[Association of single nucleotide polymorphism in CYP17 and ERα genes with endometriosis risk in southern Chinese women].

Xin Zhao, Li-li Zong, Lili Zong, Yufeng Wang, Yu-feng Wang, Ting Mao, Yong-gui Fu, Yonggui Fu, Jun Zeng, Xingqiang Rao, Xing-qiang Rao
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics · 2011 · vol. 28(3) , pp. 304–7 · doi:10.3760/cma.j.issn.1003-9406.2011.03.015 · PMID:21644229 · W2336998850
article OA: closed CC0 ⤵ 3 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study genotyped two single nucleotide polymorphisms in CYP17 and ERα genes in Chinese women and found no association with endometriosis risk.

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Abstract

OBJECTIVE: To investigate the association of single nucleotide polymorphisms in cytochrome P450 17 (CYP17) and estrogen receptor alpha (ERα ) genes with the risk of endometriosis among southern Chinese women. METHODS: Two SNPs rs743572 (CYP17 gene 34T/C) and rs9322331 (ERα gene -397T/C) were genotyped by high resolution melting curve in 432 endometriosis patients and 499 matched controls. RESULTS: There was no significant difference in the genotype frequencies of the two loci between endometriosis patients and the control subjects (P> 0.05). And there was no significant interaction effect of these two genes on the disease either. CONCLUSION: CYP17 gene and ERα gene may not be genetic risk factors for endometriosis among southern women in China.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Estrogen Receptor alpha Polymorphism, Single Nucleotide Steroid 17-alpha-Hydroxylase Asian People Asian People Endometriosis Estrogen Receptor alpha Female Genetic Predisposition to Disease Genotype Humans Risk Factors Steroid 17-alpha-Hydroxylase

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