Construction of Label-Free Sensor for Ribavirin Detection Based on Colloidal Crystal Array and Molecular Imprinting

Wei Chen, Yi Sun, Lirui Zhang, Min Fu, Kunhua Wang, Meng Gao
2022 · doi:10.2139/ssrn.4182141
preprint OA: closed
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A label-free sensor based on ribavirin-imprinted colloidal crystal arrays enables fast, selective detection of ribavirin in human serum through optical reflectance changes, offering a real-time monitoring approach for this antiviral drug.

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Abstract

Ribavirin is an important antiviral with demonstrated activity against coronaviruses, such as SARS and COVID-19. However, abuse of ribavirin will cause great environmental damage and threaten human health owing to its reproductive toxicity and teratogenicity. Therefore, an innovative detection method is demand for simple and sensitive detection of ribavirin. This work reports a label-free sensor for ribavirin detection by combination of colloidal crystal array and molecular imprinting. The imprinted colloidal crystal array (ICCA) was obtained by self-assemble of ribavirin imprinted spheres. Owing to the high ordered structure, the ICCA exhibited optical properties which changed upon binding ribavirin. The changes in reflectance wavelength enabled a fast and label-free detection of ribavirin between 5 to 60 mg/L. Moreover, the sensor showed excellent selectivity for ribavirin detection in human serum sample. Overall, the ICCA offers the advantages of high selectivity, label-free and easy operation, which may constitute an alternative approach for real-time detection of antivirals.

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