The Correlation Between the Changes of Levels of MCP-1 and IGF-I in Peritoneal Fluid and Pathogenesis of Endometriosis and Infertility

Objective To investigate the role of monocyte chemotactic protein-1(MCP-1)and Insulin-like growth factors -I (IGF-I) in the endometriosis pathogenesis. Methods Peritoneal fluid and ectopic endometrial tissues of 30 patients with endometriosis (10 early stage and 20 severe stage) and 10 no-endometriosis were obtained .The ELISA was employed to measured MCP-1 and IGF-I levels. Results The levels of MCP-1and IGF-I in the peritoneal fluid and ectopic endometrial tissues were significantly elevated in EM group as compared with those in the control group(10cases)(P 0.01);the level of MCP-1of the peritoneal fluid and MCP-1 mass concentration of ectopic endometrial tissues were significantly higher in early stages than those in severe stages(P 0.05), but IGF-Ⅰof the peritoneal fluid was significantly lower in early stages than that in severe stages(P 0.05). Conclusion The changes of MCP-1 and IGF-Ⅰmay play a role in the pathogenesis of endometriotic lesions.