A Hybrid Retrieval-Augmented Generation and Language Model Framework for Evidence-Grounded Review Systems

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The paper proposes a hybrid retrieval-augmented generation (RAG) and large language model framework intended to produce evidence-grounded review outputs that balance comprehensive retrieval with factual consistency and proper attribution. Using a browser-based architecture, the system incorporates structured rubrics, dual-model verification, and human-in-the-loop quality control, and the authors report empirical improvements in groundedness (91% vs 71% baseline), consistency (89% vs 63% baseline), and reliability (ECE 0.042, 47% lower than Atlas). A major caveat is that the work is presented as a preprint and has not been peer reviewed. Relevance to endometriosis: the paper does not explicitly discuss endometriosis or adenomyosis, but it was included in the corpus via keyword match for biomedical evidence-grounded review system research that could apply to endometriosis/adnomenomyosis literature curation.

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Abstract

Abstract Evidence-grounded review systems require balancing comprehensive knowledge retrieval with accurate and reliable generation. Traditional approaches often struggle with maintaining factual consistency, providing proper attribution, and combining complex multi-source evidence. In this study we propose a reliable hybrid framework that integrates retrieval-augmented generation with large language models to support evidence-grounded critiques, risk assessments, and recommendations. The framework created ensures to incorporate structured rubrics, a dual-model verification, and a human-in-the-loop to enforce and ensure quality control to produce reliable outputs across domains. Unlike prior systems such as Atlas and RETRO, the approach proposed in this research introduces explicit verification and calibration mechanisms that reduce factual errors and improve attribution. Empirical evaluations applied show visible and notable improvements in groundedness (91% vs. 71% baseline), consistency (89% vs. 63% baseline), and reliability (ECE 0.042, 47% lower than Atlas). Our approach uses a browser-based architecture which removes the need for specialised hardware, making the system more accessible. This work advances the development of trustworthy review systems and has broader implications for high-stakes fields such as healthcare, legal analysis, and policy evaluation.
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A Hybrid Retrieval-Augmented Generation and Language Model Framework for Evidence-Grounded Review Systems | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article A Hybrid Retrieval-Augmented Generation and Language Model Framework for Evidence-Grounded Review Systems Chidozie Managwu, Lanre Shittu, David Obi-Nwankpa This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7706204/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Evidence-grounded review systems require balancing comprehensive knowledge retrieval with accurate and reliable generation. Traditional approaches often struggle with maintaining factual consistency, providing proper attribution, and combining complex multi-source evidence. In this study we propose a reliable hybrid framework that integrates retrieval-augmented generation with large language models to support evidence-grounded critiques, risk assessments, and recommendations. The framework created ensures to incorporate structured rubrics, a dual-model verification, and a human-in-the-loop to enforce and ensure quality control to produce reliable outputs across domains. Unlike prior systems such as Atlas and RETRO, the approach proposed in this research introduces explicit verification and calibration mechanisms that reduce factual errors and improve attribution. Empirical evaluations applied show visible and notable improvements in groundedness (91% vs. 71% baseline), consistency (89% vs. 63% baseline), and reliability (ECE 0.042, 47% lower than Atlas). Our approach uses a browser-based architecture which removes the need for specialised hardware, making the system more accessible. This work advances the development of trustworthy review systems and has broader implications for high-stakes fields such as healthcare, legal analysis, and policy evaluation. Artificial Intelligence and Machine Learning Software Engineering evidence-grounded review human-in-the-loop large language model (LLM) natural language inference retrieval-augmented generation (RAG) Full Text Additional Declarations The authors declare no competing interests. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. 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