Extrauterine Low-Grade Endometrial Stromal Sarcoma: A Case Report and Review of the Literature.

Jie-Yu Li, Li JY, Chiu-Hsuan Cheng, Dah‐Ching Ding
Diagnostics (Basel, Switzerland) · 2026 · doi:10.3390/diagnostics16142157 · PMID:42510021 · PMC13409579
OA: gold CC-BY-4.0
📄 Open PDF View on PubMed View at publisher

Abstract

Background and Clinical Significance: The primary occurrence of low-grade endometrial stromal sarcoma (LG-ESS) at extrauterine sites, termed extrauterine ESS (EESS), is exceedingly rare. Case Presentation: A 49-year-old female, gravida 2 para 2 (all deliveries by cesarean section), presented with a 1-month history of epigastric and left upper quadrant abdominal pain. Abdominal computed tomography revealed a lobulated mass, measuring 4.6 cm, in the left upper quadrant with focal attachment to the splenic flexure of the colon. She underwent a laparoscopic partial gastrectomy and colectomy at a referral institution. Surgical pathology identified a 6.0 × 5.0 × 4.0 cm lobulated tumor involving the stomach with colonic invasion, diagnosed as LG-ESS (pT3N0). Immunohistochemistry showed a CD10-reactive lesion. The patient was referred to our institution for definitive gynecological surgery. After prophylactic ureteral double-J catheter insertion, she underwent laparoendoscopic single-site (LESS) total hysterectomy with bilateral salpingo-oophorectomy. The final histopathological examination of the hysterectomy specimen revealed intramural leiomyomas and benign ovarian cysts, with no evidence of ESS within the uterine corpus or adnexa. These findings confirmed a true primary EESS of nonuterine origin, consistent with AJCC stage 3 disease. The patient recovered uneventfully and was discharged during outpatient follow-up. Conclusions: This case represents one of the very few reported instances of primary LG-EESS involving the stomach and colon, simultaneously managed with a staged multidisciplinary surgical approach, including gastrointestinal resection followed by LESS hysterectomy and bilateral salpingo-oophorectomy.

My notes (saved in your browser only)

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (25)

SciLite annotations

chemicals 19
estrogen progestin progestin medroxyprogesterone acetate megestrol acetate letrozole anastrozole estrogen progestin fulvestrant estrogen estrogen tetracycline doxycycline diclofenac estrogen progesterone
organisms 1
noordeloos 2009062

Source provenance

crossref
last seen: 2026-09-07T06:26:59.603401+00:00
europepmc
last seen: 2026-09-06T09:34:12.023084+00:00
scilite
last seen: 2026-09-06T10:05:09.034756+00:00
License: CC-BY-4.0 · commercial use OK · attribution required
Per Europe PMC