Investigation of Polymeric Nanoparticles Encapsulating Natural Sources for Targeting of Cancer

Abstract Herbal medications have emerged as a prominent focus within the pharmaceutical industry due to their well-established efficacy and limited occurrence of adverse effects. Additionally, natural medicines display a comparable amount of interest in the creation of nanoparticle as compared to synthetic drugs. Polymeric nanoparticles have become an important tool for increasing drug bioavailability and enabling tailored delivery to the intended site of action. because of the analgesic, anti-inflammatory, antibacterial, and antioxidant benefits of its therapeutic qualities. Formulations were prepared using different ingredients using the solvent evaporation method. Polyvinyl alcohol, Polylactic acid was used as a biodegradable polymer, HPMC, Polyvinylpyrrolidone (PVP), and Lactose. 5- Fluorouracil is acts as an inhibitor of receptor thymidylate synthase (TS) and chemotherapeutic drug. Vaccinium Corymbosum was extracted by the Soxhlet method. The extract of the Vaccinium Corymbosum was encapsulated, Quercetin is the flavonoid that worked as a main constituent. The current study indicates that Vaccinium Corymbosum-loaded nanoparticles assist in the anti-cancer activity effectively.