Electrochemical Approach on Mechanism of an Oral Progestin in Aqueous Media and its Fully Validated Detection via a Carbon‐Metal Based Composite Sensor

Nurgül K. Bakırhan, Melek Sirin Baymak Celik, Hayati Celik, Bengi Uslu, Síbel A. Özkan
In: Electroanalysis · 2018 · vol. 30(10) , pp. 2273–2283 · doi:10.1002/elan.201800373 · W2810036653
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⚙ AI-generated summary by claude@2026-06, 2026-06-11 ⓘ

This study investigated the electrochemical oxidation mechanism of dienogest and developed a validated nano-based sensor for its sensitive detection in oral medication.

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The paper investigates the electrochemical oxidation mechanism of dienogest, a synthetic oral progestin used in endometrosis, by comparing progestins and studying dienogest in different aqueous media. Using cyclic voltammetry, differential pulse voltammetry, and square wave voltammetry, the authors develop an adsorptive stripping square wave voltammetry method and fabricate a carbon–metal composite sensor based on reduced graphene oxide, gold, and carboxylic-acid functionalized multi-walled carbon nanotubes on a glassy carbon electrode. They report fully validated direct determination of dienogest in Visanne tablets with a calibration range of 2.00×10−7 M to 6.00×10−6 M, and LOD/LOQ of 1.88×10−8 M and 6.27×10−8 M, respectively. The study’s main limitation is that the validation and application are demonstrated specifically in the context of a pharmaceutical tablet matrix rather than broader biological samples. This paper is centrally about endometriosis — it studies dienogest, an oral progestin used for endometrosis, and develops validated electrochemical detection relevant to endometriosis therapeutics.

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Abstract

Abstract Dienogest is a synthetic oral progestogen with unique pharmacological properties that is used orally in the treatment of endometrosis. The first time, the detailed electrochemical mechanism of dienogest is investigated in different aqueous mediums. Different progestins were used to understand completely oxidation mechanism. The electrochemical oxidation of dienogest was investigated systematically by cyclic voltammetry, differential pulse voltammetry, and square wave voltammetry. A simple adsorptive stripping square wave voltammetry method has been developed for the fully validated direct determination of dienogest in Visanne Tablets for the first time. Nano based sensor was fabricated with reduced graphene oxide, gold and carboxylic acid functionalized multi‐walled carbon nanotube materials, and were used on glassy carbon electrode that performed sensitive and validated analysis of dienogest by adsorptive stripping square wave voltammetry. Validation parameters were investigated in detail. The results yielded good precision, accuracy and reproducibility. Calibration range was found as 2.00×10 −7 M to 6.00×10 −6 M, with LOD and LOQ values as 1.88×10 −8 M and 6.27×10 −8 M, respectively. In the future, the developed sensor can be applied in different media such as environment, soil and water for the detection of some progestins or hormones by researchers.
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Electrochemical Approach on Mechanism of an Oral Progestin in Aqueous Media and its Fully Validated Detection via a Carbon-Metal Based Composite Sensor [ X ] Tarih 2018 Dergi Başlığı Dergi ISSN Cilt Başlığı Yayıncı Wiley-VCH Verlag Erişim Hakkı info:eu-repo/semantics/closedAccess Özet Dienogest is a synthetic oral progestogen with unique pharmacological properties that is used orally in the treatment of endometrosis. The first time, the detailed electrochemical mechanism of dienogest is investigated in different aqueous mediums. Different progestins were used to understand completely oxidation mechanism. The electrochemical oxidation of dienogest was investigated systematically by cyclic voltammetry, differential pulse voltammetry, and square wave voltammetry. A simple adsorptive stripping square wave voltammetry method has been developed for the fully validated direct determination of dienogest in Visanne Tablets for the first time. Nano based sensor was fabricated with reduced graphene oxide, gold and carboxylic acid functionalized multi-walled carbon nanotube materials, and were used on glassy carbon electrode that performed sensitive and validated analysis of dienogest by adsorptive stripping square wave voltammetry. Validation parameters were investigated in detail. The results yielded good precision, accuracy and reproducibility. Calibration range was found as 2.00×10?7 M to 6.00×10?6 M, with LOD and LOQ values as 1.88×10?8 M and 6.27×10?8 M, respectively. In the future, the developed sensor can be applied in different media such as environment, soil and water for the detection of some progestins or hormones by researchers. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Açıklama Anahtar Kelimeler Dienogest, Oxidation, Square Wave Voltammetry, Surface Modified Electrode, Validation Kaynak Electroanalysis WoS Q Değeri N/A Scopus Q Değeri Q2 Cilt 30 Sayı 10 Künye Bakirhan, N. K., Celik, M. S. B., Celik, H., Uslu, B., & Ozkan, S. A. (2018). Electrochemical Approach on Mechanism of an Oral Progestin in Aqueous Media and its Fully Validated Detection via a Carbon?Metal Based Composite Sensor. Electroanalysis, 30(10), 2273-2283.

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