[Association of single nucleotide polymorphism in CYP17 and ERα genes with endometriosis risk in southern Chinese women].

Xin Zhao, Zhao X, Li-li Zong, Lili Zong, Zong LL, Yu-feng Wang, Wang YF, Yufeng Wang, Ting Mao, Mao T, Fu YG, Yong-gui Fu, Yonggui Fu, Zeng J, Jun Zeng, Xingqiang Rao, Xing-qiang Rao, Rao XQ
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics · 2011 · vol. 28(3) , pp. 304–7 · doi:10.3760/cma.j.issn.1003-9406.2011.03.015 · PMID:21644229 · W2336998850
article OA: closed CC0 ⤵ 3 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study genotyped two single nucleotide polymorphisms in CYP17 and ERα genes in Chinese women and found no association with endometriosis risk.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To investigate the association of single nucleotide polymorphisms in cytochrome P450 17 (CYP17) and estrogen receptor alpha (ERα ) genes with the risk of endometriosis among southern Chinese women. METHODS: Two SNPs rs743572 (CYP17 gene 34T/C) and rs9322331 (ERα gene -397T/C) were genotyped by high resolution melting curve in 432 endometriosis patients and 499 matched controls. RESULTS: There was no significant difference in the genotype frequencies of the two loci between endometriosis patients and the control subjects (P> 0.05). And there was no significant interaction effect of these two genes on the disease either. CONCLUSION: CYP17 gene and ERα gene may not be genetic risk factors for endometriosis among southern women in China.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Estrogen Receptor alpha Polymorphism, Single Nucleotide Steroid 17-alpha-Hydroxylase Asian People Asian People Endometriosis Estrogen Receptor alpha Female Genetic Predisposition to Disease Genotype Humans Risk Factors Steroid 17-alpha-Hydroxylase

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cited by (3)

Cited by (3)

Source provenance

europepmc
last seen: 2026-07-27T06:15:28.040536+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:16:42.478857+00:00
License: CC0 · commercial use OK