Serum level of Soluble B7-H4(sB7-H4) and its Significance in Endometriosis

Objective: To detect the serum soluble B7-H4(sB7-H4) level in endometriosis and discuss its clinical significance. Methods: Sandwich ELISA was applied to test the serum sB7-H4 level of 43 cases of endometriosis before operation and 40 cases of endometriosis after operation, as well as 30 cases of healthy women as the control group. Results: The serum sB7-H4 level in endometriosis patients was(36.23±5.67 μg/L), which was significantly higher than that of the healthy controls(31.24±4.56 μg/L, P0.01).The serum sB7-H4 level in patients with endometriosis before operation was(36.23±5.67 μg/L), which was significantly higher than that after operation(32.54 ±4.27μg/L, P0.05). The serum sB7-H4 level was positively correlated with CA125 in the patients with endometriosis(r=0.531, P0.01). Conclusion: The sB7-H4 may be correlated with the occurrence of endometriosis. Measurement of serum B7-H4 level may contribute to the diagnosis and evaluation of the prognosis of endometriosis.