e3 (23.1%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.55pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e11 (14.9%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.6pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e0.40\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:155.15pt;border:solid windowtext 1.0pt;border-top: none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eMicropapillary features\u003csup\u003eb\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.55pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e6 (46.2%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.55pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e19 (25.7%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.6pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e0.10*\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:155.15pt;border:solid windowtext 1.0pt;border-top: none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eExtent of ADH\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e1-2 foci (focal)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cu\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026gt;\u003c/span\u003e\u003c/u\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e3 foci (extensive)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.55pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e2 (15.4%)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e11 (84.6%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.55pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e29 (39.2%)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e45 (60.8%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 88.6pt;border-color: currentcolor windowtext windowtext currentcolor;border-style: none solid solid none;border-width: medium 1pt 1pt medium;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e0.12\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003csup\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003ea\u003c/span\u003e\u003c/sup\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e1 case with images not available for review, \u003csup\u003eb\u003c/sup\u003e1 case with biopsy slides not available for review\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u003cbr\u003e\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eTable 3.\u003c/span\u003e\u003c/strong\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;Logistic regression model of low-risk features and association with upgrade with the loss of a low-risk feature\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width:426.1pt;margin-left:5.4pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 112.25pt;border: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eNumber of Low risk Features\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:79.9pt;border:solid windowtext 1.0pt;border-left: none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cu\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eNo upgrade (n=74)\u003c/span\u003e\u003c/u\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.3pt;border:solid windowtext 1.0pt;border-left: none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cu\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003eUpgrade (n=13)\u003c/span\u003e\u003c/u\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:79.85pt;border:solid windowtext 1.0pt;border-left: none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height: 200%;font-family:\"Times New Roman\",serif;'\u003eRate of No upgrade\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 73.8pt;border-color: windowtext windowtext windowtext currentcolor;border-style: solid solid solid none;border-width: 1pt 1pt 1pt medium;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height: 200%;font-family:\"Times New Roman\",serif;'\u003eOdds of upgrade\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 112.25pt;border-color: currentcolor windowtext windowtext;border-style: none solid solid;border-width: medium 1pt 1pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:79.9pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height: 200%;font-family:\"Times New Roman\",serif;'\u003e4 (5.4%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.3pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height: 200%;font-family:\"Times New Roman\",serif;'\u003e5 (38.5%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:79.85pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height: 200%;font-family:\"Times New Roman\",serif;'\u003e0.44\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 73.8pt;border-color: currentcolor windowtext windowtext currentcolor;border-style: none solid solid none;border-width: medium 1pt 1pt medium;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height: 200%;font-family:\"Times New Roman\",serif;'\u003e7.13\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 112.25pt;border-color: currentcolor windowtext windowtext;border-style: none solid solid;border-width: medium 1pt 1pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height:200%;font-family:\"Times New Roman\",serif;'\u003e1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:79.9pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp 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style='font-size:13px;line-height: 200%;font-family:\"Times New Roman\",serif;'\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:79.85pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height: 200%;font-family:\"Times New Roman\",serif;'\u003e1.00\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 73.8pt;border-color: currentcolor windowtext windowtext currentcolor;border-style: none solid solid none;border-width: medium 1pt 1pt medium;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;font-size:16px;font-family:\"Cambria\",serif;text-align:center;line-height:200%;'\u003e\u003cspan style='font-size:13px;line-height: 200%;font-family:\"Times New Roman\",serif;'\u003e--\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003e\u003ca href=\"https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/breast-cancer-facts-and-figures/breast-cancer-facts-and-figures-2019-2020.pdf\"\u003ehttps://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/breast-cancer-facts-and-figures/breast-cancer-facts-and-figures-2019-2020.pdf\u003c/a\u003e. Accessed 20 September 2020.\u003c/li\u003e\n\u003cli\u003eHartmann LC, Degnim AC, Santen RJ, Dupont WD, Ghosh K. (2015) Atypical hyperplasia of the breast\u0026mdash;Risk assessment and management options. N Engl J Med 372:78-89. https://doi.org/10.1056/NEJMsr1407164\u003c/li\u003e\n\u003cli\u003eAmin AL, Wagner JL. (2021) Contemporary management of atypical breast lesions identified on percutaneous biopsy: a narrative review. Ann Breast Surg 5:9. https://doi.org/10.21037/abs-20-117\u003c/li\u003e\n\u003cli\u003eQuinn EM, Dunne E, Flanagan F, et al. (2020) Radial scars and complex sclerosing lesions on core needle biopsy of the breast: upgrade rates and long-term outcomes. Breast Cancer Res Treat 183:677-82. https://doi.org/10.1007/s10549-020-05806-z\u003c/li\u003e\n\u003cli\u003eKiran S, Jeong YJ, Nelson ME, et al. (2018) Are we overtreating intraductal papillomas? J Surg Res 231:387-94. https://doi.org/1016/j.jss.2018.06.008\u003c/li\u003e\n\u003cli\u003eSin HP, Kreipe H. (2013) A Brief Overview of the WHO Classification of Breast Tumors, 4\u003csup\u003eth\u003c/sup\u003e Edition, Focusing on Issues and Updates from the 3\u003csup\u003erd\u003c/sup\u003e Breast Care (Basel) 8(2):149-54. https://doi.org/\u003ca href=\"https://doi.org/10.1159/000350774\"\u003e10.1159/000350774 \u003c/a\u003e\u003c/li\u003e\n\u003cli\u003eMeyer JE, Christian RL, Lester SC, et al. (1996) Evaluation of nonpalpable solid breast masses with stereotaxic large-needle core biopsy using a dedicated unit. AJR AM J Roentgenol 167:179-82. https://doi.org/10.2214/ajr.167.1.8659367\u003c/li\u003e\n\u003cli\u003eEly KA, Carter BA, Jensen RA. (2001) Core biopsy of the breast with atypical ductal hyperplasia. Am J Surg Pathol 25(8):1017-21. https://doi.org/10.1097/00000478-200108000-00005\u003c/li\u003e\n\u003cli\u003eWagoner MJ, Laronga C, Acs G. (2009) Extent and histologic pattern of atypical ductal hyperplasia present on core needle biopsy specimens of the breast can predict ductal carcinoma in situ in subsequent excision. Am J Clin Pathol 131:112-21. https://doi.org/10.1309/AJCPGHEJ2R8UYFGP\u003c/li\u003e\n\u003cli\u003eKrishnamurthy S, Bevers T, Kuerer H, Yang WT. (2012) Multidisciplinary considerations in the management of high-risk breast lesions. AJR Am J Roentgenol 198:W132-40. https://doi.org/10.2214/AJR.11.7799\u003c/li\u003e\n\u003cli\u003eRacz JM, Degnim AC. When Does Atypical Ductal Hyperplasia Require Surgical Excision? (2018) Surg Oncol Clin N Am 27(1):23-32. https://doi.org/10.1016/j.soc.2017.011\u003c/li\u003e\n\u003cli\u003eNational Comprehensive Cancer Network. Clinical practice guidelines: breast cancer screening and diagnosis, version 1. 2020, BSCR-17. (\u003ca href=\"http://www.nccn.org/professionals/physician_gls/pdf/breast-screening.pdf\"\u003ehttp://www.nccn.org/professionals/physician_gls/pdf/breast-screening.pdf\u003c/a\u003e). Accessed 20 September 2020.\u003c/li\u003e\n\u003cli\u003eNguyen CV, Albarracin CT, Whitman GJ, Lopez A, Sneige N. (2011) Atypical ductal hyperplasia in directional vacuum-assisted biopsy of breast microcalcifications: considerations for surgical excision. Ann Surg Oncol 18:752-61. https://doi.org/10.1245/s10434-010-1127-8\u003c/li\u003e\n\u003cli\u003ePena A, Shah SS, Fazzio RT, et al. (2017) Multivariate model to identify women at low risk of cancer upgrade after core needle biopsy diagnosis of atypical ductal hyperplasia. Breast Cancer Res Treat 164(2):295-04. https://doi.org/10.1007/s10549-017-4253-1\u003c/li\u003e\n\u003cli\u003eSneige N, Lim SC, Whitman GJ, et al. (2003) Atypical ductal hyperplasia diagnosed by directional vacuum-assisted stereotactic biopsy of breast microcalcifications. Am J Clin Pathol 119:248-53. https://doi.org/10.1300/0GYV-4F2L-LJAV-4GFN\u003c/li\u003e\n\u003cli\u003eForgeard C, Benchaib M, Guerin N, et al. (2008) Is surgical biopsy mandatory in case of atypical ductal hyperplasia on 11-gauge core needle biopsy? A retrospective study of 300 patients. Am Surg 196:339-45. https://doi.org/10.1016/j.amjsurg.2007.07.038\u003c/li\u003e\n\u003cli\u003eAllison KH, Eby PR, Kohr J, DeMartini WB, Lehman CD. (2011) Atypical ductal hyperplasia on vacuum-assisted breast biopsy: suspicion for ductal carcinoma in situ can stratify patients at high risk for upgrade. Hum Pathol 42:41-50. https://doi.org/10.1016/j.humpath.2010.06.011\u003c/li\u003e\n\u003cli\u003eMcGhan LJ, Pockaj BA, Wasif N, Giurescu ME, McCullough AE, Gray RJ. (2012) Atypical ductal hyperplasia on core biopsy: an automatic trigger for excisional biopsy? Ann Surg Oncol 19:3264-9. https://doi.org/10.1245/s10434-012-2575-0\u003c/li\u003e\n\u003cli\u003eUzan C, Mazouni C, Ferchiou M, et al. (2013) A model to predict the risk of upgrade to malignancy at surgery in atypical breast lesions discovered on percutaneous biopsy specimens. Ann Surg Oncol 20:2850-7. https://doi.org/10.1245/s10434-013-2989-3\u003c/li\u003e\n\u003cli\u003eMenes TS, Rosenberg R, Balch S, Jaffer S, Kerlikowske K, Miglioretti DL. (2014) Upgrade of high-risk breast lesions detected on mammography in the Breast Cancer Surveillance Consortium. Am J Surg 207:24-31. https://doi.org/10.1016/j.amjsurg.2013.05.014\u003c/li\u003e\n\u003cli\u003eElmore JG, Longton GM, Carney PA, et al. (2015) Diagnostic concordance among pathologists interpreting breast biopsy specimens. JAMA 313(11):1122-32. https://doi.org/10.1001/jama.2015.1405\u003c/li\u003e\n\u003cli\u003eHwang ES, Hyslop T, Lynch T, et al. (2019) The COMET (Comparison of Operative versus Monitoring and Endocrine Therapy) trial: a phase III randomized controlled clinical trial for low-risk ductal carcinoma in situ (DCIS). BMJ Open 9(3):e026797. https://doi.org/10.1136/bmjopen-2018-026797\u003c/li\u003e\n\u003cli\u003eElshof LE, Tryfonidis K, Slaets L, et al. (2015) Feasibility of a prospective, randomized, open-label, international multicentre, phase III, non-inferiority trial to assess the safety of active surveillance for low risk ductal carcinoma in situ \u0026ndash; The LORD study. Eur J Cancer 51(12):1497-510. https://doi.org/10.1016/j.ejca.2015.05.008\u003c/li\u003e\n\u003cli\u003eFrancis A, Thomas J, Fallowfield L, et al. (2015) Addressing overtreatment of screen detected DCIS: the LORIS trial. Eur J Cancer 51(16):2296-303. https://doi.org/10.1016/j.ejca.2015.07.017\u003c/li\u003e\n\u003cli\u003eKhoury T, Jabbour N, Peng X, et al. (2020) Atypical ductal hyperplasia and those border on ductal carcinoma in situ should be included in the active surveillance clinical trials. Am J Clin Pathol 153:131-8. https://doi.org/10.1093/ajcp/aqz143\u003c/li\u003e\n\u003cli\u003eTavassoli FA, Norris HJ. (1990) A comparison of the results of long-term follow-up for atypical intraductal hyperplasia and intraductal hyperplasia of the breast. Cancer 65:518-29. https://doi.org/10.1002/1097-0142(19900201)65:3\u0026lt;518::aid-cncr2820650324\u0026gt;3.0.co;2-o\u003c/li\u003e\n\u003cli\u003ePage DL, Dupont WD, Rogers LW, et al. (1985) Atypical hyperplastic lesions of the female breast: a long-term follow-up study. Cancer 55:2698-708. https://doi.org/10.1002/1097-0142(19850601)55:11\u0026lt;2698::aid-cncr2820551127\u0026gt;3.0.co;2-a\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Abbreviations","content":"\u003cul\u003e\n\u003cli\u003einvasive breast cancer (IBC)\u003c/li\u003e\n\u003cli\u003eductal carcinoma in situ (DCIS)\u003c/li\u003e\n\u003cli\u003eNational Comprehensive Cancer Network (NCCN)\u003c/li\u003e\n\u003cli\u003eatypical ductal hyperplasia (ADH)\u003c/li\u003e\n\u003cli\u003evacuum assisted biopsy (VAB)\u003c/li\u003e\n\u003c/ul\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cu\u003eFunding:\u003c/u\u003e The authors received no financial support for the research, authorship, and/or publication of this article.\u003c/p\u003e\n\u003cp\u003e\u003cu\u003eConflicts Of Interest/Competing Interests:\u003c/u\u003e The authors declare that there is no conflict of interest.\u003c/p\u003e\n\u003cp\u003e\u003cu\u003eAvailability Of Data And Material (Data Transparency):\u003c/u\u003e No datasets were generated or analyzed during the current study.\u003c/p\u003e\n\u003cp\u003e\u003cu\u003eCode Availability (Software Application Or Custom Code):\u003c/u\u003e No custom codes were generated or analyzed during the current study.\u003c/p\u003e\n\u003cp\u003e\u003cu\u003eAuthors' Contributions:\u003c/u\u003e ALA, ODW, OT, and JLW conceived the original idea. ODW, FF, and JLW supervised the project. ALA and JLW took the lead in writing the mansucript. SH and JW provided statistical support. All authors provided critical feedback and helped shape the research, analysis and manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cu\u003eEthics Approval: \u003c/u\u003eApproval for the study was obtained from the University of Kansas Institutional Review Board. The study was conducted in accordance with Helsinki Declaration as revised in 2013.\u003c/p\u003e\n\u003cp\u003e\u003cu\u003eConsent To Participate: As this was a retrospective review, informed consent was waived by IRB.\u003c/u\u003e\u003c/p\u003e\n\u003cp\u003e\u003cu\u003eConsent For Publication:\u003c/u\u003e No identifying information (including patients\u0026rsquo; images, names, initials, or hospital numbers) was included in recordings, written descriptions, or photographs, for this study. All personal details of patients in any part of the paper and in any supplementary materials (including illustrations) were removed before submission.\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Breast Cancer, Aytpical Ductal Hyperplasia, ADH, Breast Surgery, Upgrade, Ductal Carcinoma In Situ","lastPublishedDoi":"10.21203/rs.3.rs-388478/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-388478/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003ePurpose\u003c/h2\u003e \u003cp\u003eNCCN guidelines recommend surgical excision for all patients with atypical ductal hyperplasia (ADH) on percutaneous biopsy. Improved imaging and biopsy techniques have lower contemporary upgrade rates, challenging standard practice.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e \u003cp\u003eA retrospective analysis identified 87 percutaneous biopsies diagnosing ADH who underwent surgical excision at a single institution from 01/2008 to 10/2015. Imaging was reviewed for lesion size and residual calcifications. Biopsy slides were reviewed for ADH features. Categorical variables were analyzed using Chi-square and Fisher\u0026rsquo;s exact tests; continuous variables with T- and Wilcoxon tests. Logistic regression model was used to determine association between odds of upgrade and number of low-risk features.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e \u003cp\u003eUpgrade was identified in 13 cases (14.9%; 11 ductal carcinoma in situ and 2 invasive breast cancer). Imaging features associated with lowest risk of upgrade included imaging size\u0026thinsp;\u0026lt;\u0026thinsp;1cm (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0.004) and \u0026gt;\u0026thinsp;50% removed by biopsy (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0.03). The only pathologic feature significantly associated with upgrade was the presence of micropapillary features (\u003cem\u003ep\u0026thinsp;=\u003c/em\u003e\u0026thinsp;0.10), with lower extent of ADH (1\u0026ndash;2 foci, \u003cem\u003ep\u0026thinsp;=\u003c/em\u003e\u0026thinsp;0.12) trending toward significance. Those with the lowest risk of upgrade (0%) had all 4 low risk features (n\u0026thinsp;=\u0026thinsp;17, 20%). The loss of a low-risk feature increased the odds of upgrade by 189% (OR\u0026thinsp;=\u0026thinsp;1.89, 95% CI 0.241,0.742, \u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0.001).\u003c/p\u003e\u003ch2\u003eConclusion\u003c/h2\u003e \u003cp\u003eContemporary imaging and biopsy techniques have resulted in lower upgrade rates for ADH. Patients at lowest risk for upgrade can be identified using a scoring system and may be safely offered active surveillance over surgical excision.\u003c/p\u003e","manuscriptTitle":"Atypical ductal hyperplasia on percutaneous breast biopsy: Scoring system to identify the lowest risk for upgrade","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2021-04-28 18:46:31","doi":"10.21203/rs.3.rs-388478/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"91cbd4c3-069d-41f3-90f7-9ffeb6c260ab","owner":[],"postedDate":"April 28th, 2021","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":3946619,"name":"Oncology"}],"tags":[],"updatedAt":"2021-05-12T18:33:24+00:00","versionOfRecord":[],"versionCreatedAt":"2021-04-28 18:46:31","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-388478","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-388478","identity":"rs-388478","version":["v1"]},"buildId":"WrCJVZZCHTDjtuVLN7oU0","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}