Co-occurrence of Pediatric-Type Diffuse High-Grade Gliomas with Arteriovenous Malformations:  Case Report and Literature Review

Co-occurrence of Pediatric-Type Diffuse High-Grade Gliomas with Arteriovenous Malformations: Case Report and Literature Review | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Case Report Co-occurrence of Pediatric-Type Diffuse High-Grade Gliomas with Arteriovenous Malformations: Case Report and Literature Review Yongqin Zeng¹, Kai Chen², Tao Shi¹, Zhijie Chen¹, Xubiao Zhang¹, and 4 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6664715/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background: Pediatric-type diffuse high-grade gliomas (pDHGG) are recognized as a distinct entity in the 2021 WHO Classification of Central Nervous System Tumors, characterized by specific molecular features. Their co-occurrence with cerebral arteriovenous malformations (AVMs) is exceptionally rare, presenting significant diagnostic and therapeutic challenges. Herein, we report a rare case of concurrent pediatric diffuse high-grade glioma (pDHGG, WHO grade IV, H3-wildtype and IDH-wildtype) and a Spetzler-Martin grade I arteriovenous malformation in a pediatric patient. Case presentation: A 14-year-old male presented with recurrent seizures and progressive consciousness disturbance. Clinical assessment and neuroimaging revealed a right frontal lobe tumor (2.2×2.3×2.0 cm) closely associated with a Spetzler-Martin grade I AVM. Following preoperative endovascular embolization, complete microsurgical resection of both the tumor and AVM was achieved. Histopathology and molecular analysis confirmed pediatric diffuse high-grade glioma (WHO grade IV, H3-wildtype, IDH-wildtype). Immunohistochemistry showed positive GFAP and Olig-2, with retained ATRX expression. The patient completed standard adjuvant chemoradiotherapy (60Gy in 30 fractions with concurrent temozolomide) and remained disease-free at the 24-month follow-up. Literature review identified 8 prior cases of concurrent glioma and AVMs, mostly in males (7/8), with 75% being high-grade glioblastomas (WHO grade IV) and various AVM grades (I-III), resulting in 50% mortality despite surgery. Conclusion: Our multimodal approach in this rare case of concurrent pDHGG and AVM achieved favorable disease-free survival, highlighting the importance of comprehensive vascular assessment, staged intervention, and molecular diagnosis in managing such complex dual pathologies. Pediatric-type diffuse high-grade glioma Arteriovenous malformations Embolization Surgical resection Figures Figure 1 Figure 2 Figure 3 Figure 4 Case presentation Clinical History and Physical Examination A 14-year-old male presented to our emergency department with a two-week history of progressive neurological deterioration. The clinical manifestation began with focal motor seizures affecting the left side, which escalated in frequency from once daily to three episodes per day. Gradually, the patient exhibited worsening alteration of consciousness. Past medical history was unremarkable, and family history revealed no neurological disorders or malignancies. On admission, vital signs were within normal parameters (BP: 118/76 mmHg, HR: 82 bpm, T: 36.8°C). Neurological assessment revealed a Glasgow Coma Scale (GCS) score of 14 (E4V4M6), bilateral papilledema, and mild left hemiparesis with muscle strength 4/5. Babinski signs and meningeal irritation signs were negative. Diagnostic Workup Standard laboratory investigations, including complete blood count, coagulation profile, and serum tumor markers, were all within normal limits. Computed Tomography Angiography (CTA) and Magnetic Resonance Imaging (MRI) were performed. CTA revealed a mixed-density lesion in the right frontal lobe suggestive of a tumor, with heterogeneous enhancement post-contrast (Fig. 1A, B). A high-density vascular pattern posterior to the tumor, consistent with an AVM, was also noted (Fig. 1C). 3D reconstructed CTA clearly delineated the complex vascular architecture, including feeding arteries and draining veins (Fig. 1D). MRI confirmed a heterogeneous mass in the right frontal lobe with mixed signal intensity on T1-weighted images (Fig. 2A) and significant surrounding vasogenic edema along with flow voids suggestive of pathological vessels on T2-weighted images (Fig. 2B). Post-contrast T1-weighted images demonstrated intense, heterogeneous enhancement of the tumor and associated complex vascular components (Fig. 2C, D). Digital Subtraction Angiography (DSA) confirmed the presence of a Spetzler-Martin grade I AVM, characterized by a compact nidus fed primarily by branches of the right middle cerebral artery (MCA) with early venous drainage (Fig. 3A, B). Pre-operative Management and Surgical Intervention The patient was initially stabilized with antiseizure medication (Levetiracetam) and corticosteroids to manage cerebral edema. Given the vascular nature of the AVM component, preoperative endovascular embolization was performed. Using N-butyl cyanoacrylate (NBCA), approximately 80% reduction in blood flow to the AVM nidus was achieved (Fig. 3C, D show post-embolization status, though labeled as post-operative in the original legend, context implies pre-operative embolization result). Subsequently, the patient underwent a right frontotemporal craniotomy. Utilizing intraoperative neuromonitoring and microsurgical techniques, complete resection of both the tumor and the embolized AVM was achieved. Intraoperative indocyanine green (ICG) videoangiography confirmed the absence of residual AVM flow (Fig. 4A). The surgical field showed the embolized AVM nidus and draining veins (Fig. 4B), distinct from the posterior tumor mass which had a characteristic "fish-flesh" appearance (Fig. 4C). Pathological Analysis Microscopic examination of the resected tissue revealed a highly cellular neoplasm characterized by significant nuclear atypia, cellular pleomorphism, and frequent mitotic figures (Fig. 4D, E, F show representative histology). Features included ovoid cells, perivascular pseudorosettes, and occasional multinucleated giant cells. Microvascular proliferation was prominent. Immunohistochemical staining showed strong positivity for Glial Fibrillary Acidic Protein (GFAP) and Oligodendrocyte transcription factor 2 (Olig-2). Expression of ATRX was retained (positive). The Ki-67 proliferation index was approximately 40%. Molecular analysis confirmed the tumor was H3-wildtype and IDH-wildtype (IDH1-R132H negative by IHC). Mismatch repair (MMR) protein expression was preserved. Based on these integrated histological and molecular features, the final diagnosis was pediatric-type diffuse high-grade glioma, H3-wildtype and IDH-wildtype, WHO grade IV. Post-operative Course and Follow-up The patient's post-operative recovery was uneventful, with resolution of his hemiparesis and no new neurological deficits. Post-operative MRI confirmed gross total resection of both the tumor and the AVM, with no residual enhancement and resolution of edema (Fig. 2E, F, G, H). Adjuvant therapy consisted of fractionated external beam radiation therapy to the tumor bed (total dose 60 Gy in 30 fractions) with concurrent and adjuvant temozolomide chemotherapy according to the Stupp protocol. The patient tolerated the treatment well. He remained clinically stable and tumor-free on serial MRI scans during the 24-month follow-up period, monitored with monthly clinical assessments and quarterly MRI surveillance. Literature Review To better understand the coexistence of gliomas and AVMs, a comprehensive literature review was conducted. As of April 2025, 8 cases of concurrent glioma and AVMs have been documented in the literature[10, 13-19] detailed in Table 1. Among these cases, 7 were male and 1 was female, with an age range of 20-62 years. Regarding tumor grading, Grade IV glioblastoma (GBM) was identified in 6 cases, while Grade II astrocytoma/LGG was found in 2 cases. AVM Spetzler-Martin grading revealed Grade I in 3 cases, Grade II in 2 cases, Grade III in 2 cases, and unspecified in 1 case. Preoperative embolization was performed in 1 case, while complete surgical resection was achieved in 6 cases. Adjuvant therapy was administered in 5 cases. At final follow-up, 4 patients had died with survival periods of 7-8 months, while 4 patients remained alive with follow-up durations of 12-18 months. Discussion Pediatric-type diffuse high-grade gliomas (pDHGG) are newly defined as a category of diseases in the fifth edition of the World Health Organization Classification of Tumors of the Central Nervous System (2021)[1,2]. Compared with their adult counterparts, these tumors have unique molecular features and clinical manifestations. Characterized by specific genetic alterations, such as histone H3 mutations or changes in the MAPK pathway, they pose significant therapeutic challenges in pediatric neuro-oncology[3,4]. The molecular spectrum of pDHGG is complex, often involving driver mutations that affect chromatin remodeling and epigenetic regulation. These mutations profoundly influence tumor biology, treatment response, and overall prognosis[5,6]. Standard treatment usually includes maximal safe surgical resection followed by adjuvant radiochemotherapy, yet the outcomes for many patients remain suboptimal[4,7]. The co-occurrence of primary brain tumors with cerebral arteriovenous malformations (AVMs) is extremely rare, with reported incidences ranging from 0.2% to 2.4% in case series[8,9]. Although high-grade gliomas are known for their inherent vascularity and tumor-associated angiogenesis, the presence of a true, independent AVM adds unique diagnostic complexities and management challenges, especially regarding surgical strategy and bleeding risks[10,11]. The potential pathogenic mechanisms underlying the association of these two distinct entities, particularly in the pediatric population, remain largely speculative, with theories including shared genetic susceptibility and tumor-induced vascular remodeling[9,12]. Our patient represents the youngest case of pediatric diffuse high-grade glioma with concomitant AVM reported to date. Our molecular characterization confirmed an H3-wildtype and IDH-wildtype status, aligning with the newly defined entity of pDHGG in the 2021 WHO classification[1, 2]. The immunohistochemical profile (GFAP+, Olig-2+, ATRX retained) further supports this diagnosis and helps distinguish it from other pediatric high-grade glioma subtypes, such as those with H3 K27M mutations or IDH mutations[3, 4, 9]. Morphological assessment definitively confirmed the presence of arteriovenous malformations. The molecular mechanisms underlying this dual pathology remain speculative. Theories include shared genetic or epigenetic alterations affecting both glial cell differentiation and vascular development, or the induction of vascular changes by tumor-secreted factors like Vascular Endothelial Growth Factor (VEGF)[5, 8, 20]. The close anatomical relationship observed might suggest either a collision phenomenon or a potential shared pathogenic pathway[9]. From a management perspective, this case highlights the challenges posed by the high vascularity of the combined lesion. Literature review revealed that previous cases primarily underwent direct surgical resection, with only one patient receiving preoperative embolization[19]. Moreover, limited by various factors, complete resection was not achieved in some patients. We implemented a staged therapeutic approach—preoperative embolization followed by complete microsurgical resection. The preoperative embolization likely facilitated a safer and more complete resection by reducing intraoperative bleeding risk associated with the AVM component. The clinical outcome in our patient, demonstrating 24-month disease-free survival, represents a favorable prognosis compared to current standards. Literature review indicated that half of the previously reported cases survived less than one year, with the longest follow-up period among survivors being 18 months[10, 13-19]. This improved outcome underscores the potential benefits of modern, comprehensive treatment strategies, including advanced neuroimaging, endovascular techniques, meticulous microsurgery, and standardized adjuvant chemoradiation, even in the face of such complex dual pathologies[21]. Our experience reinforces several critical principles for managing similar rare cases. Detailed preoperative vascular assessment utilizing multimodal imaging, including MRI, CTA, and DSA, is essential for accurately mapping tumor extent and AVM angioarchitecture (feeders, nidus, drainage) to plan effective intervention[22]. For lesions with a significant AVM component, a staged interventional approach incorporating preoperative embolization can be invaluable in reducing surgical risks and facilitating complete resection[11, 21]. Equally important is accurate histopathological and molecular diagnosis according to WHO 2021 criteria, which is vital for prognostication and guiding adjuvant therapy, especially in distinguishing pDHGG subtypes[1, 2, 23]. Despite the valuable insights provided by this study, we acknowledge the limitations of a single case report. Our findings regarding the molecular mechanisms underlying this dual pathology, the long-term efficacy of staged treatment, and the universal applicability of modern comprehensive treatment strategies require further validation through larger sample studies. Sustained surveillance through long-term clinical and radiological follow-up remains necessary due to the aggressive nature of pDHGG and the potential, albeit low, risk of AVM recurrence or delayed complications[12]. These findings not only advance our understanding of the management of complex pediatric brain tumor cases involving vascular malformations but also establish a foundation for refining therapeutic strategies in pediatric neuro-oncology. Conclusions We report a rare case of concurrent pediatric-type diffuse high-grade glioma and arteriovenous malformation in a 14-year-old boy. Our management strategy—preoperative embolization, complete microsurgical resection, and adjuvant therapy—achieved 24-month disease-free survival. This case underscores the value of comprehensive vascular imaging, staged interventional approaches, and accurate molecular diagnosis in managing complex dual pathologies. The favorable outcome demonstrates the efficacy of modern multidisciplinary approaches and provides valuable insights for treating these rare conditions. Future research should explore the molecular mechanisms underlying this co-occurrence and develop standardized treatment protocols. Abbreviations AVM: Arteriovenous Malformation BP: Blood Pressure CT: Computed Tomography CTA: Computed Tomography Angiography DSA: Digital Subtraction Angiography GBM: Glioblastoma Multiforme GCS: Glasgow Coma Scale GFAP: Glial Fibrillary Acidic Protein HR: Heart Rate RT: radiotherapy TMZ :Temozolomide； ICG: Indocyanine Green IDH: Isocitrate Dehydrogenase LGG low-grade gliom MAPK: Mitogen-Activated Protein Kinase MRI: Magnetic Resonance Imaging NBCA: N-Butyl Cyanoacrylate NED: No Evidence of Disease pDHGG: Pediatric-type Diffuse High-Grade Glioma PXA :Pleomorphic Xanthoastrocytoma; VEGF: Vascular Endothelial Growth Factor WHO: World Health Organization Declarations Acknowledgements Not applicable Author contributions YQZ: Roles/Writing - original draf, Formal analysis, Writing - review & editing. KC: Writing - review & editing, Data curation, Formal analysis. TS: Funding acquisition, Formal analysis. ZJC: Data curation, Resources. XBZ: Supervision. DL: Investigation, Writing - review & editing. YYM: Resources; Software.HNL:Pathological Evidence ;TL: Conceptualization, Funding acquisition. Data availability The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request. Consent for publication Written informed consent for the publication of identifying images or other personal or clinical details was obtained from the parents or legal guardians of all participants involved. Ethics Statement This study was approved by the Medical Ethics Committee of Guangdong Sanjiu Brain Hospital (Document No.AF/SW-08/02.0, Approval No. Medical Letter (2025) No. 3). The study was conducted in accordance with the Declaration of Helsinki and followed the ethical principles outlined in the International Ethical Guidelines for Biomedical Research Involving Human Subjects by the Council for International Organizations of Medical Sciences (CIOMS). Conflicts of Interest The authors declare no conflicts of interest. Funding No funding. References Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol. 2021;23(8):1231-51.https://doi.10.1093/neuonc/noab106. Bender K, Kahn J, Perez E, Ehret F, Roohani S, Capper D et al. Diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype: case series of a new entity. Brain Tumor Pathol. 2023;40(4):204 – 14.https://doi.10.1007/s10014-023-00468-3. Castel D, Kergrohen T, Tauziède-Espariat A, Mackay A, Ghermaoui S, Lechapt E et al. Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation. Acta Neuropathol. 2020;139(6):1109-13.https://doi.10.1007/s00401-020-02142-w. Mackay A, Burford A, Carvalho D, Izquierdo E, Fazal-Salom J, Taylor KR et al. Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. Cancer Cell. 2017;32(4):520 – 37.e5.https://doi.10.1016/j.ccell.2017.08.017. Wu G, Diaz AK, Paugh BS, Rankin SL, Ju B, Li Y et al. The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nat Genet. 2014;46(5):444 – 50.https://doi.10.1038/ng.2938. Schwartzentruber J, Korshunov A, Liu XY, Jones DT, Pfaff E, Jacob K et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature. 2012;482(7384):226 – 31.https://doi.10.1038/nature10833. Castel D, Philippe C, Calmon R, Le Dret L, Truffaux N, Boddaert N et al. Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes. Acta Neuropathol. 2015;130(6):815 – 27.https://doi.10.1007/s00401-015-1478-0. Bender S, Tang Y, Lindroth AM, Hovestadt V, Jones DT, Kool M et al. Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. Cancer Cell. 2013;24(5):660 – 72.https://doi.10.1016/j.ccr.2013.10.006. Korshunov A, Schrimpf D, Ryzhova M, Sturm D, Chavez L, Hovestadt V et al. H3-/IDH-wild type pediatric glioblastoma is comprised of molecularly and prognostically distinct subtypes with associated oncogenic drivers. Acta Neuropathol. 2017;134(3):507 – 16.https://doi.10.1007/s00401-017-1710-1. Guo P, Sun W, Song LX, Cao WY, Li JP. Multimodal imaging for the diagnosis of oligodendroglioma associated with arteriovenous malformation: A case report. World J Radiol. 2024;16(8):348 – 55.https://doi.10.4329/wjr.v16.i8.348. Gmeiner M, Sonnberger M, Wurm G, Weis S. Glioblastoma with the appearance of arteriovenous malformation: pitfalls in diagnosis. Clin Neurol Neurosurg. 2013;115(5):501-6.https://doi.10.1016/j.clineuro.2012.12.009. Solomon RA, Connolly ES. Jr. Arteriovenous Malformations of the Brain. N Engl J Med. 2017;376(19):1859-66.https://doi.10.1056/NEJMra1607407. Li CR, Chen SY, Yang MY, Cheng WY, Shen CC. A Rare Triploid Involving the Coexistence of Glioblastoma Multiforme, Arteriovenous Malformation and Intracranial Aneurysm: Illustrative Case and Literature Review. Medicina (Kaunas). 2023;59(2).https://doi.10.3390/medicina59020331. Tunthanathip T, Kanjanapradit K. Glioblastoma Multiforme Associated with Arteriovenous Malformation: A Case Report and Literature Review. Ann Indian Acad Neurol. 2020;23(1):103-6.https://doi.10.4103/aian.AIAN_219_18. Chen J, Chen L, Zhang C, He J, Li P, Zhou J et al. Glioma coexisting with angiographically occult cerebrovascular malformation: A case report. Oncol Lett. 2016;12(4):2545-9.https://doi.10.3892/ol.2016.4916. Lohkamp LN, Strong C, Rojas R, Anderson M, Laviv Y, Kasper EM. Hypervascular glioblastoma multiforme or arteriovenous malformation associated Glioma? A diagnostic and therapeutic challenge: A case report. Surg Neurol Int. 2016;7(Suppl 37):S883-s8.https://doi.10.4103/2152-7806.194506. Nagańska E, Matyja E, Pucko E, Ząbek M. The coexistence of pleomorphic xanthoastrocytoma and arteriovenous malformation. A case report. Folia Neuropathol. 2013;51(3):269 – 74 .https://doi.10.5114/fn.2013.37712 Aucourt J, Jissendi P, Kerdraon O, Baroncini M. Neuroimaging features and pathology of mixed glioblastoma–AVM complex: a case report. J Neuroradiol. 2012;39(4):258 – 62 .https://doi.10.1016/j.neurad.2011.11.001 Cemil B, Tun K, Polat O, Ozen O, Kaptanoglu E. Glioblastoma multiforme mimicking arteriovenous malformation. Turk Neurosurg. 2009;19(4):433–6. Brat DJ, Aldape K, Colman H, Figrarella-Branger D, Fuller GN, Giannini C et al. cIMPACT-NOW update 5: recommended grading criteria and terminologies for IDH-mutant astrocytomas. Acta Neuropathol. 2020;139(3):603-8.https://doi.10.1007/s00401-020-02127-9. Al-Smadi AS, Ansari SA, Shokuhfar T, Malani A, Sattar S, Hurley MC et al. Safety and outcome of combined endovascular and surgical management of low grade cerebral arteriovenous malformations in children compared to surgery alone. Eur J Radiol. 2019;116:8–13.https://doi.10.1016/j.ejrad.2019.02.016. Sturm D, Bender S, Jones DT, Lichter P, Grill J, Becher O et al. Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge. Nat Rev Cancer. 2014;14(2):92–107.https://doi.10.1038/nrc3655. Karremann M, Gielen GH, Hoffmann M, Wiese M, Colditz N, Warmuth-Metz M et al. Diffuse high-grade gliomas with H3 K27M mutations carry a dismal prognosis independent of tumor location. Neuro Oncol. 2018;20(1):123 – 31.https://doi.10.1093/neuonc/nox149. Tables Table 1. Literature Review of Cases with Concurrent Glioma and Arteriovenous Malformations M, male; F, female; GBM, glioblastoma multiforme; pDHGG, pediatric-type diffuse high-grade glioma; WHO, World Health Organization; AVM, arteriovenous malformation;RT, radiotherapy; NED, no evidence of disease; m, months; LGG, low-grade gliom；PXA，Pleomorphic Xanthoastrocytoma; TMZ,Temozolomide. *Combined: Embolization + Surgery + Chemoradiation Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6664715","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Case Report","associatedPublications":[],"authors":[{"id":476139261,"identity":"e816e667-952d-49c5-91c6-41bfd19df8a6","order_by":0,"name":"Yongqin Zeng¹","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAuklEQVRIiWNgGAWjYBACNvaGxAcJFTbM/ERr4eM58Njgw5k0dskGYrXISSQ+k5zZdojf4ADRDpNITpDmbTsgbXw8eQPDj4ptRGjheZZgzHPujrHZmWcFjD1nbhOhhT0nIZmn7Fmy2Y0cA2bGNmK0MOR/OMzDdrh+8wyitXAkJDbOaDvMbCBBtBaeA8kMwEBmlgD65SBRfpFvb0j/AY7K9uSND35UEKEFCSQQHzUILaTqGAWjYBSMghECADDzP+sQL9fVAAAAAElFTkSuQmCC","orcid":"","institution":"Guangdong Sanjiu Brain Hospital","correspondingAuthor":true,"prefix":"","firstName":"Yongqin","middleName":"","lastName":"Zeng¹","suffix":""},{"id":476139262,"identity":"8f1c4e23-a839-4da7-82ad-f40f5642afd0","order_by":1,"name":"Kai Chen²","email":"","orcid":"","institution":"The First Affiliated Hospital of Guangxi Medical University Kaiyuan Langdong Hospital","correspondingAuthor":false,"prefix":"","firstName":"Kai","middleName":"","lastName":"Chen²","suffix":""},{"id":476139265,"identity":"63f48180-9107-48d5-a13c-0362504b7454","order_by":2,"name":"Tao Shi¹","email":"","orcid":"","institution":"Guangdong Sanjiu Brain Hospital","correspondingAuthor":false,"prefix":"","firstName":"Tao","middleName":"","lastName":"Shi¹","suffix":""},{"id":476139270,"identity":"5071af4f-207a-4ee3-b48a-d50fdd7a600c","order_by":3,"name":"Zhijie Chen¹","email":"","orcid":"","institution":"Guangdong Sanjiu Brain Hospital","correspondingAuthor":false,"prefix":"","firstName":"Zhijie","middleName":"","lastName":"Chen¹","suffix":""},{"id":476139273,"identity":"5e88d6a7-6ec6-405b-978f-ccc72abb5e9f","order_by":4,"name":"Xubiao Zhang¹","email":"","orcid":"","institution":"Guangdong Sanjiu Brain Hospital","correspondingAuthor":false,"prefix":"","firstName":"Xubiao","middleName":"","lastName":"Zhang¹","suffix":""},{"id":476139277,"identity":"599790c6-9872-4213-b882-d850864dc2f2","order_by":5,"name":"Da Liu¹","email":"","orcid":"","institution":"Guangdong Sanjiu Brain Hospital","correspondingAuthor":false,"prefix":"","firstName":"Da","middleName":"","lastName":"Liu¹","suffix":""},{"id":476139279,"identity":"c4c32e58-81b4-4bcd-a346-fa556d6c1db9","order_by":6,"name":"Yuanyuan Mo¹","email":"","orcid":"","institution":"Guangdong Sanjiu Brain Hospital","correspondingAuthor":false,"prefix":"","firstName":"Yuanyuan","middleName":"","lastName":"Mo¹","suffix":""},{"id":476139293,"identity":"29cd1b7b-2eab-49c0-9d0d-5a53b8010a86","order_by":7,"name":"Hainan Li³","email":"","orcid":"","institution":"Guangdong Sanjiu Brain Hospital","correspondingAuthor":false,"prefix":"","firstName":"Hainan","middleName":"","lastName":"Li³","suffix":""},{"id":476139296,"identity":"6fa10764-7222-4fc4-a541-72c1186c52f1","order_by":8,"name":"Tao Lin¹","email":"","orcid":"","institution":"Guangdong Sanjiu Brain Hospital","correspondingAuthor":false,"prefix":"","firstName":"Tao","middleName":"","lastName":"Lin¹","suffix":""}],"badges":[],"createdAt":"2025-05-14 13:38:17","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-6664715/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6664715/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":85753029,"identity":"107862bf-3fd6-4454-a435-b5a33cd98ba4","added_by":"auto","created_at":"2025-07-01 10:30:01","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":436701,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eCT Angiography (CTA) Images of a Pediatric High-Grade Glioma (pHGG) with Associated Arteriovenous Malformations (AVMs).\u003c/strong\u003e\u003cbr\u003e\n (A) Axial non-contrast CT scan showing a mixed-density lesion in the right frontal lobe. (B) Post-contrast axial CT scan revealing heterogeneous enhancement within the lesion; the white arrow indicates a prominent vessel potentially representing a feeding artery or part of the AVM nidus. (C) Another axial CT image demonstrating a high-density, serpiginous vascular structure posterior to the enhancing tumor mass, consistent with an AVM. (D) Three-dimensional (3D) reconstructed CTA image illustrating the complex vascular architecture, clearly delineating feeding arteries originating from the MCA territory and draining veins associated with the AVM.\u003c/p\u003e","description":"","filename":"floatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-6664715/v1/baa3a53776fd58c276a21073.png"},{"id":85752246,"identity":"ebd78e1c-b346-4ea3-999a-8970e34831d5","added_by":"auto","created_at":"2025-07-01 10:22:01","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":583723,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eMagnetic Resonance Imaging (MRI) Findings (Pre- and Post-operative).\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e(A) Pre-operative axial T1-weighted image reveals a heterogeneous, predominantly isointense mass in the right frontal lobe. (B) Pre-operative axial T2-weighted image demonstrates significant surrounding vasogenic edema (hyperintensity) and multiple punctate and linear flow voids within and adjacent to the mass, suggestive of high-flow pathological vessels. (C) Pre-operative post-contrast axial T1-weighted image shows intense, heterogeneous enhancement of the solid tumor component, intimately associated with enhancing vascular structures. (D) Pre-operative post-contrast sagittal T1-weighted image delineates the craniocaudal extent of the tumor and the associated vascular malformation. (E) Post-operative axial T1-weighted image shows the resection cavity with expected post-surgical changes, indicating gross total removal. (F) Post-operative axial T2-weighted sequence demonstrates marked resolution of the pre-existing vasogenic edema and normalization of signal in the adjacent brain parenchyma. (G) Post-operative post-contrast axial T1-weighted image confirms complete resection with no evidence of residual enhancing tumor or AVM. (H) Post-operative post-contrast sagittal T1-weighted image further confirms the excellent surgical outcome with no residual pathology.\u003c/p\u003e","description":"","filename":"floatimage2.png","url":"https://assets-eu.researchsquare.com/files/rs-6664715/v1/6412d1f38c2196ea4c336a1f.png"},{"id":85752251,"identity":"cba68304-b3b0-47c5-a087-54dc76ca69f1","added_by":"auto","created_at":"2025-07-01 10:22:01","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":402584,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eDigital Subtraction Angiography (DSA) and Embolization.\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e(A, B) Pre-operative DSA images (anteroposterior and lateral projections) reveal a compact AVM nidus located in the right frontal region. Enlarged arterial feeders arising from branches of the right middle cerebral artery (MCA) supply the nidus, with evidence of early venous drainage into superficial cortical veins, characteristic of arteriovenous shunting. (C,D) Post-embolization DSA images (anteroposterior and lateral projections) demonstrate significant reduction (approximately 80%) of flow within the AVM nidus following injection of NBCA glue cast (visible as radiopaque material), with preservation of normal cerebral vasculature.\u003c/p\u003e","description":"","filename":"floatimage3.png","url":"https://assets-eu.researchsquare.com/files/rs-6664715/v1/501e7c4520926256ec330165.png"},{"id":85752243,"identity":"2c0053d2-6031-4ffb-be0d-dd9b7c5376f5","added_by":"auto","created_at":"2025-07-01 10:22:01","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":1529675,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eIntraoperative and Pathological Findings.\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e(A) Intraoperative view after craniotomy. Indocyanine green (ICG) videoangiography performed before resection showed rapid filling of the AVM feeders (red arrow indicates a prominent feeding artery) and nidus, confirming high flow. (B) Surgical exposure revealing the AVM nidus (red circle), partially filled with embolic material post-embolization, and associated draining veins (white arrow). (C) The tumor mass (green circle), located posterior to the AVM, exhibiting a grayish, soft, \"fish-flesh\" appearance typical of high-grade glioma. (D, E, F) Histopathological examination (Hematoxylin and Eosin stain): (D) High cellularity with nuclear atypia and pleomorphism. (E) Perivascular arrangement of tumor cells and prominent microvascular proliferation. (F) Mitotic figures (arrowhead) and multinucleated giant cells are visible. Immunohistochemistry (not shown in figure panels but described in text) revealed GFAP(+), Olig-2(+), ATRX (retained nuclear expression, +), Ki-67 index ~40%, and IDH1-R132H(-).\u003c/p\u003e","description":"","filename":"floatimage4.png","url":"https://assets-eu.researchsquare.com/files/rs-6664715/v1/fe3e00ea667fdf0ebe4225bb.png"},{"id":100237070,"identity":"7c3bf305-1916-4e12-9103-860cb4868571","added_by":"auto","created_at":"2026-01-14 12:40:38","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":4402478,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6664715/v1/72c55d4a-9ad8-42f6-8d7a-d9ba85f4d7fe.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Co-occurrence of Pediatric-Type Diffuse High-Grade Gliomas with Arteriovenous Malformations: Case Report and Literature Review","fulltext":[{"header":"Case presentation","content":"\u003cp\u003e\u003cstrong\u003eClinical History and Physical Examination\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eA 14-year-old male presented to our emergency department with a two-week history of progressive neurological deterioration. The clinical manifestation began with focal motor seizures affecting the left side, which escalated in frequency from once daily to three episodes per day. Gradually, the patient exhibited worsening alteration of consciousness. Past medical history was unremarkable, and family history revealed no neurological disorders or malignancies. On admission, vital signs were within normal parameters (BP: 118/76 mmHg, HR: 82 bpm, T: 36.8\u0026deg;C).\u0026nbsp;Neurological assessment revealed a Glasgow Coma Scale (GCS) score of 14 (E4V4M6), bilateral papilledema, and mild left hemiparesis with muscle strength 4/5. Babinski signs and meningeal irritation signs were negative.\u003c/p\u003e\n\u003ch3\u003eDiagnostic Workup\u003c/h3\u003e\n\u003cp\u003eStandard laboratory investigations, including complete blood count, coagulation profile, and serum tumor markers, were all within normal limits. Computed Tomography Angiography (CTA) and Magnetic Resonance Imaging (MRI) were performed. CTA revealed a mixed-density lesion in the right frontal lobe suggestive of a tumor, with heterogeneous enhancement post-contrast (Fig. 1A, B). A high-density vascular pattern posterior to the tumor, consistent with an AVM, was also noted (Fig. 1C). 3D reconstructed CTA clearly delineated the complex vascular architecture, including feeding arteries and draining veins (Fig. 1D). MRI confirmed a heterogeneous mass in the right frontal lobe with mixed signal intensity on T1-weighted images (Fig. 2A) and significant surrounding vasogenic edema along with flow voids suggestive of pathological vessels on T2-weighted images (Fig. 2B). Post-contrast T1-weighted images demonstrated intense, heterogeneous enhancement of the tumor and associated complex vascular components (Fig. 2C, D). Digital Subtraction Angiography (DSA) confirmed the presence of a Spetzler-Martin grade I AVM, characterized by a compact nidus fed primarily by branches of the right middle cerebral artery (MCA) with early venous drainage (Fig. 3A, B).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003ePre-operative Management and Surgical Intervention\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe patient was initially stabilized with antiseizure medication (Levetiracetam) and corticosteroids to manage cerebral edema. Given the vascular nature of the AVM component, preoperative endovascular embolization was performed. Using N-butyl cyanoacrylate (NBCA), approximately 80% reduction in blood flow to the AVM nidus was achieved (Fig. 3C, D show post-embolization status, though labeled as post-operative in the original legend, context implies pre-operative embolization result). Subsequently, the patient underwent a right frontotemporal craniotomy. Utilizing intraoperative neuromonitoring and microsurgical techniques, complete resection of both the tumor and the embolized AVM was achieved. Intraoperative indocyanine green (ICG) videoangiography confirmed the absence of residual AVM flow (Fig. 4A). The surgical field showed the embolized AVM nidus and draining veins (Fig. 4B), distinct from the posterior tumor mass which had a characteristic \u0026quot;fish-flesh\u0026quot; appearance (Fig. 4C).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003ePathological Analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eMicroscopic examination of the resected tissue revealed a highly cellular neoplasm characterized by significant nuclear atypia, cellular pleomorphism, and frequent mitotic figures (Fig. 4D, E, F show representative histology). Features included ovoid cells, perivascular pseudorosettes, and occasional multinucleated giant cells. Microvascular proliferation was prominent. Immunohistochemical staining showed strong positivity for Glial Fibrillary Acidic Protein (GFAP) and Oligodendrocyte transcription factor 2 (Olig-2). Expression of ATRX was retained (positive). The Ki-67 proliferation index was approximately 40%. Molecular analysis confirmed the tumor was H3-wildtype and IDH-wildtype (IDH1-R132H negative by IHC). Mismatch repair (MMR) protein expression was preserved. Based on these integrated histological and molecular features, the final diagnosis was pediatric-type diffuse high-grade glioma, H3-wildtype and IDH-wildtype, WHO grade IV.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003ePost-operative Course and Follow-up\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe patient\u0026apos;s post-operative recovery was uneventful, with resolution of his hemiparesis and no new neurological deficits. Post-operative MRI confirmed gross total resection of both the tumor and the AVM, with no residual enhancement and resolution of edema (Fig. 2E, F, G, H). Adjuvant therapy consisted of fractionated external beam radiation therapy to the tumor bed (total dose 60 Gy in 30 fractions) with concurrent and adjuvant temozolomide chemotherapy according to the Stupp protocol. The patient tolerated the treatment well. He remained clinically stable and tumor-free on serial MRI scans during the 24-month follow-up period, monitored with monthly clinical assessments and quarterly MRI surveillance.\u003c/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eLiterature Review\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTo better understand the coexistence of gliomas and AVMs, a comprehensive literature review was conducted. As of April 2025, 8 cases of concurrent glioma and AVMs have been documented in the literature[10, 13-19] detailed in Table 1. Among these cases, 7 were male and 1 was female, with an age range of 20-62 years. Regarding tumor grading, Grade IV glioblastoma (GBM) was identified in 6 cases, while Grade II astrocytoma/LGG was found in 2 cases. AVM Spetzler-Martin grading revealed Grade I in 3 cases, Grade II in 2 cases, Grade III in 2 cases, and unspecified in 1 case. Preoperative embolization was performed in 1 case, while complete surgical resection was achieved in 6 cases. Adjuvant therapy was administered in 5 cases. At final follow-up, 4 patients had died with survival periods of 7-8 months, while 4 patients remained alive with follow-up durations of 12-18 months.\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003ePediatric-type diffuse high-grade gliomas (pDHGG) are newly defined as a category of diseases in the fifth edition of the World Health Organization Classification of Tumors of the Central Nervous System (2021)[1,2]. Compared with their adult counterparts, these tumors have unique molecular features and clinical manifestations. Characterized by specific genetic alterations, such as histone H3 mutations or changes in the MAPK pathway, they pose significant therapeutic challenges in pediatric neuro-oncology[3,4]. The molecular spectrum of pDHGG is complex, often involving driver mutations that affect chromatin remodeling and epigenetic regulation. These mutations profoundly influence tumor biology, treatment response, and overall prognosis[5,6]. Standard treatment usually includes maximal safe surgical resection followed by adjuvant radiochemotherapy, yet the outcomes for many patients remain suboptimal[4,7].\u003c/p\u003e\n\u003cp\u003eThe co-occurrence of primary brain tumors with cerebral arteriovenous malformations (AVMs) is extremely rare, with reported incidences ranging from 0.2% to 2.4% in case series[8,9]. Although high-grade gliomas are known for their inherent vascularity and tumor-associated angiogenesis, the presence of a true, independent AVM adds unique diagnostic complexities and management challenges, especially regarding surgical strategy and bleeding risks[10,11]. The potential pathogenic mechanisms underlying the association of these two distinct entities, particularly in the pediatric population, remain largely speculative, with theories including shared genetic susceptibility and tumor-induced vascular remodeling[9,12].\u003c/p\u003e\n\u003cp\u003eOur patient represents the youngest case of pediatric diffuse high-grade glioma with concomitant AVM reported to date. Our molecular characterization confirmed an H3-wildtype and IDH-wildtype status, aligning with the newly defined entity of pDHGG in the 2021 WHO classification[1, 2]. The immunohistochemical profile (GFAP+, Olig-2+, ATRX retained) further supports this diagnosis and helps distinguish it from other pediatric high-grade glioma subtypes, such as those with H3 K27M mutations or IDH mutations[3, 4, 9]. Morphological assessment definitively confirmed the presence of arteriovenous malformations. The molecular mechanisms underlying this dual pathology remain speculative. Theories include shared genetic or epigenetic alterations affecting both glial cell differentiation and vascular development, or the induction of vascular changes by tumor-secreted factors like Vascular Endothelial Growth Factor (VEGF)[5, 8, 20]. The close anatomical relationship observed might suggest either a collision phenomenon or a potential shared pathogenic pathway[9].\u003c/p\u003e\n\u003cp\u003eFrom a management perspective, this case highlights the challenges posed by the high vascularity of the combined lesion. Literature review revealed that previous cases primarily underwent direct surgical resection, with only one patient receiving preoperative embolization[19]. Moreover, limited by various factors, complete resection was not achieved in some patients. We implemented a staged therapeutic approach—preoperative embolization followed by complete microsurgical resection. The preoperative embolization likely facilitated a safer and more complete resection by reducing intraoperative bleeding risk associated with the AVM component.\u003c/p\u003e\n\u003cp\u003eThe clinical outcome in our patient, demonstrating 24-month disease-free survival, represents a favorable prognosis compared to current standards. Literature review indicated that half of the previously reported cases survived less than one year, with the longest follow-up period among survivors being 18 months[10, 13-19]. This improved outcome underscores the potential benefits of modern, comprehensive treatment strategies, including advanced neuroimaging, endovascular techniques, meticulous microsurgery, and standardized adjuvant chemoradiation, even in the face of such complex dual pathologies[21]. Our experience reinforces several critical principles for managing similar rare cases. Detailed preoperative vascular assessment utilizing multimodal imaging, including MRI, CTA, and DSA, is essential for accurately mapping tumor extent and AVM angioarchitecture (feeders, nidus, drainage) to plan effective intervention[22]. For lesions with a significant AVM component, a staged interventional approach incorporating preoperative embolization can be invaluable in reducing surgical risks and facilitating complete resection[11, 21]. Equally important is accurate histopathological and molecular diagnosis according to WHO 2021 criteria, which is vital for prognostication and guiding adjuvant therapy, especially in distinguishing pDHGG subtypes[1, 2, 23].\u003c/p\u003e\n\u003cp\u003eDespite the valuable insights provided by this study, we acknowledge the limitations of a single case report. Our findings regarding the molecular mechanisms underlying this dual pathology, the long-term efficacy of staged treatment, and the universal applicability of modern comprehensive treatment strategies require further validation through larger sample studies. Sustained surveillance through long-term clinical and radiological follow-up remains necessary due to the aggressive nature of pDHGG and the potential, albeit low, risk of AVM recurrence or delayed complications[12].\u003c/p\u003e\n\u003cp\u003eThese findings not only advance our understanding of the management of complex pediatric brain tumor cases involving vascular malformations but also establish a foundation for refining therapeutic strategies in pediatric neuro-oncology.\u003c/p\u003e\n"},{"header":"Conclusions","content":"\u003cp\u003eWe report a rare case of concurrent pediatric-type diffuse high-grade glioma and arteriovenous malformation in a 14-year-old boy. Our management strategy\u0026mdash;preoperative embolization, complete microsurgical resection, and adjuvant therapy\u0026mdash;achieved 24-month disease-free survival. This case underscores the value of comprehensive vascular imaging, staged interventional approaches, and accurate molecular diagnosis in managing complex dual pathologies. The favorable outcome demonstrates the efficacy of modern multidisciplinary approaches and provides valuable insights for treating these rare conditions. Future research should explore the molecular mechanisms underlying this co-occurrence and develop standardized treatment protocols.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eAVM: Arteriovenous Malformation\u003c/p\u003e\n\u003cp\u003eBP: Blood Pressure\u003c/p\u003e\n\u003cp\u003eCT: Computed Tomography\u003c/p\u003e\n\u003cp\u003eCTA: Computed Tomography Angiography\u003c/p\u003e\n\u003cp\u003eDSA: Digital Subtraction Angiography\u003c/p\u003e\n\u003cp\u003eGBM: Glioblastoma Multiforme\u003c/p\u003e\n\u003cp\u003eGCS: Glasgow Coma Scale\u003c/p\u003e\n\u003cp\u003eGFAP: Glial Fibrillary Acidic Protein\u003c/p\u003e\n\u003cp\u003eHR: Heart Rate\u003c/p\u003e\n\u003cp\u003eRT: radiotherapy\u003c/p\u003e\n\u003cp\u003eTMZ :Temozolomide；\u003c/p\u003e\n\u003cp\u003eICG: Indocyanine Green\u003c/p\u003e\n\u003cp\u003eIDH: Isocitrate Dehydrogenase\u003c/p\u003e\n\u003cp\u003eLGG low-grade gliom\u003c/p\u003e\n\u003cp\u003eMAPK: Mitogen-Activated Protein Kinase\u003c/p\u003e\n\u003cp\u003eMRI: Magnetic Resonance Imaging\u003c/p\u003e\n\u003cp\u003eNBCA: N-Butyl Cyanoacrylate\u003c/p\u003e\n\u003cp\u003eNED: No Evidence of Disease\u003c/p\u003e\n\u003cp\u003epDHGG: Pediatric-type Diffuse High-Grade Glioma\u003c/p\u003e\n\u003cp\u003ePXA :Pleomorphic Xanthoastrocytoma;\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eVEGF: Vascular Endothelial Growth Factor\u003c/p\u003e\n\u003cp\u003eWHO: World Health Organization\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eAcknowledgements\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eYQZ: Roles/Writing - original draf, Formal analysis, Writing - review \u0026amp; editing. KC: Writing - review \u0026amp; editing, Data curation, Formal analysis. TS: Funding acquisition, Formal analysis. ZJC: Data curation, Resources. XBZ: Supervision. DL: Investigation, Writing - review \u0026amp; editing. YYM: Resources; Software.HNL:Pathological Evidence ;TL: Conceptualization, Funding acquisition.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eData availability\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWritten informed consent for the publication of identifying images or other personal or clinical details was obtained from the parents or legal guardians of all participants involved.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthics Statement\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study was approved by the Medical Ethics Committee of Guangdong Sanjiu Brain Hospital (Document No.AF/SW-08/02.0, Approval No. Medical Letter (2025) No. 3). The study was conducted in accordance with the Declaration of Helsinki and followed the ethical principles outlined in the International Ethical Guidelines for Biomedical Research Involving Human Subjects by the Council for International Organizations of Medical Sciences (CIOMS).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConflicts of Interest\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare no conflicts of interest.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNo funding.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003e\u003cspan\u003eLouis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol. 2021;23(8):1231-51.https://doi.10.1093/neuonc/noab106.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eBender K, Kahn J, Perez E, Ehret F, Roohani S, Capper D et al. Diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype: case series of a new entity. Brain Tumor Pathol. 2023;40(4):204\u0026thinsp;\u0026ndash;\u0026thinsp;14.https://doi.10.1007/s10014-023-00468-3.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eCastel D, Kergrohen T, Tauzi\u0026egrave;de-Espariat A, Mackay A, Ghermaoui S, Lechapt E et al. Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation. Acta Neuropathol. 2020;139(6):1109-13.https://doi.10.1007/s00401-020-02142-w.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eMackay A, Burford A, Carvalho D, Izquierdo E, Fazal-Salom J, Taylor KR et al. Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. Cancer Cell. 2017;32(4):520\u0026thinsp;\u0026ndash;\u0026thinsp;37.e5.https://doi.10.1016/j.ccell.2017.08.017.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eWu G, Diaz AK, Paugh BS, Rankin SL, Ju B, Li Y et al. The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nat Genet. 2014;46(5):444\u0026thinsp;\u0026ndash;\u0026thinsp;50.https://doi.10.1038/ng.2938.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eSchwartzentruber J, Korshunov A, Liu XY, Jones DT, Pfaff E, Jacob K et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature. 2012;482(7384):226\u0026thinsp;\u0026ndash;\u0026thinsp;31.https://doi.10.1038/nature10833.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eCastel D, Philippe C, Calmon R, Le Dret L, Truffaux N, Boddaert N et al. Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes. Acta Neuropathol. 2015;130(6):815\u0026thinsp;\u0026ndash;\u0026thinsp;27.https://doi.10.1007/s00401-015-1478-0.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eBender S, Tang Y, Lindroth AM, Hovestadt V, Jones DT, Kool M et al. Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. Cancer Cell. 2013;24(5):660\u0026thinsp;\u0026ndash;\u0026thinsp;72.https://doi.10.1016/j.ccr.2013.10.006.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eKorshunov A, Schrimpf D, Ryzhova M, Sturm D, Chavez L, Hovestadt V et al. H3-/IDH-wild type pediatric glioblastoma is comprised of molecularly and prognostically distinct subtypes with associated oncogenic drivers. Acta Neuropathol. 2017;134(3):507\u0026thinsp;\u0026ndash;\u0026thinsp;16.https://doi.10.1007/s00401-017-1710-1.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eGuo P, Sun W, Song LX, Cao WY, Li JP. Multimodal imaging for the diagnosis of oligodendroglioma associated with arteriovenous malformation: A case report. World J Radiol. 2024;16(8):348\u0026thinsp;\u0026ndash;\u0026thinsp;55.https://doi.10.4329/wjr.v16.i8.348.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eGmeiner M, Sonnberger M, Wurm G, Weis S. Glioblastoma with the appearance of arteriovenous malformation: pitfalls in diagnosis. Clin Neurol Neurosurg. 2013;115(5):501-6.https://doi.10.1016/j.clineuro.2012.12.009.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eSolomon RA, Connolly ES. Jr. Arteriovenous Malformations of the Brain. N Engl J Med. 2017;376(19):1859-66.https://doi.10.1056/NEJMra1607407.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eLi CR, Chen SY, Yang MY, Cheng WY, Shen CC. A Rare Triploid Involving the Coexistence of Glioblastoma Multiforme, Arteriovenous Malformation and Intracranial Aneurysm: Illustrative Case and Literature Review. Medicina (Kaunas). 2023;59(2).https://doi.10.3390/medicina59020331.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eTunthanathip T, Kanjanapradit K. Glioblastoma Multiforme Associated with Arteriovenous Malformation: A Case Report and Literature Review. Ann Indian Acad Neurol. 2020;23(1):103-6.https://doi.10.4103/aian.AIAN_219_18.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eChen J, Chen L, Zhang C, He J, Li P, Zhou J et al. Glioma coexisting with angiographically occult cerebrovascular malformation: A case report. Oncol Lett. 2016;12(4):2545-9.https://doi.10.3892/ol.2016.4916.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eLohkamp LN, Strong C, Rojas R, Anderson M, Laviv Y, Kasper EM. Hypervascular glioblastoma multiforme or arteriovenous malformation associated Glioma? A diagnostic and therapeutic challenge: A case report. Surg Neurol Int. 2016;7(Suppl 37):S883-s8.https://doi.10.4103/2152-7806.194506.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eNagańska E, Matyja E, Pucko E, Ząbek M. The coexistence of pleomorphic xanthoastrocytoma and arteriovenous malformation. A case report. Folia Neuropathol. 2013;51(3):269\u0026thinsp;\u0026ndash;\u0026thinsp;74\u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e.https://doi.10.5114/fn.2013.37712\u003c/span\u003e\u003cspan address=\"http://.https://doi.10.5114/fn.2013.37712\" targettype=\"URL\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eAucourt J, Jissendi P, Kerdraon O, Baroncini M. Neuroimaging features and pathology of mixed glioblastoma\u0026ndash;AVM complex: a case report. J Neuroradiol. 2012;39(4):258\u0026thinsp;\u0026ndash;\u0026thinsp;62\u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e.https://doi.10.1016/j.neurad.2011.11.001\u003c/span\u003e\u003cspan address=\"http://.https://doi.10.1016/j.neurad.2011.11.001\" targettype=\"URL\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eCemil B, Tun K, Polat O, Ozen O, Kaptanoglu E. Glioblastoma multiforme mimicking arteriovenous malformation. Turk Neurosurg. 2009;19(4):433\u0026ndash;6.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eBrat DJ, Aldape K, Colman H, Figrarella-Branger D, Fuller GN, Giannini C et al. cIMPACT-NOW update 5: recommended grading criteria and terminologies for IDH-mutant astrocytomas. Acta Neuropathol. 2020;139(3):603-8.https://doi.10.1007/s00401-020-02127-9.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eAl-Smadi AS, Ansari SA, Shokuhfar T, Malani A, Sattar S, Hurley MC et al. Safety and outcome of combined endovascular and surgical management of low grade cerebral arteriovenous malformations in children compared to surgery alone. Eur J Radiol. 2019;116:8\u0026ndash;13.https://doi.10.1016/j.ejrad.2019.02.016.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eSturm D, Bender S, Jones DT, Lichter P, Grill J, Becher O et al. Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge. Nat Rev Cancer. 2014;14(2):92\u0026ndash;107.https://doi.10.1038/nrc3655.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eKarremann M, Gielen GH, Hoffmann M, Wiese M, Colditz N, Warmuth-Metz M et al. Diffuse high-grade gliomas with H3 K27M mutations carry a dismal prognosis independent of tumor location. Neuro Oncol. 2018;20(1):123\u0026thinsp;\u0026ndash;\u0026thinsp;31.https://doi.10.1093/neuonc/nox149.\u003c/span\u003e\u003c/li\u003e\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp\u003eTable 1. Literature Review of Cases with Concurrent Glioma and Arteriovenous Malformations\u003c/p\u003e\n\u003cp\u003e\u003cimg 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\"\u003e\u003c/p\u003e\n\u003cp\u003eM, male; F, female; GBM, glioblastoma multiforme; pDHGG, pediatric-type diffuse high-grade glioma; WHO, World Health Organization; AVM, arteriovenous malformation;RT, radiotherapy; NED, no evidence of disease; m, months; LGG, low-grade gliom；PXA，Pleomorphic Xanthoastrocytoma; TMZ,Temozolomide.\u003c/p\u003e\n\u003cp\u003e*Combined: Embolization + Surgery + Chemoradiation\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Pediatric-type diffuse high-grade glioma, Arteriovenous malformations, Embolization, Surgical resection","lastPublishedDoi":"10.21203/rs.3.rs-6664715/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6664715/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground: \u003c/strong\u003ePediatric-type diffuse high-grade gliomas (pDHGG) are recognized as a distinct entity in the 2021 WHO Classification of Central Nervous System Tumors, characterized by specific molecular features. Their co-occurrence with cerebral arteriovenous malformations (AVMs) is exceptionally rare, presenting significant diagnostic and therapeutic challenges. Herein, we report a rare case of concurrent pediatric diffuse high-grade glioma (pDHGG, WHO grade IV, H3-wildtype and IDH-wildtype) and a Spetzler-Martin grade I arteriovenous malformation in a pediatric patient.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCase presentation: \u003c/strong\u003eA 14-year-old male presented with recurrent seizures and progressive consciousness disturbance. Clinical assessment and neuroimaging revealed a right frontal lobe tumor (2.2×2.3×2.0 cm) closely associated with a Spetzler-Martin grade I AVM. Following preoperative endovascular embolization, complete microsurgical resection of both the tumor and AVM was achieved. Histopathology and molecular analysis confirmed pediatric diffuse high-grade glioma (WHO grade IV, H3-wildtype, IDH-wildtype). Immunohistochemistry showed positive GFAP and Olig-2, with retained ATRX expression. The patient completed standard adjuvant chemoradiotherapy (60Gy in 30 fractions with concurrent temozolomide) and remained disease-free at the 24-month follow-up. Literature review identified 8 prior cases of concurrent glioma and AVMs, mostly in males (7/8), with 75% being high-grade glioblastomas (WHO grade IV) and various AVM grades (I-III), resulting in 50% mortality despite surgery.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion:\u003c/strong\u003e Our multimodal approach in this rare case of concurrent pDHGG and AVM achieved favorable disease-free survival, highlighting the importance of comprehensive vascular assessment, staged intervention, and molecular diagnosis in managing such complex dual pathologies.\u003c/p\u003e","manuscriptTitle":"Co-occurrence of Pediatric-Type Diffuse High-Grade Gliomas with Arteriovenous Malformations: Case Report and Literature Review","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-07-01 10:21:56","doi":"10.21203/rs.3.rs-6664715/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"3e6e1a69-ecac-4c80-98b3-51d554420531","owner":[],"postedDate":"July 1st, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2026-04-09T10:55:37+00:00","versionOfRecord":[],"versionCreatedAt":"2025-07-01 10:21:56","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-6664715","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-6664715","identity":"rs-6664715","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}