Late-onset progression of keratoconus after therapy with selective tissue estrogenic activity regulator

Emilio A. Torres-Netto, Emílio A. Torres-Netto, J. Bradley Randleman, Bradley J. Randleman, Nikki L. Hafezi, Hafezi NL, Hafezi F, Farhad Hafezi
Journal of cataract and refractive surgery · 2019 · doi:10.1016/j.jcrs.2018.08.036 · PMID:30448005
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Abstract

We describe the association of rapid progression of keratoconus in a 49-year-old woman on selective tissue estrogenic activity regulator (STEAR) therapy for endometriosis. Approximately 4 months after initiation of therapy with STEAR therapy and 3 months after ovariectomy, Scheimpflug images showed a massive increase in the previously stable ectasia. During this period, the maximum increase in the keratometry values was 2.7 diopters (D) in the right eye and 3.8 D in the left eye. Corneal crosslinking (CXL) was performed in both eyes. This resulted in excessive flattening of 5.5 D in the right eye and 6.1 D in the left eye at 9 months postoperatively. Patients having STEAR therapy must be monitored closely for corneal changes.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Estrogen Receptor Modulators Keratoconus Keratoconus Norpregnenes Collagen Collagen Corneal Stroma Corneal Stroma Corneal Topography Cross-Linking Reagents Disease Progression Endometriosis Estrogen Receptor Modulators Female Humans Keratoconus Keratoconus Middle Aged Norpregnenes

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[{'doi': '10.13039/100001818', 'name': 'Research to Prevent Blindness, Inc.', 'awards': []}, {'doi': '10.13039/100010649', 'name': 'the International Council of Ophthalmology', 'awards': []}]

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