Increased levels of prostaglandin E2 and bcl-2 in peritoneal fluid and serum of patients with endometriosis

李志刚, 郎景和, 冷金花, 刘东远
In: Chin J Obstet Gynecol · 2005 · vol. 40(09) , pp. 598–600 · doi:10.3760/j.issn:0529-567x.2005.09.006 · W3031260811
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Abstract

目的 探讨子宫内膜异位症(内异症)患者腹腔液及血清中,前列腺素E2(PGE2)和bcl-2蛋白的含量变化及其与内异症发病的关系.方法采用酶联免疫吸附法(ELISA)检测36例内异症患者(内异症组,其中Ⅰ、Ⅱ期患者16例,Ⅲ、Ⅳ期患者20例)和30例因卵巢囊肿或浆膜下子宫肌瘤手术患者(对照组)腹腔液及血清PGE2与bcl-2含量.结果内异症组患者腹腔液中PGE2、bcl-2蛋白的含量分别为(1987±532)ng/L、(177±53)U/L,对照组为(386±215) ng/L、(86±21)U/L,两组比较,差异均有统计学意义(P<0.01).Ⅲ、Ⅳ期内异症患者腹腔液中PGE2的含量[(2221±1352)ng/L]较Ⅰ、Ⅱ期患者[(1694±381)ng/L]明显升高,差异也有统计学意义(P<0.01); Ⅲ、Ⅳ期内异症患者腹腔液中bcl-2的含量[(190±63) U/L]较Ⅰ、Ⅱ期患者[(162±49) U/L]升高,差异有统计学意义(P＜0.05).内异症组血清中的PGE2与bcl-2含量[(3787±514)ng/L、(96±44)U/L]均高于对照组[(129±97)ng/L、(53±40)U/L],差异均有统计学意义(P<0.01).Ⅲ、Ⅳ期内异症患者血清中的PGE2含量[(964±290)ng/L]也高于Ⅰ、Ⅱ期患者[(590±362)ng/L],差异也有统计学意义(P<0.01);内异症患者腹腔液中PGE2及bcl-2的含量均高于血清.结论内异症患者腹腔中高含量的PGE2与bcl-2,可能对内异症发病有影响;内异症患者腹腔液与血清中PGE2和bcl-2含量与病变的范围有一定关系。
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子宫内膜异位症患者腹腔液及血清中前列腺素E2与bcl-2蛋白的含量变化及意义 Increased levels of prostaglandin E2 and bcl-2 in peritoneal fluid and serum of patients with endometriosis 摘要目的探讨子宫内膜异位症(内异症)患者腹腔液及血清中,前列腺素E2(PGE2)和bcl-2蛋白的含量变化及其与内异症发病的关系.方法采用酶联免疫吸附法(ELISA)检测36例内异症患者(内异症组,其中Ⅰ、Ⅱ期患者16例,Ⅲ、Ⅳ期患者20例)和30例因卵巢囊肿或浆膜下子宫肌瘤手术患者(对照组)腹腔液及血清PGE2与bcl-2含量.结果内异症组患者腹腔液中PGE2、bcl-2蛋白的含量分别为(1987±532)ng/L、(177±53)U/L,对照组为(386±215) ng/L、(86±21)U/L,两组比较,差异均有统计学意义(P<0.01).Ⅲ、Ⅳ期内异症患者腹腔液中PGE2的含量[(2221±1352)ng/L]较Ⅰ、Ⅱ期患者[(1694±381)ng/L]明显升高,差异也有统计学意义(P<0.01); Ⅲ、Ⅳ期内异症患者腹腔液中bcl-2的含量[(190±63) U/L]较Ⅰ、Ⅱ期患者[(162±49) U/L]升高,差异有统计学意义(P＜0.05).内异症组血清中的PGE2与bcl-2含量[(3787±514)ng/L、(96±44)U/L]均高于对照组[(129±97)ng/L、(53±40)U/L],差异均有统计学意义(P<0.01).Ⅲ、Ⅳ期内异症患者血清中的PGE2含量[(964±290)ng/L]也高于Ⅰ、Ⅱ期患者[(590±362)ng/L],差异也有统计学意义(P<0.01);内异症患者腹腔液中PGE2及bcl-2的含量均高于血清.结论内异症患者腹腔中高含量的PGE2与bcl-2,可能对内异症发病有影响;内异症患者腹腔液与血清中PGE2和bcl-2含量与病变的范围有一定关系. 更多相关知识 - 浏览314 - 被引15 - 下载12 相似文献 - 中文期刊 - 外文期刊 - 学位论文 - 会议论文

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