Efficacy of intravenous tenecteplase bridge thrombectomy for recurrent ischemic stroke within 3 months: A case report and review

Efficacy of intravenous tenecteplase bridge thrombectomy for recurrent ischemic stroke within 3 months: A case report and review | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Case Report Efficacy of intravenous tenecteplase bridge thrombectomy for recurrent ischemic stroke within 3 months: A case report and review Cuicui Liu, Junyan Liu, Huiling Ren, Yuzhu Xu This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4231963/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background According to previous guidelines, patients who had a previous stroke within 3 months were excluded from the intravenous thrombolysis (IVT) protocol. Some studies have shown that IVT with alteplase (rt-PA) may be effective and safe in this group, but there is a lack of evidence supporting the use of tenecteplase (TNK). Case presentation An 80-year-old male admitted for acute ischemic stroke(IS)presented with consciousness and vomiting for 2 hours, who had experienced IS in the vertebrobasilar territory forty-eight days prior, treated by IVT with TNK as a bridging therapy before thrombectomy and had an excellent outcome in the 8 weeks follow up. Conclusions Patients with recurrent stroke within 3 months may also benefit from IVT combined with TNK alone or as a bridging therapy before thrombectomy. Large-scale evidence-based clinical trials are indeed to re-examine the potential use of TNK in RIS. intravenous thrombolysis recurrent ischemic stroke tenecteplase Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4231963","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Case Report","associatedPublications":[],"authors":[{"id":294262123,"identity":"7dd9fbe0-4297-492f-aa21-4ea278478290","order_by":0,"name":"Cuicui Liu","email":"","orcid":"","institution":"The Third Hospital of Hebei Medical University","correspondingAuthor":false,"prefix":"","firstName":"Cuicui","middleName":"","lastName":"Liu","suffix":""},{"id":294262124,"identity":"d7971b9f-1dff-4c79-a679-b129b3104bac","order_by":1,"name":"Junyan Liu","email":"","orcid":"","institution":"The Third Hospital of Hebei Medical University","correspondingAuthor":false,"prefix":"","firstName":"Junyan","middleName":"","lastName":"Liu","suffix":""},{"id":294262125,"identity":"247c9f92-16e0-4ed6-a649-7e9a5637af25","order_by":2,"name":"Huiling Ren","email":"","orcid":"","institution":"The Third Hospital of Hebei Medical University","correspondingAuthor":false,"prefix":"","firstName":"Huiling","middleName":"","lastName":"Ren","suffix":""},{"id":294262126,"identity":"841d0323-f4c8-41c7-bcae-1b31818f52cb","order_by":3,"name":"Yuzhu Xu","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA7UlEQVRIiWNgGAWjYBACefbmAwcS/9jI8UswsEGEDhDQYthzLPHBx4Y0Y8kZxGphuJFjbDiz4XCiwQ1itTD2nDGT5t1xOMH4dvOxRzfbGOT4biQwfi7Ao4Wdva1MmvdMep7ZnWPpxrltDMaSNxKYpWfgteXwNmkeNutisxs5ZtJALYkbbiSwMfPg9UuCGVALc+LmGfnfQFrqidCSAvR+m3PiBokcNpCWBANCWsCB/OFMmrHEjTRz45xzEoYzzzxslsanBRyVCRXAqJyR/OxxTpmNPN/x5IOf8ToMDUgAMWMDCRpGwSgYBaNgFGADAAigUjAuqMONAAAAAElFTkSuQmCC","orcid":"","institution":"The Third Hospital of Hebei Medical University","correspondingAuthor":true,"prefix":"","firstName":"Yuzhu","middleName":"","lastName":"Xu","suffix":""}],"badges":[],"createdAt":"2024-04-07 15:03:25","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4231963/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4231963/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":65571741,"identity":"8949692b-11f9-4082-a5bf-d2181e8dcc1c","added_by":"auto","created_at":"2024-09-30 06:39:37","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":337020,"visible":true,"origin":"","legend":"","description":"","filename":"Manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4231963/v1_covered_c3fe9377-7f9d-457c-9ece-ed8fc480d712.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Efficacy of intravenous tenecteplase bridge thrombectomy for recurrent ischemic stroke within 3 months: A case report and review","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"intravenous thrombolysis, recurrent ischemic stroke, tenecteplase ","lastPublishedDoi":"10.21203/rs.3.rs-4231963/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4231963/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground \u003c/strong\u003eAccording to previous guidelines, patients who had a previous stroke within 3 months were excluded from the intravenous thrombolysis (IVT) protocol. Some studies have shown that IVT with alteplase (rt-PA) may be effective and safe in this group, but there is a lack of evidence supporting the use of tenecteplase (TNK).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCase presentation \u003c/strong\u003eAn 80-year-old male admitted for acute ischemic stroke(IS)presented with consciousness and vomiting for 2 hours, who had experienced IS in the vertebrobasilar territory forty-eight days prior, treated by IVT with TNK as a bridging therapy before thrombectomy and had an excellent outcome in the 8 weeks follow up.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusions\u003c/strong\u003e Patients with recurrent stroke within 3 months may also benefit from IVT combined with TNK alone or as a bridging therapy before thrombectomy. Large-scale evidence-based clinical trials are indeed to re-examine the potential use of TNK in RIS.\u003c/p\u003e","manuscriptTitle":"Efficacy of intravenous tenecteplase bridge thrombectomy for recurrent ischemic stroke within 3 months: A case report and review","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-04-23 03:26:43","doi":"10.21203/rs.3.rs-4231963/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"956ea810-2ec9-4de2-8872-f201f397a130","owner":[],"postedDate":"April 23rd, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2024-09-30T06:39:13+00:00","versionOfRecord":[],"versionCreatedAt":"2024-04-23 03:26:43","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-4231963","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4231963","identity":"rs-4231963","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}