Primary fallopian tube cancer in the setting of endometriosis

Deeksha Pandey, Varun Bhalla, Anushri Mittal, Jyothi Shetty
International Journal of Reproduction, Contraception, Obstetrics and Gynecology · 2015 · pp. 1571–1573 · doi:10.18203/2320-1770.ijrcog20150749 · W2175109080
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-15 ⓘ

This paper reports the first case of primary fallopian tube cancer in a 45-year-old woman with a history of pelvic endometriosis, raising questions about fallopian tube endometriomas as premalignant lesions.

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This paper reports a first case of primary fallopian tube cancer arising in a patient with a history of pelvic endometriosis. A 45-year-old nulliparous, menopausal woman presented with a pelvic mass; MRI suggested ovarian malignancy, but histology from staging laparotomy confirmed bilateral primary fallopian tube cancer, and she received six cycles of adjuvant chemotherapy. The authors highlight key limitations inherent to a single case report and pose questions about whether fallopian tube endometrioma could behave as a more aggressive premalignant lesion and whether endometriomas from the fallopian tube should be managed differently from ovarian endometriomas. This paper is centrally about endometriosis—specifically, it documents primary fallopian tube cancer developing in the setting of pelvic endometriosis.

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Abstract

We report the first case of PFTC arising in the setting of pelvic endometriosis. A 45 year old nulliparous lady, menopausal lady presented with pelvic mass. She had history of pelvic endometriosis. MRI findings were suggestive of ovarian malignancy. Histological analysis of specimen obtained following staging laparotomy proved it to be a case of bilateral PFTC. She received 6 cycles of adjuvant chemotherapy. This case opens a new door to think or investigate if fallopian tube endometrioma behaves as a more aggressive premalignant lesion. This case also poses questions whether it is important to differentiate an endometrioma arising from the ovary to one which is arising from a fallopian tube. Once identified can fallopian tube endometrioma also be managed medically or should it be always removed surgically?
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Primary fallopian tube cancer in the setting of endometriosis DOI: https://doi.org/10.18203/2320-1770.ijrcog20150749Keywords: Pelvic endometriosis, Ovarian malignancyAbstract We report the first case of PFTC arising in the setting of pelvic endometriosis. A 45 year old nulliparous lady, menopausal lady presented with pelvic mass. She had history of pelvic endometriosis. MRI findings were suggestive of ovarian malignancy. Histological analysis of specimen obtained following staging laparotomy proved it to be a case of bilateral PFTC. She received 6 cycles of adjuvant chemotherapy. This case opens a new door to think or investigate if fallopian tube endometrioma behaves as a more aggressive premalignant lesion. This case also poses questions whether it is important to differentiate an endometrioma arising from the ovary to one which is arising from a fallopian tube. Once identified can fallopian tube endometrioma also be managed medically or should it be always removed surgically? Metrics References Horng HC, Teng SW, Huang BS, Sun HD, Yen MS, Wang PH, et al. Primary fallopian tube cancer: Domestic data and up-to-date review. Taiwanese journal of obstetrics & gynecology. 2014;53(3):287-92. Horng HC, Teng SW, Lai CR, Chang WH, Chang YH, Yen MS, et al. Prognostic factors of primary fallopian tube cancer in a single institute in Taiwan. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 2014;127(1):77-81. Pectasides D, Pectasides E, Economopoulos T. Fallopian tube carcinoma: a review. The oncologist. 2006;11(8):902-12. Kuhn E, Kurman RJ, Shih IM. Ovarian Cancer Is an Imported Disease: Fact or Fiction? Current obstetrics and gynecology reports. 2012 Mar;1(1):1-9. PubMed PMID: 22506137. Yuan Z, Wang L, Wang Y, Zhang T, Li L, Cragun JM, et al. Tubal origin of ovarian endometriosis. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2014;27(8):1154-62. Meng ML, Gan G, Scheng S, Bao QC, Jung ZA. Diagnosis of primary adenocarcinoma of the fallopian tube. Journal of cancer research and clinical oncology. 1985;110(2):136-40. Hanton EM, Malkasian GD, Dahlin DC, Pratt JH. Primary carcinoma of the fallopian tube. American journal of obstetrics and gynecology. 1966;94(6):832-9. Ajithkumar TV, Minimole AL, John MM, Ashokkumar OS. Primary fallopian tube carcinoma. Obstetrical & gynecological survey. 2005;60(4):247-52. Ma FH, Cai SQ, Qiang JW, Zhao SH, Zhang GF, Rao YM. MRI for differentiating primary fallopian tube carcinoma from epithelial ovarian cancer. Journal of magnetic resonance imaging: JMRI, 2014. Puls LE, Davey DD, DePriest PD, Gallion HH, van Nagell JR, Jr., Hunter JE, et al. Immunohistochemical staining for CA-125 in fallopian tube carcinomas. Gynecologic oncology. 1993;48(3):360-3. Zeppernick F, Meinhold-Heerlein I. The new FIGO staging system for ovarian, fallopian tube, and primary peritoneal cancer. Archives of gynecology and obstetrics, 2014. Usach I, Blansit K, Chen LM, Ueda S, Brooks R, Kapp DS, et al. Survival differences in women with serous tubal, ovarian, peritoneal, and uterine carcinomas. American journal of obstetrics and gynecology. 2014 Aug 18. PubMed PMID: 25149685. Epub 2014/08/26. Eng. Enzinger FM, Weiss SW. Soft tissue sarcoma. The CV Mosby Co. 1988;2:402.

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