Premetastasis

Maru Y, Yoshiro Maru
Cold Spring Harbor perspectives in medicine · 2020 · vol. 10(11) · doi:10.1101/cshperspect.a036897 · PMID:31615874 · PMC7605236
Review OA: closed
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This paper describes how primary tumor secretomes induce sterile inflammation in distant organs to establish a premetastatic microenvironment that regulates the host innate immune system and facilitates metastasis.

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Abstract

Sterile inflammation within primary tumor tissues can spread to distant organs that are devoid of tumor cells. This happens in a manner dependent on tumor-led secretome, before the actual metastasis occurs. The premetastatic microenvironment is established in this way and is at least partly regulated by hijacking the host innate immune system. The biological manifestation of premetastasis include increased vascular permeability, cell mobilization via the blood stream, degradation of the extracellular matrix, immunosuppression, and host antineoplastic activities.

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MeSH descriptors

Neoplasm Metastasis Neoplasms Animals Humans Neoplasm Metastasis Neoplasms Tumor Microenvironment

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References (99)

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