The Effect of Ecklonia stolonifera Extracts on Blood Flow and Serum Lipid Level in Ovariectomized Rats

Young-Kyoung Kim, Min-Hee Jeon, Yong-Soo Park, Yongsoo Park, Hyun-Jung Hwang, Hyunjung Hwang, Sang‐Hyeon Lee, Sang-Hyeon Lee, Sung-Gu Kim, Yuck-Young Kim, Mihyang Kim, Mi-Hyang Kim
Journal of Life Science · 2010 · vol. 20(12) , pp. 1851–1858 · doi:10.5352/jls.2010.20.12.1851 · W2035139281
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Ecklonia stolonifera extract supplementation in ovariectomized rats lowered triglyceride levels, tended to lower total cholesterol, increased HDL-cholesterol, improved blood flow, and reduced platelet aggregation.

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Abstract

Estrogen deficiency in peri- and postmenopausal women results in variety of neurovegetative, psychic and somatic symptoms, and may contribute to severe diseases within the aged female population. Ecklonia stolonifera (ES) is an edible brown algae traditionally used in fishery towns in Far East Asia. This study was performed to investigate the effects of ES extracts on blood flow and serum lipid con-centration in ovariectomized rats. Weight-matched female Sprague-Dawley strain rats were assigned to four groups. Three groups were surgically ovariectomized (OVX). The fourth group was sham operated. Rats were randomly assigned to the following groups: sham-operated rats (Sham), ovariec-tomized control rats (OVX-CON), ovariectomized rats supplemented with ES extract at 50 mg/kg bw/day (OVX-ES50) and ovariectomized rats supplemented with ES extract at 200 mg/kg bw/day (OVX-ES200). Serum total cholesterol and triglyceride contents decreased in the sham group compared to the OVX-CON group. Six weeks feeding of ES extract resulted in a significant (p<0.05) lowering of serum triglyceride and a lowering tendency of total cholesterol level. The level of Hdl-cholesterol in serum increased by supplementation of ES extracts at 50 mg/kg and 200 mg/kg bw/day (p<0.05). Blood passage time of the ES extracts-supplemented group was higher than the OVX-CON group. The ability of platelet aggregation of groups treated with ES extracts was less than that of the OVX-CON

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