REMEDY FOR ENDOMETRIOSIS

By studying the mitogen activity of MK on cultured endometrial stromal cells,it is clarified that MK stimulates the proliferation of ESC. By evaluating theMK concentration in the peritoneal fluid (PF), it is clarified that the MK levelis elevated in a female with the progress of endometriosis. It is further foundout that the MK concentration in the PF of a female under the therapy with GnRH agonistis significantly lower than the concentration in another group. It is indicatedthat MK mRNA is expressed in cells originating in peritoneal bone marrow, theperitoneal membrane and an intrauterine tissue.