Clinical characteristics and post-discharge follow-up analysis of 10 cases of congenital tuberculosis: a retrospective observational study

Clinical characteristics and post-discharge follow-up analysis of 10 cases of congenital tuberculosis: a retrospective observational study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research article Clinical characteristics and post-discharge follow-up analysis of 10 cases of congenital tuberculosis: a retrospective observational study Juan Du, Shixiao Dong, Shengnan Jia, Qiaoru Zhang, Mingyan Hei This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.2.13513/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background Congenital tuberculosis (TB) is a rare disease with a high mortality. In this study, we reviewed patients with congenital TB that were promptly treated with an anti-TB regimen, including linezolid, based on new clinical diagnosis criteria. We described the clinical manifestations, treatment, and long-term prognosis of this disease in these patients. Methods This was a retrospective observational study that enrolled patients with congenital TB that were admitted to Beijing Children’s Hospital between 2009 and 2018. Results A total of 10 congenital TB patients were enrolled. Ninety-percentage of the mothers were diagnosed at postpartum; however, none of the mothers received anti-TB treatment during pregnancy. The onset age of congenital TB ranged from 1 to 53 days. Chest computed tomography scans demonstrated pulmonary nodules in 100% of the patients and mediastinal adenopathy in 40% of the patients. Abdominal ultrasonography showed hypoechoic nodules in the liver and spleen in 40% of the patients. The positive rate of GeneXpert and T-spot were relatively high—80% and 78%, respectively. Anti-TB treatment was started when congenital TB was confirmed for 1 patient based on TB-specific tests or clinically diagnosed for the other 9 patients based on confirmed maternal TB history and typical radiological findings. Beside isoniazid, rifampicin, and pyrazinamide, linezolid was also administrated in 70% of the patients for a period of 2–6 months. One patient was reported to present with spontaneously resolved thrombocytopenia. The survival rate was 100%, and 33% of the patients have thrived and reached normal developmental milestones since the last documented follow-up. Conclusion Congenital TB is a potentially fatal disease, but early diagnosis based on maternal history, typical imaging results, and timely treatment can improve the outcome. Linezolid is safe and might be effective in reducing the mortality of congenital TB. Pediatrics Figures Figure 1 Background Tuberculosis (TB) is caused by Mycobacterium tuberculosis (Mtb). Despite advances in therapeutic and diagnostic techniques, TB continues to be a major infectious cause of morbidity and mortality worldwide, especially in developing countries [1]. Congenital TB infection by vertical transmission from infected mothers is rare, but carries a poor prognosis. The mortality rate for congenital TB is 21.7%–100%, with a higher mortality associated with delayed, or inappropriate treatment [2]. Furthermore, diagnosis in neonates is challenging because of non-specific manifestations. The outcome of infants with congenital TB who have been promptly treated is of great interest for clinicians. In this study, we present 10 patients with congenital TB that were admitted to Beijing Children’s Hospital, Capital Medical University in China. Moreover, this study had access to the follow-up information of each patient after discharge. To the best of our knowledge, this is the first study analyzing cases of congenital TB with the follow-up data. Methods 2.1 Patients and study design This was a retrospective observational study based on the in-patient electronic records of patients admitted to Beijing Children’s Hospital between 2009 and 2018. All patients were confirmed with a first diagnosis of congenital TB. They were treated and followed up in Beijing Children’s Hospital. 2.2 Diagnostic criteria Congenital TB was diagnosed according to the criteria revised by Cantwell et al [ 3]. Cantwell et al. proposed that in order for an infant to be diagnosed with congenital TB, the infant must have proven tuberculous disease and at least one of the following: 1) lesions in the first week of life, 2) a primary hepatic complex or caseating hepatic granulomas, 3) tuberculous infection of the placenta or the maternal genital tract, and 4) exclusion of the possibility of postnatal transmission by thorough investigation of contacts. 2.3 Statistical analysis Categorical data are presented as numbers (%) and continuous data as the mean and standard deviation for normal distribution data or median and percentiles for non-normal distribution data. SPSS, version 15.0 (SPSS Inc., Chicago, IL, U.S.) was used for all statistical analyses. Results 3.1 Demographic data and maternal history A total of 10 congenital TB patients were enrolled in this study from 2009 to 2018, with a male:female gender ratio of 1:1.5. Further, five (50%) of these patients were preterm. Gestational age was 35.8 (± 1.7) week. The average birth weight was 2517 (± 487) g. Two (20%) of the patients were small for gestational aged infants. There were two (20%) mothers that were diagnosed with TB, but were considered to have fully recovered prior to pregnancy. These women received in vitro fertilization (IVF) to become pregnant. TB symptoms were reported to have reoccurred during their pregnancy; however, no anti-TB treatment was given. A total of eight out of ten (80%) mothers presented with TB symptoms during pregnancy or immediately after delivery, of which only one out of the eight symptomatic mothers was diagnosed with TB during pregnancy. However, this mother was not treated, which was against all medical suggestions. Two out of ten (20%) mothers were completely asymptomatic and were not diagnosed with tuberculosis until their children were suspected of TB infection based on imaging results. Thus, 90% of the mothers were diagnosed postpartum and not one of the ten mothers received anti-TB treatment during pregnancy. Most mothers were diagnosed with miliary TB by chest radiography, and only three out of ten (30%) of the mothers were confirmed to have genital TB. 3.2 Clinical manifestations 3.2.1 Patient history The average onset day of life for congenital TB (DOL) was 25.6 (± 17.8) days with a range of 1—53 days. The most frequent clinical features were fever (100%), failure to thrive (60%), and cough (50%). Four out of nine (44%) infants received a BCG (Bacillus Calmette-Guérin) vaccination before diagnosis. 3.2.2 General laboratory findings Common laboratory findings of each patient were analyzed. The white blood cell counts of all patients were elevated, ranging from 12.49 to 32.44 × 10^9 cells/L (an average of 21.45 (± 6.30) × 10^9 cells/L), with neutrophils being the predominant (100%) cell type. The C-reactive protein (CRP) levels of all the patients were elevated to 36—163 mg/L (96.3 ± 41.4) mg/L. Nine out of ten (90%) infants and seven out of ten (70%) infants had disease complicated with anemia and hepatic dysfunction, respectively. Half of the patients were complicated with thrombocytopenia. The cerebrospinal fluid of half of the patients was abnormal, with elevated levels of lymphocytes and protein and reduced levels of glucose and chlorine. 3.2.3 Imaging findings Chest computed tomography (CT) scans were completed for all patients, which demonstrated pulmonary nodules in ten (100%) patients and mediastinal adenopathy in four (40%) patients. Abdominal ultrasonography (US) showed hypoechoic nodules in the liver and spleen in four (40%) patients. The MRI analysis from one patient demonstrated severe brain damage with cerebral infarction, hydrocephalus, encephalomalacia, and encephalatrophy. 3.2.4 TB-specific tests The positive rate of GeneXpert and T-spot were relatively high, with 4/5 (80%) and 7/9 (78%) positive rates, respectively. Further, 5/10 (50%) and 2/7 (29%) cases were positive for acid-fast bacilli (AFB) smear and tuberculin skin test, respectively. Samples of blood, cerebrospinal fluid, tracheal aspirates, gastric fluid, urine, and stool were cultured; however, only two (20%) cases were positive. The sample with the highest positivity rate of TB was gastric fluid followed by tracheal aspirates. 3.3 Diagnosis and treatment Lung tissue was involved in the disease in all patients. Two patients required mechanical ventilation at admission and were extubated 4 and 7 days later, respectively. Seven out of ten (70%) patients had multi-organ lesions. Anti-TB treatment was started as soon as congenital TB was confirmed in one patient and clinically diagnosed in the other nine patients, based on proven maternal TB history and typical radiological findings (chest CT/abdominal ultrasonography) while TB was identified later for eight out of the nine patients. TB was not identified in one patient (patient number 3), who was diagnosed with congenital TB based on proven maternal TB history, typical chest CT findings, and efficacy of anti-TB treatment. The remaining nine patients met the criteria of Cantwell et al. AFB and T-spot analysis offered evidence for TB infection in 4/9 (44%) cases. The time between the development of symptoms and the initiation of treatment varied from 3 to 57 days, with a median time of 6.5 (3.0, 15.2) days. All of the patients received a treatment regimen consisting of isoniazid (INH), rifampicin (RIF), and pyrazinamide (PZA); however, PZA was halted in two cases because of elevated alanine aminotransferase (ALT) levels. The daily dosage of anti-TB drugs used adhered to the Chinese National Formulary of Chemicals and Biological Products for Children. Corticosteroid was added to the regime for three patients, two of which had TB infection complicated with meningitis. Linezolid (LZD) was administrated as a supplementary drug for seven (70%) patients at a dosage of 10 mg/kg/dose, q12h (twice daily) to q8h (three times daily) for two to six months. The total duration for anti-TB treatment varied from two months to three years. The adverse effects were evaluated. Three (30%) patients experienced side effects, such as hepatotoxicity, from the drugs. The treatment for patients number 5 and number 10 was discontinued at six months and two months, respectively, due to severe hepatotoxicity. One patient presented thrombocytopenia during LZD treatment but recovered spontaneously without LZD withdrawal. 3.4 Outcome and follow-up The survival rate was 100% at hospital discharge, with an improved health condition for all patients. The average hospital stay duration was 23.3 (± 17.2) days. Time of fever clearance ranged from 3–49 days, with a median time of 7.0 (4.5, 20.0) days. Treatment with anti-TB drugs was continued as an outpatient procedure for all the patients. The follow up rate was 90%. There were five (56%) patients that fully recovered, of whom consecutive chest radiographs showed gradual resolution. Four (44%) patients were still under treatment, four (44%) patients failed to thrive, and three (33%) patients had TB infection complicated with neurological sequelae. Only 3/9 (33%) patients thrived and achieved normal developmental milestones. Discussion Congenital TB is defined as infection that develops as a result of an encounter between a TB-infected mother and her infant during the intrauterine period or during birth. Maternal TB can be transmitted to the fetus either transplacental or through the aspiration of infected amniotic fluid [3]. To our best knowledge, our study is the first that includes the complete clinical information of 10 congenital TB infants in China, including treatment and follow-up information. Our study provides valuable insights into congenital TB infection. Since female genital tuberculosis and tuberculous endometritis are associated with infertility, congenital TB is rare. Our data showed that 20% of the mothers were diagnosed with TB before pregnancy and received IVF. This suggests that the increasing availability of assisted reproductive technologies has a potential to increase the prevalence of congenital TB [4]. The mothers who transmit TB infection to their fetus during pregnancy are difficult to diagnose. A delay between the onset of symptoms and diagnosis occurs frequently, due to the non-specific symptoms at presentation, reluctance to perform radiography, and low index of suspicion [5]. It was not surprising that the diagnosis of some maternal TB cases was made only after the infants’ exhibited symptoms of TB and were subsequently diagnosed. One study reviewed 170 cases of congenital TB and reported that 121 (71%) mothers were diagnosed at postpartum, of which 39 cases were completely asymptomatic [2]. In our study, 70% of the mothers were diagnosed after delivery, among which two mothers were individually diagnosed by chest X-ray and T-Spot test after their babies were suspected for congenital TB. Thus, according to our study, if there is a strong suspicion of TB in the infant and the mother is not currently diagnosed with TB, then they should both be tested. According to WHO guidelines for BCG vaccination, a single dose of the BCG vaccine should be given to all healthy infants as close to the time of birth as possible [6]. However in our study, five out of ten patients had not received BCG when they were admitted to the hospital. One explanation is that the BCG vaccination is not given to preterm newborns, according to Chinese national protocol. Patients 1, 4, and 8 were preterm newborns that did not receive the BCG vaccine immediately after birth. Patient 10 presented with symptoms of TB on DOL 1, and as such, the BCG vaccination was delayed due to the uncertain TB status. The mother of patient 3 was diagnosed with TB during pregnancy, and as a result, the BCG vaccination was held for the newborn. The symptoms of postnatal TB infection are usually exhibited 4 to 8 weeks after infection [7]. Therefore, the symptoms of congenial TB could theoretically be present within two months after birth. However, Cantwell et al. analyzed 29 patients with congenital TB and reported that the onset age of TB ranged from 1 to 84 days; whereas Sonal et al. reviewed 21 congenital TB cases and reported the onset age as 1 to 90 days [3, 8]. Congenital TB symptoms commonly present in the first 2 to 3 weeks of life [2]. In our study, the onset age varied from 1 to 50 days. Clinical manifestations of congenital TB can be diverse, nonspecific, and difficult to differentiate from neonatal bacterial or viral sepsis. In our study, fever was the most frequent symptom. Nonspecific markers found in patients with congenital TB included neutrophilia, thrombocytopenia, and elevated CRP levels [2]. In our study, all of the patients presented with neutrophilia and elevated levels of CRP. Moreover, 70% of the patients with congenital TB had complications with thrombocytopenia. The imaging results of our study showed that (1) the most frequent patterns of chest CT scans were multiple pulmonary nodules and mediastinal adenopathy, and (2) abdominal US showed hypoechoic nodules in the liver and spleen in 40% of the patients. Liver and spleen nodules were similarly found in adult TB patients, but the lung TB nodule features are quite different from other lung diseases and could lead to the suspicion of congenital TB when analyzed by an experienced radiologist or TB specialist. Recently, multiple pulmonary nodules have been described as a new radiographical finding in some published studies [9]. Multiple pulmonary nodules on chest CT scans were considered as the progressive deterioration of miliary tuberculosis, consistent with caseating necrosis in a biopsy specimen [10]. Several pediatric TB specialists and radiologists in China reported that both patterns of military TB and pulmonary nodules were specific image characteristics of congenital TB [11, 12]. TB-specific investigations should be performed when there are suspicions of TB based on imaging results. The confirmation of TB infection is often challenging in newborns because markers specific to TB have poor sensitivity. For neonates, serial gastric fluid appears to be the most common specimen for TB pathogen identification. Lower sensitivity and a longer time before confirmation of culture-positive results frequently occurs in children because of decreased bacterial loads. In our study, the positive rate of AFB smear was 50% with the results available within 24 hours. Furthermore, only 20% of the cases showed a positive culture result by 13.5 to 16 days. Because of the limitation of the laboratory environment, our hospital was unable to perform drug susceptibility testing for TB. The GeneXpert assay is a hemi-nested real-time PCR test that simultaneously identifies Mtb/RIF resistance. Its diagnostic accuracy is comparable to culture in sputum samples and provides results within 24 to 48 hours [13]. The WHO recommends GeneXpert for rapid diagnosis in communities with a high burden of TB [13]. Our study results showed that GeneXpert is the most sensitive test, with an 80% positive rate. Furthermore, the result could be obtained within 24 hours. The tuberculin skin test is mostly negative in newborns since the test takes at least four weeks to be positive. In our study, two cases showed a positive tuberculin skin test result at two to three months of age. Currently, there are two types of commercially available IFN-γ release assays-the QuantiFeron TB Gold (Cellestis) and T-Spot TB (Oxford Immunotec) [14]. The latter is an enzyme-linked immunospot (ELISPOT) assay used in our hospital. Though there are concerns about the applicability of these assays to newborns due to the decreased IFN-γ production in newborns, in our study the T-Spot assay demonstrated a relatively high sensitivity and was one of the best results for initial evidence of TB in our cases. Compared to the previous congenital TB case report [3], our patients demonstrated a much better outcome with a 100% survival rate. Based on literature analysis, we theorize that the better outcomes in our study were a result of the new clinical diagnosis criteria for congenial TB and the introduction of LZD in the treatment regimen during the intensive phase of anti-TB treatment. It is understandable that maternal history and typical imaging findings might be the only basis for diagnosis of congenital TB. The clinical diagnosis criteria of congenital TB in our center was: (1) if an infant has fever, respiratory distress, hepatosplenomegaly, or other nonspecific symptoms within two months after birth, (2) if the infant’s mother was diagnosed with active TB infection perinatally, and (3) if the infant’s imaging showed miliary tuberculosis or multiple pulmonary nodules in chest CT scans or multiple focal lesions in the liver/spleen by abdominal US. Infants that meet the criteria were put into isolation, further TB investigation was started, and anti-TB treatments were initiated. This might partially explain the fairly good prognosis of the ten congenital TB patients in our study. The standard regimen for congenital TB includes INH, RIF, PZA, and ethambutol during the intensive phase for two months, followed by INH and RIF for seven to ten months during the continuation phase. Chest X-rays at the end of treatment is recommended [8, 15]. Linezolid (LZD) is a member of the oxazolidinone class of antibiotics, which exhibits bacteriostatic activity against Mtb, including multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB strains [16]. Clinical trials in adults have revealed that LZD is an important component for the treatment of MDR and XDR TB [17, 18]. As a newer anti-Gram positive antibiotic, LZD has excellent penetration to the central nervous system. Furthermore, published studies support its effectiveness and safety in treating infections caused by resistant pathogens, including staphylococcal bacteremias and cerebrospinal fluid infections, for term and preterm newborns in neonatal intensive care units [19, 20]. Li et al. reported clinical data, which demonstrated that LZD improved the early outcomes of childhood TB meningitis for 36 cases [21]. Since China has a serious epidemic of drug-resistant TB [22] and the immune system of neonates is not fully developed, our center has used LZD as a supplementary drug for congenital TB patients since 2015. In our study, LZD was administrated to seven patients, ranging in age from 4 to 70 days, for a duration of 2 to 6 months. This is most likely the first report of the long-term use of LZD for neonatal and infant congenital TB. The adverse events and side effects of LZD in our patients were monitored and evaluated by clinical symptoms, periodical whole blood counts, and serum liver/renal function analysis every one or two weeks. One patient presented with thrombocytopenia while receiving LZD, but recovered spontaneously without LZD withdrawal. Another two patients presented with hepatotoxicity during the intensive phase of treatment with INH, RIF, PZA, and LZD. However, it is difficult to differentiate the side effects induced by each drug. The low frequency of LZD-associated adverse side effects highlights the promising prospects of its use for the treatment of congenital TB. A LZD regimen during the intensive phase of anti-TB treatment might contribute to the improvement of outcomes of congenital TB. It was reported that the overall mortality for infants with congenital TB is 100% if undiagnosed, and delayed infant diagnosis carries a 5-fold higher mortality rate in comparison with prompt diagnosis and treatment [2]. In our study, responses to anti-TB drugs were good in all patients who finished the treatment, with chest X-rays revealing no infection at the end of treatment. However, only 33% of the patients in our study are currently thriving and have achieved normal developmental milestones. This study has several limitations. First, this retrospective study was conducted in a single medical center, which makes applying the study results to the general population difficult. Second, the sample size was too small to demonstrate the effectiveness of new clinical diagnosis criteria and Linezolid in reducing the mortality of congenital TB. This issue may require further cooperation from multiple centers in the future for a comprehensive study. Furthermore, the clinical decisions of LZD administration was made according to the experience from neonatologists and TB specialists, which may result in practice variability. A clinical guide for the standard treatment of congenital TB is urgently needed. In summary, congenital TB is a potentially fatal disease, but with a high index of suspicion and aggressive management, it can have a good outcome. Early diagnosis based on maternal history, typical imaging findings, and timely treatments are crucial. Multi-drug anti-TB treatment, including LZD, is safe and might be effective for infants and reduces mortality. List of abbreviations TB - Tuberculosis Mtb - Mycobacterium tuberculosis BW - birth weight IVF - in-vitro fertilization DOL - day of life WBC - white blood cell CRP - C-reactive protein CSF - cerebrospinal fluids CT - computed tomography AFB - acid-fast bacilli INH - isoniazid RIF - rifampicin PZA - pyrazinamide LZD - Linezolid US - ultrasonography MDR - multidrug-resistant XDR - extensively drug-resistant Declarations Ethics approval and consent to participate All patient information regarding diagnosis/differential diagnosis and treatment were stated as written consents and signed by the infants’ parents/legal guardians. Data in this study were de-identified after data collection. The protocols applied in this study were approved by the Ethics Committee of Beijing Children’s Hospital. The approval number is 2018-k–124. Consent for publication The patients’ parents have given their written consent to publishing patients’ clinical details and/or clinical images. Availability of data and material The datasets used and analysed during the current study are available from the authors on reasonable request. Competing interests The authors declare that they have no competing interests. Funding This study was supported by Canada Institutes of Health Research (CIHR). NICU Team of Maternal & Infant Care Program (Grant number: CTP87518) Authors’ Contributions Dr. Du, Dr. Jia and Dr. Zhang reviewed patients’ files, collected the data, carried out the analyses, drafted the initial manuscript, and reviewed and revised the manuscript. Dr. Hei and Dr. Dong designed the study, supervised the cases review and critically reviewed the manuscript for important intellectual conten. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work. Acknowledgements Not applicable Author details Juan Du Email: [email protected] Shixiao Dong Email: [email protected] Shengnan Jia Email: [email protected] Qiaoru Zhang Email: [email protected] References Global tuberculosis report 2017. Geneva: World Health Organization; 2017. Licence: CC BY-NCSA 3.0 IGO Peng W, Yang J, Liu E. Analysis of 170 cases of congenital TB reported in the literature between 1946 and 2009. Pediatr Pulmonol. 2011;46:1215–24. Cantwell MF, Shehab ZM, Costello AM, Sands L, Green WF, Ewing EP Jr, Valway SE, Onorato IM. Congenital tuberculosis. N Engl J Med. 1994;330:1051–4. Flibotte JJ, Lee GE, Buser GL, Feja KN, Kreiswirth BN, McSherry GD, Nolan SM, Tolan RW Jr, Zhang H. Infertility, in vitro fertilization and congenital tuberculosis. J Perinatol. 2013;33(7):565–8. Ormerod P. Tuberculosis in pregnancy and the puerperium. Thorax. 2001;56(6): 494–9. World Health Organization. BCG vaccines: WHO position paper. Vaccine. 2018;36(24):3408–10. Lamb GS, Starke JR. 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Linezolid versus vancomycin in the treatment of known or suspected resistant gram-positive infections in neonates. Pediatr Infect Dis J. 2003;22(9 Suppl):S158–63. Langgartner M, Mutenthaler A, Haiden N, Pollak A, Berger A. Linezolid for treatment of catheter-related cerebrospinal fluid infections in preterm infants. BMJ Case Rep. 2009;2009:bcr11.2008.1217. Li H, Lu J, Liu J, Zhao Y, Ni X, Zhao S. Linezolid is associated with improved early outcomes of childhood tuberculous meningitis. Pediatr Infect Dis J. 2016;35(6):607–10. Zhao Y, Xu S, Wang L, Chin DP, Wang S, Jiang G, Xia H, Zhou Y, Li Q, Ou X, Pang Y, Song Y, Zhao B, Zhang H, He G, Guo J, Wang Y. National survey of drug-resistant tuberculosis in China. N Engl J Med. 2012; 366(23): 2161–70. Tables Table 1 Demographic data and maternal history No. gender GA (wk) BW (g) tpye of newborn maternal age (yr) TB history before pregnancy symptoms during pregnancy maternal diagnosis time maternal TB type TB treatment during pregnancy pregnancy complications GP delivery mode PROM >18h breast feeding 1 male 35 1800 SGA 33 no yes after delivery military, genital no none G3P3 SVD unkown no 2 male 35 2400 AGA 27 no yes after delivery military no none G2P2 SVD no no 3 female term 2300 SGA 32 no yes during pregnancy pleurisy no none G2P2 SVD no no 4 female 33 +2 2100 AGA 29 yes no after suspicion of TB for the infant genital no GDM G1P1 C/S no no 5 female 37 2600 AGA 30 no no after suspicion of TB for the infant infiltrative, pleurisy no none G3P2 C/S no yes 6 male 36 + 2500 AGA 30 no yes after delivery military no none G3P1 SVD no no 7 female term 3350 AGA 35 no yes after delivery military no none G1P1 SVD no yes 8 male 34 +5 2250 AGA 27 no yes after delivery military no none G1P1 SVD no no 9 male 38 +3 2570 SGA 21 no yes after delivery military, pleurisy no none G1P1 SVD no no 10 female 37 +2 3300 AGA 42 yes yes after delivery pleurisy, genital no none G1P1 C/S no no GDM: Gestational Diabetes Mellitus; IVF: in-vitro fertilization; SVD: Spontaneous Vaginal Delivery; C/S: Cesarean Section Table 2 Patient history No. onset age (DOL) Symptoms BCG vaccination 1 40 fever; cough; seizur; failure to thrive; no 2 15 fever; tachypnea; seizure; failure to thrive unkown 3 32 fever; cough; failure to thrive no 4 25 fever no 5 13 fever; cough; seizure yes 6 31 fever; cough; anemia; failure to thrive yes 7 53 fever; seizure yes 8 28 fever; tachypnea; vomit; failure to thrive no 9 18 fever; cough; tachypnea; failure to thrive yes 10 1 fever no Table 3 General Laboratory Findings No. WBC (×10^9/L) Neutrophil (%) Hb (g/L) Platelet (×10^9/L) CRP (mg/L) ALT (U/L) HIV CSF hearing screen fundus examination 1 18.85 70.3 99 138 36 50 unknown normal not done not done 2 19.75 83.8 77 200 104 8.9 unknown pro↑ not done not done 3 21.78 64.8 87 217 65.3 105 unknown normal not done normal 4 22.8 60.5 73 218 58.6 110.7 unknown normal not done not done 5 17.99 56.2 73 103 116 38.3 neg glu↓ Passed normal 6 31.95 61.9 87 487 87.2 40.1 neg normal passed suspected optic atrophy 7 17.39 81.7 71 87 >160 119.7 neg glu and Cl↓,pro↑, WBC 326,L 72% not done not done 8 19.1 55.5 68 34 77 16.3 neg glu and Cl↓,pro↑, WBC 20, L 100% not done not done 9 32.44 78.7 93 106 163 41.3 neg glu and Cl↓ not done not done 10 12.49 62.9 70 20 96 57 neg normal Passed retinitis WBC: white blood cell; N: neutrophils; Hb: haemoglobin; PLT: platelet; CRP: C-reactive protein; glu: glucose; Cl: chlorine; pro: protein; L: lymphocytes Table 4 Imaging Findings No. chest CT abdominal ultrasonography brain MRI/CT 1 multiple pulmonary nodules; bronchopneumonia; mediastinal adenopathy hypoecho nodules in liver and spleen not completed 2 multiple pulmonary nodules normal not completed 3 multiple pulmonary nodules normal normal 4 multiple pulmonary nodules; bronchopneumonia normal normal 5 multiple pulmonary nodules hypoecho nodules in liver and spleen normal 6 multiple pulmonary nodules; mediastinal adenopathy normal not completed 7 multiple pulmonary nodules; mediastinal adenopathy hypoecho nodules in liver and spleen cerebral infarction; hydrocephalus; encephalomalacia; encephalatrophy 8 multiple pulmonary nodules normal normal 9 multiple pulmonary nodules normal normal 10 multiple pulmonary nodules; mediastinal adenopathy hypoecho nodules in liver and spleen normal CT: computed tomography; MRI: magnetic resonance imaging Table 5 TB-Specific Tests No. TST AFB smear culture gene Xpert T-spot 1 Neg gastric fluid/ tracheal aspirates neg not completed not done 2 Neg gastric fluid neg not completed pos 3 neg neg neg not completed neg 4 not completed neg neg not completed pos 5 neg neg neg not completed pos 6 not completed neg gastric fluid broncoalveolar lavage fluid: pos for TB; neg for Rifampicin resistance neg 7 pos gastric fluid gastric fluid CSF and gastric fluid: pos for TB; neg for Rifampicin resistance pos 8 pos neg neg Neg pos 9 neg gastric fluid/ tracheal aspirates neg tracheal aspirates: pos for TB; neg for Rifampicin resistance pos 10 not completed gastric fluid/ tracheal aspirates neg tracheal aspirates: pos for TB; neg for Rifampicin resistance pos TST: tuberculin skin test; AFB: acid-fast bacilli Table 6 Diagnosis and treatment No. Final diagnosis (involved organs) time of suspected DOL time of initiation treatment DOL time between onset and treatment evidence for clinical diagnosis time of TB confirmation DOL drugs and duration side effect resp support other treatment 1 lung; liver; spleen; meningitis? 50 52 12 mother’s history/chest CT/abdominal ultrasonography 54 (gastric fluid AFB) INH 3y RIF 3y none CPAP 2 lung; meningitis 17 19 4 mother’s history/chest CT 23 (gastric fluid AFB) INH unknown RIF unknown PZA unknown corticosteroid 2m none CPAP mannitol; hepatic protector 3 lung 42 42 10 mother’s history/chest CT none INH 1y RIF1y PZA 1y none none hepatic protector 4 lung 45 50 25 mother’s history/chest CT/T-spot 50 (T-spot) INH 1.5y RIF 1.5y LZD 2m none low flow O 2 hepatic protector 5 lung; liver; spleen; meningitis 69 70 57 mother’s history(X-ray)/chest CT 73 (T-spot) INH 6m RIF 6m PZA 6m LZD 6m hepatotoxicity low flow O 2 mannitol; hepatic protector; 6 lung; endobronchical 34 34 3 mother’s history/chest CT 70 (gastric fluid culture) INH1.5y RIF 1.5y PZA 9m LZD 3m none none broncoalveolar lavage once per month for 10 times; hepatic protector 7 lung; liver; spleen; meningitis 56 56 3 mother’s history/chest CT/brain CT/CSF 57 (gastric fluid AFB) INH 14m and cont RIF 14m and cont EMB 14m and cont PZA 3m LZD 4m; Corticosteroid 3m hepatotoxicity CPAP anticonvulsion; mannitol; hepatic protector 8 lung; meningitis 35 35 7 mother’s history/chest X-ray 36 (T-spot) INH 9m and cont RIF 9m and cont PZA 6m LZD 6m; none intubation mannitol; hepatic protector; 9 lung 24 24 6 mother’s history/ chest CT 24 (gastric fluid/tracheal aspirates AFB) INH 6m and cont RIF 6m and cont PZA 6m and cont LZD 6m and cont corticosteroid 1m none intubation hepatic protector 10 lung; liver; spleen; 4 4 3 mother’s history/chest CT 5 (T-spot) INH 2m D/C for severe hepatotoxicity RIF 2m D/C for severe hepatotoxicity PZA 2m D/C for severe hepatotoxicity LZD 2m D/C for severe hepatotoxicity hepatotoxicity; thrombocytopenia? none hepatic protector; INH: Isoniazid; RIF: Rifampin; PZA: Pyrazinamide; LZD: Linezolid; EMB: Ethambutol; D/C: discontinued Table 7 Outcome and follow up No. fever clearance time d Total hospital stay (d) outcome The latest F/U age General Growth CNS long term outcome 1 unknown 4 recovered 9y normal cognitive delayed 2 4 11 lost none unknown unknown 3 6 9 recovered 4y failure to thrive normal 4 12 20 recovered 3y normal normal 5 7 47 recovered 2y normal normal 6 5 17 recovered 2y normal language delayed 7 49 51 improved 1y2m failure to thrive developmental delayed 8 8 8 improved 9m normal normal 9 3 25 improved 6m failure to thrive normal 10 28 41 improved 3m failure to thrive normal Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4222","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research article","associatedPublications":[],"authors":[{"id":139113,"identity":"e08f4636-ea65-4b95-b8d2-fb27eefc5902","order_by":1,"name":"Juan Du","email":"","orcid":"https://orcid.org/0000-0001-7751-6994","institution":"Beijing Children's Hospital, Capital Medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Juan","middleName":"","lastName":"Du","suffix":""},{"id":139114,"identity":"2f664784-fac5-4802-8d02-67358fe7b739","order_by":2,"name":"Shixiao Dong","email":"","orcid":"","institution":"Beijing Children's Hospital, Capital Medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Shixiao","middleName":"","lastName":"Dong","suffix":""},{"id":139115,"identity":"f0b8819d-d2e3-4245-ba32-e3bc8813d78c","order_by":3,"name":"Shengnan Jia","email":"","orcid":"","institution":"Beijing Children's Hospital, Captial Medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Shengnan","middleName":"","lastName":"Jia","suffix":""},{"id":139116,"identity":"0ef42a20-e06a-4f8c-970a-d4a2af6e3203","order_by":4,"name":"Qiaoru Zhang","email":"","orcid":"","institution":"Beijing Children's Hospital, Capital Medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Qiaoru","middleName":"","lastName":"Zhang","suffix":""},{"id":139117,"identity":"d3a72af7-96eb-4953-8b1c-aae831c4cb9e","order_by":5,"name":"Mingyan Hei","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA2ElEQVRIiWNgGAWjYBACAwbGBoYEMJP5GIhNkha2NGK1wAGPGXFazNmbWzc83FGb2D+759uDnzsY5PnFDjB+LsCjxbLnYNuNxDPHE2fcObvdsPcMg+HM2QnM0jPwOexGIlBL27HEhhu526QZ2xgSDG4nsDHz4NNy/yFEy/wbOc+I1HKDEaSlJnHDjRw2IrWcATvsgPHGG2nmhr1tEkC/JDZL49Vy/Pizmz/b6mTn3Uh+9uBnm408v3Tywc/4tEDBYccGCEMCiImKHYY6e2JUjYJRMApGwQgFACOIVXMse9dqAAAAAElFTkSuQmCC","orcid":"","institution":"","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Mingyan","middleName":"","lastName":"Hei","suffix":""}],"badges":[],"createdAt":"2019-08-21 13:45:51","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.2.13513/v1","doiUrl":"https://doi.org/10.21203/rs.2.13513/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":585214,"identity":"69570a2b-37f2-4027-8e51-9c10573f2be7","added_by":"auto","created_at":"2020-03-03 15:40:16","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":336381,"visible":true,"origin":"","legend":"Imaging Findings: (A) No.1 Chest CT; (B) No.2 Chest X-ray; (C) No.3 Chest CT; (D) No.5 Chest CT; (E) No.6 Chest CT; (F) No.7 Chest X-ray; (G) No.7 Brain CT; (H) No.8 Chest CT; (I) No.9 Chest CT; (J) No.10 Chest CT","description":"","filename":"Fig1.png","url":"https://assets-eu.researchsquare.com/files/rs-4222/v1/Fig 1.png"},{"id":13470885,"identity":"a340f69c-fa5e-4f7a-b03c-ae5b6e0bfe23","added_by":"auto","created_at":"2021-09-16 21:07:14","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":630932,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4222/v1/f1851fde-eb13-4f69-ba5c-b49acf96b32f.pdf"}],"financialInterests":"","formattedTitle":"Clinical characteristics and post-discharge follow-up analysis of 10 cases of congenital tuberculosis: a retrospective observational study","fulltext":[{"header":"Background","content":"\u003cp\u003eTuberculosis (TB) is caused by \u003cem\u003eMycobacterium\u003c/em\u003e \u003cem\u003etuberculosis\u003c/em\u003e (Mtb). Despite advances in therapeutic and diagnostic techniques, TB continues to be a major infectious cause of morbidity and mortality worldwide, especially in developing countries [1]. Congenital TB infection by vertical transmission from infected mothers is rare, but carries a poor prognosis. The mortality rate for congenital TB is 21.7%–100%, with a higher mortality associated with delayed, or inappropriate treatment [2]. Furthermore, diagnosis in neonates is challenging because of non-specific manifestations.\u003c/p\u003e\n\u003cp\u003eThe outcome of infants with congenital TB who have been promptly treated is of great interest for clinicians. In this study, we present 10 patients with congenital TB that were admitted to Beijing Children’s Hospital, Capital Medical University in China. Moreover, this study had access to the follow-up information of each patient after discharge. To the best of our knowledge, this is the first study analyzing cases of congenital TB with the follow-up data.\u003c/p\u003e\u003cul\u003e"},{"header":"Methods","content":"\u003ch1\u003e2.1 Patients and study design\u003c/h1\u003e\n\u003cp\u003eThis was a retrospective observational study based on the in-patient electronic records of patients admitted to Beijing Children’s Hospital between 2009 and 2018. All patients were confirmed with a first diagnosis of congenital TB. They were treated and followed up in Beijing Children’s Hospital.\u003c/p\u003e\n\u003ch1 data-xsweet-outline-level=\"0\"\u003e2.2 Diagnostic criteria\u003c/h1\u003e\n\u003cp\u003eCongenital TB was diagnosed according to the criteria revised by Cantwell \u003cem\u003eet al [\u003c/em\u003e3]. Cantwell \u003cem\u003eet al.\u003c/em\u003e proposed that in order for an infant to be diagnosed with congenital TB, the infant must have proven tuberculous disease and at least one of the following: 1) lesions in the first week of life, 2) a primary hepatic complex or caseating hepatic granulomas, 3) tuberculous infection of the placenta or the maternal genital tract, and 4) exclusion of the possibility of postnatal transmission by thorough investigation of contacts.\u003c/p\u003e\n\u003ch1 data-xsweet-outline-level=\"0\"\u003e2.3 Statistical analysis\u003c/h1\u003e\n\u003cp\u003eCategorical data are presented as numbers (%) and continuous data as the mean and standard deviation for normal distribution data or median and percentiles for non-normal distribution data. SPSS, version 15.0 (SPSS Inc., Chicago, IL, U.S.) was used for all statistical analyses.\u003c/p\u003e"},{"header":"Results","content":"\u003ch1\u003e3.1 Demographic data and maternal history\u003c/h1\u003e\n\u003cp\u003eA total of 10 congenital TB patients were enrolled in this study from 2009 to 2018, with a male:female gender ratio of 1:1.5. Further, five (50%) of these patients were preterm. Gestational age was 35.8 (± 1.7) week. The average birth weight was 2517 (± 487) g. Two (20%) of the patients were small for gestational aged infants.\u003c/p\u003e\n\u003cp\u003eThere were two (20%) mothers that were diagnosed with TB, but were considered to have fully recovered prior to pregnancy. These women received \u003cem\u003ein vitro\u003c/em\u003e fertilization (IVF) to become pregnant. TB symptoms were reported to have reoccurred during their pregnancy; however, no anti-TB treatment was given. A total of eight out of ten (80%) mothers presented with TB symptoms during pregnancy or immediately after delivery, of which only one out of the eight symptomatic mothers was diagnosed with TB during pregnancy. However, this mother was not treated, which was against all medical suggestions. Two out of ten (20%) mothers were completely asymptomatic and were not diagnosed with tuberculosis until their children were suspected of TB infection based on imaging results. Thus, 90% of the mothers were diagnosed postpartum and not one of the ten mothers received anti-TB treatment during pregnancy. Most mothers were diagnosed with miliary TB by chest radiography, and only three out of ten (30%) of the mothers were confirmed to have genital TB.\u003c/p\u003e\n\u003ch1 data-xsweet-outline-level=\"0\"\u003e3.2 Clinical manifestations\u003c/h1\u003e\n\u003ch2\u003e3.2.1 Patient history\u003c/h2\u003e\u003cp\u003eThe average onset day of life for congenital TB (DOL) was 25.6 (± 17.8) days with a range of 1—53 days. The most frequent clinical features were fever (100%), failure to thrive (60%), and cough (50%). Four out of nine (44%) infants received a BCG (Bacillus Calmette-Guérin) vaccination before diagnosis.\u003c/p\u003e\n\u003ch2\u003e3.2.2 General laboratory findings\u003c/h2\u003e\n\u003cp\u003eCommon laboratory findings of each patient were analyzed. The white blood cell counts of all patients were elevated, ranging from 12.49 to 32.44 × 10^9 cells/L (an average of 21.45 (± 6.30) × 10^9 cells/L), with neutrophils being the predominant (100%) cell type. The C-reactive protein (CRP) levels of all the patients were elevated to 36—163 mg/L (96.3 ± 41.4) mg/L. Nine out of ten (90%) infants and seven out of ten (70%) infants had disease complicated with anemia and hepatic dysfunction, respectively. Half of the patients were complicated with thrombocytopenia. The cerebrospinal fluid of half of the patients was abnormal, with elevated levels of lymphocytes and protein and reduced levels of glucose and chlorine.\u003c/p\u003e\n\u003ch2\u003e3.2.3 Imaging findings\u003c/h2\u003e\n\u003cp\u003eChest computed tomography (CT) scans were completed for all patients, which demonstrated pulmonary nodules in ten (100%) patients and mediastinal adenopathy in four (40%) patients. Abdominal ultrasonography (US) showed hypoechoic nodules in the liver and spleen in four (40%) patients. The MRI analysis from one patient demonstrated severe brain damage with cerebral infarction, hydrocephalus, encephalomalacia, and encephalatrophy.\u003c/p\u003e\n\u003ch2\u003e3.2.4 TB-specific tests\u003c/h2\u003e\n\u003cp\u003eThe positive rate of GeneXpert and T-spot were relatively high, with 4/5 (80%) and 7/9 (78%) positive rates, respectively. Further, 5/10 (50%) and 2/7 (29%) cases were positive for acid-fast bacilli (AFB) smear and tuberculin skin test, respectively. Samples of blood, cerebrospinal fluid, tracheal aspirates, gastric fluid, urine, and stool were cultured; however, only two (20%) cases were positive. The sample with the highest positivity rate of TB was gastric fluid followed by tracheal aspirates.\u003c/p\u003e\n\u003ch1 data-xsweet-outline-level=\"0\"\u003e3.3 Diagnosis and treatment\u003c/h1\u003e\n\u003cp\u003eLung tissue was involved in the disease in all patients. Two patients required mechanical ventilation at admission and were extubated 4 and 7 days later, respectively. Seven out of ten (70%) patients had multi-organ lesions. Anti-TB treatment was started as soon as congenital TB was confirmed in one patient and clinically diagnosed in the other nine patients, based on proven maternal TB history and typical radiological findings (chest CT/abdominal ultrasonography) while TB was identified later for eight out of the nine patients. TB was not identified in one patient (patient number 3), who was diagnosed with congenital TB based on proven maternal TB history, typical chest CT findings, and efficacy of anti-TB treatment. The remaining nine patients met the criteria of Cantwell \u003cem\u003eet al.\u003c/em\u003e AFB and T-spot analysis offered evidence for TB infection in 4/9 (44%) cases. The time between the development of symptoms and the initiation of treatment varied from 3 to 57 days, with a median time of 6.5 (3.0, 15.2) days. All of the patients received a treatment regimen consisting of isoniazid (INH), rifampicin (RIF), and pyrazinamide (PZA); however, PZA was halted in two cases because of elevated alanine aminotransferase (ALT) levels. The daily dosage of anti-TB drugs used adhered to the Chinese National Formulary of Chemicals and Biological Products for Children. Corticosteroid was added to the regime for three patients, two of which had TB infection complicated with meningitis. Linezolid (LZD) was administrated as a supplementary drug for seven (70%) patients at a dosage of 10 mg/kg/dose, q12h (twice daily) to q8h (three times daily) for two to six months. The total duration for anti-TB treatment varied from two months to three years. The adverse effects were evaluated. Three (30%) patients experienced side effects, such as hepatotoxicity, from the drugs. The treatment for patients number 5 and number 10 was discontinued at six months and two months, respectively, due to severe hepatotoxicity. One patient presented thrombocytopenia during LZD treatment but recovered spontaneously without LZD withdrawal.\u003c/p\u003e\n\u003ch1 data-xsweet-outline-level=\"0\"\u003e3.4 Outcome and follow-up\u003c/h1\u003e\n\u003cp\u003eThe survival rate was 100% at hospital discharge, with an improved health condition for all patients. The average hospital stay duration was 23.3 (± 17.2) days. Time of fever clearance ranged from 3–49 days, with a median time of 7.0 (4.5, 20.0) days. Treatment with anti-TB drugs was continued as an outpatient procedure for all the patients. The follow up rate was 90%. There were five (56%) patients that fully recovered, of whom consecutive chest radiographs showed gradual resolution. Four (44%) patients were still under treatment, four (44%) patients failed to thrive, and three (33%) patients had TB infection complicated with neurological sequelae. Only 3/9 (33%) patients thrived and achieved normal developmental milestones.\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eCongenital TB is defined as infection that develops as a result of an encounter between a TB-infected mother and her infant during the intrauterine period or during birth. Maternal TB can be transmitted to the fetus either transplacental or through the aspiration of infected amniotic fluid [3]. To our best knowledge, our study is the first that includes the complete clinical information of 10 congenital TB infants in China, including treatment and follow-up information. Our study provides valuable insights into congenital TB infection.\u003c/p\u003e\n\u003cp\u003eSince female genital tuberculosis and tuberculous endometritis are associated with infertility, congenital TB is rare. Our data showed that 20% of the mothers were diagnosed with TB before pregnancy and received IVF. This suggests that the increasing availability of assisted reproductive technologies has a potential to increase the prevalence of congenital TB [4].\u003c/p\u003e\n\u003cp\u003eThe mothers who transmit TB infection to their fetus during pregnancy are difficult to diagnose. A delay between the onset of symptoms and diagnosis occurs frequently, due to the non-specific symptoms at presentation, reluctance to perform radiography, and low index of suspicion [5]. It was not surprising that the diagnosis of some maternal TB cases was made only after the infants’ exhibited symptoms of TB and were subsequently diagnosed. One study reviewed 170 cases of congenital TB and reported that 121 (71%) mothers were diagnosed at postpartum, of which 39 cases were completely asymptomatic [2]. In our study, 70% of the mothers were diagnosed after delivery, among which two mothers were individually diagnosed by chest X-ray and T-Spot test after their babies were suspected for congenital TB. Thus, according to our study, if there is a strong suspicion of TB in the infant and the mother is not currently diagnosed with TB, then they should both be tested.\u003c/p\u003e\n\u003cp\u003eAccording to WHO guidelines for BCG vaccination, a single dose of the BCG vaccine should be given to all healthy infants as close to the time of birth as possible [6]. However in our study, five out of ten patients had not received BCG when they were admitted to the hospital. One explanation is that the BCG vaccination is not given to preterm newborns, according to Chinese national protocol. Patients 1, 4, and 8 were preterm newborns that did not receive the BCG vaccine immediately after birth. Patient 10 presented with symptoms of TB on DOL 1, and as such, the BCG vaccination was delayed due to the uncertain TB status. The mother of patient 3 was diagnosed with TB during pregnancy, and as a result, the BCG vaccination was held for the newborn.\u003c/p\u003e\n\u003cp\u003eThe symptoms of postnatal TB infection are usually exhibited 4 to 8 weeks after infection [7]. Therefore, the symptoms of congenial TB could theoretically be present within two months after birth. However, Cantwell \u003cem\u003eet al.\u003c/em\u003e analyzed 29 patients with congenital TB and reported that the onset age of TB ranged from 1 to 84 days; whereas Sonal \u003cem\u003eet al.\u003c/em\u003e reviewed 21 congenital TB cases and reported the onset age as 1 to 90 days [3, 8]. Congenital TB symptoms commonly present in the first 2 to 3 weeks of life [2]. In our study, the onset age varied from 1 to 50 days. Clinical manifestations of congenital TB can be diverse, nonspecific, and difficult to differentiate from neonatal bacterial or viral sepsis. In our study, fever was the most frequent symptom. Nonspecific markers found in patients with congenital TB included neutrophilia, thrombocytopenia, and elevated CRP levels [2]. In our study, all of the patients presented with neutrophilia and elevated levels of CRP. Moreover, 70% of the patients with congenital TB had complications with thrombocytopenia.\u003c/p\u003e\n\u003cp\u003eThe imaging results of our study showed that (1) the most frequent patterns of chest CT scans were multiple pulmonary nodules and mediastinal adenopathy, and (2) abdominal US showed hypoechoic nodules in the liver and spleen in 40% of the patients. Liver and spleen nodules were similarly found in adult TB patients, but the lung TB nodule features are quite different from other lung diseases and could lead to the suspicion of congenital TB when analyzed by an experienced radiologist or TB specialist. Recently, multiple pulmonary nodules have been described as a new radiographical finding in some published studies [9]. Multiple pulmonary nodules on chest CT scans were considered as the progressive deterioration of miliary tuberculosis, consistent with caseating necrosis in a biopsy specimen [10]. Several pediatric TB specialists and radiologists in China reported that both patterns of military TB and pulmonary nodules were specific image characteristics of congenital TB [11, 12]. TB-specific investigations should be performed when there are suspicions of TB based on imaging results.\u003c/p\u003e\n\u003cp\u003eThe confirmation of TB infection is often challenging in newborns because markers specific to TB have poor sensitivity. For neonates, serial gastric fluid appears to be the most common specimen for TB pathogen identification. Lower sensitivity and a longer time before confirmation of culture-positive results frequently occurs in children because of decreased bacterial loads. In our study, the positive rate of AFB smear was 50% with the results available within 24 hours. Furthermore, only 20% of the cases showed a positive culture result by 13.5 to 16 days. Because of the limitation of the laboratory environment, our hospital was unable to perform drug susceptibility testing for TB. The GeneXpert assay is a hemi-nested real-time PCR test that simultaneously identifies Mtb/RIF resistance. Its diagnostic accuracy is comparable to culture in sputum samples and provides results within 24 to 48 hours [13]. The WHO recommends GeneXpert for rapid diagnosis in communities with a high burden of TB [13]. Our study results showed that GeneXpert is the most sensitive test, with an 80% positive rate. Furthermore, the result could be obtained within 24 hours. The tuberculin \u003ca href=\"javascript:;\"\u003eskin\u003c/a\u003e \u003ca href=\"javascript:;\"\u003etest\u003c/a\u003e is mostly negative in newborns since the test takes at least four weeks to be positive. In our study, two cases showed a positive \u003ca href=\"javascript:;\"\u003etuberculin\u003c/a\u003e \u003ca href=\"javascript:;\"\u003eskin\u003c/a\u003e \u003ca href=\"javascript:;\"\u003etest\u003c/a\u003e result at two to three months of age. Currently, there are two types of commercially available IFN-γ release assays-the QuantiFeron TB Gold (Cellestis) and T-Spot TB (Oxford Immunotec) [14]. The latter is an enzyme-linked immunospot (ELISPOT) assay used in our hospital. Though there are concerns about the applicability of these assays to newborns due to the decreased IFN-γ production in newborns, in our study the T-Spot assay demonstrated a relatively high sensitivity and was one of the best results for initial evidence of TB in our cases.\u003c/p\u003e\n\u003cp\u003eCompared to the previous congenital TB case report [3], our patients demonstrated a much better outcome with a 100% survival rate. Based on literature analysis, we theorize that the better outcomes in our study were a result of the new clinical diagnosis criteria for congenial TB and the introduction of LZD in the treatment regimen during the intensive phase of anti-TB treatment.\u003c/p\u003e\n\u003cp\u003eIt is understandable that maternal history and typical imaging findings might be the only basis for diagnosis of congenital TB. The clinical diagnosis criteria of congenital TB in our center was: (1) if an infant has fever, respiratory distress, hepatosplenomegaly, or other nonspecific symptoms within two months after birth, (2) if the infant’s mother was diagnosed with active TB infection perinatally, and (3) if the infant’s imaging showed miliary tuberculosis or multiple pulmonary nodules in chest CT scans or multiple focal lesions in the liver/spleen by abdominal US. Infants that meet the criteria were put into isolation, further TB investigation was started, and anti-TB treatments were initiated. This might partially explain the fairly good prognosis of the ten congenital TB patients in our study.\u003c/p\u003e\n\u003cp\u003eThe standard regimen for congenital TB includes INH, RIF, PZA, and ethambutol during the intensive phase for two months, followed by INH and RIF for seven to ten months during the continuation phase. Chest X-rays at the end of treatment is recommended [8, 15].\u003c/p\u003e\n\u003cp\u003eLinezolid (LZD) is a member of the oxazolidinone class of antibiotics, which exhibits bacteriostatic activity against Mtb, including multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB strains [16]. Clinical trials in adults have revealed that LZD is an important component for the treatment of MDR and XDR TB [17, 18]. As a newer anti-Gram positive antibiotic, LZD has excellent penetration to the central nervous system. Furthermore, published studies support its effectiveness and safety in treating infections caused by resistant pathogens, including staphylococcal bacteremias and cerebrospinal fluid infections, for term and preterm newborns in neonatal intensive care units [19, 20]. Li \u003cem\u003eet al.\u003c/em\u003e reported clinical data, which demonstrated that LZD improved the early outcomes of childhood TB meningitis for 36 cases [21]. Since China has a serious epidemic of drug-resistant TB [22] and the immune system of neonates is not fully developed, our center has used LZD as a supplementary drug for congenital TB patients since 2015. In our study, LZD was administrated to seven patients, ranging in age from 4 to 70 days, for a duration of 2 to 6 months. This is most likely the first report of the long-term use of LZD for neonatal and infant congenital TB. The adverse events and side effects of LZD in our patients were monitored and evaluated by clinical symptoms, periodical whole blood counts, and serum liver/renal function analysis every one or two weeks. One patient presented with thrombocytopenia while receiving LZD, but recovered spontaneously without LZD withdrawal. Another two patients presented with hepatotoxicity during the intensive phase of treatment with INH, RIF, PZA, and LZD. However, it is difficult to differentiate the side effects induced by each drug. The low frequency of LZD-associated adverse side effects highlights the promising prospects of its use for the treatment of congenital TB. A LZD regimen during the intensive phase of anti-TB treatment might contribute to the improvement of outcomes of congenital TB.\u003c/p\u003e\n\u003cp\u003eIt was reported that the overall mortality for infants with congenital TB is 100% if undiagnosed, and delayed infant diagnosis carries a 5-fold higher mortality rate in comparison with prompt diagnosis and treatment [2]. In our study, responses to anti-TB drugs were good in all patients who finished the treatment, with chest X-rays revealing no infection at the end of treatment. However, only 33% of the patients in our study are currently thriving and have achieved normal developmental milestones.\u003c/p\u003e\n\u003cp\u003eThis study has several limitations. First, this retrospective study was conducted in a single medical center, which makes applying the study results to the general population difficult. Second, the sample size was too small to demonstrate the effectiveness of new clinical diagnosis criteria and Linezolid in reducing the mortality of congenital TB. This issue may require further cooperation from multiple centers in the future for a comprehensive study. Furthermore, the clinical decisions of LZD administration was made according to the experience from neonatologists and TB specialists, which may result in practice variability. A clinical guide for the standard treatment of congenital TB is urgently needed.\u003c/p\u003e\n\u003cp\u003eIn summary, congenital TB is a potentially fatal disease, but with a high index of suspicion and aggressive management, it can have a good outcome. Early diagnosis based on maternal history, typical imaging findings, and timely treatments are crucial. Multi-drug anti-TB treatment, including LZD, is safe and might be effective for infants and reduces mortality.\u003c/p\u003e"},{"header":"List of abbreviations","content":"\u003cp\u003eTB - Tuberculosis\u003c/p\u003e\n\u003cp\u003eMtb - Mycobacterium tuberculosis\u003c/p\u003e\n\u003cp\u003eBW - birth weight\u003c/p\u003e\n\u003cp\u003eIVF - in-vitro fertilization\u003c/p\u003e\n\u003cp\u003eDOL - day of life\u003c/p\u003e\n\u003cp\u003eWBC - white blood cell\u003c/p\u003e\n\u003cp\u003eCRP - C-reactive protein\u003c/p\u003e\n\u003cp\u003eCSF - cerebrospinal fluids\u003c/p\u003e\n\u003cp\u003eCT - computed tomography\u003c/p\u003e\n\u003cp\u003eAFB - acid-fast bacilli\u003c/p\u003e\n\u003cp\u003eINH - isoniazid\u003c/p\u003e\n\u003cp\u003eRIF - rifampicin\u003c/p\u003e\n\u003cp\u003ePZA - pyrazinamide\u003c/p\u003e\n\u003cp\u003eLZD - Linezolid\u003c/p\u003e\n\u003cp\u003eUS - ultrasonography\u003c/p\u003e\n\u003cp\u003eMDR - multidrug-resistant\u003c/p\u003e\n\u003cp\u003eXDR - extensively drug-resistant\u003c/p\u003e"},{"header":"Declarations","content":"\u003ch1\u003eEthics approval and consent to participate\u003c/h1\u003e\n\u003cp\u003eAll patient information regarding diagnosis/differential diagnosis and treatment were stated as written consents and signed by the infants’ parents/legal guardians. Data in this study were de-identified after data collection. The protocols applied in this study were approved by the Ethics Committee of Beijing Children’s Hospital. The approval number is 2018-k–124.\u003c/p\u003e\n\u003ch1\u003eConsent for publication\u003c/h1\u003e\u003cp\u003eThe patients’ parents have given their written consent to publishing patients’ clinical details and/or clinical images.\u003c/p\u003e\n\u003ch1\u003eAvailability of data and material\u003c/h1\u003e\u003cp\u003eThe datasets used and analysed during the current study are available from the authors on reasonable request.\u003c/p\u003e\n\u003ch1\u003eCompeting interests\u003c/h1\u003e\u003cp\u003eThe authors declare that they have no competing interests.\u003c/p\u003e\n\u003ch1\u003eFunding\u003c/h1\u003e\u003cp\u003eThis study was supported by Canada Institutes of Health Research (CIHR). NICU Team of Maternal \u0026amp; Infant Care Program (Grant number: CTP87518)\u003c/p\u003e\n\u003ch1\u003eAuthors’ Contributions\u003c/h1\u003e\u003cp\u003eDr. Du, Dr. Jia and Dr. Zhang reviewed patients’ files, collected the data, carried out the analyses, drafted the initial manuscript, and reviewed and revised the manuscript.\u003c/p\u003e\n\u003cp\u003eDr. Hei and Dr. Dong designed the study, supervised the cases review and critically reviewed the manuscript for important intellectual conten.\u003c/p\u003e\n\u003cp\u003eAll authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.\u003c/p\u003e\n\u003ch1\u003eAcknowledgements\u003c/h1\u003e\u003cp\u003eNot applicable\u003c/p\u003e\n\u003ch1\u003eAuthor details\u003c/h1\u003e\u003cp\u003eJuan Du Email: \u003ca href=\"mailto:[email protected]\"\u003e\u003ca href=\"http://[email protected]\"\[email protected]\u003c/a\u003e\u003c/a\u003e\u003c/p\u003e\n\u003cp\u003eShixiao Dong Email: \u003ca href=\"mailto:[email protected]\"\u003e\u003ca href=\"http://[email protected]\"\[email protected]\u003c/a\u003e\u003c/a\u003e\u003c/p\u003e\n\u003cp\u003eShengnan Jia Email: \u003ca href=\"mailto:[email protected]\"\u003e\u003ca href=\"http://[email protected]\"\[email protected]\u003c/a\u003e\u003c/a\u003e\u003c/p\u003e\n\u003cp\u003eQiaoru Zhang Email: \u003ca href=\"http://[email protected]\"\[email protected]\u003c/a\u003e\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003eGlobal tuberculosis report 2017. Geneva: World Health Organization; 2017. Licence: CC BY-NCSA 3.0 IGO\u003c/li\u003e\u003cli\u003ePeng W, Yang J, Liu E. Analysis of 170 cases of congenital TB reported in the literature between 1946 and 2009. Pediatr Pulmonol. 2011;46:1215–24.\u003c/li\u003e\u003cli\u003eCantwell MF, Shehab ZM, Costello AM, Sands L, Green WF, Ewing EP Jr, Valway SE, Onorato IM. Congenital tuberculosis. N Engl J Med. 1994;330:1051–4.\u003c/li\u003e\u003cli\u003eFlibotte JJ, Lee GE, Buser GL, Feja KN, Kreiswirth BN, McSherry GD, Nolan SM, Tolan RW Jr, Zhang H. Infertility, in vitro fertilization and congenital tuberculosis. J Perinatol. 2013;33(7):565–8.\u003c/li\u003e\u003cli\u003eOrmerod P. Tuberculosis in pregnancy and the puerperium. Thorax. 2001;56(6): 494–9.\u003c/li\u003e\u003cli\u003eWorld Health Organization. BCG vaccines: WHO position paper. Vaccine. 2018;36(24):3408–10. \u003c/li\u003e\u003cli\u003eLamb GS, Starke JR. Tuberculosis in infants and children. Microbiol Spectr. 2017;5(2): TNMI7–0037–2016.\u003c/li\u003e\u003cli\u003ePatel S, Hermes DeSantis ER. Treatment of congenital tuberculosis. Am J Health Syst Pharm. 2008;65(21):2027–31.\u003c/li\u003e\u003cli\u003ePerez-Velez CM, Marais BJ. Tuberculosis in children. N Engl J Med. 2012;367:348–61.\u003c/li\u003e\u003cli\u003eChen A, Shih SL. Congenital tuberculosis in two infants. AJR Am J Roentgenol.2004;182(1):253–6.\u003c/li\u003e\u003cli\u003eWang X, Xu F, Huang Q, Mei H, Xu C, Chen X. Clinical and Imaging Features of congenital Tuberculosis．J Med Res. 2014; 43(2):127–30.\u003c/li\u003e\u003cli\u003eWang Y, Zhao S, Peng Y, Hong T, Yin J, Wang W. Clinical and Imaging Features of congenital Tuberculosis．Chin J Radio. 2016;50(12):981–2.\u003c/li\u003e\u003cli\u003eWorld Health Organization. Guidance for national tuberculosis programmes on the management of tuberculosis in children. 2nd edition; 2014.\u003c/li\u003e\u003cli\u003eAndersen P, Munk ME, Pollock JM, Doherty TM. Specific immune-based diagnosis of tuberculosis. Lancet. 2000;356(9235):1099–104.\u003c/li\u003e\u003cli\u003eSkevaki CL, Kafetzix DA. Tuberculosis in neonates and infants: epidemiology, pathogenesis, clinical manifestations, diagnosis, and management issues. Paediatr Drugs. 2005;7(4):219–34.\u003c/li\u003e\u003cli\u003eAlcalá L, Ruiz-Serrano MJ, Pérez-Fernández Turégano C, García De Viedma D, Díaz-Infantes M, Marín-Arriaza M, Bouza E. In vitro activities of linezolid against clinical isolates of Mycobacterium tuberculosis that are susceptible or resistant to first-line antituberculous drugs. Antimicrob Agents Chemother. 2003;47(1):416–7.\u003c/li\u003e\u003cli\u003eSchecter GF, Scott C, True L, Raftery A, Flood J, Mase S. Linezolid in the treatment of multidrug-resistant tuberculosis. Clin Infect Dis. 2010;50(1):49–55.\u003c/li\u003e\u003cli\u003eZhang L, Pang Y, Yu X, Wang Y, Gao M, Huang H, Zhao Y. Linezolid in the treatment of extensively drug-resistant tuberculosis. Infection. 2014;42(4):705–11.\u003c/li\u003e\u003cli\u003eDeville JG, Adler S, Azimi PH, Jantausch BA, Morfin MR, Beltran S, Edge-Padbury B, Naberhuis-Stehouwer S, Bruss JB. Linezolid versus vancomycin in the treatment of known or suspected resistant gram-positive infections in neonates. Pediatr Infect Dis J. 2003;22(9 Suppl):S158–63.\u003c/li\u003e\u003cli\u003eLanggartner M, Mutenthaler A, Haiden N, Pollak A, Berger A. Linezolid for treatment of catheter-related cerebrospinal fluid infections in preterm infants. BMJ Case Rep. 2009;2009:bcr11.2008.1217.\u003c/li\u003e\u003cli\u003eLi H, Lu J, Liu J, Zhao Y, Ni X, Zhao S. Linezolid is associated with improved early outcomes of childhood tuberculous meningitis. Pediatr Infect Dis J. 2016;35(6):607–10.\u003c/li\u003e\u003cli\u003eZhao Y, Xu S, Wang L, Chin DP, Wang S, Jiang G, Xia H, Zhou Y, Li Q, Ou X, Pang Y, Song Y, Zhao B, Zhang H, He G, Guo J, Wang Y. National survey of drug-resistant tuberculosis in China. N Engl J Med. 2012; 366(23): 2161–70.\u003c/li\u003e\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp style=\"line-height: 200%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 200%; font-family: verdana, geneva; color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 664.4pt; border-collapse: collapse; margin: 6.75pt -2.25pt 6.75pt -2.25pt;\" width=\"886\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"page-break-inside: avoid; height: 6.6pt;\"\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 6.6pt;\" colspan=\"16\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eTable 1 Demographic data and maternal history\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"page-break-inside: avoid; height: 56.7pt;\"\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eNo.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003egender\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eGA (wk)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eBW (g)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003etpye of newborn\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ematernal age (yr)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eTB history before pregnancy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003esymptoms during pregnancy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ematernal diagnosis time\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ematernal TB type\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eTB treatment during pregnancy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003epregnancy complications\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eGP\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003edelivery mode\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ePROM \u0026gt;18h\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ebreast feeding\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"page-break-inside: avoid; height: 3.2pt;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.2pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.2pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003emale\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.2pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e35\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.2pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e1800\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.2pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eSGA\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.2pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e33\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.2pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.2pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eyes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.2pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; 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font-family: verdana, geneva; color: #000000;\"\u003eG3P3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.2pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eSVD\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.2pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eunkown\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.2pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"page-break-inside: avoid; height: 3.7pt;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; 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font-family: verdana, geneva; color: #000000;\"\u003eGDM\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eG1P1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eC/S\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; 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height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eafter suspicion of TB for the infant\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003einfiltrative, pleurisy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enone\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eG3P2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eC/S\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; 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height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e2500\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eAGA\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e30\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eyes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eafter delivery\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003emilitary\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enone\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eG3P1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eSVD\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"page-break-inside: avoid; height: 3.7pt;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003efemale\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eterm\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e3350\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eAGA\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e35\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eyes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eafter delivery\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003emilitary\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enone\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eG1P1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eSVD\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; 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height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e2250\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eAGA\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e27\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eyes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eafter delivery\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003emilitary\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enone\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eG1P1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eSVD\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"page-break-inside: avoid; height: 3.7pt;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e9\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003emale\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e38\u003csup\u003e+3\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e2570\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eSGA\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e21\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eyes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eafter delivery\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003emilitary, \u0026nbsp;pleurisy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enone\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eG1P1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eSVD\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"page-break-inside: avoid; height: 3.7pt;\"\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e10\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003efemale\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e37\u003csup\u003e+2\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e3300\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eAGA\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e42\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eyes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eyes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eafter delivery\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003epleurisy,\u0026nbsp; genital\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enone\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eG1P1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eC/S\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.7pt;\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"page-break-inside: avoid; height: 28.3pt;\"\u003e\n\u003ctd style=\"border: none; padding: 0in 5.4pt 0in 5.4pt; height: 28.3pt;\" colspan=\"16\"\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eGDM: Gestational Diabetes Mellitus; IVF: in-vitro fertilization; SVD: Spontaneous Vaginal Delivery; C/S: Cesarean Section\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10pt; color: #000000; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 12.0pt; text-autospace: none;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eTable 2 Patient history\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 312.15pt; border-collapse: collapse; margin-left: 6.75pt; margin-right: 6.75pt;\" width=\"416\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 13.7pt;\"\u003e\n\u003ctd style=\"width: 29.35pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.7pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eNo.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.7pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.7pt;\" width=\"92\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eonset age (DOL)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 143.9pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.7pt;\" width=\"192\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eSymptoms\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.2pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 13.7pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eBCG vaccination\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 2.8pt;\"\u003e\n\u003ctd style=\"width: 29.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 2.8pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 2.8pt;\" width=\"92\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e40\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 143.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 2.8pt;\" width=\"192\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003efever; cough; seizur; failure to thrive;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 2.8pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 29.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"92\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e15\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 143.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"192\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003efever; tachypnea; seizure; failure to thrive\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eunkown\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 29.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"92\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e32\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 143.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"192\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003efever; cough; failure to thrive\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 29.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"92\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e25\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 143.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"192\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003efever\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 29.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"92\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e13\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 143.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"192\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003efever; cough; seizure\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eyes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 29.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"92\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e31\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 143.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"192\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003efever; cough; anemia; failure to thrive\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eyes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 29.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"92\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e53\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 143.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"192\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003efever; seizure\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eyes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 29.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"92\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e28\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 143.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"192\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003efever; tachypnea; vomit; failure to thrive\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 29.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e9\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"92\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e18\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 143.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"192\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003efever; cough; tachypnea; failure to thrive\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eyes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 29.35pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e10\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 68.7pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"92\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 143.9pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"192\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003efever\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.2pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eno\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp style=\"text-align: center; text-autospace: none;\"\u003e\u003cspan style=\"color: #000000; font-family: verdana, geneva; font-size: 10pt;\"\u003eTable 3 General Laboratory Findings\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 426.1pt; border-collapse: collapse; margin-left: 6.75pt; margin-right: 6.75pt;\" width=\"568\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 17.15pt;\"\u003e\n\u003ctd style=\"width: 21.85pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.15pt;\" width=\"29\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eNo.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.5pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.15pt;\" width=\"55\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eWBC\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e(\u0026times;10^9/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 43.3pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.15pt;\" width=\"58\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eNeutrophil\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e\u0026nbsp;(%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.35pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.15pt;\" width=\"38\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eHb (g/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.0pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.15pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ePlatelet\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e(\u0026times;10^9/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.15pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eCRP (mg/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 29.55pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.15pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eALT (U/L)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.75pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.15pt;\" width=\"52\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eHIV\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39.15pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.15pt;\" width=\"52\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eCSF\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.3pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.15pt;\" width=\"70\"\u003e\n\u003cp style=\"margin-right: 19.0pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ehearing screen\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 47.9pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.15pt;\" width=\"64\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003efundus examination\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 13.5pt;\"\u003e\n\u003ctd style=\"width: 21.85pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"29\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; 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height: 13.5pt;\" width=\"52\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39.15pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"52\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eglu\u0026darr;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.3pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"70\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ePassed\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 47.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"64\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enormal\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 13.5pt;\"\u003e\n\u003ctd style=\"width: 21.85pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"29\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"55\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e31.95\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 43.3pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"58\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e61.9\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"38\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e87\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e487\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e87.2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 29.55pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e40.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.75pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"52\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39.15pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"52\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enormal\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.3pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"70\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003epassed\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 47.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"64\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003esuspected optic atrophy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 40.5pt;\"\u003e\n\u003ctd style=\"width: 21.85pt; padding: 0in 5.4pt 0in 5.4pt; height: 40.5pt;\" width=\"29\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 40.5pt;\" width=\"55\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e17.39\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 43.3pt; padding: 0in 5.4pt 0in 5.4pt; height: 40.5pt;\" width=\"58\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e81.7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 40.5pt;\" width=\"38\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e71\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 40.5pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e87\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt; height: 40.5pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e\u0026gt;160\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 29.55pt; padding: 0in 5.4pt 0in 5.4pt; height: 40.5pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e119.7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.75pt; padding: 0in 5.4pt 0in 5.4pt; height: 40.5pt;\" width=\"52\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39.15pt; padding: 0in 5.4pt 0in 5.4pt; height: 40.5pt;\" width=\"52\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eglu and Cl\u0026darr;,pro\u0026uarr;,\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eWBC 326,L 72%\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.3pt; padding: 0in 5.4pt 0in 5.4pt; height: 40.5pt;\" width=\"70\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enot done\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 47.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 40.5pt;\" width=\"64\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enot done\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 40.5pt;\"\u003e\n\u003ctd style=\"width: 21.85pt; padding: 0in 5.4pt 0in 5.4pt; height: 40.5pt;\" width=\"29\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 40.5pt;\" width=\"55\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e19.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 43.3pt; padding: 0in 5.4pt 0in 5.4pt; height: 40.5pt;\" width=\"58\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e55.5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 40.5pt;\" width=\"38\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e68\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 40.5pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e34\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt; height: 40.5pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e77\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 29.55pt; padding: 0in 5.4pt 0in 5.4pt; height: 40.5pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e16.3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.75pt; padding: 0in 5.4pt 0in 5.4pt; height: 40.5pt;\" width=\"52\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39.15pt; padding: 0in 5.4pt 0in 5.4pt; height: 40.5pt;\" width=\"52\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eglu and Cl\u0026darr;,pro\u0026uarr;,\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eWBC 20, L 100%\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.3pt; padding: 0in 5.4pt 0in 5.4pt; height: 40.5pt;\" width=\"70\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enot done\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 47.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 40.5pt;\" width=\"64\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enot done\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 13.5pt;\"\u003e\n\u003ctd style=\"width: 21.85pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"29\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e9\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"55\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e32.44\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 43.3pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"58\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e78.7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"38\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e93\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e106\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e163\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 29.55pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e41.3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.75pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"52\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39.15pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"52\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eglu and Cl\u0026darr;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.3pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"70\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enot done\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 47.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"64\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enot done\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 13.5pt;\"\u003e\n\u003ctd style=\"width: 21.85pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"29\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e10\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.5pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"55\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e12.49\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 43.3pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"58\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e62.9\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 28.35pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"38\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e70\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 48.0pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e20\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"47\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e96\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 29.55pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e57\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.75pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"52\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39.15pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"52\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enormal\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.3pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"70\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ePassed\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 47.9pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"64\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eretinitis\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-align: left; text-autospace: none;\"\u003e\u003cspan style=\"color: #000000; font-family: verdana, geneva; font-size: 10pt;\"\u003eWBC: white blood cell; N: neutrophils; Hb: haemoglobin; PLT: platelet; CRP: C-reactive protein; glu: glucose; Cl: chlorine; pro: protein; L: lymphocytes\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left; text-autospace: none;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eTable 4 Imaging Findings\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 416.5pt; border-collapse: collapse; margin-left: 6.75pt; margin-right: 6.75pt;\" width=\"555\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 9.1pt;\"\u003e\n\u003ctd style=\"width: 28.5pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 9.1pt;\" width=\"38\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eNo.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 105.0pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 9.1pt;\" width=\"140\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003echest CT\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 129.75pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 9.1pt;\" width=\"173\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eabdominal ultrasonography\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 153.25pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 9.1pt;\" width=\"204\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ebrain MRI/CT\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 7.15pt;\"\u003e\n\u003ctd style=\"width: 28.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 7.15pt;\" width=\"38\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 105.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 7.15pt;\" width=\"140\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003emultiple pulmonary nodules;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ebronchopneumonia;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003emediastinal adenopathy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 129.75pt; padding: 0in 5.4pt 0in 5.4pt; height: 7.15pt;\" width=\"173\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ehypoecho nodules in liver and spleen\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 153.25pt; padding: 0in 5.4pt 0in 5.4pt; height: 7.15pt;\" width=\"204\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enot completed\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 28.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"38\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 105.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"140\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003emultiple pulmonary nodules\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 129.75pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"173\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enormal\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 153.25pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"204\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enot completed\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 28.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"38\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 105.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"140\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003emultiple pulmonary nodules\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 129.75pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"173\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enormal\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 153.25pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"204\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enormal\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 28.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"38\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 105.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"140\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003emultiple pulmonary nodules;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ebronchopneumonia\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 129.75pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"173\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enormal\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 153.25pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"204\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enormal\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 28.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"38\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 105.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"140\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003emultiple pulmonary nodules\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 129.75pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"173\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ehypoecho nodules in liver and spleen\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 153.25pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"204\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enormal\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 28.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"38\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 105.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"140\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003emultiple pulmonary nodules;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003emediastinal adenopathy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 129.75pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"173\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enormal\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 153.25pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"204\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enot completed\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.55pt;\"\u003e\n\u003ctd style=\"width: 28.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 8.55pt;\" width=\"38\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 105.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 8.55pt;\" width=\"140\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003emultiple pulmonary nodules;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003emediastinal adenopathy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 129.75pt; padding: 0in 5.4pt 0in 5.4pt; height: 8.55pt;\" width=\"173\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ehypoecho nodules in liver and spleen\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 153.25pt; padding: 0in 5.4pt 0in 5.4pt; height: 8.55pt;\" width=\"204\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ecerebral infarction; hydrocephalus; encephalomalacia; encephalatrophy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 28.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"38\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 105.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"140\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003emultiple pulmonary nodules\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 129.75pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"173\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enormal\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 153.25pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"204\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enormal\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 28.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"38\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e9\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 105.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"140\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003emultiple pulmonary nodules\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 129.75pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"173\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enormal\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 153.25pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"204\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enormal\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 28.5pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"38\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e10\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 105.0pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"140\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003emultiple pulmonary nodules;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003emediastinal adenopathy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 129.75pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"173\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ehypoecho nodules in liver and spleen\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 153.25pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"204\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enormal\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-align: left; text-autospace: none;\"\u003e\u003cspan style=\"color: #000000; font-family: verdana, geneva; font-size: 10pt;\"\u003eCT: computed tomography; MRI: magnetic resonance imaging\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eTable 5 TB-Specific Tests\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 398.55pt; border-collapse: collapse; margin-left: 6.75pt; margin-right: 6.75pt;\" width=\"531\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 2.8pt;\"\u003e\n\u003ctd style=\"width: 29.35pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 2.8pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eNo.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.0pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 2.8pt;\" width=\"81\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eTST\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.15pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 2.8pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eAFB smear\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.35pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 2.8pt;\" width=\"72\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eculture\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 139.35pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 2.8pt;\" width=\"186\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003egene Xpert\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 44.35pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 2.8pt;\" width=\"59\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eT-spot\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 7.5pt;\"\u003e\n\u003ctd style=\"width: 29.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 7.5pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 7.5pt;\" width=\"81\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eNeg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.15pt; padding: 0in 5.4pt 0in 5.4pt; height: 7.5pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003egastric fluid/\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003etracheal aspirates\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 7.5pt;\" width=\"72\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 139.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 7.5pt;\" width=\"186\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enot completed\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 44.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 7.5pt;\" width=\"59\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enot done\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 4.85pt;\"\u003e\n\u003ctd style=\"width: 29.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 4.85pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 4.85pt;\" width=\"81\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eNeg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.15pt; padding: 0in 5.4pt 0in 5.4pt; height: 4.85pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003egastric fluid\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 4.85pt;\" width=\"72\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 139.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 4.85pt;\" width=\"186\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enot completed\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 44.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 4.85pt;\" width=\"59\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003epos\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 29.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"81\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.15pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"72\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 139.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"186\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enot completed\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 44.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"59\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 13.5pt;\"\u003e\n\u003ctd style=\"width: 29.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"81\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enot completed\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.15pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"72\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 139.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"186\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enot completed\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 44.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"59\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003epos\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 29.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"81\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.15pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"72\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 139.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"186\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enot completed\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 44.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"59\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003epos\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 29.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"81\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enot completed\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.15pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"72\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003egastric fluid\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 139.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"186\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ebroncoalveolar lavage fluid: pos for TB;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg for Rifampicin resistance\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 44.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"59\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 29.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"81\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003epos\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.15pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003egastric fluid\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"72\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003egastric fluid\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 139.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"186\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eCSF and gastric fluid: pos for TB;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg for Rifampicin resistance\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 44.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"59\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003epos\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 29.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"81\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003epos\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.15pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"72\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 139.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"186\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eNeg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 44.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"59\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003epos\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 29.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e9\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"81\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.15pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003egastric fluid/\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003etracheal aspirates\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"72\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 139.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"186\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003etracheal aspirates: pos for TB;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg for Rifampicin resistance\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 44.35pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"59\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003epos\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 29.35pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"39\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e10\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.0pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"81\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enot completed\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.15pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003egastric fluid/\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003etracheal aspirates\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.35pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"72\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 139.35pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"186\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003etracheal aspirates: pos for TB;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eneg for Rifampicin resistance\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 44.35pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"59\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003epos\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eTST: tuberculin skin test; AFB: acid-fast bacilli\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; margin-left: 6.75pt; margin-right: 6.75pt;\" width=\"1009\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"page-break-inside: avoid; height: 3.2pt;\"\u003e\n\u003ctd style=\"width: 756.7pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.2pt;\" colspan=\"11\" width=\"1009\"\u003e\n\u003cp style=\"text-align: center; text-autospace: none;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eTable 6 Diagnosis and treatment\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"page-break-inside: avoid; height: 3.2pt;\"\u003e\n\u003ctd style=\"width: 26.7pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.2pt;\" width=\"36\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eNo.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.2pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eFinal diagnosis (involved organs)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.2pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003etime of suspected DOL\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.2pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003etime of initiation treatment DOL\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.2pt;\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003etime between onset and treatment\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.2pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eevidence for clinical diagnosis\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.2pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003etime of TB confirmation DOL\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.2pt;\" width=\"180\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003edrugs and duration\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.2pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eside effect\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.2pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eresp support\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.2pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eother treatment\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"page-break-inside: avoid; height: 56.7pt;\"\u003e\n\u003ctd style=\"width: 26.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"36\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003elung; liver; spleen; meningitis?\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e50\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e52\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e12\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"color: #000000; font-family: verdana, geneva; font-size: 10pt;\"\u003emother\u0026rsquo;s history/chest CT/abdominal ultrasonography\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e54 (gastric fluid AFB)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"180\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eINH 3y\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eRIF 3y\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enone\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eCPAP\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"page-break-inside: avoid; height: 56.7pt;\"\u003e\n\u003ctd style=\"width: 26.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"36\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003elung; meningitis\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e17\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e19\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"color: #000000; font-family: verdana, geneva; font-size: 10pt;\"\u003emother\u0026rsquo;s history/chest CT\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e23 (gastric fluid AFB)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"180\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eINH unknown\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eRIF unknown\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ePZA unknown\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ecorticosteroid 2m\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enone\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eCPAP\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003emannitol; hepatic protector\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"page-break-inside: avoid; height: 56.7pt;\"\u003e\n\u003ctd style=\"width: 26.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"36\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003elung\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e42\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e42\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e10\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"color: #000000; font-family: verdana, geneva; font-size: 10pt;\"\u003emother\u0026rsquo;s history/chest CT\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enone\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"180\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eINH 1y\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eRIF1y\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ePZA 1y\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enone\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enone\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ehepatic protector\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"page-break-inside: avoid; height: 56.7pt;\"\u003e\n\u003ctd style=\"width: 26.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"36\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003elung\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e45\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e50\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e25\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"color: #000000; font-family: verdana, geneva; font-size: 10pt;\"\u003emother\u0026rsquo;s history/chest CT/T-spot\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e50 (T-spot)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"180\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eINH 1.5y\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eRIF 1.5y\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eLZD 2m\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enone\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003elow flow O\u003csub\u003e2\u003c/sub\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ehepatic protector\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"page-break-inside: avoid; height: 56.7pt;\"\u003e\n\u003ctd style=\"width: 26.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"36\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003elung; liver; spleen; meningitis\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e69\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e70\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e57\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"color: #000000; font-family: verdana, geneva; font-size: 10pt;\"\u003emother\u0026rsquo;s history(X-ray)/chest CT\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e73 (T-spot)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"180\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eINH 6m\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eRIF 6m\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ePZA 6m\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eLZD 6m\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ehepatotoxicity\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003elow flow O\u003csub\u003e2\u003c/sub\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003emannitol; hepatic protector;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"page-break-inside: avoid; height: 56.7pt;\"\u003e\n\u003ctd style=\"width: 26.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"36\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003elung; endobronchical\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e34\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e34\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"color: #000000; font-family: verdana, geneva; font-size: 10pt;\"\u003emother\u0026rsquo;s history/chest CT\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e70 (gastric fluid culture)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"180\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eINH1.5y\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eRIF 1.5y\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ePZA 9m\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eLZD 3m\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enone\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enone\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ebroncoalveolar lavage once per month for 10 times; hepatic protector\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"page-break-inside: avoid; height: 56.7pt;\"\u003e\n\u003ctd style=\"width: 26.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"36\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003elung; liver; spleen; meningitis\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e56\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e56\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"color: #000000; font-family: verdana, geneva; font-size: 10pt;\"\u003emother\u0026rsquo;s history/chest CT/brain CT/CSF\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e57 (gastric fluid AFB)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"180\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eINH 14m and cont\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eRIF 14m and cont\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eEMB 14m and cont\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ePZA 3m\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eLZD 4m;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eCorticosteroid 3m\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ehepatotoxicity\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eCPAP\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eanticonvulsion; mannitol; hepatic protector\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"page-break-inside: avoid; height: 56.7pt;\"\u003e\n\u003ctd style=\"width: 26.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"36\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003elung; meningitis\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e35\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e35\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"color: #000000; font-family: verdana, geneva; font-size: 10pt;\"\u003emother\u0026rsquo;s history/chest X-ray\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e36 (T-spot)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"180\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eINH 9m and cont\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eRIF 9m and cont\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ePZA 6m\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eLZD 6m;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enone\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eintubation\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003emannitol; hepatic protector;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"page-break-inside: avoid; height: 56.7pt;\"\u003e\n\u003ctd style=\"width: 26.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"36\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e9\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003elung\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e24\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e24\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"color: #000000; font-family: verdana, geneva; font-size: 10pt;\"\u003emother\u0026rsquo;s history/ chest CT\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e24 (gastric fluid/tracheal aspirates AFB)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"180\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eINH 6m and cont\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eRIF 6m and cont\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ePZA 6m and cont\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eLZD 6m and cont\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ecorticosteroid 1m\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enone\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eintubation\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ehepatic protector\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"page-break-inside: avoid; height: 56.7pt;\"\u003e\n\u003ctd style=\"width: 26.7pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"36\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e10\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003elung; liver; spleen;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"76\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"color: #000000; font-family: verdana, geneva; font-size: 10pt;\"\u003emother\u0026rsquo;s history/chest CT\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e5 (T-spot)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 134.65pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"180\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eINH 2m D/C for severe hepatotoxicity\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eRIF 2m D/C for severe hepatotoxicity\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ePZA 2m D/C for severe hepatotoxicity\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eLZD 2m D/C for severe hepatotoxicity\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"95\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ehepatotoxicity; thrombocytopenia?\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.5pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enone\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 56.7pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ehepatic protector;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"page-break-inside: avoid; height: 7.8pt;\"\u003e\n\u003ctd style=\"width: 756.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 7.8pt;\" colspan=\"11\" width=\"1009\"\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eINH: Isoniazid; RIF: Rifampin; PZA: Pyrazinamide; LZD: Linezolid; EMB: Ethambutol; D/C: discontinued\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp style=\"text-align: center; text-autospace: none;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eTable 7 Outcome and follow up\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 437.9pt; border-collapse: collapse; margin-left: 6.75pt; margin-right: 6.75pt;\" width=\"584\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 2.8pt;\"\u003e\n\u003ctd style=\"width: 21.9pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 2.8pt;\" width=\"29\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eNo.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 84.75pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 2.8pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003efever clearance time d\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.6pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 2.8pt;\" width=\"102\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eTotal hospital stay \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e(d)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 47.9pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 2.8pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eoutcome\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.3pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 2.8pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eThe latest F/U age\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.25pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 2.8pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eGeneral Growth\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 2.8pt;\" width=\"126\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eCNS long term outcome\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 2.8pt;\"\u003e\n\u003ctd style=\"width: 21.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 2.8pt;\" width=\"29\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 84.75pt; padding: 0in 5.4pt 0in 5.4pt; height: 2.8pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eunknown\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.6pt; padding: 0in 5.4pt 0in 5.4pt; height: 2.8pt;\" width=\"102\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 47.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 2.8pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003erecovered\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.3pt; padding: 0in 5.4pt 0in 5.4pt; height: 2.8pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e9y\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.25pt; padding: 0in 5.4pt 0in 5.4pt; height: 2.8pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enormal\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 2.8pt;\" width=\"126\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003ecognitive delayed\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 21.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"29\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 84.75pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.6pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"102\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e11\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 47.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003elost\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.3pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enone\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.25pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eunknown\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"126\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eunknown\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 21.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"29\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 84.75pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.6pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"102\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e9\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 47.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003erecovered\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.3pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e4y\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.25pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003efailure to thrive\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"126\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enormal\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 21.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"29\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 84.75pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e12\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.6pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"102\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e20\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 47.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003erecovered\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.3pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e3y\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.25pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enormal\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"126\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enormal\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 21.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"29\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 84.75pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.6pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"102\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e47\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 47.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003erecovered\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.3pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e2y\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.25pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enormal\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"126\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enormal\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 4.7pt;\"\u003e\n\u003ctd style=\"width: 21.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 4.7pt;\" width=\"29\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 84.75pt; padding: 0in 5.4pt 0in 5.4pt; height: 4.7pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.6pt; padding: 0in 5.4pt 0in 5.4pt; height: 4.7pt;\" width=\"102\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e17\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 47.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 4.7pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003erecovered\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.3pt; padding: 0in 5.4pt 0in 5.4pt; height: 4.7pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e2y\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.25pt; padding: 0in 5.4pt 0in 5.4pt; height: 4.7pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enormal\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 4.7pt;\" width=\"126\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003elanguage delayed\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 21.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"29\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 84.75pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e49\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.6pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"102\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e51\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 47.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eimproved\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.3pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e1y2m\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.25pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003efailure to thrive\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"126\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003edevelopmental delayed\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 13.5pt;\"\u003e\n\u003ctd style=\"width: 21.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"29\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 84.75pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.6pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"102\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 47.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eimproved\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.3pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e9m\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.25pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"94\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enormal\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 94.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 13.5pt;\" width=\"126\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003enormal\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.3pt;\"\u003e\n\u003ctd style=\"width: 21.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"29\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e9\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 84.75pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.6pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"102\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e25\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 47.9pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003eimproved\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.3pt; padding: 0in 5.4pt 0in 5.4pt; height: 3.3pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva; color: #000000;\"\u003e6m\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.25pt; padding: 0in 5.4pt 0in 5.4pt; 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In this study, we reviewed patients with congenital TB that were promptly treated with an anti-TB regimen, including linezolid, based on new clinical diagnosis criteria. We described the clinical manifestations, treatment, and long-term prognosis of this disease in these patients.\nMethods\nThis was a retrospective observational study that enrolled patients with congenital TB that were admitted to Beijing Children’s Hospital between 2009 and 2018.\nResults\nA total of 10 congenital TB patients were enrolled. Ninety-percentage of the mothers were diagnosed at postpartum; however, none of the mothers received anti-TB treatment during pregnancy. The onset age of congenital TB ranged from 1 to 53 days. Chest computed tomography scans demonstrated pulmonary nodules in 100% of the patients and mediastinal adenopathy in 40% of the patients. Abdominal ultrasonography showed hypoechoic nodules in the liver and spleen in 40% of the patients. The positive rate of GeneXpert and T-spot were relatively high—80% and 78%, respectively. Anti-TB treatment was started when congenital TB was confirmed for 1 patient based on TB-specific tests or clinically diagnosed for the other 9 patients based on confirmed maternal TB history and typical radiological findings. Beside isoniazid, rifampicin, and pyrazinamide, linezolid was also administrated in 70% of the patients for a period of 2–6 months. One patient was reported to present with spontaneously resolved thrombocytopenia. The survival rate was 100%, and 33% of the patients have thrived and reached normal developmental milestones since the last documented follow-up.\nConclusion\nCongenital TB is a potentially fatal disease, but early diagnosis based on maternal history, typical imaging results, and timely treatment can improve the outcome. Linezolid is safe and might be effective in reducing the mortality of congenital TB.","manuscriptTitle":"Clinical characteristics and post-discharge follow-up analysis of 10 cases of congenital tuberculosis: a retrospective observational study","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2019-08-23 20:14:02","doi":"10.21203/rs.2.13513/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"b0d22298-26ac-4ea3-91a1-7674e6d50f1b","owner":[],"postedDate":"August 23rd, 2019","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":23005,"name":"Pediatrics"}],"tags":[],"updatedAt":"","versionOfRecord":[],"versionCreatedAt":"2019-08-23 20:14:02","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-4222","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"identity":"rs-4222","version":["v1"]},"buildId":"ApUGefWb6u5IBVtyqm6d5","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}